Dr. Sivakumar Sivagurunathan Moni
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Dr. Sivakumar Sivagurunathan Moni

Assistant Professor
Jazan University, Saudi Arabia

Highest Degree
Ph.D. in Pharmacy from Manonmaniam Sundaranar University, Tirunelveli, Tamil Nadu, India

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Biography

Dr. Sivakumar Sivagurunathan Moni is currently working as Assistant Professor in Division of Pharmaceutical Biotechnology, Department of Pharmaceutics, College of Pharmacy, Jazan University (Ministry of higher education), Jazan, Kingdom of Saudi Arabia. He obtained his Ph.D. in Pharmacy from Manonmaniam Sundaranar University, Tirunelveli, Tamil Nadu, India. His area of specialization includes Vaccine/Drug Delivery System, Immuno Techniques, Tissue Culture Techniques and Molecular Techniques. He is having 17 years of teaching experiences, which includes 5 years of research and managing experiences. He successfully completed 2 projects as a co investigator sponsored by Deanship of research and development, Jazan University. He was received Bharat Vidaya Shiromani Award and Rashtriya Vidaya Gaurav Gold Medal Award for Outstanding Achievements in the Field of Education, and Young Scientist Award in National Symposium. He is member of International Society for Vaccines, Indian Immunology Society, Indian Academy of Vaccinology and Immunobiology, Indian Hospital Pharmacist Association, Indian Pharmaceutical Association, and member of Seaweed utilization of India. He has published 2 books, edited 2 book chapters, 19 research articles in journals and 9 abstract in national and international conferences contributed as author/co-author.

Area of Interest:

Pharmaceutical Sciences
100%
Anticancer
62%
Drug Delivery Science and Technology
90%
Isolation of Active Principles from Plant Extracts
75%
Nanoparticles
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Anwer, T., M.N. Alruwaili, S. Alshahrani, S.S. Alqahtani and Abdulmajeed Jali, et al., 2023. Hepatoprotective potential of diosmin against hepatotoxic effect of isoniazid and rifampin in wistar rats. Hum. Exp. Toxicol., 10.1177/09603271221149199.
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  2. Alhazmi, H.A., N. Shubayr, M. Albratty, A. Najmi and S. Alshahrani, et al., 2023. Study of influence of metal ions in the diagnosis of recombinant hepatitis B surface antigen (HBsAg) using ELISA technique. J. King Saud Univ. - Sci., Vol. 35. 10.1016/j.jksus.2022.102500.
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  3. Alam, M.F., A.O. Ajeibi, M.H. Safhi, A.J.A. Alabdly and S. Alshahrani, et al., 2023. Therapeutic potential of capsaicin against cyclophosphamide-induced liver damage. J. Clin. Med., 10.3390/jcm12030911.
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  4. Unissa, R., S.S. Moni, H. Banu, S.S. Alrahef and T.K.M. Alenezi, et al., 2022. Anti-ulcer properties, cytokines, and apoptosis regulatory effects of Olea europaea leaves from Hail Province, Saudi Arabia. Not. Bot. Horti. Agrobo. Cluj-Napoca, Vol. 50. 10.15835/nbha50312891.
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  5. Syed, R.U., S.S. Moni, B. Huwaimel, A. Alobaida and A. Abdulkareem Almarshdi, et al., 2022. Bioactive principles, anti-diabetic, and anti-ulcer activities of Ducrosia anethifolia Boiss leaves from the Hail region, Saudi Arabia. Arabian J. Chem., Vol. 15. 10.1016/j.arabjc.2022.104308.
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  6. Syed, R.U., S.S. Moni, A.S. Abu Lila, M.H. Abdallah and A.S. Abouzied, et al., 2022. Spectral analysis and antiulcer potential of Lactuca sativa through the amelioration of proinflammatory cytokines and apoptosis markers. Life, Vol. 12. 10.3390/life12101641.
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  7. Sultan, M.H., S.S. Moni, O.A. Madkhali, M.A. Bakkari and S. Alshahrani et al., 2022. Characterization of cisplatin-loaded chitosan nanoparticles and rituximab-linked surfaces as target-specific injectable nano-formulations for combating cancer. Sci. Rep., Vol. 12. 10.1038/s41598-021-04427-w.
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  8. Sultan, M.H. and S.S. Moni, 2022. Spectral analysis and antibacterial effect of cold methanolic extract of Artemisia absinthium L. Braz. J. Biol., Vol. 84. 10.1590/1519-6984.264869.
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  9. S. S. Moni, M. H. Sultan, S. Alshahrani, P. Tripathi, A. Assiri, S. S. Alqahtani, M. A. Bakkari, O. A. Madkhali, M. F. Alam, A. H. Alqahtani, R. Tripathi, S. S. Pancholi, M. Ashafaq, M. E. Elmobark 2022. Physical characterization and wound healing properties of Zamzam water Braz. J. Biol., Vol. 82. 10.1590/1519-6984.262815.
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  10. Moni, S.S., S. Mohan, H.A. Makeen, H.A. Alhazmi and V.K. Basode, et al., 2022. Spectral characterization and biological evaluation of biomolecules from the peels of three orange fruits: a comparative study. Braz. J. Biol., Vol. 82. 10.1590/1519-6984.267856.
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  11. Moni, S.S., P. Tripathi, M.H. Sultan, S. Alshahrani and S.S. Alqahtani, et al., 2022. Wound-healing and cytokine-modulating potential of medicinal oil formulation comprising leaf extract of Murraya koenigii and olive oil. Braz. J. Biol., Vol. 82. 10.1590/1519-6984.256158.
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  12. Moni, S.S., M.A. Bakkari, M.H. Sultan and O.A. Madkhali, 2022. Monoclonal antibodies and their target specificity against SARS-COV-2 infections: Perspectives and challenges. Recent Pat. Biotechnol., 16: 64-78.
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  13. Moni, S.S. and A. Al Basheer, 2022. Molecular targets for cystic fibrosis and therapeutic potential of monoclonal antibodies. Saudi Pharm. J., 30: 1736-1747.
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  14. Khan, A., S.S. Moni, M. Ali, S. Mohan and H. Jan et al., 2022. Antifungal activity of plant secondary metabolites on Candida albicans: An updated review. Curr. Mol. Pharmacol., Vol. 15. 10.2174/1874467215666220304143332.
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  15. Bakkari, M.A., S.S. Moni, Abdulrahman Alshammari, A. Salawi and M.H. Sultan, et al., 2022. Design, characterization, and immune augmentation of docosahexaenoic acid nanovesicles as a potential delivery system for recombinant HBsAg protein. Vaccines, 10. 10.3390/vaccines10060954.
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  16. Alqahtani, S.S., S.S. Moni, M.H. Sultan, M.A. Bakkari and O.A. Madkhali et al., 2022. Potential bioactive secondary metabolites of Actinomycetes sp. isolated from rocky soils of the heritage village Rijal Alma, Saudi Arabia. Arabian J. Chem., Vol. 15. 10.1016/j.arabjc.2022.103793.
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  17. Alam, M.F., S.I. Hijri, S. Alshahrani, S.S. Alqahtani and Abdulmajeed M. Jali, 2022. Zingerone attenuates carfilzomib-induced cardiotoxicity in rats through oxidative stress and inflammatory cytokine network. Int. J. Mol. Sci., Vol. 23. 10.3390/ijms232415617.
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  18. Alam, M.F., S. Alshahrani, E.A. Alamer, M. Abdurrhman Alhazmi and T. Anwer, et al., 2022. Nephroprotective effects of 4-4(hydroxyl-3 methoxyphenyl)-2-butane against sodium tellurite induced acute kidney dysfunction by attenuating oxidative stress and inflammatory cytokines in rats. Arabian J. Chem., Vol. 15. 10.1016/j.arabjc.2022.103857.
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  19. Sultan, M.H., S.S. Moni, S.S. Alqahtani, H.A. Makeen and O.A. Madkhali et al., 2021. Formulation, characterization and biological evaluation of injectable nanocrystals from stem exudate gel of Caralluma retrospiciens (Ehrenb)-Part C. Arabian J. Chem., Vol. 15. 10.1016/j.arabjc.2021.103579.
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  20. Moni, S.S., M.H. Sultan, H.A. Makeen, O.A. Madkhali and M.A. Bakkari et al., 2021. Bioactive principles in exudate gel from the leaf of Aloe fleurentiniorum, traditionally used as folkloric medicine by local people of Aridah and Fayfa mountains, Saudi Arabia. Arabian J. Chem., Vol. 14. 10.1016/j.arabjc.2021.103400.
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  21. Moni, S.S., M.F. Alam, M.H. Sultan, H.A. Makeen and H.A. Alhazmi et al., 2021. Spectral analysis, in vitro cytotoxicity and antibacterial studies of bioactive principles from the leaves of Conocarpus lancifolius, a common tree of Jazan, Saudi Arabia. Braz. J. Biol., Vol. 83. 10.1590/1519-6984.244479.
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  22. Madkhali, O.A., S.S. Moni, M.H. Sultan, H.A. Bukhary and M. Ghazwani et al., 2021. Formulation and evaluation of injectable dextran sulfate sodium nanoparticles as a potent antibacterial agent. Sci. Rep., Vol. 11. 10.1038/s41598-021-89330-0.
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  23. Anwer, T., M.M. Safhi, H.A. Makeen, S. Alshahrani and R. Siddiqui et al., 2021. Antidiabetic potential of Moringa oleifera lam. leaf extract in type 2 diabetic rats, and its mechanism of action. Trop. J. Pharm. Res., 20: 97-104.
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  24. Alshahrani, S., T. Anwer, M.F. Alam, R.A. Ahmed and G. Khan et al., 2021. Effect of thymoquinone on high fat diet and STZ-induced experimental type 2 diabetes: A mechanistic insight by in vivo and in silico studies. J. Food Biochem., vol. 45. 10.1111/jfbc.13807.
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  25. Albratty, M., H.A. Alhazmi, A.M. Meraya, A. Najmi, M.S. Alam, Z. Rehman and S.S. Moni, 2021. Spectral analysis and antibacterial activity of the bioactive principles of Sargassum tenerrimum J. Agardh collected from the red sea, Jazan, Kingdom of Saudi Arabia. Braz. J. Biol., Vol. 83. 10.1590/1519-6984.249536.
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  26. Albratty, M., A.A.M. Bajawi, T.M.H. Marei, M.S. Alam and H.A. Alhazmi et al., 2021. Spectral analysis and antibacterial potential of bioactive principles of Sargassum crassifolium J. Agardh from red sea of Jazan origin. Saudi J. Biol. Sci., 28: 5745-5753.
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  27. Sultan, M.H., A.A. Zuwaiel, S.S. Moni, S. Alshahrani, S.S. Alqahtani, O. Madkhali and M.E. Elmobark, 2020. Bioactive principles and potentiality of hot methanolic extract of the leaves from Artemisia absinthium L "in vitro cytotoxicity against human MCF-7 breast cancer cells, antibacterial study and wound healing activity". Curr. Pharm. Biotechnol., 10.2174/1389201021666200928150519.
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  28. Moni, S.S., 2020. Insights on the application of matlab and chaotic principles to determine the targeted delivery of a smart drug delivery system against cancer in the experimental phase: a prospective approach. Asian J. Pharm., Vol. 14. 10.22377/ajp.v14i03.3680.
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  29. Makeen, H.A., S.J. Menachery, S.S. Moni, S.S. Alqahtani and Zia-ur-Rehman et al., 2020. Documentation of bioactive principles of the exudate gel (EG) from the stem of Caralluma retrospiciens (Ehrenb) and in vitro antibacterial activity – Part A. Arabian J. Chem., 13: 6672-6681.
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  30. Alshahrani, S., P. Tripathi, M. Ashafaq, M.H. Sultan and S.S. Moni et al., 2020. Role of renin blocker (aliskiren) on cisplatin induced-nephrotoxicity in rats. Toxin Rev., 10.1080/15569543.2020.1857772.
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  31. Alshahrani, S., A.A. Al-Sreaya, M.Y. Mashyakhi, S. Alqahtani and S.M. Sivakumar et al., 2020. Chemical characterization and antibacterial efficacy of Saudi sesame oil against human pathogenic bacteria. Environ. Conserv. J., 21: 19-29.
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  32. Alqahtani, S.S., H.A. Makeen, S.J. Menachery and S.S. Moni, 2020. Documentation of bioactive principles of the flower from Caralluma retrospiciens (Ehrenb) and in vitro antibacterial activity – Part B. Arabian J. Chem., 13: 7370-7377.
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  33. Alam, M.F., S. Alshahrani, E. Alamir, M.A. Alhazmi, T. Anwer, G. Khan and M.S. Sivagurunathan, 2020. Zingerone ameliorates tellurium induced nephrotoxicity by abating elevated serum markers in the rats. Environ. Conserv. J., 21: 125-129.
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  34. Al-bratty, M., A.Q. Hakami, H.A. Masmali, S. Alam and H.A. Alhazmi et al., 2020. The spectrum of thiazolidinediones against respiratory tract pathogenic bacteria: an in-vitro and in-silico approach. Curr. Pharm. Biotechnol., Vol. 21. 10.2174/1389201021666200618161210.
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  35. Zakir, F., F. Islam, A. Jabeen and S.S. Moni, 2019. Vaccine development: A historical perspective. Biomed. Res., Vol. 30. 10.35841/biomedicalresearch.30-19-203.
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  36. Safhi, M.M., M.F. Alam, S.M. Sivakumar and T. Anwer, 2019. Hepatoprotective potential of Sargassum muticum against STZ-induced diabetic liver damage in wistar rats by inhibiting cytokines and the apoptosis pathway. Anal. Cell. Pathol., Vol. 2019. 10.1155/2019/7958701.
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  37. Moni, S.S., M.H. Sultan, H.A. Makeen, A. Jabeen, S. Sanobar, R. Siddiqui, Z.ur. Rehman, Md. S. Alam, S. Ahmad, M.E. Elmobark and R. Moochikkal, 2019. Phytochemical and spectral analysis of the methanolic extracts of leaves of Murraya koenigii of Jazan, Saudi Arabia. Nat. Prod. Res., 10.1080/14786419.2019.1679137.
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  38. Moni, S.S., M.F. Alam, M.M. Safhi, M.H. Sultan, H.A. Makeen and M.E. Elmobark, 2019. Development of formulation methods and physical characterization of injectable sodium selenite nanoparticles for the delivery of sorafenib tosylate. Curr. Pharm. Biotechnol., 21: 659-666.
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  39. Moni, S.S., M.F. Alam, M.M. Safhi, A. Jabeen, S. Sanobar, R. Siddiqui and R. Moochikkal, 2019. Potency of nano-antibacterial formulation from Sargassum binderi against selected human pathogenic bacteria. Braz. J. Pharm. Sci., Vol. 54. 10.1590/s2175-97902018000417811.
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  40. Moni, S.S., M.F. Alam, H.A. Makeen, H.A. Alhazmi and M. Sultan et al., 2019. Solvent extraction, spectral analysis and antibacterial activity of the bioactive crystals of Sargassum aquifolium (Turner) C.Agardh from Red Sea. Nat. Prod. Res., Vol. 35. 10.1080/14786419.2019.1645659.
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  41. Moni, S.S., M.F. Alam, H.A. Makeen, A. Jabeen and S. Sanobar et al., 2019. Therapeutic potential of oleic acid nanovesicles prepared from petroleum ether extract of Sargassum binderi in streptozotocin–induced diabetic wound in Wistar rats. Trop. J. Pharm. Res., Vol. 17. 10.4314/tjpr.v17i11.2.
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  42. Elmobark, M.E., A.A. Abbass, E. Anwer, S.S. Moni, I.A. Arbab, M.H. Sultan and B.Y.M. Nour, 2019. ABO and Rhesus phenotype frequencies in multi-transfuse hemodialysis renal patient and blood donor in central Sudan. Int. J. Med. Res. Prof., 5: 28-30.
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  43. Safhi, M.M., T. Anwer, G. Khan, R. Siddiqui, S.M. Sivakumar and M.F. Alam, 2018. The combination of canagliflozin and omega-3 fatty acid ameliorates insulin resistance and cardiac biomarkers via modulation of inflammatory cytokines in type 2 diabetic rats. Korean J. Physiol. Pharmacol., Vol. 22. 10.4196/kjpp.2018.22.5.493.
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  44. Kannan, K.O., H.A. Makeen, A.A. Albarraq, A.M. Meraya, H. Sanhouri and S.S. Moni, 2018. Ticagrelor, a molecular breakthrough to modulate cytokine network in the treatment of acute myocardial infarction "perspective and prospective". Biomed. Res., Vol. 29. 10.4066/biomedicalresearch.29-18-805.
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  45. Gupta, M.M., 2018. Crystallo-co-agglomeration of valsartan for improved solubility and powder flowability. Asian J. Pharm., Vol. 12. 10.22377/ajp.v12i03.
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  46. Alam, M.F., M.M. Safhi, T. Anwer, R. Siddiqui, G. Khan and S.S. Moni, 2018. Therapeutic potential of Vanillylacetone against CCl4 induced hepatotoxicity by suppressing the serum marker, oxidative stress, inflammatory cytokines and apoptosis in Swiss albino mice. Exp. Mol. Pathol., 105: 81-88.
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  47. Alam, M.F., G. Khan, M.M. Safhi, S. Alshahrani, R. Siddiqui, S.S. Moni and T. Anwer, 2018. Thymoquinone ameliorates doxorubicin-induced cardiotoxicity in swiss albino mice by modulating oxidative damage and cellular inflammation. Cardiol. Res. Prac., Vol. 2018. 10.1155/2018/1483041.
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  48. Safhi, M.M., S.M. Sivakumar, A. Jabeen, F. Zakir and F. Islam et al., 2017. Nanoparticle system for anticancer drug delivery: targeting to overcome multidrug resistance. In: Multifunctional Systems for Combined Delivery, Biosensing and Diagnostics, Grumezescu, A.M., Elsevier London, pp: 159-169.
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  49. Sivakumar, S.M., 2016. Therapeutic potential of chitosan nanoparticles as antibiotic delivery system: challenges to treat multiple drug resistance. Asian J. Pharm., Vol. 10. 10.22377/ajp.v10i2.624.
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  50. Alam, M.F., M.M. Safhi, S.S. Moni and A. Jabeen, 2016. In Vitro Antibacterial Spectrum of Sodium selenite against selected human pathogenic bacterial strains. Scientifica, Vol. 2016. 10.1155/2016/9176273.
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  51. Sivakumar, S.M. and A. Jabeen, 2014. Status on hepatitis B virus infection and anti viral therapy: A perspective. J. Pharm. Res., 8: 1570-1578.
  52. Safhi, M.M., S.M. Sivakumar, A. Jabeen, F. Zakir, F. Islam and B.B. Barik, 2014. Chitosan nanoparticles as a sustained delivery of penicillin G prepared by ionic gelation technique. J. Pharm. Res., 8: 1352-1354.
  53. Safhi, M.M., S.M. Sivakumar, A. Jabeen and N. Sukumaran, 2014. Preparation and in vitro evaluation of HBsAg loaded dextran microparticles. Res. J. Pharm. Technol., 7: 1137-1139.
    Direct Link  |  
  54. Safhi, M.M., M.F. Alam, S.M. Sivakumar, A. Jabeen, T. Anwer, G. Khan and F. Islam, 2014. Antibacterial spectrum of black seed oil against selected human pathogenic bacteria. J. Pharm. Res., 8: 1726-1728.
    Direct Link  |  
  55. Alam, M.F., M.M. Safhi, S.M. Sivakumar, T. Anwer, G. Khan and F. Islam, 2014. Anti bacterial toxicity of Sodium Tellurite (ST) against selected bacterial strains. Res. J. Pharm. Technol., 7: 499-501.
    Direct Link  |  
  56. Sivakumar, S.M., M.M. Safhi, J. Aamena and M. Kannadasan, 2013. Pharmaceuticals aspects of Chitosan polymer "in brief". Res. J. Pharm. Technol., 6: 1439-1442.
  57. Sivakumar, S.M. and M.M. Safhi, 2013. Isolation and screening of bioactive principle from Chaetomorpha antennina against certain bacterial strains. Saudi Pharm. J., 21: 119-121.
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  58. Safhi, M.M., M. Ali, S.M. Sivakumar, A. Jabeen and Y.N. Manohara, 2013. Antibacterial studies of Catharanthus roseus of Jazan province against the selected bacterial strains. Res. J. Pharm. Technol., 6: 403-405.
  59. Moni, S., M.S. Safhi and B. Barik, 2013. Nanoparticles for triggering and regulation of immune response of vaccines: Perspective and prospective. Curr. Pharmaceut. Biotechnol., 14: 1242-1249.
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  60. Sivakumar, S.M., N. Sukumaran and M.M. Safhi, 2011. Immune augmentation of injectable PLGA-Dextran (PLDEX) a double polymeric microspheres as an adjuvant for hepatitis B vaccine. World J. Vaccines, 1: 104-108.
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  61. Sivakumar, S.M., M.M. Safhi, M. Kannadasan and N. Sukumaran, 2011. Vaccine adjuvants: Current status and prospects on controlled release adjuvancity. Saudi Pharmaceut. J., 19: 197-206.
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  62. Sivakumar, S.M., N. Sukumaran, L. Nirmala, R. Swarnalakshmi and B. Anilbabu et al., 2010. Immunopotentiation of hepatitis B vaccine using biodegradable polymers as an adjuvant. J. Microbiol. Immunol. Infect., 43: 265-270.
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  63. Sivakumar, S.M. and N. Sukumaran, 2009. Induction of immune response of hepatitis B vaccine using polyester polymer as an adjuvant. Procedia Vaccinol., 1: 164-173.
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  64. Sivakumar, S.M. and N. Sukumaran, 2009. Formulation and characterization of PLA microspheres containing hepatitis B vaccine. Int. J. Pharma Res., 2: 94-97.
  65. Nirmala, A., A. Sivakumar and A. Anilbabu, 2009. Preparation and in vitro evaluation of hepatitis B vaccine encapsulated Chitosan microparticles. Res. J. Pharm. Technol., 2: 117-119.
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  66. Sivakumar, S.M., V. Lavakumar, M. Raviraj, J. Anbu, T.S. Shanmugarajan, R. Murugesan and V. Ravichandran, 2008. Antibacterial Screening of bioactive substances from Seaweeds of South Tamilnadu. Seaweed Res. Utiliz., 31: 70-76.
  67. Sivakumar, S.M., N. Sukumaran, R. Murugesan, T.S. Shanmugarajan and J. Anbu et al., 2008. Immune augmentation of single contact hepatitis B vaccine by using PLGA microspheres as an adjuvant. Indian J. Pharmaceut. Sci., 70: 487-490.
    PubMed  |  
  68. Sivakumar, S.M., M. Raviraj, V. Lavakumar, J. Anbu, T.S. Shanmugarajan, R. Murugesan and V. Ravichandran, 2008. Isolation and Screening of bioactive principles from Hypnea musciformis (Wolfen) Lamoroux against cancer. Seaweed Res. Utiliz., 31: 1-6.
  69. Sivakumar, S.M., B. Anil Babu, L. Sivakumar, S. Sripriya, G. Srinivaso Rao and N. Sukumaran, 2007. Comprehensive strategies on hepatitis-B infection and immunization programme. Indian Pharmacist, 6: 15-17.