Dr. Arif Hussain
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Dr. Arif Hussain

Associate Professor
Manipal University, UAE


Highest Degree
Ph.D. in Molecular Oncology from Jamia Millia Islamia, India

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Biography

Dr. Arif Hussain is designated as Associate Professor at Department of Biotechnology, Manipal University Dubai Campus, Dubai, UAE. He has completed his Ph.D. in Oncology from Jamia Millia Islamia, Delhi, India. Previously he was appointed as Lecturer and Coordinator at Department of Biotechnology, IIET, Greater Noida, UP, India and Assistant Professor at School of Life Science, Manipal University Dubai Campus, Dubai, UAE. His area of research interest focuses on Signal Transduction and Systems Biology Pertaining to Cancer, to explore the Novel Chemopreventive Agents and their effect on Cancer Prevention, Gene Expression profiling to define Prognostic Factors and Cancer Biology, Molecular Epidemiology of Cancer Etiology, its progression in relation to Genetic Variation, Epigenetic changes and Gene-environment interactions, Molecular mechanisms underlying DNA Methylation in Tumor Suppressor Genes and DNA repair genes and its role in Aging and Cancer Prognosis, and Evaluation of gene families in Regulomics of genes via Epigenetic involvement i.e. DNA Methyltransferases, and Histone Deacetylase gene families. He also supervised 21 MSc thesis, and 3 BSc thesis and 1 PhD student currently in his supervision. Dr. Arif has published 20 research articles in journals. He also participated in number of workshops and conferences. He is member of scientific and technical committee and editorial review board on Biological and Life Sciences and associate editor in current research journals of biological science, technical editor for American Journal of Biochemistry and Molecular Biology, Biotechnology, Journal of Pharmacology and Toxicology, International Journal of Cancer Research, Journal of Medical Sciences and member of editorial in Journal of Tumor and member of international conference committee of International conference on oncology, international advisory board of The 1st International Online Biological Congress, third EMGEN Steering Committee, and International Conference Committee member of ICMBO 2015: 17th International Conference on Medical Biology and Oncology, Dubai, UAE.

Area of Interest:

Molecular Sciences
100%
Epigenetic
62%
Chemoprevention
90%
Cancer Research
75%
Molecular Oncology
55%

Research Publications in Numbers

Books
0
Chapters
4
Articles
55
Abstracts
0

Selected Publications

  1. Sundaram, M.K., M.Z. Ansari, A. Al Mutery, M. Ashraf and R. Nasab et al., 2018. Genistein induces alterations of epigenetic modulatory signatures in human cervical cancer cells. Anti-Cancer Agents Med. Chem. (Form. Curr. Med. Chem.-Anti-Cancer Agents), 18: 412-421.
    CrossRef  |  Direct Link  |  
  2. Sundaram, M.K., M.Z. Ansari, A.A. Mutery, M. Ashraf and R. Nasab et al., 2017. Genistein induces alterations of epigenetic modulatory signatures in human cervical cancer cells. Anti-Cancer Agents Med. Chem., (In Press). .
    PubMed  |  
  3. Vahora, H., M.A. Khan, U. Alalami and A. Hussain, 2016. The potential role of nitric oxide in halting cancer progression through chemoprevention. J. Cancer Prev., 21: 1-12.
    CrossRef  |  Direct Link  |  
  4. Khan, M.A., M.K. Sundaram, A. Hamza, U. Quraishi and D. Gunasekera et al., 2015. Sulforaphane reverses the expression of various tumor suppressor genes by targeting DNMT3B and HDAC1 in human cervical cancer cells. Evidence-Based Complement. Altern. Med., Vol. 2015. 10.1155/2015/412149.
    CrossRef  |  
  5. Khan, M.A., A. Hussain, M.K. Sundaram, U. Alalami and D. Gunasekera et al., 2015. (-)-Epigallocatechin-3-gallate reverses the expression of various tumor-suppressor genes by inhibiting DNA methyltransferases and histone deacetylases in human cervical cancer cells. Oncol. Rep., 33: 1976-1984.
    CrossRef  |  Direct Link  |  
  6. Hussain, A., C. Sharma, S. Khan, K. Shah and S. Haque, 2015. Aloe vera inhibits proliferation of human breast and cervical cancer cells and acts synergistically with cisplatin. Asian Pac. J. Cancer Prevent., 16: 2939-2946.
    Direct Link  |  
  7. Al Moosa, M.E., M.A. Khan, U. Alalami and A. Hussain, 2015. Microbiological quality of drinking water from water dispenser machines. Int. J. Environ. Sci. Dev., 6: 710-713.
    Direct Link  |  
  8. Sharma, C., A.J. Vas, P. Goala, T.M. Gheewala, T.A. Rizvi and A. Hussain, 2014. Ethanolic Neem (Azadirachta indica) leaf extract prevents growth of MCF-7 and HeLa cells and potentiates the therapeutic index of Cisplatin. J. Oncol., Vol. 2014. 10.1155/2014/321754.
    CrossRef  |  
  9. Hussain, A., T.M. Gheewala, A.J. Vas, K. Shah and P. Goala et al., 2014. Growth inhibitory and adjuvant therapeutic potential of aqueous extract of Triticum aestivum on MCF-7 and HeLa cells. Exp. Oncol., 36: 9-16.
  10. Haque, S., R.K. Mandal, N. Akhter, A.K. Panda, A. Hussain, S. Khan and M. Lohani, 2014. G894T and 4a/b polymorphisms of NOS3 gene are not associated with cancer risk: A meta-analysis. Asian Pacific J. Cancer Prevent., 16: 2929-2937.
    Direct Link  |  
  11. Rais, N., A. Hussain, Y.K. Chawla and K.K. Kohli, 2013. Association between urinary 6β-OH-Cortisol/Cortisol ratio and CYP3A5 genotypes in normotensive North Indian population. Exp. Therapeutic Med., 5: 527-532.
    PubMed  |  Direct Link  |  
  12. Hussain, A., J. Mohsin, S.A. Prabhu, S. Begum and A.N. Qel et al., 2013. Sulforaphane inhibits growth of human breast cancer cells and augments the therapeutic index of the chemotherapeutic drug, gemcitabine. Asian Pac. J. Cancer Prevent., 14: 5855-5860.
  13. Sharma, C., Q.A. Nusri, S. Begum, E. Javed, T.A. Rizvi and A. Hussain, 2012. (-)-Epigallocatechin-3-gallate induces apoptosis and inhibits invasion and migration of human cervical cancer cells. Asian Pacfic J. Cancer Prev., 13: 4815-4822.
    PubMed  |  Direct Link  |  
  14. Saxena, A., V.S. Dhillon, M. Shahid, M. Rani and T.P. Das et al., 2012. GSPT1 methylation and its polymorphic variant together increase risk of breast cancer, and its association with dietary and life style factors among breast cancer patients from Northern Indian population. Exp. Therapeutic Med., 4: 1097-1103.
  15. Hussain, A., G. Harish, S.A. Prabhu, J. Mohsin, M.A. Khan, T.A. Rizvi and C. Sharma, 2012. Inhibitory effect of genistein on the invasive potential of human cervical cancer cells via modulation of matrix metalloproteinase-9 and tissue inhibitiors of matrix metalloproteinase-1 expression. Cancer Epidemiol., 36: e387-e393.
    CrossRef  |  
  16. Hussain, A., A. Priyani, L. Sadrieh, K. Brahmbhatt and M. Ahmed et al., 2012. Concurrent Sulforaphane and Eugenol Induces Differential Effects on Human Cervical Cancer Cells. Integr. Cancer Therapies, 11: 154-165.
    CrossRef  |  PubMed  |  Direct Link  |  
  17. Sharma, C., L. Sadrieh, A. Priyani, M. Ahmed, A.H. Hassan and A. Hussain, 2011. Anti-carcinogenic effects of sulforaphane in association with its apoptosis-inducing and anti-inflammatory properties in human cervical cancer cells. Cancer Epidemiol., 35: 272-278.
    CrossRef  |  PubMed  |  Direct Link  |  
  18. Hussain, A., K. Brahmbhatt, A. Priyani, M. Ahmed and T.A. Rizvi et al., 2011. Eugenol Enhances the Chemotherapeutic Potential Of Gemcitabine and Induces Anticarcinogenic and Anti-Inflammatory Activity in Human Cervical Cancer Cells. Cancer Biotherapy Radiopharm., 26: 519-527.
    CrossRef  |  PubMed  |  Direct Link  |  
  19. Sharma, C., T. Ahmed, S. Sasidharan, M. Ahmed and A. Hussain, 2009. Use of gemcitabine and ginger extract infusion may improve the efficiency of cervical cancer treatment. Afr. J. Biotechnol., 8: 7087-7093.
    Direct Link  |  
  20. Hussain, A., S. Sasidharan, T. Ahmed, M. Ahmed and C. Sharma, 2009. Clove (Syzygium aromaticum) extract potentiates gemcitabine cytotoxic effect on human cervical cancer cell line. Int. J. Cancer Res., 5: 95-104.
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  21. Naqvi, R.A., A. Hussain, S.V. Deo, H. Kukreti and M. Chauhan et al., 2008. Hypermethylation analysis of mismatch repair genes (hmlh1 and hmsh2) in locally advanced breast cancers in Indian women. Hum Pathol., 39: 672-680.
    CrossRef  |  PubMed  |  Direct Link  |  
  22. Naqvi, R.A., A. Hussain, M. Raish, A. Noor and M. Shahid et al., 2008. Specific 5'CpG island methylation signatures of Fhit and p16 genes and their potential diagnostic relevance in indian breast cancer patients. DNA Cell Biol., 27: 517-525.
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