Dr. Juei Tang Cheng
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Dr. Juei Tang Cheng

Professor
Chang Jung Christian University, Taiwan


Highest Degree
Ph.D. in Pharmacology from Shizuoka College of Pharmacy, Shizuika, Japan

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Area of Interest:

Pharmacology and Toxicology
100%
Insulin Resistance
62%
Metabolic Syndrome
90%
Natural Products
75%
Systemic Pharmacology
55%

Research Publications in Numbers

Books
0
Chapters
2
Articles
399
Abstracts
4

Selected Publications

  1. Wu, T.T.L., H.S. Niu, L.J. Chen, J.T. Cheng and Y.C. Tong, 2016. Increase of human prostate cancer cell (DU145) apoptosis by telmisartan through PPAR-delta pathway. Eur. J. Pharmacol., 775: 35-42.
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  2. Wang, C.M., C.T. Hsu, H.S. Niu, C.H. Chang, J.T. Cheng and J.M. Shieh, 2016. Lung damage induced by hyperglycemia in diabetic rats: The role of signal transducer and activator of transcription 3 (STAT3). J. Diabetes Complications, 30: 1426-1433.
    CrossRef  |  PubMed  |  Direct Link  |  
  3. Niu, H.S., P.C. Chao, P.M. Ku, C.S. Niu, K.S. Lee and J.T. Cheng, 2016. Amarogentin ameliorates diabetic disorders in animal models. Naunyn-Schmiedeberg's Arch. Pharmacol., 389: 1215-1223.
    CrossRef  |  PubMed  |  Direct Link  |  
  4. Niu, H.S., I.M. Liu, C.S. Niu, P.M. Ku, C.T. Hsu and J.T. Cheng, 2016. Eucommia bark (Du-Zhong) improves diabetic nephropathy without altering blood glucose in type 1-like diabetic rats. Drug Des. Dev. Ther., 10: 971-978.
    CrossRef  |  PubMed  |  Direct Link  |  
  5. Niu, H.S., C.H. Chang, C.S. Niu, J.T. Cheng and K.S. Lee, 2016. Erythropoietin ameliorates hyperglycemia in type 1-like diabetic rats. Drug Des. Dev. Ther., 10: 1877-1884.
    CrossRef  |  PubMed  |  Direct Link  |  
  6. Lo, S.H., K.C. Cheng, Y.X. Li, C.H. Chang, J.T. Cheng and K.S. Lee, 2016. Development of betulinic acid as an agonist of TGR5 receptor using a new in vitro assay. Drug Des. Dev. Ther., 10: 2669-2676.
    CrossRef  |  PubMed  |  Direct Link  |  
  7. Ku, M.C., C.M. Fang, J.T. Cheng, H.C. Liang and T.F. Wang et al., 2016. Site-specific covalent modifications of human insulin by catechol estrogens: Reactivity and induced structural and functional changes. Sci. Rep., Vol. 6. 10.1038/srep28804.
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  8. Chang, W.T., J.Y. Shih, Y.H. Feng, C.Y. Chiang and Y.H. Kuo et al., 2016. The early predictive value of right ventricular strain in epirubicin-induced cardiotoxicity in patients with breast cancer. Acta Cardiologica Sinica, 32: 550-559.
    PubMed  |  
  9. Chang, W.T., J.T. Cheng and Z.C. Chen, 2016. Telmisartan improves cardiac fibrosis in diabetes through peroxisome proliferator activated receptor δ (PPARδ): From bedside to bench. Cardiovasc. Diabetol., Vol. 15. 10.1186/s12933-016-0430-5.
    CrossRef  |  PubMed  |  Direct Link  |  
  10. Yang, T.T., H.S. Niu, L.J. Chen, P.M. Ku, K.C. Lin and J.T. Cheng, 2015. Canavanine induces insulin release via activation of imidazoline I3 receptors. Clin. Exp. Pharmacol. Physiol., 42: 263-268.
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  11. Tsai, C.C., T.W. Chuang, L.J. Chen, H.S. Niu, K.M. Chung, J.T. Cheng and K.C. Lin, 2015. Increase in apoptosis by combination of metformin with silibinin in human colorectal cancer cells. World J. Gastroenterol, 21: 4169-4177.
    CrossRef  |  PubMed  |  Direct Link  |  
  12. Niu, H.S., P.M. Ku, C.S. Niu, J.T. Cheng and K.S. Lee, 2015. Development of PPAR-agonist GW0742 as antidiabetic drug: Study in animals. Drug Des. Dev. Ther., 9: 5625-5632.
    CrossRef  |  PubMed  |  Direct Link  |  
  13. Lin, C.M., J.T. Tsai, C.K. Chang, J.T. Cheng and J.W. Lin, 2015. Development of telmisartan in the therapy of spinal cord injury: Pre-clinical study in rats. Drug Des. Dev. Ther., 93: 4709-4717.
    CrossRef  |  PubMed  |  Direct Link  |  
  14. Cheng, M.F., L.J. Chen, H.S. Niu, T.T. Yang, K.C. Lin and J.T. Cheng, 2015. Signals mediating klotho-induced neuroprotection in hippocampal neuronal cells. Acta Neurobiol. Exp., 75: 60-71.
    PubMed  |  Direct Link  |  
  15. Chen, L.J., M.F. Cheng, P.M. Ku and J.T. Cheng, 2015. Cerebral klotho protein as a humoral factor for maintenance of baroreflex. Hormone Metab. Res., 47: 125-132.
    CrossRef  |  PubMed  |  Direct Link  |  
  16. Chao, P.C., C.H. Chang, H.S. Niu, G.C. Huang, L.J. Chen and J.T. Cheng, 2015. Canavanine increases glucose uptake in C2C12 cells through the activation of imidazoline I-2B receptors. Clin. Exp. Pharmacol. Physiol., 42: 1045-1050.
    CrossRef  |  PubMed  |  Direct Link  |  
  17. Chang, C.H., P.C. Chao, H.S. Niu, G.C. Huang, L.J. Chen and J.T. Cheng, 2015. Canavanine activates imidazoline I-2 receptors to reduce hyperglycemia in type 1-like diabetic rats. Chemico-Biol. Interact., 240: 304-309.
    CrossRef  |  PubMed  |  Direct Link  |  
  18. Yeh, M.C., L.J. Chen, H.S. Niu, T.T. Yang, K.C. Lin and J.T. Cheng, 2014. Signals for increase of μ-opioid receptor expression in muscle by hyperglycemia. Neurosci. Lett., 582: 109-114.
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  19. Tsai, T.C., C.H. Lin, H.H. Chung, J.T. Cheng, I.H. Chen and Y.C. Tong, 2014. Urinary bladder relaxation through activation of imidazoline receptors induced by agmatine is increased in diabetic rats. LUTS, 6: 117-123.
    CrossRef  |  Direct Link  |  
  20. Tsai, C.C., K.S. Lee, S.H. Chen, L.J. Chen, K.F. Liu and J.T. Cheng, 2014. Decrease of PPAR in type-1-like diabetic rat for higher mortality after spinal cord injury. PPAR Res., Vol. 2014. 10.1155/2014/456386.
    CrossRef  |  PubMed  |  Direct Link  |  
  21. Sheu, J.R., P.A. Thomas and J.T. Cheng, 2014. Novel drugs development for cardio-/cerebrovascular diseases. Biomed Res. Int., Vol. 2014. 10.1155/2014/467936.
    CrossRef  |  PubMed  |  Direct Link  |  
  22. Kuo, S.C., H.H. Chung, C.H. Huang and J.T. Cheng, 2014. Decrease of hyperglycemia by syringaldehyde in diabetic rats. Hormone Metab. Res., 46: 8-13.
    CrossRef  |  Direct Link  |  
  23. Kang, L., C.H. Chen, M.H. Wu, J.K. Chang, F.M. Chang and J.T. Cheng, 2014. 17β-estradiol protects against glucosamine-induced pancreatic β-cell dysfunction. Menopause, 21: 1239-1248.
    CrossRef  |  PubMed  |  Direct Link  |  
  24. Huang, K.C., Y.G. Cherng, L.J. Chen, C.T. Hsu and J.T. Cheng, 2014. Rosiglitazone is effective to improve renal damage in type-1-like diabetic rats. Hormone Metab. Res., 46: 240-244.
    CrossRef  |  Direct Link  |  
  25. Fan, E.W.C., L.J. Chen, J.T. Cheng and Y.C. Tong, 2014. Changes of urinary bladder contractility in high-fat diet-fed mice: The role of tumor necrosis factor-α. Int. J. Urol., 21: 831-835.
    CrossRef  |  PubMed  |  Direct Link  |  
  26. Cheng, K.C., A. Asakawa, Y.X. Li, H.H. Chung and H. Amitani et al., 2014. Silymarin induces insulin resistance through an increase of phosphatase and tensin homolog in Wistar rats. PLoS One, 10.1371/journal.pone.0084550.
    CrossRef  |  Direct Link  |  
  27. Chang, P.C., L.J. Chen and J.T. Cheng, 2014. Role of peroxisome proliferator-activated receptors delta (PPARdelta) in rats showing endotoxemic heart failure. J. Appl. Biomed., 12: 79-85.
    Direct Link  |  
  28. Yang, T.T., P.M. Ku, C.T. Hsu, H.H. Chung, W.J. Lee and J.T. Cheng, 2013. Mediation of AMP Kinase in the increase of glucose uptake into L6 Cells induced by activation of imidazoline I-2 receptors. Hormone Metab. Res., 45: 359-363.
    CrossRef  |  Direct Link  |  
  29. Wang, L.Y., P.M. Ku, S.H. Chen, L.J. Chen, Y.M. Yu and J.T. Cheng, 2013. Characterization of the specificity of imidazoline I-1 receptor antibody for subtype of imidazoline receptors in vitro. Hormone Metab. Res., 45: 485-489.
    CrossRef  |  Direct Link  |  
  30. Wang, L.Y., P.M. Ku, S.H. Chen, H.H. Chung, Y.M. Yu and J.T. Cheng, 2013. Insulin resistance induced by zymosan as a new animal model in mice. Hormone Metab. Res., 45: 736-740.
    CrossRef  |  Direct Link  |  
  31. Wang, L.Y., H.H. Chung and J.T. Cheng, 2013. Decrease of plasma glucose by Hibiscus taiwanensis in type-1-like diabetic rats. Evidence Based Complementary Altern. Med., 10.1155/2013/356705.
    CrossRef  |  Direct Link  |  
  32. Tzeng, J.I., M.F. Chen, H.H. Chung and J.T. Cheng, 2013. Silymarin decreases connective tissue growth factor to improve liver fibrosis in rats treated with carbon tetrachloride. Phytother. Res., 27: 1023-1028.
    CrossRef  |  Direct Link  |  
  33. Su, C.H., L.J. Chen, J.F. Liao and J.T. Cheng, 2013. Increase of phosphatase and tensin homolog by silymarin to inhibit human pharynx squamous cancer. J. Med. Food, 16: 778-784.
    CrossRef  |  Direct Link  |  
  34. Su, C.H., L.J. Chen, J.F. Liao and J.T. Cheng, 2013. Dual effects of silymarin on nasopharyngeal carcinoma cells (NPC-TW01). Forsch Komplementmed., 20: 261-266.
    CrossRef  |  Direct Link  |  
  35. Piletz, J.E., F. Aricioglu, J.T. Cheng, C.A. Fairbanks and V.H. Gilad et al., 2013. Agmatine: clinical applications after 100 years in translation. Drug Discov. Today, 18: 880-893.
    CrossRef  |  Direct Link  |  
  36. Mar, G.Y., P.M. Ku, L.J. Chen, K.C. Cheng, Y.X. Li and J.T. Cheng, 2013. Increase in cardiac M2-muscarinic receptor expression is regulated by GATA binding protein 4 (GATA-4) in streptozotocin-induced diabetic rats. Int. J. Cardiol., 167: 436-441.
    CrossRef  |  Direct Link  |  
  37. Mar, G.Y., M.T. Chou, H.H. Chung, N.H. Chiu, M.F. Chen and J.T. Cheng, 2013. Changes of imidazoline receptors in spontaneously hypertensive rats. Int. J. Exp. Pathol., 94: 17-24.
    CrossRef  |  Direct Link  |  
  38. Lo, S.H., K.S. Lee, L.J. Chen, J.T. Cheng and C.H. Chen, 2013. Increase of PPARδ by dopamine mediated via DA-1 receptor-linked phospholipase C pathway in neonatal rat cardiomyocytes. Auton. Neurosci., 177: 211-216.
    CrossRef  |  Direct Link  |  
  39. Li, Y.X., K.C. Cheng, A. Asakawa, I. Kato and Y. Sato et al., 2013. Role of musclin in the pathogenesis of hypertension in rat. PLoS One, 10.1371/journal.pone.0072004.
    CrossRef  |  Direct Link  |  
  40. Lee, W.J., H.H. Chung, Y.Z. Cheng, H.H. Lin and J.T. Cheng, 2013. Rhodiola-water extract induces B-endorphin secretion to lower blood pressure in spontaneously hypertensive rats. Phytother. Res., 27: 1543-1547.
    CrossRef  |  Direct Link  |  
  41. Lee, L.M., C.H. Lin, H.H. Chung, J.T. Cheng, I.H. Chen and Y.C. Tong, 2013. Agmatine induces rat prostate relaxation through activation of peripheral imidazoline I2-receptors. LUTS, 5: 39-43.
    CrossRef  |  Direct Link  |  
  42. Lai, Y.H., L.J. Chen and J.T. Cheng, 2013. Role of TNF-a in renal damage in mice showing hepatic steatosis induced by high fat diet. Hormone Metab. Res., 45: 38-42.
    CrossRef  |  Direct Link  |  
  43. Kuo, S.C., P.M. Ku, L.J. Chen, H.S. Niu and J.T. Cheng, 2013. Activation of receptors δ (PPARδ) by agonist (GW0742) may enhance lipid metabolism in heart both In Vivo and In Vitro. Hormone Metab. Res., 45: 880-886.
    CrossRef  |  Direct Link  |  
  44. Huang, C.W., M.C. Lai, J.T. Cheng, J.J. Tsai, C.C. Huang and S.N. Wu, 2013. Pregabalin attenuates excitotoxicity in diabetes. PLoS One, 10.1371/journal.pone.0065154.
    CrossRef  |  Direct Link  |  
  45. Chung, H.H., K.S. Lee and J.T. Cheng, 2013. Decrease of obesity by allantoin via imidazoline I 1 -receptor activation in high fat diet-fed mice. Evidence Based Complementary Altern. Med., 10.1155/2013/589309.
    CrossRef  |  Direct Link  |  
  46. Chung, H.H. and J.T. Cheng, 2013. Improvement of obesity by activation of I1-imidazoline receptors in high fat diet-fed mice. Hormone Metab. Res., 45: 581-585.
    CrossRef  |  Direct Link  |  
  47. Cherng, Y.G., C.C. Tsai, H.H. Chung, Y.W. Lai, S.C. Kuo and J.T. Cheng, 2013. Antihyperglycemic action of sinapic acid in diabetic rats. J. Agric. Food Chem., 61: 12053-12059.
    CrossRef  |  Direct Link  |  
  48. Cheng, K.C., A. Asakawa, Y.X. Li, I.M. Liu, H. Amitani, J.T. Cheng and A. Inui, 2013. Opioid μ-receptors as new target for insulin resistance. Pharmacol. Ther., 139: 334-340.
    CrossRef  |  Direct Link  |  
  49. Chen, Z.C., L.J. Chen and J.T. Cheng, 2013. Doxorubicin-induced cardiac toxicity is mediated by lowering of peroxisome proliferator-activated receptor δ expression in rats. PPAR Res., 10.1155/2013/456042.
    CrossRef  |  Direct Link  |  
  50. Chen, Z.C., K.S. Lee, L.J. Chen, L.Y. Wang, H.S. Niu and J.T. Cheng, 2013. Cardiac peroxisome proliferator-activated receptor δ (PPARδ) as a new target for increased contractility without altering heart rate. PLoS One, 10.1371/journal.pone.0064229.
    CrossRef  |  Direct Link  |  
  51. Chen, Z.C., B.C. Yu, L.J. Chen and J.T. Cheng, 2013. Increase of peroxisome proliferator-activated receptors δ (PPARδ) by digoxin to improve lipid metabolism in the heart of diabetic rats. Hormone Metab. Res., 45: 364-371.
    CrossRef  |  Direct Link  |  
  52. Chen, Y.W., P.L. Hsieh, Y.C. Chen, C.H. Hung and J.T. Cheng, 2013. Physical exercise induces excess hsp72 expression and delays the development of hyperalgesia and allodynia in painful diabetic neuropathy rats. Anesth Analg., 116: 482-490.
    CrossRef  |  Direct Link  |  
  53. Yu, H.C., L.J. Chen, K.C. Cheng, Y.X. Li, C.H. Yeh and J.T. Cheng, 2012. Silymarin inhibits cervical cancer cell through an increase of phosphatase and tensin homolog (PTEN). Phytother. Res., 26: 709-715.
    CrossRef  |  Direct Link  |  
  54. Yang, T.T., N.H. Chiu, H.H. Chung, C.T. Hsu, W.J. Lee and J.T. Cheng, 2012. Stimulatory effect of allantoin on imidazoline I1 receptors in animal and cell line. Hormone Metab. Res., 44: 879-884.
    CrossRef  |  Direct Link  |  
  55. Yang, P.S., H.T. Wu, H.H. Chung, C.T. Chen, C.W. Chi, C.H. Yeh and J.T. Cheng, 2012. Rilmenidine improves hepatic steatosis through p38-dependent pathway to higher the expression of farnesoid X receptor. Naunyn-Schmiedebergs Arch. Pharmacol., 385: 51-56.
    CrossRef  |  Direct Link  |  
  56. Wu, H.T., W. Chen, K.C. Cheng, P.M. Ku, C.H. Yeh and J.T. Cheng, 2012. Oleic acid activates peroxisome proliferator-activated receptor to compensate insulin resistance in steatotic cells. J. Nutrit. Biochem., 23: 1264-1270.
    CrossRef  |  Direct Link  |  
  57. Lin, K.C., L.R. Yeh, L.J. Chen, Y.J. Wen, K.C. Cheng and J.T. Cheng, 2012. Plasma glucose-lowering action of allantoin is induced by activation of imidazoline I-2 receptors in streptozotocin-induced diabetic rats. Hormone Metab. Res., 44: 41-46.
    CrossRef  |  Direct Link  |  
  58. Lin, C.C., L.T. Lin, M.H. Yen, J.T. Cheng, C.H. Yeh and C.H. Hsing, 2012. Renal protective effect of Xiao-Chai-Hu-Tang on diabetic nephropathy of type 1-diabetic mice. Evidence-Based Complementary Altern. Med., 10.1155/2012/984024.
    CrossRef  |  Direct Link  |  
  59. Lee, L.M., T.C. Tsai, H.H. Chung, Y.C. Tong and J.T. Cheng, 2012. Prostatic relaxation induced by agmatine is decreased in spontaneously hypertensive rats. BJU Int., 110: 253-258.
    CrossRef  |  Direct Link  |  
  60. Lee, L.M., C.S. Lin, H.H. Chung, K.C. Lin and J.T. Cheng, 2012. Urinary bladder relaxation through activation of opioid μ-receptors induced by loperamide is increased in diabetic rats. Exp. Clin. Endocrinol. Diabetes, 120: 323-328.
    CrossRef  |  Direct Link  |  
  61. Lee, L.M., C.C. Lu, H.H. Chung and J.T. Cheng, 2012. Prostatic relaxation induced by loperamide is reduced in spontaneously hypertensive rats. Sci. World J., 10.1100/2012/941685.
    CrossRef  |  Direct Link  |  
  62. Kang, L., C.H. Chen, Y.C. Cheng, C.H. Chang and C.T. Lee et al., 2012. Glucosamine-induced insulin resistance in ovariectomized rats is relevant to decreasing the expression of glucose transport protein subtype 4 in the skeletal muscle and in increasing the size of pancreatic islets. Menopause, 19: 496-502.
    CrossRef  |  Direct Link  |  
  63. Huang, C.H., M.F. Chen, H.H. Chung and J.T. Cheng, 2012. Antihyperglycemic effect of syringaldehyde in streptozotocin-induced diabetic rats. J. Nat. Prod., 75: 1465-1468.
    CrossRef  |  Direct Link  |  
  64. Chung, H.H., T.T. Yang, M.F. Chen, M.T. Chou and J.T. Cheng, 2012. Improvement of Hyperphagia by Activation of Cerebral I1-Imidazoline Receptors in Streptozotocin-induced Diabetic Mice. Hormone Metab. Res., 44: 645-649.
    CrossRef  |  Direct Link  |  
  65. Chou, M.T., S.H. Lo, K.C. Cheng, Y.X. Li, L.J. Chen and J.T. Cheng, 2012. Activation of B-adrenoceptors by dobutamine may induce a higher expression of peroxisome proliferator-activated receptors δ (PPARδ) in neonatal rat cardiomyocytes. Sci. World J., 10.1100/2012/248320.
    CrossRef  |  Direct Link  |  
  66. Cheng, Y.Z., L.J. Chen, W.J. Lee, M.F. Chen, H.J. Lin and J.T. Cheng, 2012. Increase of myocardial performance by Rhodiola-ethanol extract in diabetic rats. J. Ethnopharmacol., 144: 234-239.
    CrossRef  |  Direct Link  |  
  67. Cheng, K.C., Y.X. Li, A. Asakawa, M. Ushikai and I. Kato et al., 2012. Characterization of preptin-induced insulin secretion in pancreatic B-cells. J. Endocrinol., 215: 43-49.
    CrossRef  |  Direct Link  |  
  68. Cheng, K.C., Y.X. Li and J.T. Cheng, 2012. The use of herbal medicine in cancer-related anorexia/ cachexia treatment around the world. Curr. Pharm. Des., 18: 4819-4826.
    CrossRef  |  Direct Link  |  
  69. Chen, W., H.H. Chung and J.T. Cheng, 2012. Opiate-induced constipation is related to the activation of opioid mu2-receptors in small intestine of mice. World J. Gastroenterol., 18: 1391-1396.
    CrossRef  |  Direct Link  |  
  70. Chen, M.F., T.T. Yang, L.R. Yeh, H.H. Chung, Y.J. Wen, W.J. Lee and J.T. Cheng, 2012. Activation of imidazoline I-2B receptors by allantoin to increase glucose uptake into C2C12 Cells. Hormone Metab. Res., 44: 268-272.
    Direct Link  |  
  71. Chen, I.H., Y.C. Tong and J.T. Cheng, 2012. Metabolic syndrome decreases tissue perfusion and induces glandular hyperplasia in the fructose-fed rat prostate. Neurourol. Urodyn., 31: 600-604.
    CrossRef  |  Direct Link  |  
  72. Chen, I.H., H.H. Chung, J.T. Cheng and Y.C. Tong, 2012. Metabolic syndrome enhances prostate contractility and in vitro phenylephrine-induced a1-adrenoceptor protein expression in the fructose-fed rat. LUTS, 5: 164-167.
    CrossRef  |  Direct Link  |  
  73. Yeh, C.H., C.K. Chang, K.C. Cheng, Y.X. Li, Y.W. Zhang and J.T. Cheng, 2011. Role of bone morphogenetic proteins-7 (BMP-7) in the renal improvement effect of DangGui (Angelica sinensis) in type 1-diabetic rats. Evidence Based Complementary Altern. Med., 10.1155/2011/796723.
    CrossRef  |  Direct Link  |  
  74. Wu, H.T., C.T. Chen, K.C. Cheng, Y.X. Li, C.H. Yeh and J.T. Cheng, 2011. Pharmacological activation of peroxisome proliferator-activated receptor δ improves insulin resistance and hepatic steatosis in high fat diet-induced diabetic mice. Hormone Metab. Res., 43: 631-635.
  75. Shieh, J.P., K.C. Cheng, H.H. Chung, Y.F. Kerh, C.H. Yeh and J.T. Cheng, 2011. Plasma glucose lowering mechanisms of catalpol, an active principle from roots of Rehmannia glutinosa, in streptozotocin-induced diabetic rats. J. Agric. Food Chem., 59: 3747-3753.
    CrossRef  |  Direct Link  |  
  76. Ou, H.Y., H.T. Wu, Y.C. Yang, J.S. Wu, J.T. Cheng and C.J. Chang, 2011. Elevated retinol binding protein 4 contributes to insulin resistance in spontaneously hypertensive rats. Hormone Metab., 43: 312-318.
  77. Niu, C.S., H.T Wu, K.C. Cheng, K.C. Lin, C.T. Chen and J.T. Cheng, 2011. A novel mechanism for decreasing plasma lipid level from imidazoline I-1 receptor activation in high fat diet-fed mice. Hormone Metab., 43: 458-463.
  78. Niu, C.S., C.T. Chen, L.J. Chen, K.C. Cheng, C.H. Yeh and J.T. Cheng, 2011. Decrease of blood lipids induced by Shan-Zha (fruit of Crataegus pinnatifida) is mainly related to an increase of PPAR in liver of mice fed high-fat diet. Hormone Metab. Res., 43: 625-630.
  79. Liu, C.L., H.T. Wu, Y.H. Hsiao, C.W. Lai and C.W. Shih et al., 2011. Insulin-directed synthesis of fluorescent gold nanoclusters: Preservation of insulin bioactivity and versatility in cell imaging. Angew. Chem. Int. Ed. Eng., 50: 7056-7060.
    CrossRef  |  Direct Link  |  
  80. Lin, R.T., C.Y. Chen, C.Y. Tzeng, Y.C. Lee and Y.W. Cheng et al., 2011. Electroacupuncture improves glucose tolerance through cholinergic nerve and nitric oxide synthase effects in rats. Neurosci. Lett., 494: 114-118.
    CrossRef  |  Direct Link  |  
  81. Lee, J.P., W. Chen, H.T. Wu, K.C. Lin and J.T. Cheng, 2011. Metformin can activate imidazoline I-2 receptors to lower plasma glucose in type 1-like diabetic rats. Hormone Metab. Res., 43: 26-30.
    CrossRef  |  PubMed  |  Direct Link  |  
  82. Lee, J.P., K.C. Cheng, H.H. Chung, H.T. Wu, C.T. Chen and J.T. Cheng, 2011. Inhibition of insulin degrading enzyme by racecadotril in the brain of Wistar rats. Hormone Metab. Res., 43: 489-493.
  83. Ku, P.M., L.J. Chen, J.R. Liang, K.C. Cheng, Y.X. Li and J.T. Cheng, 2011. Molecular role of GATA binding protein 4 (GATA-4) in hyperglycemia-induced reduction of cardiac contractility. Cardiovasc. Diabetol., 10.1186/1475-2840-10-57.
    CrossRef  |  Direct Link  |  
  84. Fong,Y., K.H. Shen, L.J. Chen and J.T. Cheng, 2011. Changes of CCAAT enhancer-binding proteins (CEBPs) in the lung of streptozotocin-induced diabetic rats. Hormone Metab., 43: 261-267.
  85. Chiu, Y.J., H.H. Chung, C.H. Yeh, J.T. Cheng and S.H. Lo, 2011. Improvement of insulin resistance by Chlorella in fructose-rich chow-fed rats. Phytother. Res., 25: 1306-1312.
    CrossRef  |  Direct Link  |  
  86. Cheng, J.T., I.H. Chen, B.C. Yu and Y.C. Tong, 2011. Loperamide-induced rat prostate relaxation through activation of peripheral �-opioid receptors. Neurourol. Urodyn., 30: 468-471.
    CrossRef  |  Direct Link  |  
  87. Chen, Z.C., J.P. Shieh, H.H. Chung, C.H. Hung, H.J. Lin and J.T. Cheng, 2011. Activation of peripheral opioid μ-receptors in blood vessel may lower blood pressure in spontaneously hypertensive rats. Pharmacol., 87: 257-264.
    CrossRef  |  Direct Link  |  
  88. Chen, Z.C., B.C. Yu, L.J. Chen, K.C. Cheng, H.J. Lin and J.T. Cheng, 2011. Characterization of the mechanisms of the increase in PPARδ expression induced by digoxin in the heart using the H9c2 cell line. Br. J. Pharmacol., 163: 390-398.
    CrossRef  |  Direct Link  |  
  89. Chen, C.T., W. Chen, H.H. Chung, K.C. Cheng, C.H. Yeh and J.T. Cheng, 2011. Activation of imidazoline I-2B receptor by metformin to increase glucose uptake in skeletal muscle. Hormone Metab. Res., 43: 708-713.
    CrossRef  |  Direct Link  |  
  90. Yang, T.T., S.M. Ling, C.W. Tsao and J.T. Cheng, 2010. Opening of ATP-sensitive potassium channel by insulin in the brain-induced insulin secretion in Wistar rats. Hormone Metab. Res., 42: 110-114.
    CrossRef  |  PubMed  |  Direct Link  |  
  91. Wu, H.T., W. Chen, K.C. Cheng, C.H. Yeh, K.H. Shen and J.T. Cheng, 2010. Indomethacin activates peroxisome proliferator-Activated receptor γ to improve insulin resistance in cotton pellet granuloma model. Hormone Metab. Res., 42: 775-780.
    CrossRef  |  PubMed  |  Direct Link  |  
  92. Wu, H.T., C.K. Chang, K.C. Cheng, C.H. Chang, C.H. Yeh and J.T. Cheng, 2010. Increase of plasma insulin by racecadotril, an inhibitor of enkephalinase, in Wistar rats. Hormone Metab. Res., 42: 261-267.
    CrossRef  |  PubMed  |  Direct Link  |  
  93. Lui, T.N., C.W. Tsao, S.Y. Huang, C.H. Chang and J.T. Cheng, 2010. Activation of imidazoline I2B receptors is linked with AMP kinase pathway to increase glucose uptake in cultured C2C12 cells. Neurosci. Lett., 474: 144-147.
    CrossRef  |  PubMed  |  Direct Link  |  
  94. Lee, K.S., W.J. Yu, M.J. Wang, H.T. Wu, C.H. Chang and J.T. Cheng, 2010. Autonomic regulation of insulin secretion is changed by pentobarbital in mice. Neurosci. Lett., 479: 6-9.
    CrossRef  |  PubMed  |  Direct Link  |  
  95. Lee, K.S., A. Nishimune, H. Yoshiki, A.S. Anisuzzaman and F. Suzuki et al., 2010. Assessment of novel muscarinic acetylcholine receptors in rat cerebral cortex by a tissue segment binding method. J. Pharmacol. Sci., 112: 444-451.
    CrossRef  |  PubMed  |  Direct Link  |  
  96. Lee, H.H., C.H. Yeh, Y.T. Chen, T.C. Chi, J.T. Cheng and S.H. Lo, 2010. Effects of metformin on rosiglitazone-induced cardiac hypertrophy in mice. Biol. Pharma. Bull., 33: 1506-1510.
    CrossRef  |  PubMed  |  Direct Link  |  
  97. Huang, W.J., H.S. Niu, M.H. Lin, J.T. Cheng and F.L. Hsu, 2010. Antihyperglycemic effect of catalpol in streptozotocin-induced diabetic rats. J. Nat. Prod., 73: 1170-1172.
    CrossRef  |  PubMed  |  Direct Link  |  
  98. Fan, S.C., B.C. Yu, Z.C. Chen, L.J. Chen, H.H. Chung and J.T. Cheng, 2010. The decreased expression of peroxisome proliferator-activated receptors δ (PPARδ) is reversed by digoxin in the heart of diabetic rats. Hormone Metab. Res., 42: 637-642.
    CrossRef  |  PubMed  |  Direct Link  |  
  99. Cheng, T.C., C.C. Lu, H.H. Chung, C.C. Hsu and N. Kakizawa et al., 2010. Activation of muscarinic M-1 cholinoceptors by curcumin to increase contractility in urinary bladder isolated from Wistar rats. Neurosci. Lett., 473: 107-109.
    CrossRef  |  PubMed  |  Direct Link  |  
  100. Chang, C.H., H.T. Wu, K.C. Cheng, H.J. Lin and J.T. Cheng, 2010. Increase of β-endorphin secretion by agmatine is induced by activation of imidazoline I2A receptors in adrenal gland of rats. Neurosci. Lett., 468: 297-299.
    CrossRef  |  PubMed  |  Direct Link  |  
  101. Yeh, C.H., C.K. Chang, M.F. Cheng, H.J. Lin and J.T. Cheng, 2009. The antioxidative effect of bone morphogenetic protein-7 against high glucose-induced oxidative stress in mesangial cells. Biochem. Biophys. Res. Commun., 382: 292-297.
    CrossRef  |  PubMed  |  Direct Link  |  
  102. Yeh, C.H., C.K. Chang, M.F. Cheng, H.J. Lin and J.T. Cheng, 2009. Decrease of bone morphogenetic protein-7 (BMP-7) and its type II receptor (BMP-RII) in kidney of type 1-like diabetic rats. Hormone Metab. Res., 41: 605-611.
    CrossRef  |  PubMed  |  Direct Link  |  
  103. Yang, T.T., I.M. Liu, H.T. Wu and J.T. Cheng, 2009. Mediation of protein kinase C zeta in μ-opioid receptor activation for increase of glucose uptake into cultured myoblast C2C12 cells. Neurosci. Lett., 465: 177-180.
    CrossRef  |  PubMed  |  Direct Link  |  
  104. Yang, T.T., C.K. Chang, C.W. Tsao, Y.M. Yu, C.T. Hsu and J.T. Cheng, 2009. Activation of muscarinic M-3 receptor may decrease glucose uptake and lipolysis in adipose tissue of rats. Neurosci. Lett., 451: 57-59.
    CrossRef  |  PubMed  |  Direct Link  |  
  105. Yang, P.S., J.J. Lee, C.W. Tsao, H.T. Wu and J.T. Cheng, 2009. Stimulatory effect of stevioside on peripheral mu opioid receptors in animals. Neurosci. Lett., 454: 72-75.
    CrossRef  |  PubMed  |  Direct Link  |  
  106. Su, C.H., I.M. Liu, H.H. Chung and J.T. Cheng, 2009. Activation of I2-imidazoline receptors by agmatine improved insulin sensitivity through two mechanisms in type-2 diabetic rats. Neurosci. Lett., 457: 125-128.
    CrossRef  |  PubMed  |  Direct Link  |  
  107. Shieh, J.M., H.T. Wu, K.C. Cheng and J.T. Cheng, 2009. Melatonin ameliorates high fat diet-induced diabetes and stimulates glycogen synthesis via a PKCζ-Akt-GSK3β pathway in hepatic cells. J. Pineal Res., 47: 339-344.
    CrossRef  |  PubMed  |  Direct Link  |  
  108. Pai, H.C., C.Y. Tzeng, Y.C. Lee, C.H. Chang, J.G. Lin, J.T. Cheng and S.L. Chang, 2009. Increase in plasma glucose lowering action of rosiglitazone by electroacupuncture at bilateral Zusanli acupoints (ST.36) in rats. J. Acupunct. Meridian. Stud., 2: 147-151.
    CrossRef  |  PubMed  |  Direct Link  |  
  109. Niu, C.S., C.H. Yeh, M.F. Yeh and J.T. Cheng, 2009. Increase of adipogenesis by ginsenoside (Rh2) in 3T3-L1 cell via an activation of glucocorticoid receptor. Hormone Metab. Res., 41: 271-276.
    CrossRef  |  PubMed  |  Direct Link  |  
  110. Liu, I.M. and J.T. Cheng, 2009. Mediation of endogenous β-endorphin in the plasma glucose-lowering action of herbal products observed in type 1-like diabetic rats. Evid Based Complement Alternat Med 10.1093/ecam/nen078.
    CrossRef  |  PubMed  |  Direct Link  |  
  111. Lin, R.T., C.Y. Tzeng, Y.C. Lee, W.J. Ho, J.T. Cheng, J.G. Lin and S.L. Chang, 2009. Acute effect of electroacupuncture at the Zusanli acupoints on decreasing insulin resistance as shown by lowering plasma free fatty acid levels in steroid-background male rats. BMC Complementary Altern. Med., Vol. 9. 10.1186/1472-6882-9-26.
    CrossRef  |  Direct Link  |  
  112. Lin, C.L., A.S. Dumont, Y.F. Su, Z.K. Dai and J.T. Cheng et al., 2009. Attenuation of subarachnoid hemorrhage-induced apoptotic cell death with 17 beta-estradiol: laboratory investigation. J. Neurosurg., 111: 1014-1022.
    CrossRef  |  PubMed  |  Direct Link  |  
  113. Kuo, D.H., C.H. Yeh, P.C. Shieh, K.C. Cheng, F.A. Chen and J.T. Cheng, 2009. Effect of ShanZha, a Chinese herbal product, on obesity and dyslipidemia in hamsters receiving high-fat diet. J. Ethnopharmacol., 124: 544-550.
    CrossRef  |  PubMed  |  Direct Link  |  
  114. Huang, C.W., J.T. Cheng, J.J. Tsai, S.N. Wu and C.C. Huang, 2009. Diabetic hyperglycemia aggravates seizures and status epilepticus-induced hippocampal damage. Neurotoxicity Res., 15: 71-81.
    CrossRef  |  PubMed  |  Direct Link  |  
  115. Chien, C.S., S.C. Cheng, H.T. Wu, C.W. Tsao and J.T. Cheng, 2009. Insulin resistance induced by glucosamine in fructose-fed rats. Hormone Metab. Res., 41: 542-547.
    CrossRef  |  PubMed  |  Direct Link  |  
  116. Cheng, T.C., C.S. Lin, C.C. Hsu, L.J. Chen, K.C. Cheng and J.T. Cheng, 2009. Activation of muscarinic M-1 cholinoceptors by curcumin to increase glucose uptake into skeletal muscle isolated from Wistar rats. Neurosci. Lett., 465: 238-241.
    CrossRef  |  PubMed  |  Direct Link  |  
  117. Chang, C.H., C.W. Tsao, S.Y. Huang and J.T. Cheng, 2009. Activation of imidazoline I2B receptors by guanidine to increase glucose uptake in skeletal muscle of rats. Neurosci. Lett., 467: 147-149.
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  118. Chan, P., I.M. Liu, Y.X. Li, W.J. Yu and J.T. Cheng, 2009. Antihypertension induced by tanshinone IIA isolated from the roots of Salvia Miltiorrhiza. Evid Based Complement Alternat Med 10.1093/ecam/nep056.
    CrossRef  |  PubMed  |  Direct Link  |  
  119. Liu, I.M., S.S. Liou and J.T. Cheng, 2006. Mediation of beta-endorphin by myricetin to lower plasma glucose in streptozotocin-induced diabetic rats. J. Ethanopharmacol., 104: 199-206.
    CrossRef  |  PubMed  |  Direct Link  |  
  120. Lai, D.M., Y.K. Tu, I.M. Liu, P.F. Chen and J.T. Cheng, 2006. Mediation of β-endorphin by ginsenoside Rh2 to lower plasma glucose in streptozotocin-induced diabetic rats. Planta Med., 72: 9-13.
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