Dr. Kiyotsugu Yoshida
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Dr. Kiyotsugu Yoshida

Professor
The Jikei University School of Medicine, Japan

Highest Degree
Ph.D. in Biochemistry from The Jikei University School of Medicine, Japan

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Area of Interest:

Chemistry
100%
Signal Transduction
62%
Biochemistry
90%
Apoptosis
75%
Anticancer Drugs
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Mimoto, R., N. Taira, H. Takahashi, T. Yamaguchi and M. Okabe et al., 2013. DYRK2 controls the epithelial-mesenchymal transition in breast cancer by degrading Snail. Cancer Lett., 339: 214-225.
    PubMed  |  
  2. Yoshida, K., 2012. Functional Role for the c-Abl Tyrosine Kinase Signalling in the DNA Damage Response. In: DNA Repair: New Research, Kimura, S. and S. Shimizu (Eds.). Nova Science Publishers, New York, pp: 133-147.
  3. Taira, N., R. Mimoto, M. Kurata, T. Yamaguchi, M. Kitagawa, Y. Miki and K. Yoshida, 2012. DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells. J. Clin. Invest., 122: 859-872.
    PubMed  |  
  4. Taira, N. and K. Yoshida, 2012. Post-translational modifications of p53 tumor suppressor: Determinants of its functional targets. Histol. Histopathol., 27: 437-443.
    PubMed  |  
  5. Suzuki, K., N. Dashzeveg, Z.G. Lu, N. Taira, Y. Miki and K. Yoshida, 2012. 2012. PDCD6, a novel p53-responsive gene, targets to the nucleus in the apoptotic response to DNA damage. Cancer Sci., 103: 1788-1894.
    PubMed  |  
  6. Yoshida, K., 2011. Role for PKCδ on Apoptosis in the DNA Damage Response. In: Selected Topics in DNA Repair, Chen, C.C. (Ed.). InTech, USA., pp: 293-304.
  7. Yoshida, K., 2011. Molecular Function of the p53 Tumor Suppressor in the Apoptotic Response to DNA Damage. In: Tumor Suppressors, Nguyen, S.D. (Ed.). Nova Science Publishers, New York, pp: 229-242.
  8. Kimura, J., T. Kudoh, Y. Miki and K. Yoshida, 2011. Identification of dihydropyrimidinase-related protein 4 as a novel target of the p53 tumor suppressor in the apoptotic response to DNA damage. Int. J. Cancer, 128: 1524-1531.
    PubMed  |  
  9. Hewm, H.C., H. Liu, Y. Miki and K. Yoshida, 2011. PKCδ regulates Mdm2 independently of p53 in the apoptotic response to DNA damage. Mol. Carcinog., 50: 719-731.
  10. Hew, H.C., H. Liu, Z.G. Lu, J. Kimura, Y. Miki and K. Yoshida, 2011. Identification of Evi-1 as a novel effector of PKCδ in the apoptotic response to DNA damage. Biochim. Biophys. Acta, 1803: 285-294.
    PubMed  |  
  11. Yoshida, K. and Y. Miki, 2010. The cell death machinery governed by the p53 tumor suppressor in response to DNA damage. Cancer Sci., 101: 831-835.
    PubMed  |  
  12. Yamaguchi, T., Y. Miki and K. Yoshida, 2010. The c-Abl tyrosine kinase stabilizes Pitx1 in the apoptotic response to DNA damage. Apoptosis, 15: 927-935.
    PubMed  |  
  13. Taira, N., H. Yamamoto, T. Yamaguchi, Y. Miki and K. Yoshida, 2010. ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damage. J. Biol. Chem., 285: 4909-4919.
    PubMed  |  
  14. Nihira, K., Y. Ando, T. Yamaguchi, Y. Kagami, Y. Miki and K. Yoshida, 2010. Pim1 controls NF-κB signalling by stabilizing RelA/p65. Cell Death Differ., 17: 689-698.
  15. Kudoh, T., J. Kimura, Z.G. Lu, Y. Miki and K. Yoshida, 2010. D4S234E, a novel p53-responsive gene, induces apoptosis in response to DNA damage. Exp. Cell Res., 315: 2849-2858.
    PubMed  |  
  16. Lu, Z.G., H. Liu, T. Yamaguchi, Y. Miki and K. Yoshida, 2009. Protein kinase Cd activates RelA/p65 and nuclear factor-kB signaling in response to tumor necrosis factor-a. Cancer Res., 69: 5927-5935.
    Direct Link  |  
  17. Liu, H., H.C. Hew, Z.G. Lu, T. Yamaguchi, Y. Miki and K. Yoshida, 2009. DNA damage signalling recruits RREB-1 to the p53 tumor suppressor promoter. Biochem. J., 422: 543-551.
    PubMed  |  
  18. Yoshida, K., 2008. Role for DYRK family kinases on regulation of apoptosis. Biochem. Pharmacol., 76: 1389-1394.
    PubMed  |  
  19. Yoshida, K., 2008. Nuclear trafficking of pro-apoptotic kinases in response to DNA damage. Trends. Mol. Med., 14: 305-313.
    PubMed  |  
  20. Tomiyoshi, G., A. Nakanishi, K. Takenaka, K. Yoshida and Y. Miki, 2008. A novel BRCA2-interacting protein BJ-HCC-20A inhibits the induction of apoptosis in response to DNA damage. Cancer Sci., 99: 747-754.
    PubMed  |  
  21. Shinagawa, H., Y. Miki and K. Yoshida, 2008. BRCA1-mediated ubiquitination inhibits topoisomerase IIa activity in response to oxidative stress. Antioxid. Redox. Signal., 10: 939-950.
    PubMed  |  
  22. Nihira, K., N. Taira, Y. Miki and K. Yoshida, 2008. TTK/Mps1 controls nuclear targeting of c-Abl by 14-3-3-coupled phosphorylation in response to oxidative stress. Oncogene, 27: 7285-7295.
    PubMed  |  
  23. Kimura, J., S.T. Nguyen, H. Liu, N. Taira, Y. Miki and K. Yoshida, 2008. A functional genome-wide RNAi screen identifies TAF1 as a regulator for apoptosis in response to genotoxic stress. Nucleic Acids Res., 36: 5250-5259.
    PubMed  |  
  24. Yoshida, K., 2007. Protein Kinase C d: The Determinant for Cell Fate in Response to DNA Damage. In: New Developments in Cell Apoptosis Research, Valentino, R.G. (Ed.). Nova Science Publishers, New York, pp: 97-120.
  25. Yoshida, K., 2007. PKCδ signaling: Mechanisms of DNA damage response and apoptosis. Cell. Signal., 19: 892-901.
    PubMed  |  
  26. Yamaguchi, T., Y. Miki and K. Yoshida, 2007. Protein kinase C d activates IkB-kinase a to induce the p53 tumor suppressor in response to oxidative stress. Cell. Signal., 19: 2088-2097.
  27. Yamaguchi, T., J. Kimura, Y. Miki and K. Yoshida, 2007. The USP11 deubiquitinating enzyme controls an IkB kinase a (IKKa)-p53 signaling pathway in response to tumor necrosis factor a (TNFa). J. Biol. Chem., 282: 33943-33948.
    PubMed  |  
  28. Taira, N., K. Nihira, T. Yamaguchi, Y. Miki and K. Yoshida, 2007. DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage. Mol. Cell, 25: 725-738.
    PubMed  |  
  29. Liu, H., Z.G. Lu, Y. Miki and K. Yoshida, 2007. Protein kinase C δ induces transcription of the TP53 tumor suppressor by controlling death-promoting factor Btf in the apoptotic response to DNA damage. Mol. Cell. Biol., 27: 8480-8491.
    PubMed  |  
  30. Yoshida, K., T. Yamaguchi, H. Shinagawa, N. Taira, K.I. Nakayama and Y. Miki, 2006. Protein kinase C δ activates topoisomerase IIα to induce apoptotic cell death in response to DNA damage. Mol. Cell. Biol., 26: 3414-3431.
    PubMed  |  
  31. Yoshida, K., H. Liu and Y. Miki, 2006. Protein kinase C δ regulates Ser46 phosphorylation of p53 tumor suppressor in the apoptotic response to DNA damage. J. Biol. Chem., 281: 5734-5740.
    PubMed  |  
  32. Raina, D., R. Ahmad, S. Kumar, J. Ren, K. Yoshida, S. Kharbanda and D. Kufe, 2006. MUC1 oncoprotein blocks nuclear targeting of c-Abl in the apoptotic response to DNA damage. EMBO J., 25: 3774-3783.
    Direct Link  |  
  33. Yoshida, K., T. Yamaguchi, T. Natsume, D. Kufe and Y. Miki, 2005. JNK phosphorylation of 14-3-3 regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage. Nat. Cell Biol., 7: 278-285.
    PubMed  |  
  34. Yoshida, K. and Y. Miki, 2005. Enabling death by the Abl Tyrosine kinase: Mechanisms for nuclear shuttling of c-Abl in response to DNA damage. Cell Cycle, 4: 777-779.
    PubMed  |  
  35. Sobota, A., A. Strzelecka-Kiliszek, E. Gadkowska, K. Yoshida, K. Mrozinska and K. Kwiatkowska, 2005. Binding of IgG-opsonized particles to FcgR is an active stage of phagocytosis which involves receptor clustering and phosphorylation. J. Immunol., 175: 4450-4457.
  36. Yoshida, K. and Y. Miki, 2004. Role of BRCA1 and BRCA2 as regulators of DNA repair, transcription and cell cycle in response to DNA damage. Cancer Sci., 95: 866-871.
    PubMed  |  
  37. Abbas, T., D. White, L. Hui, K. Yoshida, D.A. Foster and J. Bargonetti, 2004. Inhibition of human p53 basal transcription by down-regulation of protein kinase C δ. J. Biol. Chem., 279: 9970-9977.
    PubMed  |  Direct Link  |  
  38. Yoshida, K., H.G. Wang, Y. Miki and D. Kufe, 2003. Protein kinase Cδ is responsible for constitutive and DNA damage-induced phosphorylation of Rad9. EMBO J., 22: 1431-1441.
  39. Xu, H., H. Zhao, W. Tian, K. Yoshida, J.B. Roullet and D.M. Cohen, 2003. Regulation of a TRP channel by tyrosine phosphorylation: Src family kinase-dependent phosphorylation of TRPV4 on Y253 mediates its response to hypotonic stress. J. Biol. Chem., 278: 11520-11527.
  40. Li, Y., W. Chen, J. Ren, W. Yu, Q. Li, K. Yoshida and D. Kufe, 2003. DF3/MUC1 signaling in multiple myeloma cells is regulated by Interleukin-7. Cancer Biol. Ther., 2: 187-193.
    PubMed  |  
  41. Yoshida, K., Y. Miki and D. Kufe, 2002. Activation of SAPK/JNK signaling by protein kinase C δ in response to DNA damage. J. Biol. Chem., 277: 48372-48378.
    PubMed  |  
  42. Yoshida, K., K. Komatsu, H.G. Wang and D. Kufe, 2002. c-Abl tyrosine kinase regulates the human Rad9 checkpoint protein in response to DNA damage. Mol. Cell. Biol., 22: 3292-3300.
    PubMed  |  
  43. Ren, X., C. Cao, L. Zhu, K. Yoshida, S. Kharbanda, R. Weichselbaum and D. Kufe, 2002. Lyn tyrosine kinase inhibits nuclear export of the p53 tumor suppressor. Cancer Biol. Ther., 1: 703-708.
    PubMed  |  
  44. Yoshida, K. and D. Kufe, 2001. Negative regulation of the SHPTP1 tyrosine phosphatase by protein kinase Cδ in response to DNA damage. Mol. Pharmacol., 60: 1431-1438.
    PubMed  |  
  45. Nakamura, M., M. Terada, K. Matsuzaki, K. Yoshida and T. Ohno, 2001. Mechanism of inhibitory effect of NCC164 on replication of human immunodeficiency virus. Microbiol. Immunol., 45: 217-223.
    PubMed  |  
  46. Ito, Y., N.C. Mishra, K. Yoshida, S. Kharbanda, S. Saxena and D. Kufe, 2001. Mitochondrial targeting of JNK/SAPK in the phorbol ester response of myeloid leukemia cells. Cell Death Differ., 8: 794-800.
    PubMed  |  
  47. Yoshida, K., R. Weichselbaum, S. Kharbanda and D. Kufe, 2000. Role for Lyn tyrosine kinase as a regulator of stress-activated protein kinase activity in response to DNA damage. Mol. Cell. Biol., 20: 5370-5380.
    PubMed  |  
  48. Kharbanda, S., S. Saxena, K. Yoshida, P. Pandey and M. Kaneki et al., 2000. Translocation of sapk/jnk to mitochondria and interaction with bcl-xl in response to dna damage. J. Biol. Chem., 275: 322-327.
    CrossRef  |  
  49. Endo, K., E. Oki, V. Biedermann, H. Kojima and K. Yoshida, 2000. Proteolytic cleavage and activation of protein kinase C μ by caspase-3 in the apoptotic response of cells to 1-β-d-arabinofuranosylcytosine and other genotoxic agents. J. Biol. Chem., 275: 18476-18481.
    CrossRef  |  
  50. Yoshida, K., S. Kharbanda and D. Kufe, 1999. Functional interaction between SHPTP1 and the Lyn tyrosine kinase in the apoptotic response to DNA damage. J. Biol. Chem., 274: 34663-34668.
    PubMed  |  
  51. Kaneki, M., S. Kharbanda, P. Pandey, K. Yoshida and M. Takekawa et al., 1999. Functional role for protein kinase C β as a regulator of stress-activated protein kinase activation and monocytic differentiation of myeloid leukemia cells. Mol. Cell. Biol., 19: 461-470.
    PubMed  |  
  52. Huang, Y., S. Nakada, T. Ishiko, T. Utsugisawa and R. Datta et al., 1999. Role for caspase-mediated cleavage of Rad51 in induction of apoptosis by DNA damage. Mol. Cell. Biol., 19: 2986-2997.
    PubMed  |  
  53. Yoshida, K., M. Nakamura and T. Ohno, 1997. Mutations of the HIV type 1 V3 loop under selection pressure with neutralizing monoclonal antibody NM-01. AIDS Res. Hum. Retroviruses, 13: 1283-1290.
    PubMed  |  
  54. Kharbanda, S., P. Pandey, L. Schofield, S. Israels and R. Roncinske et al., 1997. Role for Bcl-xL as an inhibitor of cytosolic cytochrome C accumulation in DNA damage-induced apoptosis. Proc. Natl. Acad. Sci. USA., 94: 6939-6942.
    PubMed  |  
  55. Datta, R., H. Kojima, K. Yoshida and D. Kufe, 1997. Caspase-3-mediated cleavage of protein kinase C q in induction of apoptosis. J. Biol. Chem., 272: 20317-20320.
  56. Nakamura, M., H. Okada, H. Sasaki, K. Yoshida and M. Kamada et al., 1996. Quantification of the CD55 and CD59, membrane inhibitors of complement on HIV-1 particles as a function of complement-mediated virolysis. Microbiol. Immunol., 40: 561-567.
    PubMed  |  
  57. Joki, T., M. Nakamura, K. Yoshida, S. Kunimoto, Y. Namiki, T. Abe and T. Ohno, 1996. Modification of doxorubicin molecule enhanced the early growth response gene 1 promoter activity. Jikeikai Med. J., 43: 1-7.
  58. Nakamura, M., K. Yoshida, M. Yoshida, S. Kunimoto, T. Takeuchi and T. Ohno, 1995. Eulicin inhibits human immunodeficiency virus infection and replication. J. Antibiot., 48: 1362-1363.
    PubMed  |