Dr. Sivaraman Dhanasekaran
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Dr. Sivaraman Dhanasekaran

Assistant Professor
Pandit Deendayal Energy University, Gandhinagar, Gujarat, India

Highest Degree
Ph.D. in Pharmacology and Toxicology from Tamil Nadu Dr. M.G.R. Medical University, India

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Biography

Dr. Sivaraman Dhanasekaran is currently working as Scientist C at Centre for Laboratory Animal Technology and Research, Sathyabama University, India. He has completed his Ph.D. in Pharmacology and Toxicology from The Tamil Nadu Dr. Maruthur Gopalan Ramachandran Medical University, Chennai, India. He has 6 years working experience. He has published 33 research papers in journals and 1 Book and 14 paper presentation at international conferences contributed as author/co-author. He is member of editorial board in 10 international journals. He has completed 35 commercial projects as principal investigator and 32 research projects as research coordinator. Dr. Sivaraman received honors includes Dr. A.P.J, Abdul Kalam Young Scientist Award, Second Prize for Best oral presentation, Motivation of Excellence Award 2013, Best Rotaract Academic Coordinator Award, and Best awareness program Award. He is professional member of Asian Council of Science Editors, life member of Indian Pharmacological Society, Indian Pharmacists Association, Laboratory Animal Scientist Association of India, and registered Pharmacist at Tamil Nadu state Pharmacy Council.

Area of Interest:

Pharmacology and Toxicology
100%
Neuropharmacology
62%
Alzheimer`s Disease
90%
Parkinson Disease
75%
Toxicological Studies
55%

Research Publications in Numbers

Books
2
Chapters
1
Articles
123
Abstracts
21

Selected Publications

  1. Dhanasekaran, S., P.P. Selvadoss and S.S. Manoharan, 2023. Anti-fungal potential of structurally diverse FDA-approved therapeutics targeting secreted aspartyl proteinase (SAP) of Candida albicans: An in silico drug repurposing approach. Appl. Biochem. Biotechnol., 195: 1983-1998.
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  2. Dhanasekaran, S., M. Chinnairusan and L.K. Vajravelu, 2022. Letter in response to: Alamer A, Alrashed AA, Alfaifi M, et al. Effectiveness and safety of favipiravir compared to supportive care in moderately to critically ill COVID-19 patients: A retrospective study with propensity score matching sensitivity analysis. Curr Med Res Opin. 2021;19:1-13. DOI: 10.1080/03007995.2021.1920900. Curr. Med. Res. Opin., 38: 355-356.
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  3. Sivaraman, D., K.V. Leela and V. Venugopal, 2021. ACE2 downregulation promotes thrombosis and cardiac injury in COVID-19 patients. Asian Pac. J. Trop. Med., 14: 330-332.
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  4. Dhanasekaran, S., L.K. Vajravelu and V. Venkatesalu, 2021. Risk-benefit analysis on the clinical significance of convalescent plasma therapy in the management of COVID-19. Postgrad. Med. J., 97: 467-468.
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  5. Sivaraman, D., P.S. Pradeep, S.S. Manoharan, C.R. Bhat, K.V. Leela and V. Venugopal, 2020. Revealing potential binding affinity of FDA approved therapeutics targeting main protease (3CLpro) in impairing novel coronavirus (SARSCoV-2) replication that causes COVID-19. Coronaviruses, 1: 98-107.
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  6. Sivaraman, D., P.S. Pradeep, S.S. Manoharan, C.R. Bhat, K.V. Leela and V. Venugopal, 2020. Current strategies and approaches in combating SARS-CoV-2 virus that causes COVID-19. Lett. Drug Design Dis., 17: 672-674.
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  7. Sivaraman, D., M. Arun, R. Kannan, P.S. Pradeep and P. Muralidharan, 2020. Neurocognitive investigation of Morinda tinctoria against amyloid beta-induced oxidative insult and cognitive impairment in albino mice: A phytotherapeutic approach. Phcog. Mag., 16: 255-262.
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  8. Sivaraman, D., 2020. Structural biology oriented predicative analysis of immunogenic epitopes on SARS-CoV-2 viral sequence by variable algorithms. Asian Pac. J. Trop. Med., 13: 283-284.
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  9. Sivaraman, D. and P.S. Pradeep, 2020. Revealing anti-viral potential of bio-active therapeutics targeting SARS-CoV2- polymerase (RdRp) in combating COVID-19: Molecular investigation on Indian traditional medicines. Preprints 2020, 10.20944/preprints202003.0450.v1.
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  10. Sivaraman, D. and P.S. Pradeep, 2020. Exploration of bioflavonoids targeting dengue virus NS5 RNA-dependent RNA polymerase: In silico molecular docking approach. J, App. Pharm. Sci., 10: 16-22.
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  11. Perumal, G., B. Ramasamy, A.M. Nandkumar, S. Dhanasekaran, S. Ramasamy and M. Doble, 2020. Bilayer nanostructure coated AZ31 magnesium alloy implants: in vivo reconstruction of critical-sized rabbit femoral segmental bone defect. Nanomed.: Nanotechnol., Biol. Med., Vol. 29. 10.1016/j.nano.2020.102232.
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  12. Dhanasekaran, S., P.P. Selvadoss, S.M. Solomon, R.B. Chandramouliswaran, L.K. Vajravelu and V.V. Venkatesalu, 2020. Public health awareness and knowledge dissemination essen-tially becomes a need of the hour in combating COVID-19. Iran J. Public Health, 49: 145-146.
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  13. Sivaraman, D., N. Anbu, N. Kabilan, M.P. Kumar, P. Shanmugapriya and G.J. Christian, 2019. Exploration of anti-urolithiasis potential of traditional siddha formulations amukkara chooranam and karisalai karpam chooranam by struvite crystal growth inhibition assay. Pharmacogn. J., 11: 683-688.
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  14. Shanmugapriya, P., D. Sivaraman, G.J. Christian, K. Rajalakshmi and J.R. Gladys, 2019. Hepatoprotective potential of novel siddha formulation Santha Santhrodhaya Mathirai against paracetamol and methotrexate induced hepatotoxicity in chang liver cell line model. J. Pharm. Sci. Res., 11: 2379-2384.
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  15. Pradeep, P.S., S. Manisha, J.M.A. Nayaki, D. Sivaraman, R. Selvaraj and S. Seeni, 2019. Potential antioxidant and anti-inflammatory action of Hypericum hookerianum extracts in a liposome system evaluated with zebrafish embryos. J. Microencapsulation. 10.1080/02652048.2019.1631400.
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  16. Vinayak, S., R.S. Gayatri, D. Sivakumar, Sivaraman, A. Sundaresan and V. Banumathi, 2018. Standardization and physio chemical analysis of Siddha Herbo mineral distillate Sanjeevi theeneer. Eur. J. Pharm. Med. Res., 5: 409-441.
  17. Vinayak, S., R. Gayatri, S. Sivakumar, D. Sivaraman, A. Sundaresan and V. Banumathi, 2018. Evaluation of hepatoprotective potential of classical Siddha Distillate Sanjeevi Theeneer against paracetamol induced hepatotoxicity in Zebrafish (Danio rerio) model. Int. J. Curr. Res. Chem. Pharm. Sci., 5: 44-49.
  18. Vinayak, S., K. Thangadurai, R. Gayatri, D. Sivaraman, A. Sundaresan, S. Sivakumar and V. Banumathi, 2018. Identification of phytocomponents from Novel Siddha formulation Oma Theeneer by GCMS analysis. Int. J. Adv. Res. Biol. Sci., 5: 17-24.
  19. Vinayak, S., K. Thangadurai, R. Gayatri, D. Sivaraman, A. Sundaresan and V. Banumathi, 2018. Identification and validation of fractional distillate from embelia ribes (vaividangam) and its active phytocomponents through GCMS. WJPPS., 7: 1314-1324.
  20. Sivaraman, D., 2018. Toxicity profiling of liposome encapsulated chlorogenic acid formulation in zebrafish embryos at different developmental stages. Int. J. Pharma Bio Sci., 9: 31-37.
  21. Sivaraman, D., 2018. Preclinical study on expression of Bax and Bcl-2 apoptotic regulatory proteins on amyloid beta (Aβ 25-35) induced oxidative stress in Alzheimer's mice. J. Chem. Pharm. Res., 10: 158-164.
  22. Raghavan, N., G. Vignesh, N. Mohana, D. Sivaraman and P.S. Pradeep, 2018. Bone remodeling around photochemical fortified-calcium silicate implants in long term rabbit femur model. Trends Biomater. Artif. Org, 32: 26-30.
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  23. Dhanasekaran, S., 2018. Evaluation of AChE enzyme inhibition potential of Indian medicinal herbs Ficus hispida, Morinda tinctoria, Sapindus emarginatus and their significance in Alzheimer's disease therapy. Res. J. Biotechnol., 13: 110-115.
  24. Suganya, K.U., K. Govindaraju, D. Sivaraman, R. Selvaraj, R. Manikandan and V.G. Kumar, 2017. Nanotoxicity assessment of functionalized gold nanoparticles in Sprague-dawley rats. J. Cluster Sci., 28: 2933-2951.
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  25. Sivaraman, D., 2017. Study on exploration and evaluation of novel phyto components targeting DPP-4 enzyme in the treatment of type-1 diabetes by molecular docking analysis. Int. J. Scient. Eng. Res., 8: 947-968.
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  26. Sivaraman, D., 2017. Evaluation of anti-urolithiasis potential of indian medicinal herbs ficus hispida, morinda tinctoria and sapindus emarginatus by struvite crystal growth inhibition assay. Int. J. ChemTech Res., 10: 436-447.
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  27. Sivaraman, D. and P. Muralidharan, 2017. Identification of novel phytocomponents from the leaf of morinda tinctoria a potential Indian medicinal herb by GCMS analysis. Res. J. Pharm. Biol. Chem. Sci., 8: 223-228.
  28. Nair, V.S., R. Gayatri, S. Sivakumar, D. Sivaraman, S. Viswesaran and V. Banumathi, 2017. A review on theeneerand dravagam (Distillates) used in siddhamedicine and their biomedical application in chemistry and healthcare system. Int. J. Med. Res. Pharm. Sci., 4: 32-48.
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  29. Anbarasan, K., C. Sasikala, D. Sivaraman and P. Shanmugapriya, 2017. In-vitro evaluation of anti-urolithiasis potential of Karuvanga chendoorum by struvite crystal growth inhibition assay. World J. Pharm. Pharm. Sci., 6: 862-871.
  30. Sivaraman, D., P. Panneerselvam and P. Muralidharan, 2016. Memory and brain neurotransmitter restoring potential of hydroalcoholic extract of Ipomoea aquatica forsk on amyloid beta Aβ (25-35) induced cognitive deficits in Alzheimer’s mice. Int. J. Pharmacol., 12: 52-65.
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  31. Sivaraman, D. and J. Srikanth, 2016. Discovery of novel monoamine oxidase-B inhibitors by molecular docking approach for Alzheimer‟s and Parkinson‟s disease treatment. Int. J. Pharm. Sci. Rev. Res., 40: 245-250.
  32. Kiruthiga, R. and D. Sivaraman, 2016. Evaluation of anti-cancer potential of indian medicinal herbs Morinda tinctoria and Ficus hispida using hela cell line by MTT assay method. World J. Pharm. Pharm. Sci., 5: 1658-1670.
  33. Christian, G.J., R.S. Ramaswamy, D. Sivaraman, M. Nijavizhi and S. Anusha, 2016. Anti microbial screening of siddha herbo-mineral medicinal formulation kanagalinga mezhugu against selected urogenital and enteric pathogens. IOSR J. Dent. Med. Sci., 1: 38-43.
  34. Vignesh, G., N. Raghavan, D. Sivaraman, N. Mohana and R. Selvaraj, 2015. Relevance of 3D bioprinting in tissue engineering application-concept and perspectives. Trends Biomater. Artif. Organs, Vol. 29. .
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  35. Sivaraman, D., R. Selvaraj, B.J. Dare, N. Mohana, R.N. Raghavan and G. Vignesh, 2015. Reproductive and developmental toxicity prediction by in-vitro methods: A review on alternatives for laboratory animal research. Int. J. PharmTech Res., 8: 474-479.
  36. Sivaraman, D., P. Panneerselvam and P. Muralidharan, 2015. Revealing hallmark histology of hippocampus neurons in beta-amyloid induced alzheimer's mice and investigation of neuroprotective effect of Ipomoea aquatic Forsk, an Indian medicinal herb. J. Chem. Pharm. Res., 7: 424-434.
  37. Sivaraman, D., P. Panneerselvam and P. Muralidharan, 2015. Brain free radical quenching capacity of Ipomoea aquatica by rejuvenating vital anti-oxidant enzymes on beta-amyloid induced stress in swiss albino mice. Der Pharmacia Lettre, 7: 1-12.
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  38. Sivaraman, D., G. Vignesh, R. Selvaraj and B.J. Dare, 2015. Identification of potential monoamine oxidase inhibitor from herbal source for the treatment of major depressive disorder: An in-silico screening approach. Der Pharma Chemica, 7: 224-234.
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  39. Sivaraman, D. and P. Panneerselvam, 2015. Screening of potential glycogen synthase kinase-3β inhibitors from herbal lead by in-silico docking technique. Int. J. ChemTech Res., 8: 834-842.
  40. Selvaraj, R., N.M. Kumar and D. Sivaraman, 2015. Arabinogalactan protein-A potent immuno stimulator. Int. J. Pharmacogn. Phytochem. Res., 7: 732-734.
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  41. Mohana, N., R.N. Raghavan, D. Sivaraman, G. Vignesh, D. Saravanan and R. Selvaraj, 2015. Staphylococcus aureus infected subcutaneous abscess in Guinea pig: A case study. Res. J. Pharm. Biol. Chem. Sci., 6: 1-4.
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  42. Dhanasekaran, S., P. Perumal and M. Palayan, 2015. In-vitro screening for acetylcholinesterase enzyme inhibition potential and antioxidant activity of extracts of Ipomoea aquatica Forsk: Therapeutic lead for Alzheimer's disease. J. Appl. Pharm. Sci., 5: 12-16.
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  43. Sivaraman, D., P. Panneerselvam and P. Muralidharan, 2014. Isolation, characterization and insilico pharmacological screening of medicinally important bio-active phytoconstituents from the leaves of ipomoea aquatica forsk. Int. J. Pharm. Pharm. Sci. 6: 262-267.
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  44. Sivaraman, D., P. Panneerselvam, P.M. uralidharan, K. Karthickeyan and R.V. Kumar, 2013. Insilico identification of potential acetylcholinesterase inhibitors from ipomoea aquatica forsk for the treatment of alzheimers disease. Int. J. Res. Pharm. Biomed. Sci. 4 : 1002-1010.
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  45. Sivaraman, D., P. Panneerselvam, P. Muralidharan, T.P. Prabhu and R.V. Kumar, 2013. Identification of potential plant sterols from ipomoea aquatica forsk for alzheimer's disease by gc-ms analysis. World J. Pharm. Pharm. Sci., 3: 661-666.
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  46. Sivaraman, D., P. Panneerselvam, P. Muralidharan, T.P. Prabhu and R. Vijayakumar, 2013. Green synthesis, characterization and anti-microbial activity of silver nanoparticles produced using Ipomoea aquatica forsk leaf extract. Int. J. Pharma. Sci. Res., 4: 2280-2285.
  47. Sivaraman, D., P. Panneerselvam, P. Muralidharan and T.P. Prabhu, 2013. Preclinical toxicological profile of hydroalcholic leaf extract of Ipomoea aquatica forsk an Indian medicinal plant. Pharmacologia, 4: 107-116.
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  48. Kannan, R., D. Sivaraman, P. Muralidharan and N. Deepakvenkataraman, 2013. Neuroprotective effect of hydro alcoholic effect of Areca catechu Linn on β-amyloid induced cognitive dysfunction in mice. Int. J. Res. Ayurveda Pharm., 4: 747-753.
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  49. Sivaraman, D., S.S. Kumar, P. Muralidharan and H. Rahman, 2012. Effect of Hemidesmus indicus on cerebral infract ischemia-reperfusion injured rats by four vessel occlusion method. Pharmacologia, 3: 91-102.
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  50. Sivaraman, D., P. Muralidharan and P. Panneerselvam, 2012. Ameliorating effect of ethanol leaf extract of Ficus hispida Linn. on Amyloid beta Aβ (25-35) induced cognitive deficits and oxidative stress in Alzheimer's mice. Int. J. Pharmacol., 8: 212-223.
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  51. Sivaraman, D., P. Muralidharan and H. Rahman, 2012. Evaluation of the anxiolytic effect of methanol leaf extract of Ficus hispida Linn. in corticosterone induced anxiety in young adult mice. Pharmacologia, 3: 467-471.
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  52. Prabhu, T.P., P. Pannerselvam, S. Selvakumari, R. Vijaykumar and D. Sivaraman, 2012. Effect of ethanolic and ethylacetate extract of Merremia emarginata (Burm.F) in rheumatoid arthritis. Int. Res. J. Pharmacy, 3: 264-268.
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  53. Sivaraman, D. and P. Muralidharan, 2011. Cytoprotective effect of Morinda tinctoria Roxb. against surgical and chemical factor induced gastric and duodenal ulcers in rats. Ulcers, 2011 : 1-9.
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  54. Prabhu, T.P., P. Panneerselvam, S. Selvakumari and D. Sivaraman, 2011. In vitro and in vivo anticancer activity of Ethanolic extract of Canthium parviflorum Lam on DLA and Hela cell lines. Int. J. Drug Dev. Res., 3: 280-285.
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  55. Sivaraman, D., P. Muralidaran and S.S. Kumar, 2010. Evaluation of anti-microbial and anti-inflammatory activity of methanol leaf extract of Ipomoea aquatica Forsk. Res. J. Pharm. Biol. Chem. Sci., 1: 258-264.
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  56. Sivaraman, D., K.S.R. Kumar and P. Muralidaran, 2010. Effect of ethanolic seed extract of Mucuna pruriens (L.) Dc. var. utilis on haloperidol induced tardive dyskinesia in rats. Int. J. Pharm. Sci. Rev. Res., 3: 106-113.
  57. Sivaraman, D., G. Manoj and P. Muralidharan, 2010. Evaluation of Antiulcer Activity of Polyherbal Formulations in Rats. LAP Lambert Academic Publishing, Germany, ISBN: 9783838377445, Pages: 132.
  58. Sivaraman, D. and P. Muralidharan, 2010. Neuroprotective Effect of Methanolic Leaf extract of Ficus hispida Linn on β-Amyloid (25-35) Induced Cognitive Dysfunction in Mice. LAP Lambert Academic Publishing, Germany, ISBN-13: 978-3-8383-7695-0, Pages: 92.
  59. Sivaraman, D. and P. Muralidharan, 2010. CNS depressant and antiepileptic activities of the methanol leaf extract of (Ipomoea aquatica Forsk). E-J. Chem., 7: 1555-1561.
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  60. Sivaraman, D. and P. Muralidaran, 2010. Nootropic effect of Ipomoea aquatica forsk in rat hippocampus. Int. J. Pharm. Tech. Res., 2: 475-479.
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  61. Sivaraman, D. and P. Muralidaran, 2010. Hypolipidemic activity of Ipomoea aquatica Forsk. leaf extracts on lipid profile in hyperlipidemic rats. Int. J. Pharm. Biol. Arch., 1: 175-179.
  62. Sivaraman, D. and P. Muralidaran, 2010. Evaluation of anti-microbial and anti-inflammatory activity of Morinda tinctoria Roxb. Asian J. Exp. Biol. Sci., 1: 08-13.
  63. Sivaraman, D. and P. Muralidaran, 2010. Evaluation of anti arthritic potential of Ipomoea aquatica Forsk in Freund`s adjuvant induced arthritis rats. Int. J. Contemporary Res. Rev., 1: 1-5.
  64. Sivaraman, D. and P. Muralidaran, 2010. Anti-ulcerogenic evaluation of root extract of Ficus hispida Linn. in aspirin ulcerated rats. Afr. J. Pharm. Pharmacol., 4: 79-82.
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  65. Rahman, H., P. Muralidharan, D. Sivaraman, B. Kartika and D. Saha, 2010. Evaluation of anxiolytic activity of ethanolic extracts from the leaves of Trichosanthes cucumerina L. in mice. Der Pharm. Sin., 1: 86-94.
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  66. Rahman, H., P. Muralidharan, D. Sivaraman and D. Saha, 2010. Continuous sleep deprivation for 5 days produces loss of memory in mice and may be a cause of Alzheimer's disease. Ann. Biol. Res., 1: 185-193.
  67. Sivaraman, D. and P. Muralidaran, 2009. Sedative and anticonvulsant activities of the methanol leaf extract of Ficus hispida Linn. Drug Invention Today, 1: 23-27.
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  68. Sivaraman, D. and P. Muralidaran, 2009. Evaluation of antidiabetic activity of Morinda tinctoria Roxb in streptozotocin induced diabetic rats. Asian Biomed., 3: 433-437.
  69. Sivaraman, D. and P. Muralidaran, 2009. Acetylcholine enhancing activity of methanol leaf extract of Ficus hispida Linn in rat hippocampus. J. Herbal Med. Toxicol., 3: 147-150.
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  70. Sivaraman, D. and P. Muralidaran, 2008. Anti-ulcerogenic evaluation of the ethanolic extract of water spinach (Ipomoea aquatica Forsk) in aspirin ulcerated rats. J. Pharm. Res., 1: 143-147.
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