Dr. Sang Hee Lee
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Dr. Sang Hee Lee

Professor
Myongji University, South Korea


Highest Degree
Ph.D. in Biochemistry from Seoul National University, South Korea

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Biography

Prof. Sang Hee Lee joined the Drug Resistance Proteomics Laboratory, Department of Biological Sciences, Myongji University (MJU), as a Professor, in September 2003. His first faculty position was associate professor at Youngdong University, since March 1995 after two years of post-doctoral research at School of Pharmacy, University of Wisconsin-Madison, U.S.A. His postdoctoral research, focused on the regulation of antibiotic biosynthesis, was funded by National Institute of Health, U.S.A. He received his Ph.D. degree in Biochemistry (Structural Proteomics) from Seoul National University (SNU), Republic of Korea in 1993, and a Master`s degree in Microbiology (Antimicrobial Resistance) from the same University, in 1990. In 1988, Prof. Lee received his bachelor`s degree with honors from the same University, majoring in Microbiology/Biotechnology. After which, he received Alumni Foundation Scholarship from the same University and Pre-doctoral Fellowship from Foundation of Research Center for Molecular Microbiology from 1988 to 1991.



He has been a member of the American Microbiology Society, U.S.A., since 2001. He is also a member of the Microbiological Society of Korea and of the Korean Society for Microbiology and Biotechnology. He has authored many scientific papers published in peer-reviewed journals, some of which were the first in the field of Infectious Diseases. He has moderated sessions at several International Symposia. Prof. Lee`s research within Myongji University centered on as follows: i) Antimicrobial resistances in clinical microorganisms (molecular epidemiology of antimicrobial-resistant pathogens); ii) Biochemistry and X-ray crystal structure (Structural Proteomics) of ESBLs (extended-spectrum β-lactamases) and carbapenemases causing antimicrobial resistances; iii) Structure-based drug design and target-oriented structural genomics; iv) Biosynthesis (or its regulation) of antimicrobials from industrial microorganisms; v) Overproduction (genetic engineering) of antimicrobials. He brings to his research a unique combination of expertise in Molecular Microbiology, Biochemistry, and Structural Biology for finding out antibiotic resistance mechanisms in clinical bacterial pathogens. In recognition of his outstanding contributions to these areas, Prof. Lee has been awarded a Honor Prize (SNU, 1987), the 2001 University Award of Accomplishment, the Prime Minister Award (2003), the Outstanding Professional Award (ABI, 2004), the International Order of Merit (IBC, 2004), the IBC Lifetime Achievement Award (2005), the Best Research Award (MJU, 2006 and 2008), the Best Paper Award in JM, etc.



His biography has been included in the Marquis Who`s Who in Medicine and Healthcare, in Science and Engineering, and in the World from 2002 to date. Prof. Lee is currently a Deputy Director General and Scientific Adviser of IBC, a consultant in Korean Business Newspaper, a consultant in Korean Broadcasting System, an evaluator in Korea Institute of S&T Evaluation and Planning, an evaluator in French National Research Agency, and the Editor in The Journal of Microbiology, Recent Patents on Anti-Infective Drug Discovery (Bentham Science Publishers Ltd., U.S.A), The Open Pharmacology Journal (Bentham Science Publishers Ltd.), Research Journal of Microbiology (Editor-in-Chief; Academic Journals Inc., U.S.A), etc.

Area of Interest:

Biomedical Sciences
100%
Antimicrobial Resistance
62%
Biochemistry
90%
Biosynthesis
75%
Genetic Engineering
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
12
Abstracts
0

Selected Publications

  1. Pak J., J.H. Lee and S.H. Lee, 2013. A novel biological approach to treat chondromalacia patellae. PLoS ONE, Vol. 8. 10.1371/journal.pone.0064569.
    CrossRef  |  Direct Link  |  
  2. Lee, J.H., I.K. Bae and S.H. Lee, 2012. New definitions of extended-spectrum β-lactamase conferring worldwide emerging antibiotic resistance. Med. Res. Rev., 32: 216-232.
    CrossRef  |  Direct Link  |  
  3. Park, K.S., J.H. Lee, U. Jeong da, J.J. Lee and X. Wu et al., 2011. Determination of pentapeptide repeat units in the Qnr proteins by the structure-based alignment approach. Antimicrob. Agents Chemother., 55: 4475-4478.
    CrossRef  |  PubMed  |  Direct Link  |  
  4. Song, J.S., S.J. Jang, J.J. Lee, J.H. Lee and I.K. Bae et al., 2010. Association of blaCMY-10 gene with a novel complex class 1 integron carrying an ISCR1 element in clinical isolates from Korea. Clin. Microbiol. Infect., 16: 1013-1017.
    CrossRef  |  Direct Link  |  
  5. Lee, J.H., S.H. Jeong, S.S. Cha and S.H. Lee, 2009. New disturbing trend in antimicrobial resistance of Gram-negative pathogens. PLoS Pathog., 5: e1000221-e1000221.
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  6. Nam, T.W., H.I. Jung, Y.J. An, Y.H. Park, S.H. Lee, Y.J. Seok and S.S. Cha, 2008. Analyses of Mlc-IIBGlc interaction and a plausible molecular mechanism of Mlc inactivation by membrane sequestration. Proceed. Natl. Acad. Sci. US Am., 105: 3751-3756.
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  7. Cha, S.S., H.I. Jung, H. Jeon, Y.J. An and I.K. Kim et al., 2008. Crystal structure of filamentous aggregates of human DJ-1 formed in an inorganic phosphate-dependent manner. J. Biol. Chem., 283: 34069-34075.
    CrossRef  |  Direct Link  |  
  8. Lee, J.H., S.H. Jeong, S.S. Cha and S.H. Lee, 2007. A lack of drugs for antibiotic-resistant Gram-negative bacteria. Nat. Rev. Drug. Discovery, 6: 938-939.
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  9. Lee, S.H., S.H. Jeong and S.S. Cha, 2006. Screening for carbapenem-resistant Gram-negative bacteria. Lancet Infect. Dis., 6: 682-684.
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  10. Kim, J.Y., H.I. Jung, Y.J. An, J.H. Lee and S.J. Kim et al., 2006. Structural basis for the extended substrate spectrum of CMY-10, a plasmid-encoded class C β-lactamase. Mol. Microbiol. 60: 907-916.
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  11. Lee, S.H., S.H. Jeong and S.S. Cha, 2005. Minimising antibiotic resistance. Lancet Infect. Dis., 5: 668-670.
    CrossRef  |  
  12. Lee, J.H., J.H. Shin, I.H. Roe, S.G. Sohn and J.H. Lee et al., 2005. Impact of clarithromycin resistance on eradication of Helicobacter pylori in infected adults. Antimicrobial Agents Chemoth., 49: 1600-1603.
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