Dr. Seung Joon Baek
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Dr. Seung Joon Baek

Professor
Department of Veterinary Medicine, Seoul National University, Gwanak-gu, Seoul, South Korea

Highest Degree
Ph.D. in Human Genetics from University of Maryland School of Medicine, USA

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Area of Interest:

Molecular Sciences
100%
Biotechnology
62%
Genetics
90%
Biochemistry
75%
Molecular Biology
55%

Research Publications in Numbers

Books
0
Chapters
2
Articles
216
Abstracts
2

Selected Publications

  1. Pan, K., H. Chen, S.J. Baek and Q. Zhong, 2018. Self-assembled curcumin-soluble soybean polysaccharide nanoparticles: Physicochemical properties and in vitro anti-proliferation activity against cancer cells. Food Chem., 246: 82-89.
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  2. Zhang, Y., L.A. Moszczynski, Q. Liu, J. Jiang and D. Zhao et al., 2017. Over-expression of Growth Differentiation Factor 15 (GDF15) preventing cold Ischemia Reperfusion (I/R) injury in heart transplantation through Foxo3a signaling. Oncotarget, 8: 36531-36544.
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  3. Zhang, X., S. Zhang, S. Baek and M.D. Best, 2017. A boronic acid assay for the detection of mucin-1 glycoprotein from cancer cells. ChemBioChem, 18: 1578-1582.
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  4. Zhang, X., P. Sukamporn, S. Zhang, K.W. Min and S.J. Baek, 2017. 3,3'-diindolylmethane downregulates cyclin D1 through triggering endoplasmic reticulum stress in colorectal cancer cells. Oncol. Rep., 38: 569-574.
    CrossRef  |  Direct Link  |  
  5. Sukamporn, P., S.J. Baek, W. Gritsanapan, S. Chirachanchai, T. Nualsanit and P. Rojanapanthu, 2017. Self-assembled nanomicelles of damnacanthal-loaded amphiphilic modified chitosan: Preparation, characterization and cytotoxicity study. Mater. Sci. Eng.: C, 77: 1068-1077.
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  6. Santos, M.B., V.C. Pinhanelli, M.A. Garcia, G. Silva and S.J. Baek et al., 2017. Antiproliferative and pro-apoptotic activities of 2'- and 4'-aminochalcones against tumor canine cells. Eur. J. Med. Chem., 138: 884-889.
    CrossRef  |  Direct Link  |  
  7. Bortolotto, L.F.B., F.R. Barbosa, G. Silva, T.A. Bitencourt and R.O. Beleboni et al., 2017. Cytotoxicity of trans-chalcone and licochalcone A against breast cancer cells is due to apoptosis induction and cell cycle arrest. Biomed. Pharmacother., 85: 425-433.
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  8. Sukamporn, P., P. Rojanapanthu, G. Silva, X. Zhang, W. Gritsanapan and S.J. Baek, 2016. Damnacanthal and its nanoformulation exhibit anti-cancer activity via cyclin D1 down-regulation. Life Sci., 152: 60-66.
    CrossRef  |  Direct Link  |  
  9. Silva, G., M. Marins, A.L. Fachin, S.H. Lee and S.J. Baek, 2016. Anti-cancer activity of trans-chalcone in osteosarcoma: Involvement of Sp1 and p53. Mol. Carcinog., 55: 1438-1448.
    CrossRef  |  Direct Link  |  
  10. Shin, Y.S., S.U. Kang, J.K. Park, Y.E. Kim and Y.S. Kim et al., 2016. Anti-cancer effect of (-)-epigallocatechin-3-gallate (EGCG) in head and neck cancer through repression of transactivation and enhanced degradation of β-catenin. Phytomedicine, 23: 1344-1355.
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  11. Min, K.W., S.H. Lee and S.J. Baek, 2016. Moonlighting proteins in cancer. Cancer Lett., 370: 108-116.
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  12. Min, K.W., J.L. Liggett, G. Silva, W.W. Wu and R. Wang et al., 2016. NAG-1/GDF15 accumulates in the nucleus and modulates transcriptional regulation of the Smad pathway. Oncogene, 35: 377-388.
    CrossRef  |  Direct Link  |  
  13. Ha, T., Z. Lou, S.J. Baek and S.H. Lee, 2016. Tolfenamic acid downregulates β-catenin in colon cancer. Int. Immunopharmacol., 35: 287-293.
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  14. Wong, J., Y. Kim, Y. Park, S.H. Lee, S.J. Baek and Y. Park, 2015. Isomer specificity of conjugated linoleic acid on suppression of osteosarcomas. J. Nat. Sci., Vol. 1, No. 4. .
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  15. Cekanova, M., R.I. Fernando, N. Siriwardhana, M. Sukhthankar and C. de la Parra et al., 2015. BCL-2 family protein, BAD is down-regulated in breast cancer and inhibits cell invasion. Exp. Cell Res., 331: 1-10.
    CrossRef  |  Direct Link  |  
  16. Pan, K., Y. Luo, Y. Gan, S.J. Baek and Q. Zhong, 2014. pH-driven encapsulation of curcumin in self-assembled casein nanoparticles for enhanced dispersibility and bioactivity. Soft Matter, 10: 6820-6830.
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  17. Liggett, J.L., X. Zhang, T.E. Eling and S.J. Baek, 2014. Anti-tumor activity of non-steroidal anti-inflammatory drugs: Cyclooxygenase-independent targets. Cancer Lett., 346: 217-224.
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  18. Liggett, J.L., K.W. Min, D. Smolensky and S.J. Baek, 2014. A novel COX-independent mechanism of sulindac sulfide involves cleavage of epithelial cell adhesion molecule protein. Exp. Cell Res., 326: 1-9.
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  19. Liggett, J.L., C.K. Choi, R.L. Donnell, K.D. Kihm and J.S. Kim et al., 2014. Nonsteroidal anti-inflammatory drug sulindac sulfide suppresses structural protein Nesprin-2 expression in colorectal cancer cells. Biochim. Biophys. Acta (BBA)-Gen. Subj., 1840: 322-331.
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  20. Huang, E.C., Y. Zhao, G. Chen, S.J. Baek and M.F. McEntee et al., 2014. Zyflamend, a polyherbal mixture, down regulates class I and class II histone deacetylases and increases p21 levels in castrate-resistant prostate cancer cells. BMC Complement. Altern. Med., Vol. 14. 10.1186/1472-6882-14-68.
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  21. Chrysovergis, K., X. Wang, J. Kosak, S.H. Lee and J.S. Kim et al., 2014. NAG-1/GDF15 prevents obesity by increasing thermogenesis, lipolysis and oxidative metabolism. Int. J. Obesity, 38: 1555-1564.
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  22. Chang, J.W., S.U. Kang, J.W. Choi, Y.S. Shin, S.J. Baek, S.H. Lee and C.H. Kim, 2014. Tolfenamic acid induces apoptosis and growth inhibition in anaplastic thyroid cancer: Involvement of nonsteroidal anti-inflammatory drug-activated gene-1 expression and intracellular reactive oxygen species generation. Free Radic. Biol. Med., 67: 115-130.
    CrossRef  |  Direct Link  |  
  23. Zhang, X., S.H. Lee, K.W. Min, M.F. McEntee, J.B. Jeong, Q. Li and S.J. Baek, 2013. The involvement of endoplasmic reticulum stress in the suppression of colorectal tumorigenesis by tolfenamic acid. Cancer Prev. Res., 6: 1337-1347.
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  24. Zhang, X., K.W. Min, J. Liggett and S.J. Baek, 2013. Disruption of the transforming growth factor-β pathway by tolfenamic acid via the ERK MAP kinase pathway. Carcinogenesis, 34: 2900-2907.
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  25. Wang, X., S.J. Baek and T.E. Eling, 2013. The diverse roles of nonsteroidal anti-inflammatory drug activated gene (NAG-1/GDF15) in cancer. Biochem. Pharmacol., 85: 597-606.
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  26. Pandith, H., X. Zhang, S. Thongpraditchote, Y. Wongkrajang, W. Gritsanapan and S.J. Baek, 2013. Effect of Siam weed extract and its bioactive component scutellarein tetramethyl ether on anti-inflammatory activity through NF-κB pathway. J. Ethnopharmacol., 147: 434-441.
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  27. Pandith, H., X. Zhang, J. Liggett, K.W. Min, W. Gritsanapan and S.J. Baek, 2013. Hemostatic and wound healing properties of Chromolaena odorata leaf extract. Int. Scholarly Res. Not., Vol. 2013. 10.1155/2013/168269.
    CrossRef  |  Direct Link  |  
  28. Pan, K., Q. Zhong and S.J. Baek, 2013. Enhanced dispersibility and bioactivity of curcumin by encapsulation in casein nanocapsules. J. Agric. Food Chem., 61: 6036-6043.
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  29. Lee, S.H., K.W. Min, X. Zhang and S.J. Baek, 2013. 3,3'-diindolylmethane induces Activating Transcription Factor 3 (ATF3) via ATF4 in human colorectal cancer cells. J. Nutr. Biochem., 24: 664-671.
    CrossRef  |  Direct Link  |  
  30. Kim, J.M., J.P. Kosak, J.K. Kim, G. Kissling and D.R. Germolec et al., 2013. NAG-1/GDF15 transgenic mouse has less white adipose tissue and a reduced inflammatory response. Mediat. Inflamm., Vol. 2013. 10.1155/2013/641851.
    CrossRef  |  Direct Link  |  
  31. Kang, S.U., B.S. Lee, S.H. Lee, S.J. Baek, Y.S. Shin and C.H. Kim, 2013. Expression of NSAID-activated gene-1 by EGCG in head and neck cancer: Involvement of ATM-dependent p53 expression. J. Nutr. Biochem., 24: 986-999.
    CrossRef  |  Direct Link  |  
  32. Jeong, J.B., X. Yang, R. Clark, J. Choi, S.J. Baek and S.H. Lee, 2013. A mechanistic study of the proapoptotic effect of tolfenamic acid: Involvement of NF-κB activation. Carcinogenesis, 34: 2350-2360.
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  33. Jeong, J.B., J. Choi, S.J. Baek and S.H. Lee, 2013. Reactive oxygen species mediate tolfenamic acid-induced apoptosis in human colorectal cancer cells. Arch. Biochem. Biophys., 537: 168-175.
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  34. Imchen, T., J. Manasse, K.W. Min and S.J. Baek, 2013. Characterization of PPAR dual ligand MCC-555 in AOM-induced colorectal tumorigenesis. Exp. Toxicol. Pathol., 65: 919-924.
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  35. Zhang, X., K.W. Min, J. Wimalasena and S.J. Baek, 2012. Cyclin D1 degradation and p21 induction contribute to growth inhibition of colorectal cancer cells induced by epigallocatechin-3-gallate. J. Cancer Res. Clin. Oncol., 138: 2051-2060.
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  36. Whitlock, N.C. and S.J. Baek, 2012. The anticancer effects of resveratrol: Modulation of transcription factors. Nutr. Cancer, 64: 493-502.
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  37. Nualsanit, T., P. Rojanapanthu, W. Gritsanapan, S.H. Lee, D. Lawson and S.J. Baek, 2012. Damnacanthal, a noni component, exhibits antitumorigenic activity in human colorectal cancer cells. J. Nutr. Biochem., 23: 915-923.
    CrossRef  |  PubMed  |  Direct Link  |  
  38. Min, K.W., X. Zhang, T. Imchen and S.J. Baek, 2012. A peroxisome proliferator-activated receptor ligand MCC-555 imparts anti-proliferative response in pancreatic cancer cells by PPARgamma-independent up-regulation of KLF4. Toxicol. Applied Pharmacol., 263: 225-232.
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  39. Lee, S.H., R.L. Richardson, R.H. Dashwood and S.J. Baek, 2012. Capsaicin represses transcriptional activity of β-catenin in human colorectal cancer cells. J. Nutr. Biochem., 23: 646-655.
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  40. Kang, S.U., Y.S. Shin, H.S. Hwang, S.J. Baek, S.H. Lee and C.H. Kim, 2012. Tolfenamic acid induces apoptosis and growth inhibition in head and neck cancer: Involvement of NAG-1 expression. PLoS ONE, Vol. 7. 10.1371/journal.pone.0034988.
    CrossRef  |  Direct Link  |  
  41. Whitlock, N.C., J.H. Bahn, S.H. Lee, T.E. Eling and S.J. Baek, 2011. Resveratrol-induced apoptosis is mediated by early growth response-1, Kruppel-like factor 4 and activating transcription factor 3. Cancer Prev. Res., 4: 116-127.
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  42. Wang, X., S.J. Baek and T. Eling, 2011. COX inhibitors directly alter gene expression: Role in cancer prevention? Cancer Metastasis Rev., 30: 641-657.
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  43. Nualsanit, T., P. Rojanapanthu, W. Gritsanapan, T. Kwankitpraniti, K.W. Min and S.J. Baek, 2011. Damnacanthal-induced anti-inflammation is associated with inhibition of NF-κB activity. Inflamm. Allergy-Drug Targets, 10: 455-463.
    CrossRef  |  Direct Link  |  
  44. Margraves, C., K. Kihm, S.Y. Yoon, C.K. Choi, S.H. Lee, J. Liggett and S.J. Baek, 2011. Simultaneous measurements of cytoplasmic viscosity and intracellular vesicle sizes for live human brain cancer cells. Biotechnol. Bioeng., 108: 2504-2508.
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  45. Krisanapun, C., S.H. Lee, P. Peungvicha, R. Temsiririrkkul and S.J. Baek, 2011. Antidiabetic activities of Abutilon indicum (L.) sweet are mediated by enhancement of adipocyte differentiation and activation of the GLUT1 promoter. Evidence-Based Complement. Altern. Med., Vol. 2011. 10.1093/ecam/neq004.
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  46. Huang, E.C., G. Chen, S.J. Baek, M.F. McEntee and J.J. Collier et al., 2011. Zyflamend reduces the expression of androgen receptor in a model of castrate-resistant prostate cancer. Nutr. Cancer, 63: 1287-1296.
    CrossRef  |  PubMed  |  Direct Link  |  
  47. Flatland, B., M.M. Fry, S.J. Baek, J.H. Bahn and C.J. LeBlanc et al., 2011. May-Hegglin anomaly in a dog. Vet. Clin. Pathol., 40: 207-214.
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  48. Close, D.M., R.E. Hahn, S.S. Patterson, S.A. Ripp, G.S. Sayler and S.J. Baek, 2011. Comparison of human optimized bacterial luciferase, firefly luciferase and green fluorescent protein for continuous imaging of cell culture and animal models. J. Biomed. Opt., Vol. 16, No. 4. 10.1117/1.3564910.
    CrossRef  |  Direct Link  |  
  49. Baek, S.J. and N.C. Whitlock, 2011. Molecular Targets of Resveratrol in Carcinogenesis. In: Evidence-Based Anticancer Herbal Medicine, Cho, W.C.S. (Ed.). Springer Science, USA., ISBN: 978-94-007-0526-5, pp: 319-347.
  50. Zhong, Y., C. Krisanapun, S.H. Lee, T. Nualsanit, C. Sams, P. Peungvicha and S.J. Baek, 2010. Molecular targets of apigenin in colorectal cancer cells: Involvement of p21, NAG-1 and p53. Eur. J. Cancer, 46: 3365-3374.
    CrossRef  |  Direct Link  |  
  51. Sukhthankar, M., S. Alberti and S.J. Baek, 2010. (−)-Epigallocatechin-3-Gallate (EGCG) post-transcriptionally and post-translationally suppresses the cell proliferative protein TROP2 in human colorectal cancer cells. Anticancer Res., 30: 2497-2503.
    Direct Link  |  
  52. Sukhthankar, M., C.K. Choi, A. English, J.S. Kim and S.J. Baek, 2010. A potential proliferative gene, NUDT6, is down-regulated by green tea catechins at the posttranscriptional level. J. Nutr. Biochem., 21: 98-106.
    CrossRef  |  Direct Link  |  
  53. Rojsanga, P., M. Sukhthankar, C. Krisanapun, W. Gritsanapan, D.B. Lawson and S.J. Baek, 2010. In vitro anti-proliferative activity of alcoholic stem extract of Coscinium fenestratum in human colorectal cancer cells. Exp. Therapeut. Med., 1: 181-186.
    CrossRef  |  Direct Link  |  
  54. Lee, S.H., J.H. Bahn, N.C. Whitlock and S.J. Baek, 2010. Activating Transcription Factor 2 (ATF2) controls tolfenamic acid-induced ATF3 expression via MAP kinase pathways. Oncogene, 29: 5182-5192.
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  55. Lee, S.H., C. Krisanapun and S.J. Baek, 2010. NSAID-activated gene-1 as a molecular target for capsaicin-induced apoptosis through a novel molecular mechanism involving GSK3β, C/EBPβ and ATF3. Carcinogenesis, 31: 719-728.
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  56. Kim, H.J., J.H. Ryu, C.H. Kim, J.W. Lim and U.Y. Moon et al., 2010. Epicatechin gallate suppresses oxidative stress-induced MUC5AC overexpression by interaction with epidermal growth factor receptor. Am. J. Respir. Cell Mol. Biol., 43: 349-357.
    CrossRef  |  PubMed  |  Direct Link  |  
  57. Kim, C.H., S. Kwon, J.H. Bahn, K. Lee, S.I. Jun, P.D. Rack and S.J. Baek, 2010. Effects of atmospheric nonthermal plasma on invasion of colorectal cancer cells. Applied Phys. Lett., Vol. 96, No. 24. 10.1063/1.3449575.
    CrossRef  |  Direct Link  |  
  58. Kim, C.H., J.H. Bahn, S.H. Lee, G.Y. Kim, S.I. Jun, K. Lee and S.J. Baek, 2010. Induction of cell growth arrest by atmospheric non-thermal plasma in colorectal cancer cells. J. Biotechnol., 150: 530-538.
    CrossRef  |  Direct Link  |  
  59. Close, D.M., S.S. Patterson, S. Ripp, S.J. Baek, J. Sanseverino and G.S. Sayler, 2010. Autonomous bioluminescent expression of the bacterial luciferase gene cassette (lux) in a mammalian cell line. PLoS ONE, Vol. 5. 10.1371/journal.pone.0012441.
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  60. Choi, C.K., M. Sukhthankar, C.H. Kim, S.H. Lee, A. English, K.D. Kihm and S.J. Baek, 2010. Cell adhesion property affected by cyclooxygenase and lipoxygenase: Opto-electric approach. Biochem. Biophys. Res. Commun., 391: 1385-1389.
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  61. Cekanova, M., S.H. Lee, M.F. McEntee and S.J. Baek, 2010. MCC-555-induced NAG-1 expression is mediated in part by KLF4. Eur. J. Pharmacol., 637: 30-37.
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  62. Peretich, A., M. Cekanova, S. Hurst, S.J. Baek and M. Dhar, 2009. PPARγ Agonists Down-Regulate the Expression of Atp10c mRNA during adipogenesis. Open Obesity J., 1: 41-48.
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  63. Kambe, A., H. Yoshioka, H. Kamitani, T. Watanabe, S.J. Baek and T.E. Eling, 2009. The cyclooxygenase inhibitor sulindac sulfide inhibits EP4 expression and suppresses the growth of glioblastoma cells. Cancer Prev. Res., 2: 1088-1099.
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  64. Iguchi, G., K. Chrysovergis, S.H. Lee, S.J. Baek, R. Langenbach and T.E. Eling, 2009. A reciprocal relationship exists between non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) and cyclooxygenase-2. Cancer Lett., 282: 152-158.
    CrossRef  |  PubMed  |  Direct Link  |  
  65. Fry, M.M., C.A. Kirk, J.L. Liggett, G.B. Daniel and S.J. Baek et al., 2009. Changes in hepatic gene expression in dogs with experimentally induced nutritional iron deficiency. Vet. Clin. Pathol., 38: 13-19.
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  66. Choi, H.J., Y.S. Chung, H.J. Kim, U.Y. Moon and Y.H. Choi et al., 2009. Signal pathway of 17β-estradiol-induced MUC5B expression in human airway epithelial cells. Am. J. Respir. Cell Mol. Biol., 40: 168-178.
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  67. Cekanova, M., S.H. Lee, R.L. Donnell, M. Sukhthankar, T.E. Eling, S.M. Fischer and S.J. Baek, 2009. Nonsteroidal anti-inflammatory drug-activated gene-1 expression inhibits urethane-induced pulmonary tumorigenesis in transgenic mice. Cancer Prev. Res., 2: 450-458.
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  68. Baek, S.J., M.F. McEntee and A.M. Legendre, 2009. Cancer chemopreventive compounds and canine cancer. Vet. Pathol., 46: 576-588.
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  69. Baek, S.J. and M. Sukthanka, 2009. Green Tea Catechins in Colorectal Cancer. In: Handbook of Green Tea and Health Research, McKinley, H. and M. Jamieson (Eds.). Nova Science Publishers, USA., ISBN: 978-1-60741-045-4, pp: 325-345.
  70. Yamaguchi, K., N.C. Whitlock, J.L. Liggett, A.M. Legendre, M.M. Fry and S.J. Baek, 2008. Molecular characterisation of canine nonsteroidal anti-inflammatory drug-activated gene (NAG-1). Vet. J., 175: 89-95.
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  71. Yamaguchi, K., M. Cekanova, M.F. McEntee, J.H. Yoon and S.M. Fischer et al., 2008. Peroxisome proliferator-activated receptor ligand MCC-555 suppresses intestinal polyps in ApcMin/+ mice via extracellular signal-regulated kinase and peroxisome proliferator-activated receptor-dependent pathways. Mol. Cancer Therapeut., 7: 2779-2787.
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  72. Sukhthankar, M., K. Yamaguchi, S.H. Lee, M.F. McEntee, T.E. Eling, Y. Hara and S.J. Baek, 2008. A green tea component suppresses posttranslational expression of basic fibroblast growth factor in colorectal cancer. Gastroenterology, 134: 1972-1980.
    PubMed  |  
  73. Lee, S.H., M. Cekanova and S.J. Baek, 2008. Multiple mechanisms are involved in 6-gingerol-induced cell growth arrest and apoptosis in human colorectal cancer cells. Mol. Carcinog., 47: 197-208.
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  74. Lee, S.H., J.H. Bahn, C.K. Choi, N.C. Whitlock, A.E. English, S. Safe and S.J. Baek, 2008. ESE-1/EGR-1 pathway plays a role in tolfenamic acid-induced apoptosis in colorectal cancer cells. Mol. Cancer Therapeut., 7: 3739-3750.
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  75. Kim, H.J., S.H. Park, S.Y. Park, U.Y. Moon and B.D. Lee et al., 2008. Epigallocatechin-3-gallate inhibits interleukin-1β-induced MUC5AC gene expression and MUC5AC secretion in normal human nasal epithelial cells. J. Nutr. Biochem., 19: 536-544.
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  76. Cekanova, M., J.S. Yuan, X. Li, K. Kim and S.J. Baek, 2008. Gene alterations by peroxisome proliferator-activated receptor γ agonists in human colorectal cancer cells. Int. J. Oncol., 32: 809-819.
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  77. Baek, S.J. and S.H. Lee, 2008. Anti-Cancer Property of Epicatechin Gallate in Colon Cancer Cells. In: Beer in Health and Disease Prevention, Preedy, V.R. (Ed.). Elsevier, New York, USA., ISBN-13: 978-0123738912, pp: 871-878.
  78. Piyanuch, R., M. Sukhthankar, G. Wandee and S.J. Baek, 2007.. Berberine, a natural isoquinoline alkaloid, induces NAG-1 and ATF3 expression in human colorectal cancer cells. Cancer Lett., 258: 230-240.
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  79. Fernando, R., J.S. Foster, A. Bible, A. Strom and R.G. Pestell et al., 2007. Breast cancer cell proliferation is inhibited by bad: Regulation of cyclin D1. J. Biol. Chem., 282: 28864-28873.
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  80. Cho, K.N., M. Sukhthankar, S.H. Lee, J.H. Yoon and S.J. Baek, 2007. Green tea catechin (−)-epicatechin gallate induces tumour suppressor protein ATF3 via EGR-1 activation. Eur. J. Cancer, 43: 2404-2412.
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  81. Yamaguchi, K., S.H. Lee, T.E. Eling and S.J. Baek, 2006. A novel peroxisome proliferator-activated receptor γ ligand, MCC-555, induces apoptosis via posttranscriptional regulation of NAG-1 in colorectal cancer cells. Mol. Cancer Therapeut., 5: 1352-1361.
    CrossRef  |  Direct Link  |  
  82. Yamaguchi, K., S.H. Lee, J.S. Kim, J. Wimalasena, S. Kitajima and S.J. Baek, 2006. Activating transcription factor 3 and early growth response 1 are the novel targets of LY294002 in a phosphatidylinositol 3-kinase-independent pathway. Cancer Res., 66: 2376-2384.
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  83. Yamaguchi, K., J.L. Liggett, N.C. Kim and S.J. Baek, 2006. Anti-proliferative effect of horehound leaf and wild cherry bark extracts on human colorectal cancer cells. Oncol. Rep., 15: 275-281.
    CrossRef  |  PubMed  |  Direct Link  |  
  84. Wu, W.W., G. Wang, S.J. Baek and R.F. Shen, 2006. Comparative study of three proteomic quantitative methods, DIGE, cICAT and iTRAQ, using 2D gel- or LC- MALDI TOF/TOF. J. Proteome Res., 5: 651-658.
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  85. Martinez, J.M., T. Sali, R. Okazaki, C. Anna and M. Hollingshead et al., 2006. Drug-induced expression of nonsteroidal anti-inflammatory drug-activated gene/macrophage inhibitory cytokine-1/prostate-derived factor, a putative tumor suppressor, inhibits tumor growth. J. Pharmacol. Exp. Therapeut., 318: 899-906.
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  86. Lim, Y.C., S.H. Lee, M.H. Song, K. Yamaguchi and J.H. Yoon et al., 2006. Growth inhibition and apoptosis by (−)-epicatechin gallate are mediated by cyclin D1 suppression in head and neck squamous carcinoma cells. Eur. J. Cancer, 42: 3260-3266.
    CrossRef  |  Direct Link  |  
  87. Lambert, J.R., J.A. Kelly, M. Shim, W.E. Huffer and S.K. Nordeen et al., 2006. Prostate derived factor in human prostate cancer cells: Gene induction by vitamin D via a p53-dependent mechanism and inhibition of prostate cancer cell growth. J. Cell. Physiol., 208: 566-574.
    CrossRef  |  Direct Link  |  
  88. Eling, T.E., S.J. Baek, M. Shim and C.H. Lee, 2006. NSAID activated gene (NAG-1), a modulator of tumorigenesis. J. Biochem. Mol. Biol., 39: 649-655.
    PubMed  |  Direct Link  |  
  89. Baek, S.J., R. Okazaki, S.H. Lee, J. Martinez and J.S. Kim et al., 2006. Nonsteroidal anti-inflammatory drug-activated gene-1 over expression in transgenic mice suppresses intestinal neoplasia. Gastroenterology, 131: 1553-1560.
    CrossRef  |  Direct Link  |  
  90. Baek, S.J. and T.E. Eling, 2006. Changes in gene expression contribute to cancer prevention by COX inhibitors. Progr. Lipid Res., 45: 1-16.
    CrossRef  |  Direct Link  |  
  91. Yoon, J.H. and S.J. Baek, 2005. Molecular targets of dietary polyphenols with anti-inflammatory properties. Yonsei Med. J., 46: 585-596.
    CrossRef  |  Direct Link  |  
  92. Whelan, J., M.M. McEntee and S.J. Baek, 2005. Dietary Polyunsaturated Fatty Acids, Eicosanoids and Intestinal Tumorigenesis. In: Carcinogenic and Anticarcinogenic Food Components, Baer-Dubowska, W., A. Bartoszek and D. Malejka-Giganti (Eds.). Chapter 8, CRC Press, Boca Raton, FL., USA., ISBN-13: 9781420039269, pp: 157-176.
  93. Lee, S.H., K. Yamaguchi, J.S. Kim, T.E. Eling, S. Safe, Y. Park and S.J. Baek, 2005. Conjugated linoleic acid stimulates an anti-tumorigenic protein NAG-1 in an isomer specific manner. Carcinogenesis, 27: 972-981.
    CrossRef  |  Direct Link  |  
  94. Lee, S.H., J.S. Kim, K. Yamaguchi, T.E. Eling and S.J. Baek, 2005. Indole-3-carbinol and 3,3'-diindolylmethane induce expression of NAG-1 in a p53-independent manner. Biochem. Biophys. Res. Commun., 328: 63-69.
    CrossRef  |  Direct Link  |  
  95. Kim, J.S., S.J. Baek, T. Sali and T.E. Eling, 2005. The conventional nonsteroidal anti-inflammatory drug sulindac sulfide arrests ovarian cancer cell growth via the expression of NAG-1/MIC-1/GDF-15. Mol. Cancer Therapeut., 4: 487-493.
    CrossRef  |  Direct Link  |  
  96. Kim, J.S., S.J. Baek, F.G. Bottone Jr., T. Sali and T.E. Eling, 2005. Overexpression of 15-lipoxygenase-1 induces growth arrest through phosphorylation of p53 in human colorectal cancer cells. Mol. Cancer Res., 3: 511-517.
    CrossRef  |  Direct Link  |  
  97. Kim, J.H., K. Yamaguchi, S.H. Lee, P.K. Tithof, G.S. Sayler, J.H. Yoon and S.J. Baek, 2005. Evaluation of polycyclic aromatic hydrocarbons in the activation of early growth response-1 and peroxisome proliferator activated receptors. Toxicol. Sci., 85: 585-593.
    CrossRef  |  Direct Link  |  
  98. Cho, K.N., J.Y. Choi, C.H. Kim, S.J. Baek and K.C. Chung et al., 2005. Prostaglandin E2 induces MUC8 gene expression via a mechanism involving ERK MAPK/RSK1/cAMP response element binding protein activation in human airway epithelial cells. J. Biol. Chem., 280: 6676-6681.
    CrossRef  |  Direct Link  |  
  99. Chintharlapalli, S., S. Papineni, S.J. Baek, S. Liu and S. Safe, 2005. 1,1-Bis(3'-indolyl)-1-(p-substitutedphenyl)methanes are peroxisome proliferator-activated receptor γ agonists but decrease HCT-116 colon cancer cell survival through receptor-independent activation of early growth response-1 and nonsteroidal anti-inflammatory drug-activated gene-1. Mol. Pharmacol., 68: 1782-1792.
    CrossRef  |  PubMed  |  Direct Link  |  
  100. Baek, S.J., J.S. Kim, S.M. Moore, S.H. Lee, J. Martinez and T.E. Eling, 2005. Cyclooxygenase inhibitors induce the expression of the tumor suppressor gene EGR-1, which results in the up-regulation of NAG-1, an antitumorigenic protein. Mol. Pharmacol., 67: 356-364.
    CrossRef  |  PubMed  |  Direct Link  |  
  101. Yamaguchi, K., S.H. Lee, T.E. Eling and S.J. Baek, 2004. Identification of nonsteroidal anti-inflammatory drug-activated gene (NAG-1) as a novel downstream target of phosphatidylinositol 3-kinase/AKT/GSK-3β pathway. J. Biol. Chem., 279: 49617-49623.
    CrossRef  |  Direct Link  |  
  102. Martinez, J.M., S.J. Baek, D.M. Mays, P.K. Tithof, T.E. Eling and N.J. Walker, 2004. EGR1 is a novel target for AhR agonists in human lung epithelial cells. Toxicol. Sci., 82: 429-435.
    CrossRef  |  Direct Link  |  
  103. Kim, K.S., J.H. Yoon, J.K. Kim, S.J. Baek and T.E. Eling et al., 2004. Cyclooxygenase inhibitors induce apoptosis in oral cavity cancer cells by increased expression of nonsteroidal anti-inflammatory drug-activated gene. Biochem. Biophys. Res. Commun., 325: 1298-1303.
    CrossRef  |  Direct Link  |  
  104. Jain, A.K., S.M. Moore, K. Yamaguchi, T.E. Eling and S.J. Baek, 2004. Selective NSAIDs induce thymosin β-4 and alter actin cytoskeletal organization in human colorectal cancer cells. J. Pharmacol. Exp. Ther., 311: 885-891.
    CrossRef  |  PubMed  |  Direct Link  |  
  105. Fry, M.M., J.L. Liggett and S.J. Baek, 2004. Molecular cloning and expression of canine hepcidin. Vet. Clin. Pathol., 33: 223-227.
    CrossRef  |  Direct Link  |  
  106. Baek, S.J., J.S. Kim, J.B. Nixon, R.P. DiAugustine and T.E. Eling, 2004. Expression of NAG-1, a transforming growth factor-β superfamily member, by troglitazone requires the early growth response gene EGR-1. J. Biol. Chem., 279: 6883-6892.
    CrossRef  |  Direct Link  |  
  107. Baek, S.J., J.S. Kim, F.R. Jackson, T.E. Eling, M.F. McEntee and S.H. Lee, 2004. Epicatechin gallate-induced expression of NAG-1 is associated with growth inhibition and apoptosis in colon cancer cells. Carcinogenesis, 25: 2425-2432.
    CrossRef  |  Direct Link  |  
  108. Wilson, L.C., S.J. Baek, A. Call and T.E. Eling, 2003. Nonsteroidal anti-inflammatory drug-activated gene (NAG-1) is induced by genistein through the expression of p53 in colorectal cancer cells. Int. J. Cancer, 105: 747-753.
    CrossRef  |  Direct Link  |  
  109. Nixon, J.B., H. Kamitani, S.J. Baek and T.E. Eling, 2003. Evaluation of eicosanoids and NSAIDs as PPARγ ligands in colorectal carcinoma cells. Prostaglandins Leukotrienes Essent. Fatty Acids, 68: 323-330.
    CrossRef  |  Direct Link  |  
  110. Newman, D., M. Sakaue, J.S. Koo, K.S. Kim, S.J. Baek, T. Eling and A.M. Jetten, 2003. Differential regulation of nonsteroidal anti-inflammatory drug-activated gene in normal human tracheobronchial epithelial and lung carcinoma cells by retinoids. Mol. Pharmacol., 63: 557-564.
    CrossRef  |  Direct Link  |  
  111. Lee, C.H., Y.S. Jang, S.J. Her, Y.M. Moon, S.J. Baek and T. Eling, 2003. Nordihydroguaiaretic acid, an antioxidant, inhibits transforming growth factor-β activity through the inhibition of Smad signaling pathway. Exp. Cell Res., 289: 335-341.
    CrossRef  |  Direct Link  |  
  112. Kim, K.S., J.H. Shin, S.J. Baek and J.H. Yoon, 2003. Expression of non-steroidal anti-inflammatory drug-activated gene-1 in human nasal mucosa and cultured nasal epithelial cells: A preliminary investigation. Acta Oto-Laryngol., 123: 857-861.
    CrossRef  |  Direct Link  |  
  113. Baek, S.J., L.C. Wilson, L.C. His and T.E. Eling, 2003. Troglitazone, a Peroxisome Proliferator-Activated Receptor γ (PPARγ) ligand, selectively induces the early growth response-1 gene independently of PPARγ: A novel mechanism for its anti-tumorigenic activity. J. Biol. Chem., 278: 5845-5853.
    CrossRef  |  Direct Link  |  
  114. Kim, K.S., S.J. Baek, G.P. Flake, C.D. Loftin, B.F. Calvo and T.E. Eling, 2002. Expression and regulation of nonsteroidal anti-inflammatory drug-activated gene (NAG-1) in human and mouse tissue. Gastroenterology, 122: 1388-1398.
    CrossRef  |  Direct Link  |  
  115. Bottone, F.G., S.J. Baek, J.B. Nixon and T.E. Eling, 2002. Diallyl disulfide (DADS) induces the antitumorigenic NSAID-activated gene (NAG-1) by a p53-dependent mechanism in human colorectal HCT 116 cells. J. Nutr., 132: 773-778.
    CrossRef  |  Direct Link  |  
  116. Baek, S.J., L.C. Wilson, C.H. Lee and T.E. Eling, 2002. Dual function of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Inhibition of cyclooxygenase and induction of NSAID-activated gene. J. Pharmacol. Exp. Therapeut., 301: 1126-1131.
    CrossRef  |  Direct Link  |  
  117. Baek, S.J., L.C. Wilson and T.E. Eling, 2002. Resveratrol enhances the expression of non-steroidal anti-inflammatory drug-activated gene (NAG-1) by increasing the expression of p53. Carcinogenesis, 23: 425-432.
    CrossRef  |  Direct Link  |  
  118. Kameda, H., J.I. Risinger, B.B. Han, S.J. Baek, J.C. Barrett, W.C. Glasgow and T.E. Eling, 2001. Identification of epidermal growth factor receptor-Grb2-associated binder-1-SHP-2 complex formation and its functional loss during neoplastic cell progression. Cell Growth Differ., 12: 307-318.
    PubMed  |  Direct Link  |  
  119. Kameda, H., J.I. Risinger, B.B. Han, S.J. Baek and J.C. Barrett et al., 2001. Expression of Gab1 lacking the pleckstrin homology domain is associated with neoplastic progression. Mol. Cell. Biol., 21: 6895-6905.
    CrossRef  |  Direct Link  |  
  120. Ikawa, H., H. Kameda, H. Kamitani, S.J. Baek, J.B. Nixon, L.C. His and T.E. Eling, 2001. Effect of PPAR activators on cytokine-stimulated cyclooxygenase-2 expression in human colorectal carcinoma cells. Exp. Cell Res., 267: 73-80.
    CrossRef  |  Direct Link  |  
  121. Fritsche, E., S.J. Baek, L.M. King, D.C. Zeldin, T.E. Eling and D.A. Bell, 2001. Functional characterization of cyclooxygenase-2 polymorphisms. J. Pharmacol. Exp. Therapeut., 299: 468-476.
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  122. Baek, S.J., K.S. Kim, J.B. Nixon, L.C. Wilson and T.E. Eling, 2001. Cyclooxygenase inhibitors regulate the expression of a TGF-β superfamily member that has proapoptotic and antitumorigenic activities. Mol. Pharmacol., 59: 901-908.
    Direct Link  |  
  123. Baek, S.J., J.M. Horowitz and T.E. Eling, 2001. Molecular cloning and characterization of human nonsteroidal anti-inflammatory drug-activated gene promoter: Basal transcription is mediated by Sp1 and Sp3. J. Biol. Chem., 276: 33384-33392.
    CrossRef  |  Direct Link  |  
  124. Hsi, L.C., S.J. Baek and T.E. Eling, 2000. Lack of cyclooxygenase-2 activity in HT-29 human colorectal carcinoma cells. Exp. Cell Res., 256: 563-570.
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  125. Lee, K.D., S.J. Baek and R.F. Shen, 1996. Multiple factors regulating the expression of human thromboxane synthase gene. Biochem. J., 319: 783-791.
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  126. Baek, S.J., K.D. Lee and R.F. Shen, 1996. Genomic structure and polymorphism of the human thromboxane synthase-encoding gene. Gene, 173: 251-256.
    CrossRef  |  Direct Link  |  
  127. Shen, R.F., L. Zhang, S.J. Baek, H.H. Tai and K.D. Lee, 1994. The porcine thromboxane synthase-encoding cDNA: Sequence, mRNA expression and enzyme production m Sf9 insect cells. Gene, 140: 261-265.
    CrossRef  |  Direct Link  |  
  128. Lee, K.D., S.J. Baek and R.F. Shen, 1994. Cloning and characterization of the human thromboxane synthase gene promoter. Biochem. Biophys. Res. Commun., 201: 379-387.
    CrossRef  |  Direct Link  |  
  129. Xia, Z., R.F. Shen, S.J. Baek and H.H. Tai, 1993. Expression of two different forms of cDNA for thromboxane synthase in insect cells and site-directed mutagenesis of a critical cysteine residue. Biochem. J., 295: 457-461.
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  130. Song, S.I., C.H. Kim, S.J. Baek and Y.D. Choi, 1993. Nucleotide sequences of cDNAs encoding the precursors for soybean (Glycine max) trypsin inhibitors (Kunitz type). Plant Physiol., 101: 1401-1402.
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  131. Chase, M.B., S.J. Baek, D.C. Purtell, S. Schwartz and R.F. Shen, 1993. Mapping of the human thromboxane synthase gene (TBXAS1) to chromosome 7q34-q35 by two-color fluorescence in situ hybridization. Genomics, 16: 771-773.
    CrossRef  |  Direct Link  |  
  132. Song, S.I., C.H. Kim, S.J. Baek and Y.D. Choi, 1991. Molecular cloning and nucleotide sequencing of cDNA encoding the precursor for soybean trypsin inhibitor (Kunitz type). Mol. Cells, 1: 317-324.