Dr. Muhammad Mukhtar
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Dr. Muhammad Mukhtar

Professor
American University of Ras Al Khaimah, UAE

Highest Degree
PostDoc Fellow in Biosciences from Thomas Jefferson University, Philadelphia, USA

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Biography

Dr. Muhammad Mukhtar holds a position of Professor of Biotechnology at American University of Ras Al Khaimah, Ras Al Khaimah, United Arab Emirates. He earned his PhD in Biosciences from Drexel University of Philadelphia, Pennsylvania, and M.Phil in Biochemistry from University of Agriculture, Faisalabad. Previously he was appointed as Research Officer/Lecturer in Biochemistry at University of Agriculture, Faisalabad, Pakistan, Graduate Teaching/Research Assistant and Assistant Professor at Drexel University, Philadelphia, PA, Post-Doctoral Fellow/Research Associate and Research Assistant Professor of Medicine at Thomas Jefferson University Medical College (The Sidney Kimmel Medical College at Thomas Jefferson University), and Professor of Biochemistry at Department of Biochemistry, PMAS Arid Agriculture University Rawalpindi, Pakistan. Dr. Mukhtar received honors includes Cholistan Award 2013 for educational services in Pakistan, Asian Education Leadership Award 2012, Award for outstanding contribution in academia, Lifetime Academic Achievement Award, Outstanding Clinical Faculty Award, Outstanding Visa Award for conducting biomedical research in USA, The UNESCO-American Society for Microbiology Travel Award and Sigma Xi First President Award. He is professional member of American Society for Microbiology, International Brain Research Organization (IBRO), Dental Informatics, Online Community, University of Pittsburgh, School of Medicine, PA, USA, National Academic Council of Institute of Policy Studies, Islamabad, Pakistan, The Society for Redox Biology and Medicine, and American Association for the Advancement of Sciences, Washington, DC, USA. Dr. Mukhtar has successfully supervised 7 post doctoral fellow, 2 PhD, 30 Master/MPhil, 5 Advised medical graduates in their residency for clinical research and 50 Undergraduate Students. He also served as member as well as advisor of over 30 different committee. He is member of Middle East Molecular Biology Society (MEMBS) Advisory Board and reviewer for Journal of Virology, Journal of Neurovirology, Virology, Free Radicals Research, Medical Science Monitor, and Protein and Peptide Letters, Journal of AIDS and HIV Research, World Journal of Clinical Infectious Diseases, Cambridge University Press, New York - Life Sciences Book Reviewer, and Bentham Sciences - Biological Sciences Book Reviewer. His research mainly focused on understanding the passage of viruses into brain and devising strategies for protecting brain from viruses and other infectious agents. He has completed 17 funded research projects as principal investigator and co-investigator. He is also acting as Consulting Editor for Neurobehavioral HIV Medicine, Editor for Journal of AIDS and HIV Research, and member, editorial review board for Journal of American Acad Research. He also delivered number of invited lectures at scientific meeting. Dr. Mukhtar has published 68 research articles in international refereed journals as well as 55 conference papers 1 book and 8 book chapters and 9 meeting reports contributed as author/co-author.

Area of Interest:

Biomedical Sciences
100%
Viral Infections
62%
Viral Neuropathogenesis
90%
Meningoencephalitis
75%
Brain Disorders
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Aslam, A., M.I. Shahzad, S. Parveen, H. Ashraf, N. Naz, S.S. Zehra and M. Mukhtar et al., 2016. Evaluation of Antiviral Potential of Different Cholistani Plants against Infectious Bursal Disease and Infectious Bronchitis Virus. Pak. Vet. J., .
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  2. Rasool, K.G., M.A. Khan, A.S. Aldawood, M. Tufail, M. Mukhtar and M. Takeda, 2015. Identification of Proteins Modulated in the Date Palm Stem Infested with Red Palm Weevil (Rhynchophorus ferrugineus Oliv.) Using Two Dimensional Differential Gel Electrophoresis and Mass Spectrometry. Int. J. Mol. Sci., 16: 19326-19346.
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  3. Mukhtar, M. and L.D. Griffin, 2015. Bioremediation-A Beneficial Use of Biotechnology and Allied Engineering Technologies in Oil Producing Regions. Int. J. Sustainable Water Environ. Syst., 7: 83-85.
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  4. Malik, S., S. Ahmad, A. Sadiq, K. Alam, H.M. Wariss, I. Ahmad and M. Mukhtar et al., 2015. A comparative ethno-botanical study of Cholistan (an arid area) and Pothwar (a semi-arid area) of Pakistan for traditional medicines. J. Ethnobiol. Ethnomed., Vol. 11, 10.1186/s13002-015-0018-2.
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  5. Shamim, T., A. Mahmood and M. Mukhtar, 2014. Antihyperglycemic and Hypolipidemic Effects of Methanolic Extract of Euphorbia Prostrata on Alloxan Induced Induced Diabetic Rabbits. Eur. Sci. J., .
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  6. Rasool, K.G., M.A. Khan, A.S. Aldawood, M. Tufail, M. Mukhtar and M. Takeda, 2014. Optimization of protein isolation from date palm plants and its utilization in differential proteomics associated with red palm weevil infestation. Pak. J. Agric. Sci, 51: 907-917.
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  7. Ahmad, S., K. Alam, H.M. Wariss, S. Anjum and M. Mukhtar, 2014. Ethnobotanical Studies of Plant Resources of Cholistan Desert, Pakistan. Int. J. Sci. Res., 3: 1782-1788.
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  8. Wariss, H.M., M. Mukhtar, S. Anjum, G.R. Bhatti, S.A. Pirzada and K. Alam, 2013. Floristic Composition of the Plants of the Cholistan Desert, Pakistan. Am. J. Plant Sci., 4: 58-65.
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  9. Saqib, M.A.N., M. Fatima, I.N. Awan, M.I. Shahzad, S.K.A. Rizvi, M. Mukhtar and A. Khanum, 2013. Optimized conditions for high-level solubilization and purification of recombinant camel growth hormone in Escherichia coli. Afr. J. Biotechnol., 10: 13284-13291.
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  10. Mukhtar, M., K.G. Rasool, M.P. Parrella, Q.I. Sheikh, A. Pain, L.V. Lopez-Llorca and A.S. Aldawood et al., 2011. New Initiatives for Management of Red Palm Weevil Threats to Historical Arabian Date Palms. Florida Entomol., 94: 733-736.
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  11. Parveen, Z., M. Mukhtar and R.J. Pomerantz, 2010. Generation of Retroviral Particles for the Spleen Necrosis Virus (SNV)-Based Vector System and Their Use in Transduction of Various Cell Types. Cold Spring Harbor Protoc., 10.1101/pdb.prot5435.
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  12. Parveen, Z., E. Acheampong, R.J. Pomerantz, M. Mukhtar, K. Goodkin, P. Shapshak and A. Verma, 2009. Neurovirological aspects of HIV infection in the HAART era. In: The spectrum of neuro-AIDS disorders: pathophysiology, diagnosis, and treatment Goodkin, K. et al., (Ed.). ASM Press, pp 123-135.
  13. Arshad, M., I. Hussain, M.Y. Ashraf, S. Noureen and M. Mukhtar, 2009. Study on agromorphological variation in germplasam of Lasiurus scindicus from Cholistan desert, Pakistan. Pak. J. Bot., 41: 1331-1337.
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  14. Ahmad, T., K. Sohail, M. Rizwan, M. Mukhtar, R. Bilal and A. Khanum, 2009. Prevalence of Helicobacter pylori pathogenicity-associated cagA and vacA genotypes among Pakistani dyspeptic patients. FEMS Immunol. Med. Microbiol., 55: 34-38.
    PubMed  |  
  15. Acheampong, E.A., C. Roschel, M. Mukhtar, A. Srinivasan, M. Rafi, R.J. Pomerantz and Z. Parveen, 2009. Combined effects of hyperglycemic conditions and HIV-1 Nef: a potential model for induced HIV neuropathogenesis. Virol. J., Vol. 6, 10.1186/1743-422X-6-183.
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  16. Shahzad, M.I., K. Naeem, M. Mukhtar and A. Khanum, 2008. Passive immunization against highly pathogenic Avian Influenza Virus (AIV) strain H7N3 with antiserum generated from viral polypeptides protect poultry birds from lethal viral infection. Virol. J., 4: 144-144.
    PubMed  |  
  17. Owe-Young, R., N.L. Webster, M. Mukhtar, R.J. Pomerantz, G. Smythe, D. Walker and B.J. Brew, 2008. Kynurenine pathway metabolism in human blood-brain-barrier cells: implications for immune tolerance & neurotoxicity. J. Neurochem., 105: 1346-1357.
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  18. Mukhtar, M., M. Arshad, M. Ahmad, R.J. Pomerantz, B. Wigdahl and Z. Parveen, 2008. Antiviral potentials of medicinal plants. Virus Res., 131: 111-120.
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  19. Parveen, Z., M. Mukhtar and R. Pomerantz, 2007. Spleen Necrosis Virus-Based Vectors. In: Gene Transfer: Delivery and Expression of DNA and RNA - A Laboratory Manual. Friedmann, T. and J.Rossi, (Ed.). Cold Spring Harbor Laboratory Press, pp 83-90.
  20. Parveen, Z., E. Acheampong, R.J. Pomerantz, J.M. Jacobson, B. Wigdahl and M. Mukhtar, 2007. Effects of Highly Active Antiretroviral Therapy on HIV-1-Associated Oral Complications. Curr. HIV Res., 5: 281-292.
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  21. Cheng, X., M. Mukhtar, E.A. Acheampong, A. Srinivasan, M. Rafi, R.J. Pomerantz and Z. Parveen, 2007. HIV-1 Vpr Potently Induces Programmed Cell Death in the CNS in Vivo. DNA Cell Biol., 26: 116-131.
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  22. Argyris, E.G., E. Acheampong, F. Wang, J. Huang, K. Chen, M. Mukhtar and H. Zhang, 2007. The interferon-induced expression of APOBEC3G in human blood-brain barrier exerts a potent intrinsic immunity to block HIV-1 entry to central nervous system. Virol., 367: 440-451.
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  23. Acheampong, E., Z. Parveen, A. Mengistu, N. Ngoubilly and B. Wigdahl et al., 2007. Cholesterol-depleting statin drugs protect postmitotically differentiated human neurons against ethanol- and human immunodeficiency virus type 1-induced oxidative stressIn Vitro. J. Virol., 81: 1492-1501.
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  24. Lossinsky, A.S., A. Jong, M. Fiala, M. Mukhtar, K.F. Buttle and M. Ingram, 2006. The histopathology of Candida albicans invasion in neonatal rat tissues and in the human blood-brain barrier in culture revealed by light, scanning, transmission and immunoelectron microscopy scanning. Histol. Histopathol., 21: 1029-1041.
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  25. Barodka, V.M., E. Acheampong, G. Powell, L. Lobach, D.A. Logan, Z. Parveen and M. Mukhtar, 2006. Antimicrobial effects of liquid anesthetic isoflurane on Candida albicans. J. Transl. Med., 10.1186/1479-5876-4-46.
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  26. Nunnari, G., Y. Xu, E.A. Acheampong, J. Fang, R. Daniel, C. Zhang and R.J. Pomerantz et al., 2005. Exogenous IL-7 induces Fas-mediated human neuronal apoptosis: potential effects during human immunodeficiency virus type 1 infection. J. Neurovirol., 11: 319-328.
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  27. Mukhtar, M., E. Acheampong, Z. Parveen and R.J. Pomerantz, 2005. T-cells and excitotoxicity. NeuroMol. Med., 7: 265-273.
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  28. Mukhtar, M., E. Acheampong, M.A. Khan, M. BouHamdan and R.J. Pomerantz, 2005. Down-modulation of the CXCR4 co-receptor by intracellular expression of a single chain variable fragment (SFv) inhibits HIV-1 entry into primary human brain microvascular endothelial cells and post-mitotic neurons. Mol. Brain Res., 135: 48-57.
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  29. Mukhtar, M., 2005. Human Immunodeficiency Virus Type 1 (Hiv-1) Europathogenesis In In Vitro Models. J. Cell Tissue Res., 5: 507-512.
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  30. Mukhtar, M., 2005. Evolution of biomarkers: drug discovery to personalized medicine. Drug Discovery Today, 10: 1216-1218.
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  31. Marusich, E.I., Z. Parveen, D. Strayer, M. Mukhtar, R.C. Dornburg and R.J. Pomerantz, 2005. Spleen necrosis virus-based vector delivery of anti-HIV-1 genes potently protects human hematopoietic cells from HIV-1 infection. Virol., 332: 258-271.
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  32. Fang, J., E. Acheampong, R. Dave, F. Wang, M. Mukhtar and R.J. Pomerantz, 2005. The RNA helicase DDX1 is involved in restricted HIV-1 Rev function in human astrocytes. Virol., 336: 299-307.
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  33. Chen, W., Z. Tang, P. Fortina, P. Patel, S. Addya, S. Surrey and R.J. Pomerantz et al., 2005. Ethanol potentiates HIV-1 gp120-induced apoptosis in human neurons via both the death receptor and NMDA receptor pathways. Virol., 334: 59-73.
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  34. Acheampong, E.A., Z. Parveen, L.W. Muthoga, V. Wasmuth-Peroud and M. Kalayeh et al., 2005. Molecular interactions of human immunodeficiency virus type 1 with primary human oral Keratinocytes. J. Virol., 79: 8440-8453.
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  35. Acheampong, E.A., Z. Parveen, L.W. Muthoga, M. Kalayeh, M. Mukhtar and R.J. Pomerantz, 2005. Human immunodeficiency virus type 1 Nef potently induces apoptosis in primary human brain microvascular endothelial cells via the activation of caspases. J. Virol., 79: 4257-4269.
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  36. Acheampong, E., M. Mukhtar and R. Pomerantz, 2005. Alcohol and HIV-1 Neuropathogenesis. In: The Neurology of AIDS. Gendelman et al., (Eds.). Oxford University, Press, United Kingdom, pp 541-551.
  37. Zhou, N., J. Fang, M. Mukhtar, E. Acheampong and R.J. Pomerantz, 2004. Inhibition of HIV-1 fusion with small interfering RNAs targeting the chemokine coreceptor CXCR4. Gene Ther., 11: 1703-1712.
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  38. Parveen, Z., M. Mukhtar, A. Goodrich, E. Acheampong, R. Dornburg and R.J. Pomerantz,, 2004. Cross-packaging of human immunodeficiency virus type 1 vector RNA by spleen necrosis virus proteins: Construction of a new generation of spleen necrosis virus-derived retroviral vectors. J. Virol., 78: 6480-6488.
    PubMed  |  Direct Link  |  
  39. Mukhtar, M., R. Dornburg and R. Pomerantz, 2004. Gene Therapy and HIV-1 Infection. In: Gene and Cell Therapy: Therapeutic Mechanisms and Strategies. Templeton, N. (Ed.). Marcel Dekker, Inc., New York, pp 641- 656.
  40. Argyris, E.G., J. Kulkosky, M.E. Meyer, Y. Xu, M. Mukhtar, R.J. Pomerantz and K.J. Williams, 2004. The perlecan heparan sulfate proteoglycan mediates cellular uptake of HIV-1 Tat through a pathway responsible for biological activity. Virol., 330: 481-486.
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  41. Zhou, N., X. Fan, M. Mukhtar, J. Fang, C.A. Patel, G.C. DuBois and R.J. Pomerantz, 2003. Cell-cell fusion and internalization of the CNS-based, HIV-1 co-receptor, APJ. Virol., 307: 22-36.
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  42. Zhou, N., J. Fang, E. Acheampong, M. Mukhtar and R.J. Pomerantz, 2003. Binding of ALX40-4C to APJ, a CNS-based receptor, inhibits its utilization as a co-receptor by HIV-1. Virol., 312: 196-203.
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  43. Parveen, Z., M. Mukhtar, M. Rafi, D.A. Wenger and K.M. Siddiqui et al., 2003. Cell-type-specific gene delivery into neuronal cells in vitro and in vivo. J. Virol., 314: 74-83.
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  44. Fan, X., N. Zhou, X. Zhang, M. Mukhtar, Z. Lu, J. Fang and R.J. Pomerantz et al., 2003. Structural and Functional Study of the Apelin-13 Peptide, an Endogenous Ligand of the HIV-1 Coreceptor, APJ. Biochem., 42: 10163-10168.
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  45. Argyris, E.G., E. Acheampong, G. Nunnari, M. Mukhtar, K.J. Williams and R.J. Pomerantz, 2003. Human immunodeficiency virus type 1 enters primary human brain microvascular endothelial cells by a mechanism involving cell surface proteoglycans independent of lipid rafts. J. Virol., 77: 12140-12151.
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  46. Patel, C.A., M. Mukhtar, S. Harley, J. Kulkosky and R.J. Pomerantz, 2002. Lentiviral expression of HIV-1 Vpr induces apoptosis in human neurons. J. Neurovirol., 8: 86-99.
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  47. Mukhtar, M., S. Harley, P. Chen, M. BouHamdan, C. Patel, E. Acheampong and R.J. Pomerantz, 2002. Primary Isolated Human Brain Microvascular Endothelial Cells Express Diverse HIV/SIV-Associated Chemokine Coreceptors and DC-SIGN and L-SIGN. Virol., 297: 78-88.
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  48. Acheampong, E., M. Mukhtar, Z. Parveen, N. Ngoubilly, N. Ahmad, C. Patel and R.J. Pomerantz, 2002. Ethanol Strongly Potentiates Apoptosis Induced by HIV-1 Proteins in Primary Human Brain Microvascular Endothelial Cells. Virol., 304: 222-234.
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  49. Mukhtar, M., Z. Parveen and R.J. Pomerantz, 2001. AIDS Vaccine 2001. Advances in AIDS research. IDrugs 4: 1144-1146.
  50. BouHamdan, M., D.S. Strayer, D. Wei, M. Mukhtar, L.X. Duan, J. Hoxie and R.J. Pomerantz, 2001. Inhibition of HIV-1 infection by down-regulation of the CXCR4 co-receptor using an intracellular single chain variable fragment against CXCR4. Gene Ther., 8: 408-418.
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  51. Patel, C.A., M. Mukhtar and R.J. Pomerantz, 2000. Vpr induces apoptosis in human neuronal cells. j.virol., 74: 9717-9726.
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  52. Mukhtar, M., Z. Parveen and R.J. Pomerantz, 2000. Technology evaluation: PRO-542, Progenics Pharmaceuticals inc. Curr. Opin. Mol. Ther., 2: 697-702.
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  53. Mukhtar, M., H. Duke, M. Bouhamdan and R.J. Pomerantz, 2000. Anti-Human Immunodeficiency Virus Type 1 Gene Therapy in Human Central Nervous System-Based Cells: An Initial Approach against a Potential Viral Reservoir. Hum. Gene Ther., 11: 347-359.
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  54. Shaheen, F., A.V. Sison, L. McIntosh, M. Mukhtar and R.J.J. Pomerantz, 1999. Analysis of HIV-1 in the cervicovaginal secretions and blood of pregnant and nonpregnant women. Hum. Virol., 2: 154-166.
    PubMed  |  
  55. Mukhtar, M. and R.J. Pomerantz, 1999. Development of an in vitro blood-brain barrier model to study molecular neuropathogenesis and neurovirologic disorders induced by human immunodeficiency virus type 1 infection. J. Hum. Virol., 3: 324-334.
  56. Bagasra, O., M. Amjad and M. Mukhtar, 1999. Liposomes in Gene Therapy. In: Gene Therapy: Principles and Applications. Balnkenstein, T. (Ed.). Birkhauser Verlag, Berlin, pp 61-71.
  57. Mukhtar, M., Z. Parveen and D.A. Logan, 1998. Isolation of RNA from the filamentous fungus Mucor circinelloides. J. Microbiol. Methods, 33: 115-118.
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  58. Mukhtar, M., Z. Parveen and O. Bagasra, 1997. Human Gene Therapy: Dreams to realization. In: Recombinant Protein Protocols: Detection and Isolation (Methods in Molecular Biology). Tuan, R.S. (Ed.). Humana Press, Totowa, New Jersey, pp 415-437.
  59. Mukhtar, M. and O. Bagasra, 1997. Computer Assisted Designing of Primers and Probes. In: In situ PCR Techniques. Bagasra, O. (Ed.). John Wiley & Sons, Inc., New York, ISBN-10: 9780471159469, pp 109-118.
  60. Niikura, M., G. Dornadula, H. Zhang, M. Mukhtar, D. Lingxun, K. Khalili and R.J. Pomerantz et al., 1996. Mechanisms of transcriptional transactivation and restriction of human immunodeficiency virus type I replication in an astrocytic glial cell. Oncogene, 13: 313-322.
  61. Mukhtar, M., N.F. Kaufer and D.A. Logan, 1996. Cloning and sequence analysis of a putative transcription factor (MTF1) gene from Mucor circinelloides. Biochem. Mol. Biol. Int., 38: 791-799.
  62. Mukhtar, M., L. Duan, O. Bagasra and R.J. Pomerantz, 1996. Evaluation of relative promoter strengths of the HIV-1-LTR and a chimeric RSV-LTR in T lymphocytic cells and peripheral blood mononuclear cells: promoters for anti-HIV-1 gene therapies. Gene Ther., 3: 725-730.
  63. Pourrezaei, K., I. Shvets, M. DeLaurentis, R.L. Boxman, R.B. Beard, N. Croitoriu and R. Rastogi et al., 1994. Development of antimicrobial and antithrombogenic coatings for inside and outside of medical catheters. Surf. Coat. Technol., 68-69: 669-674.
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  64. Mukhtar, M., D.A. Logan and N.F. Kaufer, 1994. A procedure to construct partial genomic libraries for gene cloning from fungi. BioTech., 17: 640-642.
  65. Zaman, K., M. Mukhtar, H. Siddique and H. Miszta, 1992. The Effect of Aluminum On the Stromal Cells (in Vitro) On Bone Marrow in Rats. Toxicol. Ind. Health, 8: 103-109.
  66. Mukhtar, M., D.A. Logan and N.F. Kaufer, 1992. The carboxypeptidase Y-encoding gene from Candida albicans and its transcription during yeast-to-hyphae conversion. Gene, 121: 173-177.
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  67. Mukhtar, M. and K.M. Khan, 1988. Present status of nitrates and nitrites in vegetables. Pak. J. Agric. Sci., 25: 314-317.
  68. N. Iqbal, M. Mukhtar and K.M. Khan, 1987. Studies on enzyme activity in normal and saline soils. Pak. J. Agric. Sci., 24: 157-161.
  69. Mukhtar, M. and K.M. Khan, 1982. Effects of salinity on soil catalase, phosphatase and urease transformation of plants residue in soil. Pak. J. Agric. Sci., 19: 79-85.