Dr. Palanisamy Arulselvan
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Dr. Palanisamy Arulselvan

Visiting Professor
School of Bio-Engineering, Centre for Materials Engineering and Regenerative Medicine, Bharath Institute of Higher Education and Research, Selaiyur, Chennai, India


Highest Degree
PostDoc Fellow in Biotechnology from Academia Sinica, Taiwan

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Biography

Dr. Palanisamy Arulselvan is currently working as Research Fellow in Institute of Bioscience, Universiti Putra Malaysia, Malaysia. He has completed his doctorate degree from University of Madras, India. He has good research experience in diverse areas of Biochemistry and Biotechnology, to name a few: Natural products mainly focusing on pharmacological action of bioactive compounds, inflammation, Nanodrug delivery system. To his credit, he has published more than 60 research papers and reviews in international peer-reviewed journals. He won many research awards in national and international level from different organization. Currently, he has secured few research grants and supervising research students and also serving as an editorial board member/reviewer of few scientific journals.

Area of Interest:

Pharmacology and Toxicology
100%
Nanomedicine
62%
Drug Delivery System
90%
Natural Products
75%
Diabetes
55%

Research Publications in Numbers

Books
0
Chapters
5
Articles
98
Abstracts
2

Selected Publications

  1. Simanullang, R.H., P.C. Situmorang, J.M. Siahaan, S.S. Widjaja and M. Mutiara, 2022. Effects of Zanthoxylum acanthopodium on MMP-9 and GLUT-1 expression and histology changes in rats with cervical carcinoma. Pharmcia, 69: 911-920.
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  2. Saifullah, B., P. Arulselvan, S. Fakurazi, T.J. Webster, N. Bullo, M.Z. Hussein and M.E. El Zowalaty, 2022. Development of a novel anti-tuberculosis nanodelivery formulation using magnesium layered hydroxide as the nanocarrier and pyrazinamide as a model drug. Sci Rep., Vol. 12. 10.1038/s41598-022-15953-6.
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  3. Zhao, W., Y. Lao, Y. Liu, J. Niu, Z. Xiao, P. Arulselvan and J. Shen, 2021. Escin induces apoptosis in ovarian cancer cell line by triggering S-phase cell cycle arrest and p38 MAPK/ERK pathway inhibition. J. King Saud Uni. Sci., Vol. 34. 10.1016/j.jksus.2021.101644.
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  4. Yang, Z., H. Shi, A. Chinnathambi, S.H. Salmen and S.A. Alharbi et al., 2021. Arbutin exerts anticancer activity against rat C6 glioma cells by inducing apoptosis and inhibiting the inflammatory markers and P13/Akt/mTOR cascade. J. Biochem. Mol. Toxicol., Vol. 35. 10.1002/jbt.22857.
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  5. Iyappan, P., 2021. Fucoxanthin induced apoptotic cell death in oral squamous carcinoma (KB) cells. Bioinformation, 17: 181-191.
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  6. Iyappan, P., 2021.  D-carvone induced ROS mediated apoptotic cell death in human leukemic cell lines (Molt-4). Bioinformation, 17: 171-180.
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  7. Hussein-Al-Ali, S.H., M.Z. Hussein, S. Bullo and P. Arulselvan, 2021. Chlorambucil-iron oxide nanoparticles as a drug delivery system for leukemia cancer cells. Int. J. Nanomed., 16: 6205-6216.
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  8. Chen, X., M. Zhang, M. Ahmed, K.M. Surapaneni, V.P. Veeraraghavan and P. Arulselvan, 2021. Neuroprotective effects of ononin against the aluminium chloride-induced alzheimer`s disease in rats. Saudi J. Bio. Sci., 8: 4232-4239.
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  9. Tan, W.S., P. Arulselvan, S.F. Ng, C.N.M. Taib, M.N. Sarian and S. Fakurazi, 2020. Healing effect of vicenin-2 (VCN-2) on human dermal fibroblast (HDF) and development VCN-2 hydrocolloid film based on alginate as potential wound dressing. BioMed. Res. Int., Vol. 2020. 10.1155/2020/4730858.
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  10. Cui, Y.C., Y.S. Qiu, Q. Wu, G. Bu and S.W. Teh et al., 2020. Hypoxic-mediated oxidative stress condition and hydroxyapatite-inducing osteogenic differentiation of human mesenchymal stem cells: a mathematical modeling study. J. Biomed. Nanotechnol., 16: 910-921.
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  11. Tan, W.S., P. Arulselvan, S.F. Ng, C.N.M. Taib, M.N. Sarian and S. Fakurazi, 2019. Improvement of diabetic wound healing by topical application of Vicenin-2 hydrocolloid film on Sprague Dawley rats. BMC Complement. Altern. Med., Vol. 19. 10.1186/s12906-018-2427-y.
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  12. Chen, L., C. Gnanaraj, P. Arulselvan, H. El-Seedi and H. Teng, 2019. A review on advanced microencapsulation technology to enhance bioavailability of phenolic compounds: Based on its activity in the treatment of Type 2 Diabetes. Trends Food Sci. Technol., 85: 149-162.
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  13. Teng, H.,B. Yuan, S. Gothai, P. Arulselvan, X. Song and L. Chen, 2018. Dietary triterpenes in the treatment of type 2 diabetes: To date. Trends Food Sci. Technol., 72: 34-44.
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  14. Seema, D.M.J., B. Saifullah, M. Selvanayagam, S. Gothai and M.Z. Hussein et al., 2018. Designing of the anticancer nanocomposite with sustained release properties by using graphene oxide nanocarrier with phenethyl isothiocyanate as anticancer agent. Pharmaceutics, Vol. 10. 10.3390/pharmaceutics10030109.
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  15. Muniandy, K., S. Gothai, W.S. Tan, S.S. Kumar and N.M. Esa et al., 2018. In vitro wound healing potential of stem extract of Alternanthera sessilis. Evid.-Based Complement. Altern. Med., Vol. 2018. .
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  16. Muniandy, K., S. Gothai, K.M.H. Badran, S.S. Kumar, N.M. Esa and P. Arulselvan, 2018. Suppression of proinflammatory cytokines and mediators in LPS-Induced RAW 264.7 macrophages by stem extract of alternanthera sessilis via the inhibition of the NF-κB pathway. J. Immunol. Res., Vol. 2018. 10.1155/2018/3430684.
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  17. Moniri, M., A.B. Moghaddam, S. Azizi, R.A. Rahim, W.Z. Saad et al., 2018. Molecular study of wound healing after using biosynthesized BNC/Fe3O4 nanocomposites assisted with a bioinformatics approach. Int. J. Nanomed., Volume 13: 2955-2971.
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  18. Mohsin, S.M.N., M.Z. Hussein, S.H. Sarijo, S. Fakurazi, P. Arulselvan and Y.H. Taufiq-Yap, 2018. Nanolayered composite with enhanced ultraviolet ray absorption properties from simultaneous intercalation of sunscreen molecules. Int. J. Nanomed., 13: 6359-6374.
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  19. Jiang, X., P. Ganesan, T. Rengarajan, D.K. Choi and P. Arulselvan, 2018. Cellular phenotypes as inflammatory mediators in Parkinson’s disease: Interventional targets and role of natural products. Biomed. Pharmacother., 106: 1052-1062.
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  20. Gothai, S., K. Muniandy, C. Gnanaraj, I.A.A. Ibrahim and N. Shahzad et al., 2018. Pharmacological insights into antioxidants against colorectal cancer: A detailed review of the possible mechanisms. Biomed. Pharmacother., 107: 1514-1522.
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  21. Sakinah, S., S.P. Priya, S. Kumari, F. Amira and K. Poorani et al., 2017. Impact of dengue virus (serotype DENV-2) infection on liver of BALB/c mice: A histopathological analysis. Tissue Cell, 49: 86-94.
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  22. Rajan, M., R.A. Praphakar, D. Govindaraj, P. Arulselvan and S.S. Kumar, 2017. Cytotoxicity assessment of palbociclib-loaded chitosan-polypropylene glycol nano vehicles for cancer chemotherapy. Mater. Today Chem., 6: 26-33.
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  23. Rajan, M., P. Krishnan, P. Pradeepkumar, M. Jeyanthinath and M. Jeyaraj et al., 2017. Magneto-chemotherapy for cervical cancer treatment with camptothecin loaded Fe3O4 functionalized β-cyclodextrin nanovehicle. RSC Adv., 7: 46271-46285.
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  24. Kumaran, S.K., M.F.A. Bakar, H. Mohd-Padil, S. Mat-Sharani and S. Sakinah et al., 2017. 3D modelling of the pathogenic Leptospira protein LipL32: A bioinformatics approach. Acta Trop., 176: 433-439.
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  25. Krishnan, P., M. Rajan, S. Kumari, S. Sakinah and S.P. Priya et al., 2017. Efficiency of newly formulated camptothecin with β-cyclodextrin-EDTA-Fe3O4 nanoparticle-conjugated nanocarriers as an anti-colon cancer (HT29) drug. Scient. Rep., Vol. 7. 10.1038/s41598-017-09140-1.
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  26. Gothai, S., K. Muniandy, M.A. Zarin, T.W. Sean and S.S. Kumar et al., 2017. Chemical composition of Moringa oleifera ethyl acetate fraction and its biological activity in diabetic human dermal fibroblasts. Pharmacogn. Mag., 13: S462-S469.
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  27. Ganesan, P., P. Arulselvan and D.K. Choi, 2017. Phytobioactive compound-based nanodelivery systems for the treatment of type 2 diabetes mellitus-current status. Int. J. Nanomed., 12: 1097-1111.
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  28. Danjuma, L., M.P. Ling, R.A. Hamat, A. Higuchi and A.A. Alarfaj et al., 2017. Genomic plasticity between human and mycobacterial DNA: A review. Tuberculosis, 107: 38-47.
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  29. Barahuie, F., D. Dorniani, B. Saifullah, S. Gothai and M.Z. Hussein et al., 2017. Sustained release of anticancer agent phytic acid from its chitosan-coated magnetic nanoparticles for drug-delivery system. Int. J. Nanomed., 12: 2361-2372.
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  30. Saifullah, B., M.E. El Zowalaty, P. Arulselvan, S. Fakurazi, T.J. Webster, B.M. Geilich and M.Z. Hussein, 2016. Synthesis, characterization and efficacy of antituberculosis isoniazid zinc aluminum-layered double hydroxide based nanocomposites. Int. J. Nanomed., 11: 3225-3237.
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  31. Poorani, K., N. Kannan, A.Z. Aris, P. Arulselvan and S. Fakurazi, 2016. Possible Application of Bio-Analytical Assays in the Biological Impact Assessment of Persistent Organic Pollutants (POPs) in Mangrove Sediments in South East Asia with Particular Reference to Malaysia. In: Persistent Organic Chemicals in the Environment: Status and Trends in the Pacific Basin Countries, Volume II: Temporal Trends, Loganathan, B.G., J.S. Khim, P.R.S. Kodavanti and S. Masunaga (Eds.). Chapter 9, American Chemical Society, USA., ISBN-13: 9780841231986, pp: 203-222.
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  32. Muniandy, K., S. Gothai, P. Arulselvan and S. Fakurazi, 2016. Ultraviolet B-induced inflammation and nuclear factor-kappa B activation: A short review. J. Pharmacol. Toxicol. Invest, 2: 1-3.
  33. Muhammad, A.A., P. Arulselvan, P.S. Cheah, F. Abas and S. Fakurazi, 2016. Evaluation of wound healing properties of bioactive aqueous fraction from Moringa oleifera Lam on experimentally induced diabetic animal model. Drug Des Devel Ther., 10: 1715-1730.
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  34. Karthivashan G., A.U. Kura, P. Arulselvan, N.Md. Isa, and S. Fakurazi, 2016. The modulatory effect of moringa oleifera leaf extract on endogenous antioxidant systems and inflammatory markers in an acetaminophen-induced nephrotoxic mice model. PeerJ, Vol. 4. 10.7717/peerj.2127.
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  35. Gothai, S., P. Ganesan, S.Y. Park, S. Fakurazi, D.K. Choi and P. Arulselvan, 2016. Natural phyto-bioactive compounds for the treatment of type 2 diabetes: Inflammation as a target. Nutrients, 8: 461-461.
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  36. Gothai, S., P. Arulselvan, W.S. Tan and S. Fakurazi, 2016. Wound healing properties of ethyl acetate fraction of Moringa oleifera in normal human dermal fibroblasts. J. Intercult. Ethnopharmacol., 5: 1-6.
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  37. Dorniani, D., B. Saifullah, F. Barahuie, P. Arulselvan, M.Z.B. Hussein, S. Fakurazi and L.J. Twyman, 2016. Graphene oxide-gallic acid nanodelivery system for cancer therapy. Nanoscale Res. Lett., Vol. 11. 10.1186/s11671-016-1712-2.
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  38. Barahuie, F., M.Z. Hussein, P. Arulselvan, S. Fakurazi and Z. Zainal, 2016. Controlled in vitro release of the anticancer drug chlorogenic acid using magnesium/aluminium-layered double hydroxide as a nanomatrix. Sci. Adv. Mater., 8: 501-513.
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  39. Arulselvan, P., W.S. Tan, S. Gothai, K. Muniandy and S. Fakurazi et al., 2016. Anti-inflammatory potential of ethyl acetate fraction of Moringa oleifera in downregulating the NF-κB signaling pathway in lipopolysaccharide-stimulated macrophages. Molecules, Vol. 21. 10.3390/molecules21111452.
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  40. Arulselvan, P., M.T. Fard, W.S. Tan, S. Gothai, S. Fakurazi, M.E. Norhaizan and S.S. Kumar, 2016. Role of antioxidants and natural products in inflammation. Oxid. Med. Cell. Longevity, Vol. 2016. 10.1155/2016/5276130.
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  41. Tan, W.S., P. Arulselvan, G. Karthivashan and S. Fakurazi, 2015. Moringa oleifera flower extract suppresses the activation of inflammatory mediators in lipopolysaccharide-stimulated RAW 264.7 macrophages via NF-κB pathway. Mediat. Inflammat., 10.1155/2015/720171.
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  42. Syarina, P.N.A., G. Karthivashan, F. Abas, P. Arulselvan and S. Fakurazi, 2015. Wound healing potential of Spirulina platensis extracts on human dermal fibroblast cells. EXCLI J., 14: 385-393.
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  43. Rahman, H.S., A. Rasedee, C.W. How N.A. Zeenathul and M.S. Chartrand et al., 2015. Antileukemic effect of zerumbone-loaded nanostructured lipid carrier in WEHI-3B cell-induced murine leukemia model. Int. J. Nanomed., 10: 1649-1666.
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  44. Muhammad, A.A., G. Karthivashan, P. Arulselvan and S. Fakurazi, 2015. In vitro antioxidant properties of bioactive fraction of Moringa oleifera. J. Nat. Prod. Biomed. Res., 1: 51-56.
  45. Karthivashan, G., P. Arulselvan, S.W. Tan and S. Fakurazi, 2015. The molecular mechanism underlying the hepatoprotective potential of Moringa oleifera leaves extract against acetaminophen induced hepatotoxicity in mice. J. Funct. Foods, 17: 115-126.
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  46. Karthivashan, G., P. Arulselvan, A.R. Alimon, I.S. Ismail and S. Fakurazi, 2015. Competing role of bioactive constituents in Moringa oleifera extract and conventional nutrition feed on the performance of cobb 500 broilers. BioMed. Res. Int. 10.1155/2015/970398.
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  47. Karthivashan, G., P. Arulselvan and S. Fakurazi, 2015. Pathways involved in acetaminophen hepatotoxicity with specific targets for inhibition/downregulation. RSC Adv., 5: 62040-62051.
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  48. Fard, M.T., P. Arulselvan, G. Karthivashan, S.K. Adam and S. Fakurazi, 2015. Bioactive extract from Moringa oleifera inhibits the pro-inflammatory mediators in lipopolysaccharide stimulated macrophages. Pharmacogn. Mag., 11: S556-S563.
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  49. Adewoyin, M., S.M.N. Mohsin, P. Arulselvan, M.Z. Hussein and S. Fakurazi, 2015. Enhanced anti-inflammatory potential of cinnamate-zinc layered hydroxide in lipopolysaccharide-stimulated RAW 264.7 macrophages. Drug Design Dev. Therapy, 9: 2475-2484.
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  50. Tan, J.M., P. Arulselvan, S. Fakurazi, H. Ithnin and M.Z. Hussein, 2014. A review on characterizations and biocompatibility of functionalized carbon nanotubes in drug delivery design. J. Nanomater. 10.1155/2014/917024.
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  51. Tan, J.M., G. Karthivashan, P. Arulselvan, S. Fakurazi and M.Z. Hussein, 2014. Sustained release and cytotoxicity evaluation of carbon nanotube-mediated drug delivery system for betulinic acid. J. Nanomater. 10.1155/2014/862148.
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  52. Tan, J.M., G. Karthivashan, P. Arulselvan, S. Fakurazi and M.Z. Hussein, 2014. Characterization and in vitro sustained release of silibinin from pH responsive carbon nanotube-based drug delivery system. J. Nanomater. 10.1155/2014/439873.
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  53. Tan, J.M., G. Karthivashan, P. Arulselvan, S. Fakurazi and M.Z. Hussein, 2014. Characterization and in vitro studies of the anticancer effect of oxidized carbon nanotubes functionalized with betulinic acid. Drug Design Dev. Therapy, 8: 2333-2343.
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  54. Tan, J.M., G. Karthivashan, P. Arulselvan, S. Fakurazi and M.Z. Hussein, 2014. In vitro nanodelivery of silibinin as an anticancer drug under pH response. J. Drug Delivery Sci. Technol., 24: 579-584.
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  55. Sellamuthu, P.S., P. Arulselvan, S. Fakurazi and M. Kandasamy, 2014. Beneficial effects of mangiferin isolated from Salacia chinensis on biochemical and hematological parameters in rats with streptozotocin-induced diabetes. Pak. J. Pharmaceut. Sci., 27: 161-167.
    PubMed  |  Direct Link  |  
  56. Saifullah, B., P. Arulselvan, M.E. El Zowalaty, S. Fakurazi, T.J. Webster, B.M. Geilich and M.Z. Hussein, 2014. Development of a biocompatible nanodelivery system for tuberculosis drugs based on isoniazid-Mg/Al layered double hydroxide. Int. J. Nanomed., 9: 4749-4762.
    CrossRef  |  
  57. Saifullah, B., P. Arulselvan, M.E. El Zowalaty, S. Fakurazi, T.J. Webster, B. Geilich and M.Z. Hussein, 2014. Development of a highly biocompatible antituberculosis nanodelivery formulation based on para-aminosalicylic acid-zinc layered hydroxide nanocomposites. Scient. World J. 10.1155/2014/401460.
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  58. Saifullah, B., M.E. El Zowalaty, P. Arulselvan, S.S. Fakurazi, T.J. Webster, B.M. Geilich and M.Z. Hussein, 2014. Antimycobacterial, antimicrobial and biocompatibility properties of para-aminosalicylic acid with zinc layered hydroxide and Zn/Al layered double hydroxide nanocomposites. Drug Des. Dev. Therapy, 8: 1029-1036.
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  59. Mohsin, S.M.N., M.Z. Hussein, S.H. Sarijo, S. Fakurazi, P. Arulselvan and Y.H. Taufiq-Yap, 2014. Optimization of UV absorptivity of layered double hydroxide by intercalating organic UV- absorbent molecules. J. Biomed. Nanotechnol., 10: 1490-1500.
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  60. Mohsin, S.M.N., M.Z. Hussein, S.H. Sarijo, S. Fakurazi, P. Arulselvan and Y.H. Taufiq-Yap, 2014. Characterisation and cytotoxicity assessment of uv absorbers-intercalated zinc/aluminium-layered double hydroxides on dermal fibroblast cells. Sci. Adv. Mater., 6: 648-658.
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  61. Kura, A.U., S. Fakurazi, M.Z. Hussein and P. Arulselvan, 2014. Nanotechnology in drug delivery: The need for more cell culture based studies in screening. Chem. Central J., Vol. 8. 10.1186/1752-153X-8-46.
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  62. Kura, A.U., M.Z. Hussein, S. Fakurazi and P. Arulselvan, 2014. Layered double hydroxide nanocomposite for drug delivery systems; Bio-distribution, toxicity and drug activity enhancement. Chem. Central J., Vol. 8. .
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  63. Hussein-Al-Ali, S.H., P. Arulselvan, S. Fakurazi and M.Z. Hussein, 2014. The in vitro therapeutic activity of betulinic acid nanocomposite on breast cancer cells (MCF-7) and normal fibroblast cell (3T3). J. Mater. Sci., 49: 8171-8182.
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  64. Hussein-Al-Ali, S.H., P. Arulselvan, M.Z. Hussein, S. Fakurazi, M. Ismail, D. Dorniani and M.E. El Zowalaty, 2014. Synthesis, characterization, controlled release and cytotoxic effect of anthranilic acid-loaded chitosan and polyethylene glycol-magnetic nanoparticles on murine macrophage raw 264.7 cells. Nano, Vol. 9. 10.1142/S1793292014500167.
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  65. Hussein-Al-Ali, S.H., P. Arulselvan, M.Z. Hussein, S. Fakurazi and D. Dorniani, 2014. Arginine-chitosan- and arginine-polyethylene glycol-conjugated superparamagnetic nanoparticles: Preparation, cytotoxicity and controlled-release. J. Biomater. Applic., 29: 186-198.
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  66. Barahuie, F., M.Z. Hussein, P. Arulselvan, S. Fakurazi and Z. Zainal, 2014. Drug delivery system for an anticancer agent, chlorogenate-Zn/Al-layered double hydroxide nanohybrid synthesised using direct co-precipitation and ion exchange methods. J. Solid State Chem., 217: 31-41.
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  67. Arulselvan, P., H.A.A. Ghofar, G. Karthivashan, M.F.A. Halim, M.S.A. Ghafar and S. Fakurazi, 2014. Antidiabetic therapeutics from natural source: A systematic review. Biomed. Prevent. Nutr., 4: 607-617.
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  68. Sharifudin, S.A., S. Fakurazi, M.T. Hidayat, I. Hairuszah, M.A. Moklas and P. Arulselvan, 2013. Therapeutic potential of Moringa oleifera extracts against acetaminophen-induced hepatotoxicity in rats. Pharmaceut. Biol., 51: 279-288.
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  69. Sellamuthu, P.S., P. Arulselvan, S. Kamalraj, S. Fakurazi and M. Kandasamy, 2013. Protective nature of mangiferin on oxidative stress and antioxidant status in tissues of streptozotocin-induced diabetic rats. ISRN Pharmacol. 10.1155/2013/750109.
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  70. Sellamuthu, P.S., P. Arulselvan, B.P. Muniappan, S. Fakurazi and M. Kandasamy, 2013. Mangiferin from Salacia chinensis prevents oxidative stress and protects pancreatic β-cells in streptozotocin-induced diabetic rats. J. Med. Food, 16: 719-727.
    CrossRef  |  PubMed  |  
  71. Saifullah, B., M.Z. Hussein, S.H. Hussein-Al-Ali, P. Arulselvan and S. Fakurazi, 2013. Sustained release formulation of an anti-tuberculosis drug based on para-amino salicylic acid-zinc layered hydroxide nanocomposite. Chem. Central J., Vol. 7. 10.1186/1752-153X-7-72.
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  72. Saifullah, B., M.Z. Hussein, S.H. Hussein-Al-Ali, P. Arulselvan and S. Fakurazi, 2013. Antituberculosis nanodelivery system with controlled-release properties based on para-amino salicylate-zinc aluminum-layered double-hydroxide nanocomposites. Drug Design Dev. Therapy, 7: 1365-1375.
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  73. Pauzi, N.A.S., A.A. Muhammad, S. Fakurazi, P. Arulselvan and Z. Ahmad, 2013. Preliminary study of the optimization of protocol for development of type 2 diabetic model in rats. Indian J. Sci. Technol., 6: 4960-4965.
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  74. Naidu, K.R.M., S.I. Khalivulla, S. Rasheed, S. Fakurazi, P. Arulselvan, O. Lasekan and F. Abas, 2013. Synthesis of Bisindolylmethanes and their cytotoxicity properties. Int. J. Mol. Sci., 14: 1843-1853.
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  75. Muhammad, A.A., N.A.S. Pauzi, P. Arulselvan, F. Abas and S. Fakurazi, 2013. In vitro wound healing potential and identification of bioactive compounds from Moringa oleifera Lam. BioMed. Res. Int. 10.1155/2013/974580.
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  76. Mohsin, S.M.N., M.Z. Hussein, S.H. Sarijo, S. Fakurazi, P. Arulselvan and T.Y.Y. Hin, 2013. Synthesis of (cinnamate-zinc layered hydroxide) intercalation compound for sunscreen application. Chem. Central J., Vol. 7. 10.1186/1752-153X-7-26.
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  77. Kura, A.U., S.H.H. Al Ali, M.Z. Hussein, S. Fakurazi and P. Arulselvan, 2013. Development of a controlled-release anti-Parkinsonian nanodelivery system using levodopa as the active agent. Int. J. Nanomed., 8: 1103-1110.
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  78. Karthivashan, G., M.T. Fard, P. Arulselvan, F. Abas and S. Fakurazi, 2013. Identification of bioactive candidate compounds responsible for oxidative challenge from hydro-ethanolic extract of Moringa oleifera leaves. J. Food Sci., 78: C1368-C1375.
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  79. Huang, Y.T., C.C. Wen, Y.H. Chen, W.C. Huang and L.T. Huang et al., 2013. Dietary uptake of Wedelia chinensis extract attenuates dextran sulfate sodium-induced colitis in mice. PLoS One. 10.1371/journal.pone.0064152.
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  80. Fakurazi, S., S.A. Rahman, M.T. Hidayat, H. Ithnin, M.A. Moklas and P. Arulselvan, 2013. The combination of mitragynine and morphine prevents the development of morphine tolerance in mice. Molecules, 18: 666-681.
    CrossRef  |  PubMed  |  Direct Link  |  
  81. Barahuie, F., M.Z. Hussein, S.H. Hussein-Al-Ali, S. Fakurazi, P. Arulselvan and Z. Zainal, 2013. Preparation and controlled-release studies of a protocatechuic acid-magnesium/aluminum-layered double hydroxide nanocomposite. Int. J. Nanomed., 8: 1975-1987.
    CrossRef  |  Direct Link  |  
  82. Barahuie, F., M.Z. Hussein, P. Arulselvan, S. Fakurazi and Z. Zainal, 2013. Development of the anticancer potential of a chlorogenate-zinc layered hydroxide nanohybrid with controlled release property against various cancer cells. Sci. Adv. Mater., 5: 1983-1993.
    Direct Link  |  
  83. Arulselvan, P., G. Karthivashan and S. Fakurazi, 2013. Hepatoprotective nature of phytoextracts against hepatotoxin induced animal models: A review. J. Chem. Pharmaceut. Res., 5: 233-239.
    Direct Link  |  
  84. Shamima, A.R., S. Fakurazi, M.T. Hidayat, I. Hairuszah, M.A.M. Moklas and P.Arulselvan, 2012. Antinociceptive action of isolated mitragynine from Mitragyna speciosa through activation of opioid receptor system. Int. J. Mol. Sci., 13: 11427-11442.
    CrossRef  |  
  85. Sellamuthu, P.S., P. Arulselvan, B.P. Muniappan, S. Fakurazi and M. Kandasamy, 2012. Nfluence of mangiferin on membrane bound phosphatases and lysosomal hydrolases in streptozotocin induced diabetic rats. Latin Am. J. Pharm., 31: 1013-1020.
    Direct Link  |  
  86. Sellamuthu, P.S., P. Arulselvan, B.P. Muniappan, S. Fakurazi and M. Kandasamy, 2012. Influence of mangiferin on membrane bound phosphatases and lysosomal hydrolases in streptozotocin induced diabetic rats. Latin Am. J. Pharm., 31: 1013-1020.
    Direct Link  |  
  87. Sellamuthu, P.S., P. Arulselvan, B.P. Muniappan and M. Kandasamy, 2012. Effect of mangiferin isolated from Salacia chinensis regulates the kidney carbohydrate metabolism in streptozotocin-induced diabetic rats. Asian-Pac. J. Trop. Biomed., 2012: S1583-S1587.
    Direct Link  |  
  88. Naidu, K.R.M., B.S. Krishna, M.A. Kumar, P. Arulselvan, S.I. Khalivulla and O. Lasekan, 2012. Design, synthesis and antiviral potential of 14-aryl/heteroaryl-14H-dibenzo[a,j]xanthenes using an efficient polymer-supported catalyst. Molecules, 17: 7543-7555.
    CrossRef  |  PubMed  |  
  89. Naidu, K.R., K.S. Kumar, P. Arulselvan, C.B. Reddy and O. Lasekan, 2012. Synthesis of α-hydroxy phosphonates and their antioxidant properties. Arch. Pharm., 345: 957-963.
    CrossRef  |  PubMed  |  
  90. Fakurazi, S., S.A. Sharifudin and P. Arulselvan, 2012. Moringa oleifera hydroethanolic extracts effectively alleviate acetaminophen-induced hepatotoxicity in experimental rats through their antioxidant nature. Molecules, 17: 8334-8350.
    CrossRef  |  Direct Link  |  
  91. Arulselvan, P., A. Umamaheswari and S. Fakurazi, 2012. Therapeutic Approaches for Diabetes with Natural Antioxidants. In: Medicinal Plants as Antioxidant Agents: Understanding their Mechanism of Action and Therapeutic Efficacy, Capasso, A. (Ed.). Chapter 11, Research Signpost, Trivandrum, Kerala, India, ISBN: 978-81-308-0509-2, pp: 237-266.
    Direct Link  |  
  92. Wen, C.C., LF. Shyur, J.T. Jan, P.H. Liang and C.J. Kuo et al., 2011. Traditional Chinese medicine herbal extracts of Cibotium barometz, Gentiana scabra, Dioscorea batatas, Cassia tora and Taxillus chinensis inhibit SAR-CoV replication. J. Traditional Complementary Med., 1: 41-50.
    Direct Link  |  
  93. Wei, W.C., S.Y. Lin, Y.J. Chen, C.C. Wen and C.Y. Huang et al., 2011. Topical application of marine briarane-type diterpenes effectively inhibits 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and dermatitis in murine skin. J. Biomed. Sci., 18: 94-94.
    CrossRef  |  PubMed  |  
  94. Chih-Chun, W., C. Hui-Ming, C. Swey-Shen, H. Li-Ting and C. Wei-Ting et al., 2011. Specific microtubule-depolymerizing agents augment efficacy of dendritic cell-based cancer vaccines. J. Biomed. Sci., 18: 44-44.
    PubMed  |  
  95. Arulselvan, P., W. Chih-Chun, L. Chun-Wen, W. Wen-Chi and Y. Ning-Sun, 2011. Phytochemicals from Allium fistulosum L. extract effectively inhibit colorectal tumor growth: Cellular mechanisms and nutritional applications. J. National Cancer Inst. .
  96. Arulselvan, P., W. Chih-Chun and Y. Ning-Sun, 2011. Anti-inflammatory potential of Allium fistulosum L. extract in dextran sulfate sodium induced ulcerative colitis in mice. Mol. Nutr. Food Res. .
  97. Subramanian, S. and P. Arulselvan, 2009. Evaluation of hypolipidemic properties of Murraya koenigii leaves studied in streptozotocin induced diabetic rats. Biomedicine, 29: 220-225.
  98. Arulselvan, P. and S. Subramanian, 2008. Ultrastructural and biochemical abnormalities in the liver of streptozotocin-diabetic rats: Protective effects of Murraya koenigii. J. Pharmacol. Toxicol., 3: 190-202.
    CrossRef  |  Direct Link  |  
  99. Subramanian, S., D.S. Kumar, P. Arulselvan, G.P. Senthilkumar and U.S.M. Rao, 2007. Evaluation of anti-ulcerogenic potential of Aloe vera leaf gel extract studied in experimental rats. J. Pharmacol. Toxicol., 2: 85-97.
    CrossRef  |  Direct Link  |  
  100. Rajasekaran, S., N. Sriram, P. Arulselvan and S. Subramanian, 2007. Effect of Aloe vera leaf gel extract on membrane bound phosphatases and lysosomal hydrolases in rats with streptozotocin diabetes. Pharmazie, 62: 221-225.
    Direct Link  |  
  101. Arulselvan, P. and S.P. Subramanian, 2007. Beneficial effects of Murraya koenigii leaves on antioxidant defense system and ultra structural changes of pancreatic β-cells in experimental diabetes in rats. Chem. Biol. Interact., 165: 155-164.
    CrossRef  |  Direct Link  |  
  102. Arulselvan, P. and S. Subramanian, 2007. Effect of Murraya koenigii leaf extract on carbohydrate metabolism studied in streptozotocin induced diabetic rats. Int. J. Biol. Chem., 1: 21-28.
    CrossRef  |  Direct Link  |  
  103. Subramanian, S., D.S. Kumar, P. Arulselvan and G.P. Senthilkumar, 2006. In vitro antibacterial and antifungal activities of ethanolic extract of aloe vera leaf gel. J. Plant Sci., 1: 348-355.
    CrossRef  |  Direct Link  |  
  104. Subramanian, S., D.S. Kumar and P. Arulselvan, 2006. Wound healing potential of Aloe vera leaf gel studied in experimental rabbits. Asian J. Biochem., 1: 178-185.
    CrossRef  |  Direct Link  |  
  105. Kumar, G.P.S., P. Arulselvan, D.S. Kumar and S.P. Subramanian, 2006. Anti-diabetic activity of fruits of Terminalia chebula on streptozotocin induced diabetic rats. J. Health Sci., 52: 283-291.
    CrossRef  |  
  106. Arulselvan, P., G.P. Senthilkumar, S.D. Kumar and S. Subramanian, 2006. Anti-diabetic effect of Murraya koenigii leaves on streptozotocin induced diabetic rats. Pharmazie, 61: 874-877.
    Direct Link  |