Dr. Ying-Ju  Lin
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Dr. Ying-Ju Lin

Professor
China Medical University, Taiwan


Highest Degree
Ph.D. in Life Science from National Tsing Hua University, Taiwan

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Area of Interest:

Public Health
100%
Immunogenetics
62%
Epidemiology
90%
Virology
75%
Rheumatology
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Lin, Y.J., C.C. Lai, C.H. Lai, S.C. Sue and C.W. Lin et al., 2013. Inhibition of enterovirus 71 infections and viral IRES activity by Fructus gardenia and geniposide. Eur. J. Med. Chem., 62: 206-213.
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  2. Lin, Y.J., Y.C. Lan, Y.C. Huang, T.H. Lin and S.M. Huang et al., 2012. Effects of cytokine and cytokine receptor gene variation on high anti-HB titers: Following up on Taiwan's neonatal hepatitis B immunization program. Clin. Chim. Acta, 413: 1194-1198.
    CrossRef  |  PubMed  |  Direct Link  |  
  3. Lin, Y.J., Y.C. Chang, N.W. Hsiao, J.L. Hsieh and C.Y. Wang et al., 2012. Fisetin and rutin as 3C protease inhibitors of enterovirus A71. J. Virolog. Methods, 182: 93-98.
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  4. Lin, W.Y., C.C. Lee, H.P. Liu, I.C. Chou and J.J. Sheu et al., 2012. Association of genetic variations in X-ray repair cross-complementing group 1 and Tourette syndrome. J. Clin. Lab. Anal., 26: 321-324.
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  5. Li, S.W., T.C. Yang, L. Wan, Y.J. Lin, F.J. Tsai, C.C. Lai and C.W. Lin, 2012. Correlation between TGF-β1 expression and proteomic profiling induced by severe acute respiratory syndrome coronavirus papain-like protease. Proteomics, 12: 3193-3205.
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  6. Huang, C.M., P.H. Huang, C.L. Chen, Y.J. Lin, C.H. Tsai, W.L. Huang and F.J. Tsai, 2012. Association of toll-like receptor 9 gene polymorphism in Chinese patients with systemic lupus erythematosus in Taiwan. Rheumatol. Int., 32: 2105-2109.
    CrossRef  |  PubMed  |  Direct Link  |  
  7. Chiu, Y.F., B. Sugden, P.J. Chang, L.W. Chen and Y.J. Lin et al., 2012. Characterization and intracellular trafficking of Epstein-Barr virus BBLF1, a protein involved in virion maturation. J. Virol., 86: 9647-9655.
    PubMed  |  Direct Link  |  
  8. Chen, S.Y., L. Wan, C.M. Huang, Y.C. Huang and J.J. Sheu et al., 2012. Association of the C-285T and A5954G polymorphisms in the DNA repair gene OGG1 with the susceptibility of rheumatoid arthritis. Rheumatol. Int., 32: 1165-1169.
    CrossRef  |  PubMed  |  Direct Link  |  
  9. Chang, C.Y., H.L. Chan, H.Y. Lin, T.D. Way and M.C. Kao et al., 2012. Rhein induces apoptosis in human breast cancer cells. Evid. Based Complement. Alternat. Med. 10.1155/2012/952504.
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  10. Tsai, F.J., C.W. Lin, C.C. Lai, Y.C. Lan and C.H. Lai et al., 2011. Kaempferol inhibits enterovirus 71 replication and internal ribosome entry site (IRES) activity through FUBP and HNRP proteins. Food Chem., 128: 312-322.
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  11. Lin, Y.J., Y.C. Lan, L. Wan, T.H. Lin and D.Y. Chen et al., 2011. Serological surveillance and IL-10 genetic variants on anti-HBs titers: Hepatitis B vaccination 20 years after neonatal immunization in Taiwan. Clin. Chim. Acta, 412: 766-773.
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  12. Li, S.W., C.C. Lai, J.F. Ping, F.J. Tsai and L. Wan et al., 2011. Severe acute respiratory syndrome coronavirus papain-like protease suppressed α interferon-induced responses through downregulation of extracellular signal-regulated kinase 1-mediated signalling pathways. J. Gen. Virol., 92: 1127-1140.
    CrossRef  |  
  13. Lan, Y.C., T.H. Lin, J.D. Tsai, Y.C. Yang and C.T. Peng et al., 2011. Molecular epidemiology of the 2005 enterovirus 71 outbreak in central Taiwan. Scand. J. Infect. Dis., 43: 354-359.
    CrossRef  |  
  14. Lai, M.T., C.H. Hua, M.H. Tsai, L. Wan and Y.J. Lin et al., 2011. Talin-1 overexpression defines high risk for aggressive oral squamous cell carcinoma and promotes cancer metastasis. J. Pathol., 224: 367-376.
    CrossRef  |  PubMed  |  Direct Link  |  
  15. Chen, S.Y., Y.J. Lin, J.S. Chang, Y.C. Huang and J.J. Sheu et al., 2011. Association between 17 β-HSD8 polymorphisms and Kawasaki disease among Han Chinese children in Taiwan. ScienceAsia, 37: 214-218.
    Direct Link  |  
  16. Chang, H.C., D.R. Doerge, C. Hsieh, Y. Lin and F. Tsai, 2011. The covalent binding of genistein to the non-prosthetic-heme-moiety of bovine lactoperoxidase leads to enzymatic inactivation. Biomed. Environ. Sci., 24: 284-290.
    CrossRef  |  
  17. Sheu, J.J., Y.J. Lin, J.S. Chang, L. Wan and S.Y. Chen et al., 2010. Association of COL11A2 polymorphism with susceptibility to Kawasaki disease and development of coronary artery lesions. Int. J. Immunogenet., 37: 487-492.
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  18. Liu, Y.H., C.H. Chen, S.Y. Chen, Y.J. Lin and W.L. Liao et al., 2010. Association of Phospholipase A2 receptor 1 polymorphisms with idiopathic membranous nephropathy in Chinese patients in Taiwan. J. Biomed. Sci., Vol. 17. 10.1186/1423-0127-17-81.
    CrossRef  |  
  19. Lin, Y.J., Y.C. Lan, L. Wan, C.M. Huang and C.W. Lin et al., 2010. The NBS1 genetic polymorphisms and the risk of the systemic lupus erythematosus in taiwanese patients. J. Clin. Immunol., 30: 643-648.
    CrossRef  |  
  20. Lin, Y.J., L. Wan, C.M. Huang, J.J. Sheu and S.Y. Chen et al., 2010. IL-10 and TNF-α promoter polymorphisms in susceptibility to systemic lupus erythematosus in Taiwan. Clin. Exp. Rheumat., 28: 318-324.
    PubMed  |  Direct Link  |  
  21. Lin, Y.J., J.G. Peng and S.C. Wu, 2010. Characterization of the GXXXG motif in the first transmembrane segment of Japanese encephalitis virus precursor membrane (prM) protein. J. Biomed. Sci., Vol., 17. 10.1186/1423-0127-17-39.
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  22. Lin, H.J., Y.J. Kung, Y.J. Lin, J.J. Sheu and B.H. Chen et al., 2010. Association of the Lumican gene functional 3'-UTR polymorphism with high myopia. Invest. Ophthalmol. Visual Sci., 51: 96-102.
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  23. Lai, C.H., N.W. Chang, C.F. Lin, C.D. Lin and Y.J. Lin et al., 2010. Proteomics-based identification of haptoglobin as a novel plasma biomarker in oral squamous cell carcinoma. Clin. Chim. Acta, 411: 984-991.
    CrossRef  |  
  24. Huang, Y.C., Y.J. Lin, J.S. Chang, S.Y. Chen and L. Wan et al., 2010. Single nucleotide polymorphism rs2229634 in the ITPR3 gene is associated with the risk of developing coronary artery aneurysm in children with Kawasaki disease. Int. J. Immunogenet., 37: 439-443.
    CrossRef  |  PubMed  |  
  25. Huang, Y.C., Y.J. Lin, J.S. Chang, S.Y. Chen and L. Wan et al., 2010. Haplotype of BAK1 (BCL2 antagonist killer 1) polymorphisms associated with the risk of developing Kawasaki disease in Taiwanese children. Sci. Asia, 36: 125-129.
  26. Hsueh, K.C., Y.J. Lin, J.S. Chang, L. Wan and F.J. Tsai, 2010. BTNL2 gene polymorphisms may be associated with susceptibility to Kawasaki disease and formation of coronary artery lesions in Taiwanese children. Eur. J. Pediatr., 169: 713-719.
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  27. Hsueh, K.C., Y.J. Lin, H.C. Lin and C.Y. Lin, 2010. Serum leptin and adiponectin levels correlate with severity of allergic rhinitis. Pediatr. Allergy Immunol., 21: e155-e159.
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  28. Hsieh, Y.Y., Y.J. Lin, C.C. Chang, D.Y. Chen and C.M. Hsu et al., 2010. Human lymphocyte antigen B-associated transcript 2, 3 and 5 polymorphisms and haplotypes are associated with susceptibility of Kawasaki disease and coronary artery aneurysm. J. Clin. Lab. Anal., 24: 262-268.
    CrossRef  |  PubMed  |  Direct Link  |  
  29. Chen, S.Y., L. Wan, C.M. Huang, Y.C. Huang and J.J. Sheu et al., 2010. Genetic polymorphisms of the DNA repair gene MPG may be associated with susceptibility to rheumatoid arthritis. J. Applied Genet., 51: 519-521.
    CrossRef  |  
  30. Yang, T.C., S.L. Shiu, P.H. Chuang, Y.J. Lin, L. Wan, Y.C. Lan and C.W. Lin, 2009. Japanese encephalitis virus NS2B-NS3 protease induces caspase 3 activation and mitochondria-mediated apoptosis in human medulloblastoma cells. Virus Res., 143: 77-85.
    CrossRef  |  
  31. Wan, L., Y.J. Lin, J.J. Sheu, C.M. Huang and Y. Tsai et al., 2009. Analysis of ERCC2/XPD functional polymorphisms in systemic lupus erythematosus. Int. J. Immunogenetics, 36: 33-37.
    CrossRef  |  
  32. Wan, L., Y.J. Kung, Y.J. Lin, C.C. Liao and J.J. Sheu et al., 2009. Th1 and Th2 cytokines are elevated in HCV-infected SVR(-) patients treated with interferon-α. Biochem. Biophys. Res. Commun., 379: 855-860.
    CrossRef  |  
  33. Sheu, J.J., C.H. Hua, L. Wan, Y.J. Lin and M.T. Lai et al., 2009. Functional genomic analysis identified epidermal growth factor receptor activation as the most common genetic event in oral squamous cell carcinoma. Cancer Res., 69: 2568-2576.
    CrossRef  |  
  34. Liu, H.P., Y.J. Lin, W.Y. Lin, L. Wan and J.J. Sheu et al., 2009. A novel genetic variant of BMP2K contributes to high myopia. J. Clin. Lab. Anal., 23: 362-367.
    CrossRef  |  PubMed  |  Direct Link  |  
  35. Lin, Y.J., Y.C. Hou, C.H. Lin, Y.A. Hsu and J.J. Sheu et al., 2009. Puerariae radix isoflavones and their metabolites inhibit growth and induce apoptosis in breast cancer cells. Biochem. Biophys. Res. Commun., 378: 683-688.
    CrossRef  |  
  36. Lin, Y.J., R.H. Chen, L. Wan, J.C. Sheu and C.M. Huang et al., 2009. Association of TNF-α gene polymorphisms with systemic lupus erythematosus in Taiwanese patients. Lupus, 18: 974-979.
    CrossRef  |  PubMed  |  
  37. Lin, Y.J., L. Wan, J.Y. Wu, J.J.C. Sheu and C.W. Lin et al., 2009. HLA-E gene polymorphism associated with kawasaki disease susceptibility and formation of coronary artery aneurysms. Arthritis Rheumat., 60: 604-610.
    CrossRef  |  
  38. Lin, Y.J., L. Wan, C.M. Huang, S.Y. Chen and Y.C. Huang et al., 2009. Polymorphisms in the DNA repair gene XRCC1 and associations with systemic lupus erythematosus risk in the Taiwanese Han Chinese population. Lupus, 18: 1246-1251.
    CrossRef  |  
  39. Hsueh, K.C., C.Y. Lin and Y.J. Lin, 2009. Serum levels of resistin in allergic rhinitis and its relationship with disease severity. Am. J. Rhinol. Allergy, 23: 365-369.
    CrossRef  |  PubMed  |  Direct Link  |  
  40. Chang, H.L., C.H. Tang, Y.M. Hsu, L. Wan and Y.F. Chang et al., 2009. Nosocomial outbreak of infection with multidrug-resistant Acinetobacter baumannii in a medical center in Taiwan. Infect. Control Hosp. Epidemiol., 30: 34-38.
    CrossRef  |  
  41. Wan, L., C.W. Lin, Y.J. Lin, J.J. Sheu and B.H. Chen et al., 2008. Type I IFN induced IL1-Ra expression in hepatocytes is mediated by activating STAT6 through the formation of STAT2: STAT6 heterodimer. J. Cell. Mol. Med., 12: 876-888.
    CrossRef  |  
  42. Lin, Y.J., L. Wan, J.J.C. Sheu, C.M. Huang and C.W. Lin et al., 2008. G/T polymorphism in the interleukin-2 exon 1 region among Han Chinese systemic lupus erythematosus patients in Taiwan. Clin. Immunol., 129: 36-39.
    CrossRef  |  
  43. Lin, Y.J., L. Wan, J.J.C. Sheu, C.M. Huang and C.W. Lin et al., 2008. A/C polymorphism in the interleukin-18 coding region among Taiwanese systemic lupus erythematosus patients. Lupus, 17: 124-127.
    CrossRef  |  
  44. Lin, Y.J. and S.C. Wu, 2008. Histidine at residue ninety nine and the transmembrane region of the precursor membrane prM protein are important for the prM-E heterodimeric formation of Japanese encephalitis virus. J. Virol., 79: 8535-8544.
  45. Lin, C.W., C.W. Cheng, T.C. Yang, S.W. Li and M.H. Cheng et al., 2008. Interferon antagonist function of Japanese encephalitis virus NS4A and its interaction with DEAD-box RNA helicase DDX42. Virus Res., 137: 49-55.
    CrossRef  |  
  46. Lin, C.W., C.F. Wu, N.W. Hsiao, C.Y. Chang and S.W. Li et al., 2008. Aloe-emodin is an interferon-inducing agent with antiviral activity against Japanese encephalitis virus and enterovirus 71. Int. J. Antimicrob. Agents, 32: 355-359.
    CrossRef  |  
  47. Lai, C.H., S.H. Fang, Y.K. Rao, Y. Geethangili and C.H. Tang et al., 2008. Inhibition of Helicobacter pylori-induced inflammation in human gastric epithelial AGS cells by Phyllanthus urinaria extracts. J. Ethnopharmacol., 118: 522-526.
    CrossRef  |  
  48. Huang, S.H., T.C. Yang, M.H. Tsai, I.S. Tsai and H.C. Lu et al., 2008. Gold nanoparticle-based RT-PCR and real-time quantitative RT-PCR assays for detection of Japanese encephalitis virus. Nanotechnology, Vol. 19. 10.1088/0957-4484/19/40/405101.
    CrossRef  |  
  49. Hsueh, K.C., Y.J. Lin, J.S. Chang, L. Wan, Y.H. Tsai, CH. Tsai and F.J. Tsai, 2008. Influence of interleukin 18 promoter polymorphisms in susceptibility to kawasaki disease in Taiwan. J. Rheumatology, 35: 1408-1413.
    Direct Link  |  
  50. Hsueh, K.C., Y.J. Lin, J.S. Chang, L. Wan and Y.H. Tsai et al., 2008. Association of vascular endothelial growth factor C-634 G polymorphism in Taiwanese children with Kawasaki disease. Pediat. Cardiol., 29: 292-296.
    CrossRef  |  
  51. Lin, Y.J., L. Wan, C.C. Lee, C.M. Huang and Y. Tsai et al., 2007. Disease association of the interleukin-18 promoter polymorphisms in Taiwan Chinese systemic lupus erythematosus patients. Genes Immun., 8: 302-307.
    Direct Link  |  
  52. Lin, C.W., H.D. Huang, S.Y. Shiu, W.J. Chen and M.H. Tsai et al., 2007. Functional determinants of NS2B for activation of Japanese encephalitis virus NS3 protease. Virus Res., 127: 88-94.
    CrossRef  |  
  53. Lee, C.C., W.Y. Lin, L. Wan, Y. Tsai and Y.J. Lin et al., 2007. Interleukin-18 gene polymorphism but not interleukin-2 gene polymorphism, is associated with rheumatoid arthritis. Immunogenetics, 59: 433-439.
    CrossRef  |  
  54. Wu, S.C., Y.J. Lin, J.W. Chou and C.W. Lin, 2004. Construction and characterization of a Fab recombinant protein for Japanese encephalitis virus neutralization. Vaccine, 23: 163-171.
    CrossRef  |  
  55. Wu, S.C., Y.J. Lin and C.H. Yu, 2003. Baculovirus-insect cell expression, purification and immunological studies of the full-length Japanese encephalitis virus envelope protein. Enzyme Microb. Technol., 33: 438-444.
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