Dr. Qiang Liu
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Dr. Qiang Liu

Professor
Department of Neurobiology and BioPhysics, University of Science and Technology of China, Hefei, Anhui, China


Highest Degree
Ph.D. in Biochemistry from University of Pennsylvania, USA

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Area of Interest:

Biomedical Sciences
100%
Clinical Research
62%
Neuro Stem Cell
90%
Molecular Biology
75%
Oncology
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
35
Abstracts
1

Selected Publications

  1. Liu, Q., J. Zhang, C. Zerbinatti, Y. Zhan and B.J. Kolber et al., 2011. Lipoprotein receptor LRP1 regulates leptin signaling and energy homeostasis in the adult central nervous system. PLoS Biol., 9: e1000575-e1000575.
    PubMed  |  
  2. Kanekiyo, T., J. Zhang, Q. Liu, C.C. Liu, L. Zhang and G. Bu, 2011. Heparan sulphate proteoglycan and the low-density lipoprotein receptor-related protein 1 constitute major pathways for neuronal amyloid-β uptake. J. Neurosci., 31: 1644-1651.
  3. Zhang, J., Y. Li, Q. Liu, W. Lu and G. Bu, 2010. Wnt signaling activation and mammary gland hyperplasia in MMTV-LRP6 transgenic mice: Implication for breast cancer tumorigenesis. Oncogene, 29: 539-549.
    PubMed  |  
  4. Liu, Q., J. Zhang, J. Trotter, C. Cheng and X. Han et al., 2010. Lipoprotein receptor LRP1 regulates age-dependent synaptic and neuronal degeneration by modulating brain lipid metabolism. J. Neurosci., 30: 17068-17078.
  5. Jen, A., C.J. Parkyn, R.C. Mootoosamy, M.J. Ford and A. Warley et al., 2010. Neuronal low-density lipoprotein receptor-related protein 1 binds and endocytoses prion fibrils via receptor cluster 4. J. Cell Sci., 123: 246-255.
    Direct Link  |  
  6. Fuentealba, R., Q. Liu, J. Zhang, T. Kanekiyo and G. Bu, 2010. Low-density lipoprotein receptor-related protein 1 (LRP1) mediates neuronal Aβ42 uptake and lysosomal accumulation. PLoS ONE., 5: e11884-e11884.
    CrossRef  |  
  7. Liu, Q., J. Zhang, H. Tran, M.M. Verbeek, K. Reiss, S. Estus and G. Bu, 2009. LRP1 shedding in human brain: roles of ADAM10 and ADAM17. Mol. Neurodegener., 4: 17-17.
    CrossRef  |  
  8. Grear, K.E., I.F. Ling, J.F. Simpson, J.L. Furman and C.R. Simmons et al., 2009. Expression of SORL1 and a novel SORL1 splice variant in normal and Alzheimers disease brain. Mol. Neurodegener., 4: 46-46.
    CrossRef  |  
  9. Fuentealba, R.A., Q. Liu, T. Kanekiyo, J. Zhang and G. Bu, 2009. Low density lipoprotein receptor-related protein 1 promotes anti-apoptotic signaling in neurons by activating Akt survival pathway. J. Biol Chem., 284: 34045-34053.
    PubMed  |  
  10. Yamada, K., T. Hashimoto, C. Yabuki, Y. Nagae and M. Tachikawa et al., 2008. The low density lipoprotein receptor-related protein 1 mediates uptake of amyloid beta peptides in an in vitro model of the blood-brain barrier cells. J. Biol. Chem., 283: 34554-34562.
    PubMed  |  
  11. Parkyn, C.J., E.G. Vermeulen, R.C. Mootoosamy, C. Sunyach and C. Jacobsen et al., 2008. LRP1 controls biosynthetic and endocytic trafficking of neuronal prion protein. J. Cell. Sci., 121: 773-783.
    CrossRef  |  Direct Link  |  
  12. Zhang, Y.W., R. Wang, Q. Liu, H. Zhang, F.F. Liao and H. Xu, 2007. Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression. Proc. Natl. Acad. Sci. USA., 104: 10613-10618.
    CrossRef  |  
  13. Liu, Q., J. Zhang, H. Zhu, C. Qin, Q. Chen and B. Zhao, 2007. Dissecting the signaling pathway of nicotine-mediated neuroprotection in a mouse Alzheimer disease model. FASEB J., 21: 61-73.
    CrossRef  |  
  14. Liu, Q., C.V. Zerbinatti, J. Zhang, H.S. Hoe and B. Wang et al., 2007. Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1. Neuron, 56: 66-78.
    PubMed  |  
  15. Zhang, J., Q. Liu, Q. Chen, N.Q. Liu and F.L. Li et al., 2006. Nicotine attenuates beta-amyloid-induced neurotoxicity by regulating metal homeostasis. FASEB J., 20: 1212-1214.
    CrossRef  |  
  16. Liu, Q. and B. Zhao, 2004. Nicotine attenuates beta-amyloid peptide-induced neurotoxicity, free radical and calcium accumulation in hippocampal neuronal cultures. Br. J. Pharmacol., 141: 746-754.
    PubMed  |  
  17. Liu, Q. and B. Zhao, 2004. Nicotine attenuates beta-amyloid peptide induced neurotoxicity. Free Radic. Biol. Med., 36: S106-S106.
  18. Liu, Q., Y. Tao and B.L. Zhao, 2003. ESR study on scavenging effect of nicotine on free radicals. Applied Magn. Reson., 24: 105-112.
    CrossRef  |