Dr. Rajesh Ramesh Ugale
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Dr. Rajesh Ramesh Ugale

Professor
Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, India

Highest Degree
Ph.D. in Pharmaceutical Sciences from Nagpur University, Nagpur, India

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Area of Interest:

Pharmacology and Toxicology
100%
Pharmacy
62%
Immunohistochemistry
90%
Psychopharmacology
75%
Neuropharmacology
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
29
Abstracts
0

Selected Publications

  1. Gakare, S.G., S.S. Varghese, P.P. Patni, S.A. Wagh and R.R. Ugale, 2022. Prevention of glutamate excitotoxicity in lateral habenula alleviates ethanol withdrawal-induced somatic and behavioral effects in ethanol dependent mice. Behav. Brain Res., Vol. 416. 10.1016/j.bbr.2021.113557.
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  2. Liu, J., G.P. Shelkar, L.P. Sarode, D.Y. Gawande and F. Zhao et al., 2021. Facilitation of GLuN2C-containing NMDA receptors in the external globus pallidus increases firing of fast spiking neurons and improves motor function in a hemiparkinsonian mouse model. Neurobiology Dis., Vol. 150. 10.1016/j.nbd.2021.105254.
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  3. Mahale, A., R. Kumar, L.P. Sarode, S. Gakare, A. Prakash and R.R. Ugale, 2020. Dapsone prolong delayed excitotoxic neuronal cell death by interacting with proapoptotic/survival signaling proteins. J. Stroke Cerebrovascular Dis., 10.1016/j.jstrokecerebrovasdis.2020.104848.
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  4. Siddiqui, S.A., S. Singh, R. Ugale, V. Ranjan and R. Kanojia et al., 2019. Regulation of HDAC1 and HDAC2 during consolidation and extinction of fear memory. Brain Res. Bull., 150: 86-101.
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  5. Shelkar, G.P., R. Pavuluri, P.J. Gandhi, A. Ravikrishnan and D.Y. Gawande et al., 2019. Differential effect of NMDA receptor GluN2C and GluN2D subunit ablation on behavior and channel blocker-induced schizophrenia phenotypes. Sci. Rep., 10.1038/s41598-019-43957-2.
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  6. Gawai, P., R. Upadhyay, S.G. Gakare, L. Sarode, S.M. Dravid and R.R. Ugale, 2019. Antipsychotic-like profile of CIQ isomers in animal models of schizophrenia. Behav. Pharmacol., 31: 524-534.
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  7. Singh, S., S.A. Siddiqui, S. Tripathy, S. Kumar and S. Saha et al., 2018. Decreased level of histone acetylation in the infralimbic prefrontal cortex following immediate extinction may result in deficit of extinction memory. Brain Res. Bull., 140: 355-364.
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  8. Siddiqui, S.A., S. Singh, V. Ranjan, R. Ugale, S. Saha and A. Prakash, 2017. Enhanced histone acetylation in the infralimbic prefrontal cortex is associated with fear extinction. Cell. Mol. Neurobiol., 37: 1287-1301.
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  9. Shelkar, G.P., S.G. Gakare, S. Chakraborty, S.M. Dravid and R.R. Ugale, 2016. Interactions of nitric oxide with α2-adrenoceptors within the locus coeruleus underlie the facilitation of inhibitory avoidance memory by agmatine. Br. J. Pharmacol., 173: 2589-2599.
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  10. Gupta, S.C., A. Ravikrishnan, J. Liu, Z. Mao and R. Pavuluri et al., 2016. The NMDA receptor GluN2C subunit controls cortical excitatory-inhibitory balance, neuronal oscillations and cognitive function. Scient. Rep., Vol. 6. 10.1038/srep38321.
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  11. Gupta, S.C., A. Ravikrishnan, J. Liu, Z. Mao and R. Pavuluri et al., 2016. The NMDA receptor GluN2C subunit controls cortical excitatory-inhibitory balance, neuronal oscillations and cognitive function. Sci. Rep., Vol. 6. 10.1038/srep38321.
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  12. Suryavanshi, P.S., R.R. Ugale, D. Yilmazer-Hanke, D.J. Stairs and S.M. Dravid, 2014. GluN2C/GluN2D subunit-selective NMDA receptor potentiator CIQ reverses MK-801-induced impairment in prepulse inhibition and working memory in Y-maze test in mice. Br. J. Pharmacol., 171: 799-809.
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  13. Thakre, P.P., M.R. Tundulwar, C.T. Chopde and R.R. Ugale, 2013. Neurosteroid allopregnanolone attenuates development of nicotine withdrawal behavior in mice. Neurosci. Lett., 541: 144-149.
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  14. Sameer, S.M., S.S. Chakraborty and R.R. Ugale, 2013. Agmatine attenuates acquisition but not the expression of ethanol conditioned place preference in mice: A role for imidazoline receptors. Behav. Pharmacol., 24: 87-94.
    PubMed  |  
  15. Nitharwal, R.K., H. Patel, M.S. Karchuli and R.R. Ugale, 2013. Chemoprotective potential of Coccinia indica against cyclophosphamide-induced toxicity. Indian J. Pharmacol., 45: 502-507.
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  16. Kotagale, N.R., S.H. Shirbhate, P. Shukla and R.R. Ugale, 2013. Agmatine attenuates neuropathic pain in sciatic nerve ligated rats: Modulation by hippocampal sigma receptors. Eur. J. Pharmacol., 714: 424-431.
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  17. Gupta, S.C., B.G. Hillman, A. Prakash, R.R. Ugale, D.J. Stairs and S.M. Dravid, 2013. Effect of D‐cycloserine in conjunction with fear extinction training on extracellular signal‐regulated kinase activation in the medial prefrontal cortex and amygdala in rat. Eur. J. Neurosci., 37: 1811-1822.
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  18. Taksande, B.G., N.R. Kotagale, K.T. Nakhate, P.D. Mali and D.M. Kokare et al., 2011. Agmatine in the hypothalamic paraventricular nucleus stimulates feeding in rats: Involvement of neuropeptide Y. Br. J. Pharmacol., 164: 704-718.
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  19. Zhang, H., A.J. Sakharkar, G. Shi, R. Ugale, A. Prakash and S.C. Pandey, 2010. Neuropeptide Y signaling in the central nucleus of amygdala regulates alcohol-drinking and anxiety-like behaviors of alcohol-preferring rats. Alcohol. Clin. Exp. Res., 34: 451-461.
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  20. Taksande, B.G., N.R. Kotagale, M.R. Patel, G.P. Shelkar, R.R. Ugale and C.T. Chopde, 2010. Agmatine, an endogenous imidazoline receptor ligand modulates ethanol anxiolysis and withdrawal anxiety in rats. Eur. J. Pharmacol., 637: 89-101.
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  21. Kotagale, N.R., B.G. Taksande, A.Y. Gahane, R.R. Ugale and C.T. Chopde, 2010. Repeated agmatine treatment attenuates nicotine sensitization in mice: Modulation by α 2-adrenoceptors. Behav. Brain Res., 213: 161-174.
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  22. Taksande, B.G., N.R. Kotagale, S.J. Tripathi, R.R. Ugale and C.T. Chopde, 2009. Antidepressant like effect of selective serotonin reuptake inhibitors involve modulation of imidazoline receptors by agmatine. Neuropharmacology, 57: 415-424.
    CrossRef  |  
  23. Pandey, S.C., R. Ugale, H. Zhang, L. Tang and A. Prakash, 2008. Brain chromatin remodeling: A novel mechanism of alcoholism. J. Neurosci., 28: 3729-3737.
  24. Pandey, S.C., H. Zhang, R. Ugale, A. Prakash, T. Xu and K. Misra, 2008. Effector immediate-early gene arc in the amygdala plays a critical role in alcoholism. J. Neurosci., 28: 2589-2600.
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  25. Ugale, R.R., A.N. Sharma, D.M. Kokare, K. Hirani, N.K. Subhedar and C.T. Chopde, 2007. Neurosteroid allopregnanolone mediates anxiolytic effect of etifoxine in rats. Brain Res., 1184: 193-201.
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  26. Sharma, A.N., C.T. Chopde, K. Hirani, D.M. Kokare and R.R. Ugale, 2007. Chronic progesterone treatment augments while dehydroepiandrosterone sulphate prevents tolerance to ethanol anxiolysis and withdrawal anxiety in rats. Eur. J. Pharmacol., 567: 211-222.
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  27. Hirani, K., A.N. Sharma, N.S. Jain, R.R. Ugale and C.T. Chopde, 2005. Evaluation of GABAergic neuroactive steroid 3α-hydroxy-5α-pregnane-20-one as a neurobiological substrate for the anti-anxiety effect of ethanol in rats. Psychopharmacology, 180: 267-278.
  28. Ugale, R.R., N. Mittal, K. Hirani and C.T. Chopde, 2004. Essentiality of central GABAergic neuroactive steroid allopregnanolone for anticonvulsant action of fluoxetine against pentylenetetrazole-induced seizures in mice. Brain Res., 1023: 102-111.
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  29. Ugale, R.R., K. Hirani, M. Morelli and C.T. Chopde, 2004. Role of neuroactive steroid allopregnanolone in antipsychotic-like action of olanzapine in rodents. Neuropsychopharmacology, 29: 1597-1609.
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