Dr. Yu Ru Kou
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Dr. Yu Ru Kou

Professor
National Yang-Ming University, Taiwan

Highest Degree
Ph.D. in Physiology from University of Kentucky, USA

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Area of Interest:

Biomedical Sciences
100%
Molecular Biology
62%
Respiratory Physiology
90%
Critical Care Medicine
75%
Neurophysiology
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Zhao, J.F., L.C. Ching, Y.R. Kou, S.J. Lin, J. Wei, S.K. Shyue and T.S. Lee, 2013. Activation of TRPV1 prevents OxLDL-induced lipid accumulation and TNF-α-induced inflammation in macrophages: Role of liver X receptor α. Med. Inflamm., 10.1155/2013/925171.
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  2. Wei, J., L.C. Ching, J.F. Zhao, S.K. Shyue, H.F. Lee, Y.R. Kou and T.S. Lee, 2013. Essential role of transient receptor potential vanilloid type 1 in evodiamine-mediated protection against atherosclerosis. Acta Physiol., 207: 299-307.
  3. W.H. Tsai, S.L. Lai, I.T. Li, H.Y. Chien, C.H. Shih, Y.R. Kou and H.C. Hsu, 2013. Annexin A1 mediates the anti-adhesive effects of dexamethasone during the cell-cell interaction between the all-trans retinoic acid-treated acute promyelocytic leukemic cells and endothelial cells. J. Cell. Biochem., 114: 551-557.
    CrossRef  |  Direct Link  |  
  4. Shen, C.M., S.C. Lin, D.M. Niu and Y.R. Kou, 2013. Development of monocyte toll-like receptor 2 and toll-like receptor 4 in preterm newborns during the first few months of life. Pediatr Res., 73: 685-691.
    CrossRef  |  PubMed  |  
  5. Perng, D.W., T.M. Chang, J.Y. Wang, C.C. Lee and S.W. Lu et al., 2013. Inflammatory role of AMP-activated protein kinase signaling in an experimental model of toxic smoke inhalation injury. Crit. Care Med., 41: 120-132.
    CrossRef  |  PubMed  |  
  6. Pan, S.W., H.K. Kao, W.K. Yu, T.C. Lien, Y.W. Chen, J.H. Wang and Y.R. Kou, 2013. Synergistic impact of low serum albumin on intensive care unit admission and high blood urea nitrogen during intensive care unit stay on post-intensive care unit mortality in critically ill elderly patients requiring mechanical ventilation. Geriatr. Gerontol. Int., 13: 107-115.
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  7. Liu, B.Y., T.L. Tsai, C.Y. Ho, S.W. Lu, C.J. Lai and Y.R. Kou, 2013. Role of TRPA1 and TRPV1 in the ROS-dependant sensory irritation of superior laryngeal capsaicin-sensitive afferents by cigarette smoke in anesthetized rats. Pulm. Pharmacol. Ther., 26: 364-372.
  8. Lin, Y.J., Y.S. Lin, C.J. Lai, Z.F. Yuan, T. Ruan and Y.R. Kou, 2013. Perivagal antagonist treatment in rats selectively blocks the reflex and afferent responses of vagal lung C fibers to intravenous agonists. J. Applied Physiol., 114: 361-370.
  9. Lin, Y.J., H.H. Hsu, T. Ruan and Y.R. Kou, 2013. Mediator mechanisms involved in TRPV1, TRPA1 and P2X receptor-mediated sensory transduction of pulmonary ROS by vagal lung C-fibers in rats. Respir. Physiol. Neurobiol., 189: 1-9.
    CrossRef  |  Direct Link  |  
  10. Kao, J.H., H.K. Kao, Y.W. Chen, W.K. Yu and S.W. Pan et al., 2013. Impact and predictors of prolonged chest tube duration in mechanically ventilated patients with acquired pneumothorax. Respir. Care, 58: 2093-2100.
  11. Fan, W.J., Y.T. Li, J.J. Chen, S.C. Chen, Y.S. Lin, Y.R. Kou and C.W. Peng, 2013. Sexually dimorphic urethral activity in response to pharmacological activation of 5-HT1A receptors in the rat. Am. J. Physiol. Renal Physiol., 305: F1332-F1342.
    CrossRef  |  PubMed  |  
  12. Chuang, K.H., C.S. Lu, Y.R. Kou and Y.L. Wu, 2013. Cell cycle regulation by glucosamine in human pulmonary epithelial cells. Pulm. Pharmacol. Ther., 26: 195-204.
  13. Zhao, J.F., L.C. Ching, Y.C. Huang, C.Y. Chen, A.N. Chiang, Y.R. Kou, S.K. Shyue and T.S. Lee, 2012. Molecular mechanism of curcumin on the suppression of cholesterol accumulation in macrophage foam cells and atherosclerosis. Mol. Nut. Food Res., 56: 691-701.
    CrossRef  |  Direct Link  |  
  14. Yu, Y.B., Y.W. Liao, K.H. Su, T.M. Chang, S.K. Shyue, Y.R. Kou, 2012. Lee TS. Prior exercise training alleviates the lung inflammation induced by subsequent exposure to environmental cigarette smoke. Acta. Physiol., 205: 532-540.
  15. Tsai, W.H., H.Y. Chien, C.H. Shih, S.L. Lai and I.T. Li et al., 2012. Annexin A1 mediates the anti-inflammatory effects during the granulocytic differentiation process in all-trans retinoic acid-treated acute promyelocytic leukemic cells. J. Cell. Physiol., 227: 3661-3669.
    CrossRef  |  
  16. Tsai, W.H., C.H. Shih, H.Y. Wu, H.Y. Chien and Y.C. Chiang et al., 2012. Role of lipoxin A4 in the cell-to-cell interaction between all-trans retinoic acid-treated acute promyelocytic leukemic cells and alveolar macrophages. J. Cell. Physiol., 227: 1123-1129.
    CrossRef  |  
  17. Su, K.H., Y.B. Yu, H.H. Hou, J.F. Zhao and Y.R. Kou et al., 2012. AMP-activated protein kinase mediates erythropoietin-induced activation of endothelial nitric oxide synthase. J. Cell. Physiol., 227: 3053-3062.
  18. Lee, T.S. and Y.R. Kou, 2012. Enhancing endothelial progenitor cell therapy for critical limb ischemia by extracorporeal shock wave. Crit. Care Med., 40: 332-333.
    CrossRef  |  PubMed  |  
  19. Lee, H.F., T.S. Lee and Y.R. Kou, 2012. Anti-inflammatory and neuroprotective effects of triptolide on traumatic brain injury in rats. Respir Physiol. Neurobiol., 182: 1-8.
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  20. Hou, H.H., B.D. Hammock, K.H. Su, C. Morisseau and Y.R. Kou et al., 2012. N-terminal domain of soluble epoxide hydrolase negatively regulates the VEGF-mediated activation of endothelial nitric oxide synthase. Cardiovasc Res., 93: 120-129.
    CrossRef  |  
  21. Ching, L.C., C.Y. Chen, K.H. Su, H.H. Hou, S.K. Shyue, Y.R. Kou and T.S. Lee, 2012. Implication of AMP-activated protein kinase in transient receptor potential vanilloid type 1-mediated activation of endothelial nitric oxide synthase. Mol. Med., 18: 805-815.
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  22. Chen, S.C., W.M. Grill, W.J. Fan, Y.R. Kou, Y.S. Lin, C.H. Lai and C.W. Peng, 2012. Bilateral pudendal afferent stimulation improves bladder emptying in rats with urinary retention. BJU. Int., 109: 1051-1058.
    CrossRef  |  PubMed  |  
  23. Tsai, T.H., S.F. Chen, T.Y. Huang, C.F. Tzeng and A.S. Chiang et al., 2011. Impaired CD14 and CD36 expression, bacterial clearance and toll-like receptor 4-MYD88 signaling in caveolin-1-deleted macrophages and mice. Shock, 35: 92-99.
  24. Tang, G.J., H.Y. Wang, J.Y. Wang, C.C. Lee and H.W. Tseng et al., 2011. Novel role of AMP-activated protein kinase signaling in cigarette smoke induction of IL-8 in human lung epithelial cells and lung inflammation in mice. Free Radic. Biol. Med., 50: 1492-1502.
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  25. Su, K.H., S.K. Shyue, Y.R. Kou, L.C. Ching, A.N. Chiang et al., 2011. TS. β Common receptor integrates the erythropoietin signaling in activation of endothelial nitric oxide synthase. J. Cell. Physiol., 226: 3330-3339.
  26. Shih, R.H., S.E. Cheng, L.D. Hsiao, Y.R. Kou and C.M. Yang, 2011. Cigarette smoke extract upregulates heme oxygenase-1 via PKC/NADPH oxidase/ROS/PDGFR/PI3K/Akt pathway in mouse brain endothelial cells. J. Neuroinflamm., Vol. 8. 10.1186/1742-2094-8-104.
    CrossRef  |  Direct Link  |  
  27. Powell, F.L. and Y.R. Kou, 2011. Inflammation and cardio-respiratory control: Foreword. Respir. Physiol. Neurobiol., 178: 359-361.
  28. Pan, S.W., H.K. Kao, T.C. Lien, Y.W. Chen and Y.R. Kou and J.H. Wang, 2011. Acute kidney injury on ventilator initiation day independently predicts prolonged mechanical ventilation in intensive care unit patients. J. Crit. Care, 26: 586-592.
  29. Lee, T.S. and Y.R. Kou, 2011. How alcohol impairs the granulocyte expansion during septicemia. Crit. Care Med., 39: 2194-2195.
    CrossRef  |  PubMed  |  
  30. Kou, Y.R., K. Kwong and L.Y. Lee, 2011. Airway inflammation and hypersensitivity induced by chronic smoking. Respir. Physiol. Neurobiol., 178: 395-405.
    CrossRef  |  Direct Link  |  
  31. Ching, L.C., Y.R. Kou, S.K. Shyue, K.H. Su and J. Wei et al., 2011. Molecular mechanisms of activation of endothelial nitric oxide synthase mediated by transient receptor potential vanilloid type 1. Cardiovasci. Res., 91: 492-501.
    CrossRef  |  PubMed  |  
  32. Chiang, C.H., C.H. Chuang, S.L. Liu, T.S. Lee, Y.R. Kou and H. Zhang, 2011. Apocynin attenuates ventilator-induced lung injury in an isolated and perfused rat lung model. Intensive Care Med., 37: 1360-1367.
    CrossRef  |  Direct Link  |  
  33. Cheng, S.E., C.C. Lin, I.T. Lee, C.K. Hsu, Y.R. Kou and C.M. Yang, 2011. Cigarette smoke extract regulates cytosolic phospholipase A2 expression via NADPH oxidase/MAPKs/AP-1 and p300 in human tracheal smooth muscle cells. J. Cell. Biochem., 112: 589-599.
    CrossRef  |  Direct Link  |  
  34. Cheng, L.C., K.H. Su, Y.R. Kou, S.K. Shyue and L.C. Ching et al., 2011. α-Lipoic acid ameliorates foam cell formation via liver X receptor α-dependent upregulation of ATP-binding cassette transporters A1 and G1. Free Radic. Biol. Med., 50: 47-54.
  35. Chen, C.Y., S.K. Shyue, L.C. Ching, K.H. Su and Y.L. Wu et al., 2011. Wogonin promotes cholesterol efflux by increasing protein phosphatase 2B-dependent dephosphorylation at ATP-binding cassette transporter-A1 in macrophages. J. Nut. Biochem., 22: 1015-1021.
    CrossRef  |  Direct Link  |  
  36. Chen, C.H., S. Xirasagar, C.C. Lin, L.H. Wang and Y.R. Kou, 2011. Lin HC. Risk of adverse perinatal outcomes with antithyroid treatment during pregnancy: A nationwide population-based study. BJOG., 118: 1365-1373.
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  37. Chen, C.H., M.C. Huang, H.C. Liu, C.J. Huang, H.C. Lin and Y.R. Kou, 2011. Increased risk of preterm birth among women with mitral valve prolapse: A nationwide, population-based study. Ann. Epidemiol., 21: 391-398.
  38. Bien, M.Y., Y.S. Lin, C.H. Shih, Y.L. Yang and H.W. Lin et al., 2011. Comparisons of predictive performance of breathing pattern variability measured during T-piece, automatic tube compensation, and pressure support ventilation for weaning intensive care unit patients from mechanical ventilation. Crit. Care Med., 39: 2253-2262.
    CrossRef  |  PubMed  |  
  39. Wu, Y.L., Y.R. Kou, H.L. Ou, H.Y. Chien and K.H. Chuang et al., 2010. Glucosamine regulation of LPS-mediated inflammation in human bronchial epithelial cells. Eur. J. Pharmacol., 635: 219-226.
    CrossRef  |  Direct Link  |  
  40. Tsai, J.Y., K.H. Su, S.K. Shyue, Y.R. Kou and Y.B. Yu et al., 2010. EGb761 ameliorates the formation of foam cells by regulating the expression of SR-A and ABCA1: Role of haem oxygenase-1. Cardiovasc Res., 88: 415-423.
    CrossRef  |  PubMed  |  
  41. Shih, R.H., I.T. Lee, H.L. Hsieh, Y.R. Kou and C.M. Yang, 2010. Cigarette smoke extract induces HO-1 expression in mouse cerebral vascular endothelial cells: Involvement of c-Src/NADPH oxidase/PDGFR/JAK2/STAT3 pathway. J. Cell. Physiol., 225: 741-750.
    CrossRef  |  Direct Link  |  
  42. Lu, K.Y., L.C. Ching, K.H. Su, Y.B. Yu and Y.R. Kou et al., 2010. Erythropoietin suppresses the formation of macrophage foam cells: Role of liver X receptor alpha. Circulation, 121: 1828-1837.
  43. Lin, Y.S., C.C. Hsu, M.Y. Bien, H.C. Hsu, H.T. Weng and Y.R. Kou, 2010. Activations of TRPA1 and P2X receptors are important in ROS-mediated stimulation of capsaicin-sensitive lung vagal afferents by cigarette smoke in rats. J. Applied Physiol., 108: 1293-1303.
    Direct Link  |  
  44. Lin, C.C., I.T. Lee, Y.L. Yang, C.W. Lee, Y.R. Kou and C.M. Yang, 2010. Induction of COX-2/PGE2/IL-6 is crucial for cigarette smoke extract-induced airway inflammation: Role of TLR4-dependent NADPH oxidase activation. Free Radic. Biol. Med., 48: 240-254.
    CrossRef  |  Direct Link  |  
  45. Lee, T.S., C.C. Pan, C.C. Peng, Y.R. Kou and C.Y. Chen et al., 2010. Anti-atherogenic effect of berberine on LXRα-ABCA1-dependent cholesterol efflux in macrophages. J. Cell. Biochem., 111: 104-110.
    CrossRef  |  Direct Link  |  
  46. Kou, Y.R. and T.S. Lee, 2010. Intratracheal siRNA for the in vivo silencing of caspase-3: A novel therapy for acute lung injury? Crit. Care Med., 38: 1223-1224.
  47. Cheng, S.E., I.T. Lee, C.C. Lin, Y.R. Kou and C.M.Yang, 2010. Cigarette smoke particle-phase extract induces HO-1 expression in human tracheal smooth muscle cells: role of the c-Src/NADPH oxidase/MAPK/Nrf2 signaling pathway. Free Radic. Biol. Med., 48: 1410-1422.
    CrossRef  |  Direct Link  |  
  48. Chen, C.H., Y.R. Kou, C.S. Chen and H.C. Lin, 2010. Seasonal variation in the incidence of spontaneous pneumothorax and its association with climate: A nationwide population-based study. Respirology, 15: 296-302.
    CrossRef  |  PubMed  |  
  49. Yang, C.M., I.T. Lee, C.C. Lin, Y.L. Yang, S.F. Luo, Y.R. Kou and L.D. Hsiao, 2009. Cigarette smoke extract induces COX-2 expression via a PKCalpha/c-Src/EGFR, PDGFR/PI3K/Akt/NF-kappaB pathway and p300 in tracheal smooth muscle cells. Am. J. Physiol. Lung. Cell. Mol. Physiol., 297: L892-L902.
    CrossRef  |  PubMed  |  
  50. Tsai, T.L., S.Y. Chang, C.Y. Ho and Y.R. Kou, 2009. Role of ATP in the ROS-mediated laryngeal airway hyperreactivity induced by laryngeal acid-pepsin insult in anesthetized rats. J. Applied Physiol., 106: 1584-1592.
    CrossRef  |  PubMed  |  
  51. Tsai, C.Y., T.S. Lee, Y.R. Kou and Y.L. Wu, 2009. Glucosamine inhibits IL-1beta-mediated IL-8 production in prostate cancer cells by MAPK attenuation. J. Cell. Biochem., 108: 489-498.
  52. Su, K.H., J.Y. Tsai, Y.R. Kou, A.N. Chang and S.H. Hsiao et al., 2009. Valsartan regulates the interaction of angiotensin II type 1 receptor and endothelial nitric oxide synthase via Src/PI3K/Akt signalling. Cardiovasc. Res., 82: 468-475.
    CrossRef  |  PubMed  |  Direct Link  |  
  53. Shen, C.M., S.C. Lin, D.M. Niu and Y.R. Kou, 2009. Labor increases the surface expression of two Toll-like receptors in the cord blood monocytes of healthy term newborns. Acta. Paediatr., 98: 959-962.
  54. Lin, Y.S., R.L. Lin, M.Y. Bien, C.Y. Ho and Y.R. Kou, 2009. Sensitization of capsaicin-sensitive lung vagal afferents by anandamide in rats: Role of transient receptor potential vanilloid 1 receptors. J. Applied Physiol., 106: 1142-1152.
    CrossRef  |  PubMed  |  
  55. Lee, T.S., C.Y. Lin, J.Y. Tsai, Y.L. Wu and K.H. Su et al., 2009. Resistin increases lipid accumulation by affecting class A scavenger receptor, CD36 and ATP-binding cassette transporter-A1 in macrophages. Life Sci., 84: 97-104.
    CrossRef  |  
  56. Kou, Y.R. and M.Y. Bien, 2009. Ventilatory management of acute lung injury by neurally adjusted ventilatory assist and PEEP. Crit. Care Med., 34: 3055-3056.
  57. Kao, H.K., T.C. Lien, Y.R. Kou and J.H. Wang, 2009. Assessment of myocardial injury in the emergency department independently predicts the short-term poor outcome in patients with severe carbon monoxide poisoning receiving mechanical ventilation and hyperbaric oxygen therapy. Pulm. Pharmacol. Ther., 22: 473-477.
    CrossRef  |  Direct Link  |  
  58. Hsu, C.L., Y.L. Wu, G.J. Tang, T.S. Lee and Y.R. Kou, 2009. Ginkgo biloba extract confers protection from cigarette smoke extract-induced apoptosis in human lung endothelial cells: Role of heme oxygenase-1. Pulm. Pharmacol. Ther., 22: 286-296.
    CrossRef  |  Direct Link  |  
  59. Hsu, C.C., M.Y. Bien, Y.T. Huang, T. Ruan, Y.R. Kou and Y.S. Lin, 2009. N-arachidonyl dopamine sensitizes rat capsaicin-sensitive lung vagal afferents via activation of TRPV1 receptors. Respir. Physiol. Neurobiol., 167: 323-332.
  60. Cheng, S.E., S.F. Shue-Fen Luo, M.J. Jou, C.C. Lin and Y.R. Kou et al., 2009. Cigarette smoke extract induces cytosolic phospholipase A2 expression via NADPH oxidase, MAPKs, AP-1 and NF-kappaB in human tracheal smooth muscle cells. Free Radic. Biol. Med., 46: 948-960.
    PubMed  |  
  61. Wu, Y.L., H.H. Chuang, Y.R. Kou, T.S. Lee and S.H. Lu et al., 2008. Regulation of LH receptor and PGF2alpha receptor signaling by the regulator of G protein signaling 2 (RGS2) in human and mouse granulosa cells. Chin. J. Physiol., 51: 282-291.
    Direct Link  |  
  62. Lee, T.S., Y.J. Liu, G.J. Tang, H.W. Yien, Y.L. Wu and Y.R. Kou, 2008. Wood smoke extract promotes both apoptosis and proliferation in rat alveolar epithelial type II cells: The role of oxidative stress and heme oxygenase-1. Crit. Care Med., 36: 2597-2606.
  63. Ho, C.Y., C.T. Tan, H.H. Tsai and Y.R. Kou, 2008. Ozone-induced nasal hyperresponsiveness to tachykinins in guinea pigs. Am. J. Rhinol., 22: 463-467.
    Direct Link  |  
  64. Cheng, Y.S., T.S. Lee, H.C. Hsu, Y.R. Kou and Y.L. Wu, 2008. Characterization of the transcriptional regulation of the regulator of G protein signaling 2 (RGS2) gene during 3T3-L1 preadipocyte differentiation. J. Cell. Biochem., 105: 922-930.
  65. Yang, Y.L., G.J. Tang, Y.L. Wu, H.W. Yien, T.S. Lee and Y.R. Kou, 2007. Exacerbation of wood smoke-induced acute lung injury by mechanical ventilation using moderately high tidal volume in mice. Respir. Physiol. Neurobiol., 160: 99-108.
  66. Tsai, W.H., H.C. Hsu, C.C. Lin, C.K. Ho and Y.R. Kou, 2007. Role of IL-8 and GRO-alpha in the chemotactic transmigration of all-trans retinoic acid-activated promyelocytic leukemic cells toward alveolar epithelial cells. Crit. Care Med., 35: 974-985.
  67. Lee, L.Y., N.K. Burki, D.C. Gerhardstein, Q. Gu, Y.R. Kou and J. Xu, 2007. Airway irritation and cough evoked by inhaled cigarette smoke: Role of neuronal nicotinic acetylcholine receptors. Pulm. Pharmacol. Thera, 20: 355-364.
  68. Kou, Y.R. and H.W. Yien, 2007. Inadequate mechanical ventilation as the first or the second hit in a two-hit model: Is there any difference in the injurious impact? Crit. Care Med., 35: 2658-2659.
  69. Tsai, T.L., S.Y. Chang, C.Y. Ho and Y.R. Kou, 2006. Neural and hydroxyl radical mechanisms underlying laryngeal airway hyperreactivity induced by laryngeal acid-pepsin insult in anesthetized rats. J. Applied Physiol., 101: 328-338.
  70. Ruan, T., Y.S. Lin, K.S. Lin and Y.R. Kou, 2006. Mediator mechanisms involved in TRPV1 and P2X receptor-mediated, ROS-evoked bradypneic reflex in anesthetized rats. J. Applied Physiol., 101: 644-654.
  71. Iba, M.M., J. Fung, L. Chung, J. Zhao and B. Winnik et al., 2006. Differential inducibility of rat pulmonary CYP1A1 by cigarette smoke and wood smoke. Mutat. Res., 14: 1-11.
  72. Huang, P.S., G.J. Tang, C.H. Chen and Y.R. Kou, 2006. Whole-body moderate hypothermia confers protection from wood smoke-induced acute lung injury in rats: The therapeutic window. Crit. Care Med., 34: 1160-1167.
    PubMed  |  
  73. Tsai, W.H., Y.M. Lee, B. Ing-Tiau Kuo, C.K. Ho and P.T. Liao et al., 2005. Increased seroprevalence of human herpesvirus 8 in patients with hematological disorders. Acta Haematol, 114: 95-98.
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  74. Ruan, T., Y.S. Lin, K.S. Lin and Y.R. Kou, 2005. Sensory transduction of pulmonary reactive oxygen species by capsaicin-sensitive vagal lung afferent fibres in rats. J. Physiol., 565: 563-578.
    PubMed  |  
  75. Ruan, T., Q. Gu, Y.R. Kou and L.Y. Lee, 2005. Hyperthermia increases sensitivity of pulmonary C-fibre afferents in rats. J. Physiol., 565: 295-308.
    PubMed  |  
  76. Liu, P.L., Y.L. Chen, Y.H. Chen, S.J. Lin and Y.R. Kou, 2005. Wood smoke extract induces oxidative stress-mediated caspase-independent apoptosis in human lung endothelial cells: Role of AIF and EndoG. Am. J. Physiol. Lung Cell Mol. Physiol., 289: L739-L749.
  77. Lai, C.J., T. Ruan and Y.R. Kou, 2005. The involvement of hydroxyl radical and cyclooxygenase metabolites in the activation of lung vagal sensory receptors by circulatory endotoxin in rats. J. Applied Physiol., 98: 620-628.
    PubMed  |  
  78. Bien, M.Y., H.W. Yien, S.S. Hseu, J.H. Wang and Y.R. Kou, 2005. Instability of spontaneous breathing patterns in patients with persistent vegetative state. Respir. Physiol. Neurobiol., 145: 163-175.
    CrossRef  |  
  79. Bien, M.Y., S.S. Hseu, H.W. Yien, B.I. Kuo, Y.T. Lin, J.H. Wang and Y.R. Kou, 2004. Breathing pattern variability: A weaning predictor in postoperative patients recovering from systemic inflammatory response syndrome. Intensive. Care Med., 30: 241-247.
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  80. Ruan, T., C.Y. Ho and Y.R. Kou, 2003. Afferent vagal pathways mediating respiratory reflexes evoked by ROS in the lungs of anesthetized rats. J. Applied Physiol., 94: 1987-1998.
    PubMed  |  
  81. Jeng, M.J., Y.R. Kou, C.C. Sheu and B. Hwang, 2003. Effects of exogenous surfactant supplementation and partial liquid ventilation on acute lung injury induced by wood smoke inhalation in newborn piglets. Crit. Care Med., 31: 1166-1174.
  82. Tang, G.J., Y.L. Yang and Y.R. Kou, 2002. Involvement of tachykinin NK1 and NK2 receptors in changes in lung mechanics and airway microvascular leakage during the early phase of endotoxemia in Guinea pigs. J. Biomed. Sci., 9: 415-423.
  83. Lai, C.J., C.Y. Ho and Y.R. Kou, 2002. Activation of lung vagal sensory receptors by circulatory endotoxin in rats. Life Sci., 70: 2125-2138.
  84. Jeng, M.J., Y.R. Kou, C.C. Sheu and B. Hwang, 2002. Effects of partial liquid ventilation with FC-77 on acute lung injury in newborn piglets. Pediatr. Pulmonol., 33: 12-21.
    CrossRef  |  
  85. Ho, C.Y. and Y.R. Kou, 2002. Mechanisms of wood smoke-induced increases in nasal airway resistance and reactivity in rats. Eur. J. Pharmacol., 436: 127-134.
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  86. Lin, Y.S., C.Y. Ho, G.J. Tang and Y.R. Kou, 2001. Alleviation of wood smoke-induced lung injury by tachykinin receptor antagonist and hydroxyl radical scavenger in guinea pigs. Eur. J. Pharmacol., 425: 141-148.
    CrossRef  |  Direct Link  |  
  87. Hsu, T.H. and Y.R. Kou, 2001. Airway hyperresponsiveness to bronchoconstrictor challenge after wood smoke exposure in guinea pigs. Life Sci., 68: 2945-2956.
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  88. Lin, Y.S., C.Y. Ho, S.Y. Chang and Y.R. Kou, 2000. Laryngeal C-fiber afferents are not involved in the apneic response to laryngeal wood smoke in anesthetized rats. Life Sci., 66: 1695-1704.
  89. Lin, Y.S. and Y.R. Kou, 2000. Acute neurogenic airway plasma exudation and edema induced by inhaled wood smoke in guinea pigs: Role of tachykinins and hydroxyl radical. Eur. J. Pharmacol., 394: 139-148.
    CrossRef  |  
  90. Kumar, G.K., Y.R. Kou, J.L. Overholt and N.R. Prabhakar, 2000. Involvement of substance P in neutral endopeptidase modulation of carotid body sensory responses to hypoxia. J. Applied Physiol., 88: 195-202.
  91. Hsu, T.H., Y.L. Lai and Y.R. Kou, 2000. Wood smoke-induced airway hyperreactivity in guinea pigs: Time course, and role of leukotrienes and hydroxyl radical. Life Sci., 66: 971-980.
    CrossRef  |  
  92. Ho, C.L. and Y.R. Kou, 2000. Protective and defensive airway reflexes evoked by nasal exposure to wood smoke in anesthetized rats. J. Applied Physiol., 88: 863-870.
    Direct Link  |  
  93. Chen, H.F., B.P. Lee and Y.R. Kou, 2000. Different roles of two subgroups of lung vagal C-fiber afferents in the tachypneic response to pulmonary air embolism in dogs. Chin. J. Physiol., 43: 185-190.
  94. Chen, H.F. and Y.R. Kou, 2000. Vagal and mediator mechanisms underlying the tachypnea caused by pulmonary air embolism in dogs. J. Applied Physiol., 88: 1247-1253.
    Direct Link  |  
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