Dr. Yangchao Chen
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Dr. Yangchao Chen

Associate Professor
Chinese University of Hong Kong, Hong Kong

Highest Degree
Ph.D. in Biochemistry and Molecular Biology from Sun Yat-sen University, China

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Area of Interest:

Molecular Sciences
100%
Gastroenterology
62%
Cancer Research
90%
Cell Biology
75%
Proteomics
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Xiao, Z. and Y. Chen, 2017. Identification of small molecule modulators of microRNA by library screening. Methods Mol. Biol., 1517: 169-178.
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  2. Li, C.H., Z. Xiao, J.H.M. Tong, K.F. To, X. Fang, A.S. Cheng and Y. Chen, 2017. EZH2 coupled with HOTAIR to silence microRNA-34a by the induction of heterochromatin formation in human pancreatic ductal adenocarcinoma. Int. J. Cancer, 140: 120-129.
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  3. Wong, C.H., Y.J. Li and Y.C. Chen, 2016. Therapeutic potential of targeting acinar cell reprogramming in pancreatic cancer. World J. Gastroenterol., 22: 7046-7057.
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  4. Tang, W., M. Han, B. Ruan, W. Jin and J. Lou et al., 2016. Overexpression of GOLPH3 is associated with poor survival in non-small-cell lung cancer. Am. J. Transl. Res., 8: 1756-1762.
    PubMed  |  Direct Link  |  
  5. Siu, G.K.Y., F. Zhou, M.K. Yu, L. Zhang and T. Wang et al., 2016. Hepatitis C virus NS5A protein cooperates with phosphatidylinositol 4-kinase IIIα to induce mitochondrial fragmentation. Scient. Rep., Vol. 6. 10.1038/srep23464.
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  6. Ma, J.Y., X. Zhou, J. Fu, C.Y. He and R. Feng et al., 2016. In vivo metabolite profiling of a purified ellagitannin isolated from Polygonum capitatum in rats. Molecules, Vol. 21, No. 9. 10.3390/molecules21091110.
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  7. Li, C.H. and Y. Chen, 2016. Diagnostic potential of lncRNAs in cancer. EBioMedicine, 7: 7-8.
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  8. Lau, O.C., B. Shen, C.O. Wong, Y.W. Tjong and C.Y. Lo et al., 2016. TRPC5 channels participate in pressure-sensing in aortic baroreceptors. Nat. Commun., Vol. 7. 10.1038/ncomms11947.
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  9. Hao, Y., A.W. Chow, W.C. Yip, C.H. Li and T.F. Wan et al., 2016. G protein-coupled estrogen receptor inhibits the P2Y receptor-mediated Ca2+ signaling pathway in human airway epithelia. Pflugers Archiv-Eur. J. Physiol., 468: 1489-1503.
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  10. Feng, H.Y. and Y.C. Chen, 2016. Role of bile acids in carcinogenesis of pancreatic cancer: An old topic with new perspective. World J. Gastroenterol., 22: 7463-7477.
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  11. Cheung, R.C.F., T.B. Ng, J.H. Wong, Y. Chen and W.Y. Chan, 2016. Marine natural products with anti-inflammatory activity. Applied Microbiol. Biotechnol., 100: 1645-1666.
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  12. Zhu, R., M.T. Mok, W. Kang, S.S. Lau and W.K. Yip et al., 2015. Truncated HBx-dependent silencing of GAS2 promotes hepatocarcinogenesis through deregulation of cell cycle, senescence and p53-mediated apoptosis. J. Pathol., 237: 38-49.
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  13. Xiao, Z. and Y. Chen, 2015. Small molecule targeting miR-34a for cancer therapy. Mol. Cell. Oncol., Vol. 2, No. 1. 10.4161/23723556.2014.977160.
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  14. Shen, J., Z. Xiao, W.K. Wu, M.H. Wang and K.F. To et al., 2015. Epigenetic silencing of miR-490-3p reactivates the chromatin remodeler SMARCD1 to promote Helicobacter pylori-induced gastric carcinogenesis. Cancer Res., 75: 754-765.
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  15. Li, X.Y., Z.X. Zhao, M. Huang, R. Feng and C.Y. He et al., 2015. Effect of Berberine on promoting the excretion of cholesterol in high-fat diet-induced hyperlipidemic hamsters. J. Transl. Med., Vol. 13. 10.1186/s12967-015-0629-3.
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  16. Li, C.H. and Y. Chen, 2015. Targeting EZH2 for cancer therapy: Progress and perspective. Curr. Protein Pept. Sci., 16: 559-570.
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  17. Li, C.H. and Y. Chen, 2015. Small and long non-coding RNAs: Novel targets in perspective cancer therapy. Curr. Genom., 16: 319-326.
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  18. Feng, R., J.W. Shou, Z.X. Zhao, C.Y. He and C. Ma et al., 2015. Transforming berberine into its intestine-absorbable form by the gut microbiota. Scient. Rep., Vol. 5. 10.1038/srep12155.
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  19. Zhao, J., Y. Feng, H. Yan, Y. Chen and J. Wang et al., 2014. Β-arrestin2/miR-155/GSK3β regulates transition of 5′-azacytizine-induced Sca-1-positive cells to cardiomyocytes. J. Cell. Mol. Med., 18: 1562-1570.
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  20. Zhang, Y., J. Liu, X.Y. Tian, W.T. Wong and Y. Chen et al., 2014. Inhibition of bone morphogenic protein 4 restores endothelial function in db/db diabetic mice. Arterioscler. Thromb. Vasc. Biol., 34: 152-159.
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  21. Xiao, Z., S.C. Chow, C.H. Li, S.C. Tang, S.K. Tsui, Z. Lin and Y. Chen, 2014. Role of microRNA-95 in the anticancer activity of Brucein D in hepatocellular carcinoma. Eur. J. Pharmacol., 728: 141-150.
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  22. Xiao, Z., C.H. Li, S.L. Chan, F. Xu and L. Feng et al., 2014. A small-molecule modulator of the tumor-suppressor miR34a inhibits the growth of hepatocellular carcinoma. Cancer Res., 74: 6236-6247.
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  23. Wang, J., L. Dong, L. Xu, E.S. Chu and Y. Chen et al., 2014. B cell CLL/lymphoma 6 member B inhibits hepatocellular carcinoma metastases in vitro and in mice. Cancer Lett., 355: 192-200.
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  24. Tang, S.C. and Y.C. Chen, 2014. Novel therapeutic targets for pancreatic cancer. World J. Gastroenterol., 20: 10825-10844.
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  25. Ma, J.Y., X. Zhou, J. Fu, T. Hu and P.M. Or et al., 2014. Metabolite profiling analysis of FR429, an ellagitannin purified from Polygonum capitatum, in rat and human liver microsomes, cytosol and rat primary hepatocytes in vitro. Chemico-Biol. Interact., 220: 33-40.
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  26. Li, C.H., F. Xu, S. Chow, L. Feng, D. Yin, T.B. Ng and Y. Chen, 2014. Hepatitis B virus X protein promotes hepatocellular carcinoma transformation through interleukin-6 activation of microRNA-21 expression. Eur. J. Cancer, 50: 2560-2569.
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  27. Lee, K.Y., K.Y.Y. Chan, K.S. Tsang, Y.C. Chen and H.F. Kung et al., 2014. Ubiquitous expression of MAKORIN-2 in normal and malignant hematopoietic cells and its growth promoting activity. PLoS ONE, Vol. 9. 10.1371/journal.pone.0092706.
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  28. He, C.Y., J. Fu, J.Y. Ma, R. Feng and X.S. Tan et al., 2014. Biotransformation and in vitro metabolic profile of bioactive extracts from a traditional Miao-nationality herbal medicine, Polygonum capitatum. Molecules, 19: 10291-10308.
    CrossRef  |  PubMed  |  Direct Link  |  
  29. Wang, Y., J.Y. Ma, S.C. Chow, C.H. Li and Z.G. Xiao et al., 2013. A potential antitumor ellagitannin, davidiin, inhibited hepatocellular tumor growth by targeting EZH2. Tumor Biol.,. 10.1007%2Fs13277-013-1025-3.
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  30. Li, C.H., K.F. To, J.H. Tong, Z. Xiao and T. Xia et al., 2013. Enhancer of zeste homolog 2 silences microRNA-218 in human pancreatic ductal adenocarcinoma cells by inducing formation of heterochromatin. Gastroenterology, 144: 1086-1097.
    CrossRef  |  
  31. Li, C.H. and Y. Chen, 2013. Targeting long non-coding RNAs in cancer: Progress and perspective. Int. J. Biochem. Cell Biol., 45: 1895-1910.
  32. Chen, Y., B.C. Wong, C.H. Li, X. Zhang and S.S. Lee, 2013. Triple combination lentiviral vector-based haematopoietic stem cell gene therapy for inhibition of drug-resistant HIV-1. Hong Kong Med. J., 19: 24-26.
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  33. Wong, C.C.M., L. Zhang, Z.J. Li, W.K.K. Wu and S.X. Ren et al., 2012. Protective effects of cathelicidin-encoding Lactococcus lactis in murine ulcerative colitis. J. Gastroenterol. Hepatol., 27: 1205-1212.
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  34. Tian, X.Y., L.H. Yung, W.T. Wong, J. Liu and F.P. Leung et al., 2012. Bone morphogenic protein-4 induces endothelial cell apoptosis through oxidative stress-dependent p38MAPK and JNK pathway. J. Mol. Cell. Cardiol., 52: 237-244.
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  35. Fu, J., J.Y. Ma, X.F. Zhang, Y. Wang and R. Feng et al., 2012. Identification of metabolites of FR429, a potential antitumor ellagitannin, transformed by rat intestinal bacteria in vitro, based on liquid chromatography-ion trap-time of flight mass spectrometry analysis. J. Pharm. Biomed. Anal., 71: 162-167.
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  36. Fok, K.L., C.M. Chung, S.Q. Yi, X. Jiang and X. Sun et al., 2012. STK31 maintains the undifferentiated state of colon cancer cells. Carcinogenesis, 33: 2044-2053.
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  37. Zhang, J.F., M.L. He, Q.I. Dong, W.D. Xie and Y.C. Chen et al., 2011. Aqueous extracts of Fructus Ligustri Lucidi enhance the sensitivity of human colorectal carcinoma DLD-1 cells to doxorubicin-induced apoptosis via Tbx3 suppression. Integr. Cancer Ther., 10: 85-91.
    PubMed  |  
  38. Yue, Y., F. Jin, R. Deng, J. Cai and Y. Chen et al., 2011. Revisit complexation between DNA and polyethylenimine-effect of uncomplexed chains free in the solution mixture on gene transfection. J. Control Release, 155: 67-76.
    CrossRef  |  
  39. Yip, W.K., A.S.L. Cheng, R. Zhu, S.K. Lau and Y. Chen et al., 2011. Carboxyl-terminal truncated HBx regulates a distinct microRNA transcription program in hepatocellular carcinoma development. PLoS One, Vol. 6. 10.1371/journal.pone.0022888.
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  40. Lu, J., M.L. He, L. Wang, Y. Chen and X. Liu et al., 2011. MiR-26a inhibits cell growth and tumorigenesis of nasopharyngeal carcinoma through repression of EZH2. Cancer Res., 71: 225-233.
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  41. Lan, F.F., H. Wang, Y. Chen, C.Y. Chan and S.S. Ng et al., 2011. Hsa-let-7g inhibits proliferation of hepatocellular carcinoma cells by downregulation of c-Myc and upregulation of p16(INK4A). Int. J. Cancer, 128: 319-331.
    CrossRef  |  
  42. Cheng, A.S.L., S.S. Lau, Y. Chen, Y. Kondo and M.S. Li et al., 2011. EZH2-mediated concordant repression of wnt antagonists promotes β-catenin-dependent hepatocarcinogenesis. Cancer Res., 71: 4028-4039.
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  43. Cai, M.Y., Z.T. Tong, F. Zheng, Y.J. Liao and Y. Wang et al., 2011. EZH2 protein: A promising immunomarker for the detection of hepatocellular carcinomas in liver needle biopsies. Gut, 60: 967-976.
    CrossRef  |  
  44. Zhang, J.F., G. Li, C.Y. Chan, C.L. Meng and M.C. Lin et al., 2010. Flavonoids of herba epimedii regulate osteogenesis of human mesenchymal stem cells through BMP and Wnt/β-catenin signaling pathway. Mol. Cell Endocrinol., 314: 70-74.
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  45. Xiang-Yong, L., C. Yang-Chao, Z. Ke-Yuan, Z. Mei-Hong, L. Hai-Qing, K. Hsiang-Fu and Z. Xin, 2010. Overexpression of Bax Inhibitor-1 (BI-1) induces cell transformation in NIH3T3 cells. Cell Biol. Int., 34: 1099-1104.
    CrossRef  |  
  46. Wu, G.Q., Y.J. Liao, Z.Q. Qin, L.R. He and Y. Chen et al., 2010. PYRIN domain of NALP2 inhibits cell proliferation and tumor growth of human glioblastoma. Plasmid, 64: 41-50.
    CrossRef  |  
  47. Wong, W.T., X.Y. Tian, Y. Chen, F.P. Leung and S.L. Wong et al., 2010. COX-2 up-regulation and prostaglandin F2α mediate bone morphogenic protein 4-induced endothelial dysfunction in hypertension. Circ. Res., 107: 984-991.
  48. Rao, Z.Y., M.Y. Cai, G.F. Yang, L.R. He and S.J. Mai et al., 2010. EZH2 supports ovarian carcinoma cell invasion and/or metastasis via regulation of TGF- β1 and is a predictor of outcome in ovarian carcinoma patients. Carcinogenesis, 31: 1576-1583.
    CrossRef  |  
  49. Jiang, L., Y. Chen, C.Y. Chan, G. Lu, H. Wang, J.C. Li and H.F. Kung, 2010. Dynamic transcriptional changes of TIEG1 and TIEG2 during mouse tissue development. Anat. Rec., 293: 858-864.
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  50. Hua, W.F., Y.S. Fu, Y.J. Liao, W.J. Xia and Y. Chen et al., 2010. Curcumin induces down-regulation of EZH2 expression through the MAPK pathway in MDA-MB-435 human breast cancer cells. Eur. J. Pharmacol., 637: 16-21.
    CrossRef  |  
  51. He, L.R., M.Z. Liu, B.K. Li, H.L. Rao and Y.J. Liao et al., 2010. High expression of EZH2 is associated with tumor aggressiveness and poor prognosis in patients with esophageal squamous cell carcinoma treated with definitive chemoradiotherapy. Int. J. Cancer, 127: 138-147.
    CrossRef  |  
  52. Diao, S., J.F. Zhang, H. Wang, Y. Chen and H.F. Kung, 2010. Proteomic identification of microRNA-122a target proteins in hepatocellular carcinoma. Proteomics, 10: 3723-3731.
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  53. Chen, Y., D. Xie, W.Y. Li, C.M. Cheung and H. Yao et al., 2010. RNAi targeting EZH2 inhibits tumor growth and liver metastasis of pancreatic cancer in vivo. Cancer Lett., 297: 109-116.
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  54. Chen, S.C., G. Lu, C.Y. Chan, Y. Chen, D.T. Yew, Z.T. Feng and H.F. Kung, 2010. Microarray profile of brain aging-related genes in the frontal cortex of SAMP8. J. Mol. Neurosci., 41: 12-16.
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  55. An, X., S.S. Ng, D. Xie, Y.X. Zeng and J. Sze et al., 2010. Functional characterisation of Cell Cycle-Related Kinase (CCRK) in colorectal cancer carcinogenesis. Eur. J. Cancer, 46: 1752-1761.
    CrossRef  |  
  56. Zhang, B., Y.X. Bai, H.H. Ma, F. Feng and R. Jin et al., 2009. Silencing PinX1 compromises telomere length maintenance as well as tumorigenicity in telomerase-positive human cancer cells. Cancer Res., 69: 75-83.
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  57. Xia, H., Y. Qi, S.S. Ng, X. Chen and S. Chen et al., 2009. Microrna-146b inhibits glioma cell migration and invasion by targeting MMPs. Brain Res., 1269: 158-165.
    CrossRef  |  PubMed  |  
  58. Xia, H., Y. Qi, S.S. Ng, X. Chen and S. Chen et al., 2009. MicroRNA-15b regulates cell cycle progression by targeting cyclins in glioma cells. Biochem. Biophys. Res. Commun., 380: 205-210.
    CrossRef  |  PubMed  |  
  59. Wang, X., Y. Chen, Q.B. Han, C.Y. Chan and H. Wang et al., 2009. Proteomic identification of molecular targets of gambogic acid: Role of stathmin in hepatocellular carcinoma. Proteomics, 9: 242-253.
    CrossRef  |  PubMed  |  
  60. Moorman, J., Y. Zhang, B. Liu, G. Lesage and Y. Chen et al., 2009. HIV-1 gp120 primes lymphocytes for opioid-induced, beta-arrestin 2-dependent apoptosis. Biochim. Biophys. Acta, 1793: 1366-1371.
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  61. Ma, Y., J. Yu, H.L. Chan, Y.C. Chen and H. Wang et al., 2009. Glucose-regulated protein 78 is an intracellular antiviral factor against hepatitis B virus. Mol. Cell Proteomics, 8: 2582-2594.
    PubMed  |  
  62. Liu, L.X., N.P. Lee, V.W. Chan, W. Xue and L. Zender et al ., 2009. Targeting cadherin-17 inactivates wnt signaling and inhibits tumor growth in liver carcinoma. Hepatology, 50: 1453-1463.
    PubMed  |  Direct Link  |  
  63. Liang, B., M.L. He, C.Y. Chan, Y.C. Chen and X.P. Li et al., 2009. The use of folate-PEG-grafted-hybranched-PEI nonviral vector for the inhibition of glioma growth in the rat. Biomaterials, 30: 4014-4020.
    CrossRef  |  
  64. Li, Z., M.L. He, H. Yao, Q.M. Dong and Y.C. Chen et al., 2009. Inhibition of HBV replication and gene expression in vitro and in vivo with a single AAV vector delivering two shRNA molecules. BMB Rep., 42: 59-64.
    Direct Link  |  
  65. Li, M., J. Wang, S.S. Ng, C.Y. Chan and M.L. He et al., 2009. Adenosine diphosphate-ribosylation factor 6 is required for epidermal growth factor-induced glioblastoma cell proliferation. Cancer, 115: 4959-4972.
    CrossRef  |  PubMed  |  
  66. Jiang, L., Y. Chen, C.Y. Chan, X. Wang and L. Lin et al., 2009. Down-regulation of stathmin is required for TGF β inducible early gene 1 induced growth inhibition of pancreatic cancer cells. Can. Lett., 274: 101-108.
    CrossRef  |  PubMed  |  
  67. Dong, Q., Z. Liu, Y. Chen, C.Y. Chan and M.C. Lin et al., 2009. High level virion production and surface antigen expression with 1.5 copies of hepatitis B viral genome. J. Virol. Methods, 159: 135-140.
    CrossRef  |  PubMed  |  
  68. Deng, R., Y. Yue, F. Jin, Y. Chen, H.F. Kung, M.C. Lin and C. Wu, 2009. Revisit the complexation of PEI and DNA - how to make low cytotoxic and highly efficient PEI gene transfection non-viral vectors with a controllable chain length and structure? J. Control Release, 140: 40-46.
    CrossRef  |  PubMed  |  
  69. Li, Z., H. Yao, Y. Ma, Q. Dong and Y. Chen et al., 2008. Inhibition of HBV gene expression and replication by stably expressed interferon-α 1 via adeno-associated viral vectors. J. Gene Med., 10: 619-627.
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  70. Dong, Q., H.L.Y. Chan, Z. Liu, D.P. Chan, B. Zhang and Y. Chen et al., 2008. A1762T/G1764A mutations of hepatitis b virus, associated with the increased risk of hepatocellular carcinoma, reduce basal core promoter activities. Biochem. Biophys. Res. Commun., 374: 773-776.
    CrossRef  |  PubMed  |  
  71. Chen, Y., Y.T. Cheung, L.D. Kong, T.B. Ng and C.F. Qiao et al., 2008. Transcriptional regulation of corticotrophin releasing factor gene by furocoumarins isolated from seeds of Psoralea corylifolia. Life Sci., 82: 1117-1121.
    CrossRef  |  PubMed  |  
  72. Ng, S.S., Y.T. Cheung, X.M. An, Y.C. Chen and M. Li et al., 2007. Cell cycle-related kinase: A novel candidate oncogene in human glioblastoma. J. Natl. Cancer Inst., 99: 936-948.
    Direct Link  |  
  73. Ng, S.S., Y. Gao, D.H. Chau, G.H. Li and L. Lai et al., 2007. A novel glioblastoma cancer gene therapy using AAV-mediated long-term expression of human TERT C-terminal polypeptide. Cancer Gene Ther., 14: 561-572.
    Direct Link  |  
  74. Chen, Y., M.C. Lin, H. Yao, H. Wang and A.Q. Zhang et al., 2007. Lentivirus-mediated RNA interference targeting enhancer of zeste homolog 2 inhibits hepatocellular carcinoma growth through down-regulation of stathmin. Hepatology, 46: 200-208.
    CrossRef  |  
  75. Chen, Y., M.C. Lin, H. Wang, C.Y. Chan and L. Jiang et al., 2007. Proteomic analysis of EZH2 downstream target proteins in hepatocellular carcinoma. Proteomics, 7: 3097-3104.
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  76. Song, C.Z., K. Keller, Y. Chen and G. Stamatoyannopoulos, 2003. Functional interplay between CBP and PCAF in acetylation and regulation of transcription factor KLF13 activity. J. Mol. Biol., 329: 207-215.
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  77. Chen, Y., G. Stamatoyannopoulos and C.Z. Song, 2003. Down-regulation of CXCR4 by inducible small interfering rna inhibits breast cancer cell invasion in vitro. Cancer Res., 63: 4801-4804.
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  78. Chen, Y., C. Song and C.Q. Luo, 2003. Short hairpin RNAs induced RNA interference in human cells. Ai Zheng, 22: 566-570.
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  79. Song, C.Z., K. Keller, Y. Chen, K. Murata and G. Stamatoyannopoulos, 2002. Transcription coactivator CBP has direct DNA binding activity and stimulates transcription factor DNA binding through small domain. Biochem. Biophys. Res. Commun., 296: 118-124.
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  80. Zhang, Y., Y. Chen, K. Zhou, K. Cai and T. Liang, 2001. Bcl-xS mediated sensitization of human nasopharyngeal carcinoma cells to camptothecin-induced apoptosis. Chin. Arch. Otolaryngeal. Head Neck Surg, 8: 114-117.
  81. Zhang, Y., Y. Chen, K. Zhou and T. Liang, 2001. Bcl-xS promotes arsenic trioxide-induced apoptosis in nasopharyngeal carcinoma cells. Chin. J. Otorhinolaryngol. Skull Base Surg., 7: 95-97.
    Direct Link  |  
  82. Zhang, Y., Y. Chen, K. Zhou and K. Cai, 2001. Mitochondrial mechanisms of CPT-induced apoptosis in nasopharyngeal carcinoma cells. J. Clin. Otorhinolaryngol., 15: 309-311.
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  83. Xie, T., D. Tang, Y. Chen, C.Q. Liu and K. Zhou, 2001. Clinical characteristics of angiotension converting enzyme gene polymorphism in chronic gloperulonephritis and primary nephrotic syndrome. Guangdong Med. J., 22: 11-12.
  84. Chen, Y., Y. Zhang, K. Zhou and G. Ling, 2001. Transcription and expression of bcl-x gene in two cell lines of nasopharyngeal carcinoma. J. Guangdong Med. College, 1: 8-9.
  85. Chen, Y., Y. Zhang, K. Zhou and G. Ling, 2001. GFP used as a reporter gene for optimizing lipofection. J. Guangdong Med. College, 3: 28-29.
    Direct Link  |  
  86. Chen, Y., Y. Zhang and K. Zhou, 2001. Preliminary studies of apoptosis in human nasopharyngeal carcinoma CNE-2Z cells induced by arsenic trioxide and its mechanism. Ai Zheng, 20: 61-65.
  87. Chen, Y., M. Zhou, Y. Zhang and K. Zhou, 2001. Cisplatin induced apoptosis in nasopharyngeal cancer cells and decrease membrane potential. Ai Zheng, 20: 887-888.
  88. Chen, Y., Y. Zhang, K. Zhou, M. Zhou and T. Liang, 2000. Bcl-xS gene sensitizes nasopharyngeal carcinoma cells to cisplatin-induced apoptosis. Chin. J. Cancer Biother, 8: 84-87.
  89. Chen, Y. and K. Zhou, 1999. Bcl-x gene and its regulation on apoptosis. Prog. Biochem. Biophys., 26: 534-537.