Dr. Hui Xu
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Dr. Hui Xu

Professor
Northwest A&F University, China

Highest Degree
Ph.D. in Medical Science from Zhejiang Agriculture University, China

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Area of Interest:

Biomedical Sciences
100%
Structural Modification
62%
Medical Chemistry
90%
Medical Genetics
75%
Pharmaceutics
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Yu, X., G. Feng, J. Huang and H. Xu, 2016. Evaluation of some quinoline-based hydrazone derivatives as insecticidal agents. RSC Adv., 6: 30405-30411.
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  2. Yu, M., G. Liu, Y. Zhang, T. Feng, M. Xu and H. Xu, 2016. Design, synthesis and evaluation of novel isoxazolines/oxime sulfonates of 2′(2′,6′)-(Di)chloropodophyllotoxins as insecticidal agents. Scient. Rep., Vol. 6. 10.1038/srep33062.
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  3. Yang, C., X. Zhi and H. Xu, 2016. Advances on semisynthesis, total synthesis and structure-activity relationships of Honokiol and Magnolol derivatives. Mini Rev. Med. Chem., 16: 404-426.
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  4. Li, Q., X. Huang, S. Li, J. Ma, M. Lv and H. Xu, 2016. Semisynthesis of esters of fraxinellone C4/10-oxime and their pesticidal activities. J. Agric. Food Chem., 64: 5472-5478.
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  5. Huang, J. and H. Xu, 2016. Matrine: Bioactivities and structural modifications. Curr. Top. Med. Chem., 16: 3365-3378.
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  6. Guo, Y., R. Yang and H. Xu, 2016. New insecticidal agents from halogenation/acylation of the furyl-ring of fraxinellone. Scient. Rep., Vol. 6. 10.1038/srep35321.
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  7. Yu, X., G. Ding, X. Zhi and H. Xu, 2015. Insight into reduction of obacunone and their ester derivatives as insecticidal agents against Mythimna separata Walker. Bioorg. Med. Chem. Lett., 25: 25-29.
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  8. Yu, X., D. Shi, X. Zhi, Q. Li, X. Yao and H. Xu, 2015. Synthesis and Quantitative Structure-Activity Relationship (QSAR) study of C7-oxime ester derivatives of obacunone as insecticidal agents. RSC Adv., 5: 31700-31707.
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  9. Yang, C., X. Zhi and H. Xu, 2015. Synthesis of benzoxazole derivatives of honokiol as insecticidal agents against Mythimna separata Walker. Bioorg. Med. Chem. Lett., 25: 2217-2219.
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  10. Wang, R., X. Zhi, J. Li and H. Xu, 2015. Synthesis of novel oxime sulfonate derivatives of 2′(2′,6′)-(Di)chloropicropodophyllotoxins as insecticidal agents. J. Agric. Food Chem., 63: 6668-6674.
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  11. Qu, H., M. Lv, X. Yu, X. Lian and H. Xu, 2015. Discovery of some piperine-based phenylsulfonylhydrazone derivatives as potent botanically narcotic agents. Scient. Rep., Vol. 5. 10.1038/srep13077.
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  12. Fan, L., X. Zhi, Z. Che and H. Xu, 2015. Insight into 2α-chloro-2′(2′,6′)-(Di)halogenopicropodophyllotoxins reacting with carboxylic acids mediated by BF3·Et2O. Scient. Rep., Vol. 5. 10.1038/srep16285.
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  13. Zhi, X., X. Yu, C. Yang, G. Ding, H. Chen and H. Xu, 2014. Synthesis of 4β-acyloxypodophyllotoxin analogs modified in the C and E rings as insecticidal agents against Mythimna separata Walker. Bioorg. Med. Chem. Lett., 24: 765-772.
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  14. Zhi, X., C. Yang, X. Yu and H. Xu, 2014. Synthesis and insecticidal activity of new oxime derivatives of podophyllotoxin-based phenazines against Mythimna separata Walker. Bioorg. Med. Chem. Lett., 24: 5679-5682.
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  15. Zhang, Y., Y. Yan, S. Chen, Z. Gao and H. Xu, 2014. 'Naked-eye' quinoline-based 'reactive' sensor for recognition of Hg2+ ion in aqueous solution. Bioorg. Med. Chem. Lett., 24: 5373-5376.
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  16. Wang, Y., X. Yu, X. Zhi, X. Xiao, C. Yang and H. Xu, 2014. Synthesis and insecticidal activity of novel hydrazone compounds derived from a naturally occurring lignan podophyllotoxin against Mythimna separata (Walker). Bioorg. Med. Chem. Lett., 24: 2621-2624.
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  17. Wang, J., X. Yu, X. Zhi and H. Xu, 2014. Synthesis and insecticidal activity of new deoxypodophyllotoxin derivatives modified in the D-ring. Bioorg. Med. Chem. Lett., 24: 4542-4545.
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  18. Fan, L., Y. Guo, X. Zhi, X. Yu and H. Xu, 2014. Stereoselective synthesis of 2α-chloropicropodophyllotoxins and insecticidal activity of their esters against oriental armyworm, Mythimna separata Walker. J. Agric. Food Chem., 62: 3726-3733.
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  19. Zhi, X.Y., C. Yang, R. Zhang, Y. Hu, Y.Z. Ke and H. Xu, 2013. Natural products-based insecticidal agents 13. Semisynthesis and insecticidal activity of novel phenazine derivatives of 4β-acyloxypodophyllotoxin modified in the E-ring against Mythimna separata walker in vivo. Ind. Crops Prod., 42: 520-526.
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  20. Yang, C., Y. Shao, X.Y. Zhi, H. Qu, X. Yu, X. Yao and H. Xu, 2013. Semisynthesis and Quantitative Structure-Activity Relationship (QSAR) study of some cholesterol-based hydrazone derivatives as insecticidal agents. Bioorg. Med. Chem. Lett., 23: 4806-4812.
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  21. Yan, Y., Z. Che, X. Yu, X. Zhi, J. Wang and H. Xu, 2013. Fluorescence on-off-on chemosensor for sequential recognition of Fe3+ and Hg2+ in water based on tetraphenylethylene motif. Bioorganic Med. Chem., 21: 508-513.
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  22. Wang, J., X. Zhi, X. Yu and H. Xu, 2013. Synthesis and insecticidal activity of new deoxypodophyllotoxin-based phenazine analogues against Mythimna separata Walker. J. Agric. Food Chem., 61: 6336-6343.
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  23. Qu, H., X. Yu, X.Y. Zhi, M. Lv and H. Xu, 2013. Natural-product-based insecticidal agents 14. Semisynthesis and insecticidal activity of new piperine-based hydrazone derivatives against Mythimna separata Walker in vivo. Bioorg. Med. Chem. Lett., 23: 5552-5557.
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  24. He, S., Y. Shao, L. Fan, Z. Che and H. Xu et al., 2013. Synthesis and quantitative structure-activity relationship (QSAR) study of novel 4-acyloxypodophyllotoxin derivatives modified in the A and C rings as insecticidal agents. J. Agric. Food Chem., 61: 618-625.
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  25. Guo, Y., Y.Y. Yan, X.Y. Zhi, C. Yang and H. Xu, 2013. Phenanthroimidazole-based thiobenzamide as an effective sensor for highly selective detection of mercury(II). Bioorg. Med. Chem. Lett., 23: 3382-3384.
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  26. Guo, Y., L. Fan, J. Wang, C. Yang, H. Qu and H. Xu, 2013. Stereoselective synthesis of 4α-acyloxy-2α/β-bromopodophyllotoxin derivatives as insecticidal agents. Tetrahedron, 69: 774-781.
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  27. Guo, Y., H. Qu, X.Y. Zhi, X. Yu, C. Yang and H. Xu, 2013. Semisynthesis and insecticidal activity of some fraxinellone derivatives modified in the B ring. J. Agric. Food Chem., 61: 11937-11944.
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  28. Che, Z., X. Yu, X. Zhi, L. Fan, X. Yao and H. Xu, 2013. Synthesis of novel 4α-(acyloxy)-2′(2′,6′)-(Di)halogenopodophyllotoxin derivatives as insecticidal agents. J. Agric. Food Chem., 61: 8148-8155.
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  29. Che, Z., X. Yu, L. Fan and H. Xu, 2013. Insight into dihalogenation of E-ring of podophyllotoxins and their acyloxyation derivatives at the C4 position as insecticidal agents. Bioorg. Med. Chem. Lett., 23: 5592-5598.
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  30. Che, Z., S. Zhang, Y. Shao, L. Fan and H. Xu et al., 2013. Synthesis and quantitative structure-activity relationship (QSAR) study of novel N-arylsulfonyl-3-acylindole arylcarbonyl hydrazone derivatives as nematicidal agents. J. Agric. Food Chem., 61: 5696-5705.
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  31. Wang, Y., Y. Shao, Y. Wang, L. Fan and X. Yu et al., 2012. Synthesis and Quantitative Structure-Activity Relationship (QSAR) study of novel isoxazoline and oxime derivatives of podophyllotoxin as insecticidal agents. J. Agric. Food Chem., 60: 8435-8443.
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  32. Guo, Y., Y.Y. Yan, C. Yang, X. Yu, X.Y. Zhi and H. Xu, 2012. Regioselective synthesis of fraxinellone-based hydrazone derivatives as insecticidal agents. Bioorg. Med. Chem. Lett., 22: 5384-5387.
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  33. Guo, Y., Y. Yan, X. Yu, Y. Wang, X.Y. Zhi and H. Xu, 2012. Synthesis and insecticidal activity of some novel fraxinellone-based esters. J. Agric. Food Chem., 60: 7016-7021.
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  34. Fan, L.L., Z.P. Che, R. Zhang, X. Yu, X.Y. Zhi and H. Xu, 2012. Synthesis of benzopyrano[4,3-b](N-arylsulfonyl)indoles and benzopyrano[3,4-b](N-arylsulfonyl)indoles via intramolecular palladium-catalyzed aryl-aryl coupling reaction. Mol. Diversity, 16: 415-421.
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  35. Dai, H., Y. Yan, Y. Guo, L. Fan, Z. Che and H. Xu, 2012. A selective and sensitive turn-on fluorescent chemosensor for recognition of Hg2+ ion in water. Chem. Eur. J., 18: 11188-11191.
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  36. Xu, H., X. Xiao, X.F. Zhao, Y. Guo and X.J. Yao, 2011. Unexpectedly convenient and stereoselective synthesis of 4α-acyloxy-2-chloropodophyllotoxins in the presence of BF3.Et2O. Bioorg. Med. Chem. Lett., 21: 4008-4012.
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  37. Xu, H., Q. Wang and Y. Guo, 2011. Stereoselective synthesis of 4α-Alkyloxy-2-α/β-bromopodophyllotoxin derivatives as insecticidal agents. Chem. Eur. J., 17: 8299-8303.
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  38. Xu, H. and L.L. Fan, 2011. Synthesis and antifungal activities of novel 5,6-dihydro-indolo[1,2-a]quinoxaline derivatives. Eur. J. Med. Chem., 46: 1919-1925.
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  39. Xu, H. and L.L. Fan, 2011. Antifungal agents. Part 4: Synthesis and antifungal activities of novel indole[1,2-c]-1,2,4-benzotriazine derivatives against phytopathogenic fungi in vitro. Eur. J. Med. Chem., 46: 364-366.
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  40. Xu, H. and J.L. Zhang, 2011. Natural products-based insecticidal agents 9. Design, semisynthesis and insecticidal activity of 28-acyloxy derivatives of toosendanin against Mythimna separata Walker in vivo. Bioorg. Med. Chem. Lett., 21: 1974-1977.
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  41. Xu, H. and J.L. Zhang, 2011. Natural products-based insecticidal agents 11. Synthesis and insecticidal activity of novel 4α-arylsulfonyloxybenzyloxy-2β-chloropodophyllotoxin derivatives against Mythimna separate Walker in vivo. Bioorg. Med. Chem. Lett., 21: 5177-5180.
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  42. Dai, H. and H. Xu, 2011. A water-soluble 1,8-naphthalimide-based turn on fluorescent chemosensor for selective and sensitive recognition of mercury ion in water. Bioorg. Med. Chem. Lett., 21: 5141-5144.
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  43. Xu, H., X. Xiao and Q.T. Wang, 2010. Natural products-based insecticidal agents 7. Semisynthesis and insecticidal activity of novel 4α-alkyloxy-2-chloropodophyllotoxin derivatives against Mythimna separata Walker In vivo. Bioorg. Med. Chem. Lett., 20: 5009-5012.
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  44. Xu, H. and Y.Y. Wang, 2010. Antifungal agents. Part 5: Synthesis and antifungal activities of aminoguanidine derivatives of N-arylsulfonyl-3-acylindoles. Bioorg. Med. Chem. Lett., 20: 7274-7277.
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  45. Xu, H. and X.Q. He, 2010. Natural products-based insecticidal agents 6. Design, semisynthesis, and insecticidal activity of novel monomethyl phthalate derivatives of podophyllotoxin against Mythimna separata Walker In vivo. Bioorg. Med. Chem. Lett., 20: 4503-4506.
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  46. Xu, H. and X. Zeng, 2010. Synthesis of diaryl-azo derivatives as potential antifungal agents. Bioorg. Med. Chem. Lett., 20: 4193-4195.
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  47. Xu, H. and J.J. Wang, 2010. Natural products-based insecticidal agents 5. Design, semisynthesis and insecticidal activity of novel 4`-substituted benzenesulfonate derivatives of 4-deoxypodophyllotoxin against Mythimna separata Walker in vivo. Bioorgan. Med. Chem. Lett., 20: 2500-2502.
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  48. Ran, J.Q., N. Huang, H. Xu, L.M. Yang, M. Lv and Y.T. Zheng, 2010. Anti HIV-1 agents 5: Synthesis and anti-HIV-1 activity of some N-arylsulfonyl-3-acetylindoles In vitrom. Bioorg. Med. Chem. Lett., 20: 3534-3536.
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  49. Lv, M. and H. Xu, 2010. Dipyridodiazepinone analogs as human immunodeficiency virus type 1-specific non-nucleoside reverse transcriptase inhibitors: An overview. Curr. Med. Chem., 17: 1874-1898.
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  50. Xu, H., M. Lv and X. Tian, 2009. A review on hemisynthesis, biosynthesis, biological activities, mode of action and structure-activity relationship of podophyllotoxins: 2003-2007. Curr. Med. Chem., 16: 327-349.
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  51. Xu, H., J. Wang, H. Sun, M. Lv, X. Tian, X. Yao and X. Zhang, 2009. Semisynthesis and Quantitative Structure-Activity Relationship (QSAR) study of novel aromatic esters of 4'-demethyl-4-deoxypodophyllotoxin as insecticidal agents. J. Agric. Food Chem., 57: 7919-7923.
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  52. Xu, H. and X. Xiao, 2009. Natural products-based insecticidal agents 4. Semisynthesis and insecticidal activity of novel esters of 2-chloropodophyllotoxin against Mythimna separate Walker in vivo. Bioorg. Med. Chem. Lett., 19: 5415-5418.
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  53. Xu, H. and M. Lv, 2009. Developments of indoles as anti-HIV-1 inhibitors. Curr. Pharmaceut. Design, 15: 2120-2148.
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  54. Lv, M. and H. Xu, 2009. Overview of naphthalimide analogs as anticancer agents. Curr. Med. Chem., 16: 4797-4813.
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