Prof. Dr. Mohd.  Rais Bin Mustafa
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Prof. Dr. Mohd. Rais Bin Mustafa

Professor
University of Malaya, Malaysia


Highest Degree
Ph.D. in Pharmacology from University of Wales, U.K

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Area of Interest:

Pharmacology and Toxicology
100%
Pharmacology
62%
Traditional Medicine
90%
Natural Product
75%
Health Science
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Hasanpourghadi, M., A.K. Pandurangan and M.R. Mustafa, 2018. Modulation of oncogenic transcription factors by bioactive natural products in breast cancer. Pharmacol. Res., 128: 376-388.
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  2. Wong, P.F., J. Jamal, K.L. Tong, E.S. Khor and C.E. Yeap et al., 2017. Deregulation of hsa-miR-20b expression in TNF-α-induced premature senescence of human pulmonary microvascular endothelial cells. Microvascular Res., 114: 26-33.
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  3. Ling, W.C., M.R. Mustafa, P.M. Vanhoutte and D.D. Murugan, 2017. Chronic administration of sodium nitrite prevents hypertension and protects arterial endothelial function by reducing oxidative stress in angiotensin II-infused mice. Vascular Pharmacol., 102: 11-20.
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  4. Ling, W.C., J. Liu, C.W. Lau, D.D. Murugan, M.R. Mustafa and Y. Huang, 2017. Treatment with salvianolic acid B restores endothelial function in angiotensin II-induced hypertensive mice. Biochem. Pharmacol., 136: 76-85.
    CrossRef  |  Direct Link  |  
  5. Kunasegaran, T., M.R. Mustafa, F.I. Achike and D.D. Murugan, 2017. Quercetin and pioglitazone synergistically reverse endothelial dysfunction in isolated aorta from fructose-streptozotocin (F-STZ)-induced diabetic rats. Eur. J. Pharmacol., 799: 160-170.
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  6. Hasanpourghadi, M., C.Y. Looi, A.K. Pandurangan, G. Sethi, W.F. Wong and M.R. Mustafa, 2017. Phytometabolites targeting the warburg effect in cancer cells: A mechanistic review. Curr. Drug Targets, 18: 1086-1094.
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  7. Hasanpourghadi, M., C.Y. Looi, A.K. Pandurangan, G. Sethi, W.F. Wong and M.R. Mustafa, 2017. Phytometabolites targeting the warburg effect in cancer cells: A mechanistic review. Curr. Drug Targets, 18: 1086-1094.
    CrossRef  |  Direct Link  |  
  8. Hasanpourghadi, M., A.K. Pandurangan, C. Karthikeyan, P. Trivedi and M.R. Mustafa, 2017. Mechanisms of the anti-tumor activity of Methyl 2-(-5-fluoro-2-hydroxyphenyl)-1 H-benzo [d] imidazole-5-carboxylate against breast cancer in vitro and in vivo. Oncotarget, 8: 28840-28853.
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  9. Dai, X., L. Wang, A. Deivasigamni, C.Y. Looi and C. Karthikeyan et al., 2017. A novel benzimidazole derivative, MBIC inhibits tumor growth and promotes apoptosis via activation of ROS-dependent JNK signaling pathway in hepatocellular carcinoma. Oncotarget, 8: 12831-12842.
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  10. Choy, K.W., Y.S. Lau, D. Murugan and M.R. Mustafa, 2017. Chronic treatment with paeonol improves endothelial function in mice through inhibition of endoplasmic reticulum stress-mediated oxidative stress. PloS One, Vol. 12. 10.1371/journal.pone.0178365.
    CrossRef  |  
  11. Shanmugam, M.K., J.H. Lee, E.Z.P. Chai, M.M. Kanchi and S. Kar et al., 2016. Cancer prevention and therapy through the modulation of transcription factors by bioactive natural compounds. Seminars Cancer Biol., 40: 35-47.
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  12. Pandurangan, A.K., N. Mohebali, M. Hasanpourghadi, C.Y. Looi, M.R. Mustafa and N. Mohd Esa, 2016. Boldine suppresses dextran sulfate sodium‐induced mouse experimental colitis: NF‐κB and IL‐6/STAT3 as potential targets. Biofactors, 42: 247-258.
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  13. Ling, W.C., D.D. Murugan, Y.S. Lau, P.M. Vanhoutte and M.R. Mustafa, 2016. Sodium nitrite exerts an antihypertensive effect and improves endothelial function through activation of eNOS in the SHR. Sci. Rep., Vol. 6. 10.1038/srep33048.
    CrossRef  |  
  14. Leong, K.H., C.Y. Looi, X.M. Loong, F.K. Cheah and U. Supratman et al., 2016. Cycloart-24-ene-26-ol-3-one, a new Cycloartane isolated from leaves of Aglaia Exima triggers tumour necrosis factor-receptor 1-mediated caspase-dependent apoptosis in colon cancer cell line. PloS One, Vol. 11. 10.1371/journal.pone.0152652.
    CrossRef  |  
  15. Leong, K.H., C.Y. Looi, X.M. Loong, F.K. Cheah and U. Supratman et al., 2016. Cycloart-24-ene-26-ol-3-one, a new Cycloartane isolated from leaves of Aglaia Exima triggers tumour necrosis factor-receptor 1-mediated caspase-dependent apoptosis in colon cancer cell line. PloS One, Vol. 11. 10.1371/journal.pone.0152652.
    CrossRef  |  
  16. Kunasegaran, T., M.R. Mustafa, D.D. Murugan and F.I. Achike, 2016. The bioflavonoid quercetin synergises with PPAR-γ agonist pioglitazone in reducing angiotensin-II contractile effect in fructose-streptozotocin induced diabetic rats. Biochimie, 125: 131-139.
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  17. Hasanpourghadi, M., C. Karthikeyan, A.K. Pandurangan, C.Y. Looi and P. Trivedi et al., 2016. Targeting of tubulin polymerization and induction of mitotic blockage by Methyl 2-(5-fluoro-2-hydroxyphenyl)-1 H-benzo [d] imidazole-5-carboxylate (MBIC) in human cervical cancer HeLa cell. J. Exp. Clin. Cancer Res., Vol. 35. 10.1186/s13046-016-0332-0.
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  18. Choy, K.W., M.R. Mustafa, Y.S. Lau, J. Liu and D. Murugan, 2016. Paeonol protects against endoplasmic reticulum stress-induced endothelial dysfunction via AMPK/PPARδ signaling pathway. Biochem. Pharmacol., 116: 51-62.
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  19. Sadagopan, S.K.A., N. Mohebali, C.Y. Looi, M. Hasanpourghadi and A.K. Pandurangan et al., 2015. Forkhead box transcription factor (FOXO3a) mediates the cytotoxic effect of vernodalin in vitro and inhibits the breast tumor growth in vivo. J. Exp. Clin. Cancer Res., Vol. 34. 10.1186/s13046-015-0266-y.
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  20. Saadatdoust, Z., A.K. Pandurangan, S.K.A. Sadagopan, N.M. Esa, A. Ismail and M.R. Mustafa, 2015. Dietary cocoa inhibits colitis associated cancer: A crucial involvement of the IL-6/STAT3 pathway. J. Nutr. Biochem., 26: 1547-1558.
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  21. Murugan, D., Y.S. Lau, W.C. Lau, M.R. Mustafa and Y. Huang, 2015. Angiotensin 1-7 protects against angiotensin II-induced endoplasmic reticulum stress and endothelial dysfunction via mas receptor. PloS One, Vol. 10. 10.1371/journal.pone.0145413.
    CrossRef  |  
  22. Ling, W.C., Y.S. Lau, D.D. Murugan, P.M. Vanhoutte and M.R. Mustafa, 2015. Sodium nitrite causes relaxation of the isolated rat aorta: By stimulating both endothelial NO synthase and activating soluble guanylyl cyclase in vascular smooth muscle. Vascular Pharmacol., 74: 87-92.
    CrossRef  |  Direct Link  |  
  23. Lau, Y.S., W.C. Ling, D. Murugan, C.Y. Kwan and M.R. Mustafa, 2015. Endothelium-dependent relaxation effect of Apocynum venetum leaf extract via Src/PI3K/Akt signalling pathway. Nutrients, 7: 5239-5253.
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  24. Lau, Y.S., W.C. Ling and M.R.M. Dharmani Murugan, 2015. Boldine ameliorates vascular oxidative stress and endothelial dysfunction: Therapeutic implication for hypertension and diabetes. J. Cardiovascular Pharmacol., 65: 522-531.
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  25. Lai, S.L., P.F. Wong, T.K. Lim, Q. Lin and M.R. Mustafa, 2015. iTRAQ-based proteomic identification of proteins involved in anti-angiogenic effects of Panduratin A on HUVECs. Phytomedicine, 22: 203-212.
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  26. Lai, S.L., P.F. Wong, T.K. Lim, Q. Lin and M.R. Mustafa, 2015. Cytotoxic mechanisms of panduratin A on A375 melanoma cells: A quantitative and temporal proteomics analysis. Proteomics, 15: 1608-1621.
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  27. Iman, V., H. Karimian, S. Mohan, Y.H. Hobani, M.I. Noordin, M.R. Mustafa and S.M. Noor, 2015. In vitro and in vivo anti-angiogenic activity of girinimbine isolated from Murraya koenigii. Drug Design Dev. Therapy, 9: 1281-1292.
    CrossRef  |  Direct Link  |  
  28. Arya, A., M.M.J. Al-Obaidi, R.B. Karim, H. Taha and A.K. Khan et al., 2015. Extract of Woodfordia fruticosa flowers ameliorates hyperglycemia, oxidative stress and improves β-cell function in streptozotocin-nicotinamide induced diabetic rats. J. Ethnopharmacol., 175: 229-240.
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  29. Shawish, H.B., M. Paydar, C.Y. Looi, Y.L. Wong and E. Movahed et al., 2014. Nickel (II) complexes of polyhydroxybenzaldehyde N4-thiosemicarbazones: Synthesis, structural characterization and antimicrobial activities. Transition Metal Chem., 39: 81-94.
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  30. Rusmili, M.R.A., T.Y. Tee, M.R. Mustafa, I. Othman and W.C. Hodgson, 2014. Isolation and characterization of α-elapitoxin-Bf1b, a postsynaptic neurotoxin from Malaysian Bungarus fasciatus venom. Biochem. Pharmacol., 88: 229-236.
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  31. Rusmili, M.R.A., T.T. Yee, M.R. Mustafa, I. Othman and W.C. Hodgson, 2014. In-vitro neurotoxicity of two Malaysian krait species (Bungarus candidus and Bungarus fasciatus) venoms: Neutralization by monovalent and polyvalent antivenoms from Thailand. Toxins, 6: 1036-1048.
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  32. Liew, S.Y., C.Y. Looi, M. Paydar, F.K. Cheah and K.H. Leong et al., 2014. Subditine, a new monoterpenoid indole Alkaloid from bark of Nauclea subdita (Korth.) Steud. Induces apoptosis in human prostate cancer cells. PloS One, Vol. 9. 10.1371/journal.pone.0087286.
    CrossRef  |  
  33. Jamal, J., M.R. Mustafa and P.F. Wong, 2014. Paeonol protects against premature senescence in endothelial cells by modulating Sirtuin 1 pathway. J. Ethnopharmacol., 154: 428-436.
    CrossRef  |  Direct Link  |  
  34. Tiong, S.H., C.Y. Looi, H. Hazni, A. Arya and M. Paydar et al., 2013. Antidiabetic and antioxidant properties of alkaloids from Catharanthus roseus (L.) G. Don. Molecules, 18: 9770-9784.
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  35. Mohan, S., S.I. Abdelwahab, S.C. Cheah, M.A. Sukari, S. Syam, N. Shamsuddin and M. Rais Mustafa, 2013. Apoptosis effect of girinimbine isolated from Murraya koenigii on lung cancer cells in vitro. Evidence-Based Complementary Alter. Med., Vol. 2013. 10.1155/2013/689865.
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  36. Looi, C.Y., B. Moharram, M. Paydar, Y.L. Wong and K.H. Leong et al., 2013. Induction of apoptosis in melanoma A375 cells by a chloroform fraction of Centratherum anthelminticum (L.) seeds involves NF-κB, p53 and Bcl-2-controlled mitochondrial signaling pathways. BMC Complement. Altern. Med., Vol. 13. 10.1186/1472-6882-13-166.
    CrossRef  |  PubMed  |  Direct Link  |  
  37. Looi, C.Y., A. Arya, F.K. Cheah, B. Muharram and K.H. Leong et al., 2013. Induction of apoptosis in human breast cancer cells via caspase pathway by vernodalin isolated from Centratherum anthelminticum (L.) seeds. PloS One, Vol. 8. 10.1371/journal.pone.0056643.
    CrossRef  |  
  38. Leong, X.F., M.R. Mustafa and K. Jaarin, 2013. Nigella sativa and its protective role in xidative stress and hypertension. Evidence-Based Complementary Alter. Med., Vol. 2013. 10.1155/2013/120732.
    CrossRef  |  
  39. Lee, S.T., P.F. Wong, J.D. Hooper and M.R. Mustafa, 2013.. Alpha-tomatine synergises with paclitaxel to enhance apoptosis of androgen-independent human prostate cancer PC-3 cells in vitro and in vivo. Phytomedicine, 20: 1297-1305.
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  40. Lee, S.T., P.F. Wong, H. He, J.D. Hooper and M.R. Mustafa, 2013. Alpha-tomatine attenuation of in vivo growth of subcutaneous and orthotopic xenograft tumors of human prostate carcinoma PC-3 cells is accompanied by inactivation of nuclear factor-kappa B signaling. PLoS One, Vol. 8. 10.1371/journal.pone.0057708.
    CrossRef  |  
  41. Lau, Y.S., X.Y. Tian, Y. Huang, D. Murugan, F.I. Achike and M.R. Mustafa, 2013. Boldine protects endothelial function in hyperglycemia-induced oxidative stress through an antioxidant mechanism. Biochem. Pharmacol., 85: 367-375.
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  42. Lau, Y.S., X.Y. Tian, M.R. Mustafa, D. Murugan and J. Liu et al., 2013. Boldine improves endothelial function in diabetic db/db mice through inhibition of angiotensin II‐mediated BMP4‐oxidative stress cascade. Br. J. Pharmacol., 170: 1190-1198.
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  43. Lau, Y.S., X.Y. Tian, M.R. Mustafa, D. Murugan and J. Liu et al., 2013. Boldine improves endothelial function in diabetic db/db mice through inhibition of angiotensin II‐mediated BMP4‐oxidative stress cascade. Br. J. Pharmacol., 170: 1190-1198.
    CrossRef  |  
  44. Jong, H.L., M.R. Mustafa, P.M. Vanhoutte, S. AbuBakar and P.F. Wong, 2013. MicroRNA 299-3p modulates replicative senescence in endothelial cells. Physiol. Genomics, 45: 256-267.
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  45. Gummadi, V.R., S. Rajagopalan, C.Y. Looi, M. Paydar and G.A. Renukappa et al., 2013. Discovery of 7-azaindole based Anaplastic Lymphoma Kinase (ALK) inhibitors: Wild type and mutant (L1196M) active compounds with unique binding mode. Bioorganic Med. Chem. Lett., 23: 4911-4918.
    CrossRef  |  Direct Link  |  
  46. Cheah, S.C., S.L. Lai, S.T. Lee, A.H.A. Hadi and M.R. Mustafa, 2013. Panduratin A, a possible inhibitor in metastasized A549 cells through inhibition of NF-kappa B translocation and chemoinvasion. Molecules, 18: 8764-8778.
    CrossRef  |  Direct Link  |  
  47. Arya, A., C.Y. Looi, W.F. Wong, M.I. Noordin, S. Nyamathulla, M.R. Mustafa and M.A. Mohd, 2013. In vitro antioxidant, PTP-1B inhibitory effects and in vivo hypoglycemic potential of selected medicinal plants. Int. J. Pharmacol., 9: 50-57.
    Direct Link  |  
  48. Zandi, K., R. Lani, P.F. Wong, B.T. Teoh and S.S. Sam et al., 2012. Flavone enhances dengue virus type-2 (NGC Strain) infectivity and replication in Vero cells. Molecules, 17: 2437-2445.
    CrossRef  |  Direct Link  |  
  49. Zandi, K., B.T. Teoh, S.S. Sam, P.F. Wong, M.R. Mustafa and S. AbuBakar, 2012. Novel antiviral activity of baicalein against dengue virus. BMC Complement. Altern. Med., Vol. 12. 10.1186/1472-6882-12-214.
    CrossRef  |  Direct Link  |  
  50. Tan, P.J., D.R. Appleton, M.R. Mustafa and H.B. Lee, 2012. Rapid identification of cyclic tetrapyrrolic photosensitisers for photodynamic therapy using on‐line hyphenated LC‐PDA‐MS Coupled with photo‐cytotoxicity assay. Phytochem. Analysis, 23: 52-59.
    CrossRef  |  Direct Link  |  
  51. Liew, S.Y., M.R. Mukhtar, A.H.A. Hadi, K. Awang and M.R. Mustafa et al., 2012. Naucline, a new indole alkaloid from the bark of Nauclea officinalis. Molecules, 17: 4028-4036.
    CrossRef  |  Direct Link  |  
  52. Leong, X.F., J. Salimon, M.R. Mustafa and K. Jaarin, 2012. Effect of repeatedly heated palm olein on blood pressure-regulating enzymes activity and lipid peroxidation in rats. Malaysian J. Med. Sci., 19: 20-29.
    Direct Link  |  
  53. Lau, Y.S., A. Machha, F.I. Achike, D. Murugan and M.R. Mustafa, 2012. The aporphine alkaloid boldine improves endothelial function in spontaneously hypertensive rats. Exp. Biol. Med., 237: 93-98.
    CrossRef  |  
  54. Lai, S.L., S.C. Cheah, P.F. Wong, S.M. Noor and M.R. Mustafa, 2012. In vitro and in vivo anti-angiogenic activities of Panduratin A. PloS One, Vol. 7. 10.1371/journal.pone.0038103.
    CrossRef  |  
  55. Johari, J., A. Kianmehr, M.R. Mustafa, S. Abubakar and K. Zandi, 2012. Antiviral activity of baicalein and quercetin against the Japanese encephalitis virus. Int. J. Mol. Sci., 13: 16785-16795.
    CrossRef  |  Direct Link  |  
  56. Arya, A., S.C. Cheah, C.Y. Looi, H. Taha, M.R. Mustafa and M.A. Mohd, 2012. The methanolic fraction of Centratherum anthelminticum seed downregulates pro-inflammatory cytokines, oxidative stress and hyperglycemia in STZ-nicotinamide-induced type 2 diabetic rats. Food Chem. Toxicol., 50: 4209-4220.
    CrossRef  |  
  57. Arya, A., C.Y. Looi, S.C. Cheah, M.R. Mustafa and M.A. Mohd, 2012. Anti-diabetic effects of Centratherum anthelminticum seeds methanolic fraction on pancreatic cells, β-TC6 and its alleviating role in type 2 diabetic rats. J. Ethnopharmacol., 144: 22-32.
    CrossRef  |  PubMed  |  
  58. Arya, A., A.M. Mohd, M. Achoui, S.C. Cheah and S. Mohan et al., 2012. Chloroform fraction of Centratherum anthelminticum (L.) seed inhibits tumor necrosis factor alpha and exhibits pleotropic bioactivities: Inhibitory role in human tumor cells. Evidence-Based Complement. Altern. Med., 10.1155/2012/627256.
    CrossRef  |  Direct Link  |  
  59. Arbab, I.A., C.Y. Looi, A.B. Abdul, F.K. Cheah and W.F. Wong et al., 2012. Dentatin induces apoptosis in prostate cancer cells via Bcl-2, Bcl-xL, Survivin downregulation, caspase-9, -3/7 activation, and NF-κB inhibition. Evidence-Based Complementary Altern. Med., 10.1155/2012/856029.
    CrossRef  |  PubMed  |  Direct Link  |  
  60. Abdelwahab, S.I., W.S. Koko, M.M.E. Taha, S. Mohan and M. Achoui et al., 2012. In vitro and in vivo anti-inflammatory activities of columbin through the inhibition of cycloxygenase-2 and nitric oxide but not the suppression of NF-κB translocation. Eur. J. Pharmacol., 678: 61-70.
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  61. Abdel-Wahab, S.I., A.W.H. Mohamed, O.Y. Mohamed, M. Oall and M.M.E. Taha et al., 2012. Erectogenic effects of Clerodendron capitatum: Involvement of phosphodiesterase type-5 inhibition. Evidence-Based Complement. Altern. Med. 10.1155/2012/137386.
    CrossRef  |  Direct Link  |  
  62. Zandi, K., B.T. Teoh, S.S. Sam, P.F. Wong, M.R. Mustafa and S. AbuBakar, 2011. In vitro antiviral activity of fisetin, rutin and naringenin against dengue virus type-2. J. Med. Plants Res., 5: 5534-5539.
  63. Yeh-Siang, L., G. Subramaniam, A.H.A. Hadi, D. Murugan and M.R. Mustafa, 2011. Reactive oxygen species-induced impairment of endothelium-dependent relaxations in rat aortic rings: Protection by methanolic extracts of Phoebe grandis. Molecules, 16: 2990-3000.
  64. Liew, S.Y., M.R. Mukhtar, K. Awang, M.R. Mustafa and S.W. Ng, 2011. 1-(1-Hydroxyethyl)-7, 8-dihydroindolo [2, 3-a] pyridine [3, 4-g] quinolizin-5 (13H)-one (angustoline) monohydrate from Nauclea subdita (Rubiaceae). Acta Crystallographica Section E: Struct. Rep. Online, 67: o1727-o1728.
    CrossRef  |  
  65. Lee, S.T., P.F. Wong, S.C. Cheah and M.R. Mustafa, 2011. Alpha-tomatine induces apoptosis and inhibits nuclear factor-kappa B activation on human prostatic adenocarcinoma PC-3 cells. PLoS One, Vol. 6. 10.1371/journal.pone.0018915.
    CrossRef  |  
  66. Jaarin, K., M.R. Mustafa and X.F. Leong, 2011. The effects of heated vegetable oils on blood pressure in rats. Clinics, 66: 2125-2132.
  67. Chong, Y.M., W.F. Yin, C.Y. Ho, M.R. Mustafa and A.H.A. Hadi et al., 2011. Malabaricone C from Myristica cinnamomea exhibits anti-quorum sensing activity. J. Nat. Prod., 74: 2261-2264.
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  68. Cheah, S.C., D.R. Appleton, S.T. Lee, M.L. Lam, A.H.A. Hadi and M.R. Mustafa, 2011. Panduratin A inhibits the growth of A549 cells through induction of apoptosis and inhibition of NF-κB translocation. Molecules, 16: 2583-2598.
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  69. Muharis, S.P., A.G.M. Top, D. Murugan and M.R. Mustafa, 2010. Palm oil tocotrienol fractions restore endothelium dependent relaxation in aortic rings of streptozotocin-induced diabetic and spontaneously hypertensive rats. Nutr. Res., 30: 209-216.
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  70. Leong, X.F., M.R. Mustafa, S. Das and K. Jaarin, 2010. Association of elevated blood pressure and impaired vasorelaxation in experimental sprague-dawley rats fed with heated vegetable oil. Lipid Health Dise., Vol. 9. 10.1186/1476-511X-9-66.
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  71. Khan, H., I. Ali, K. Arif-ullah, M. Ahmed and Z. Shah et al., 2010. Purification and biochemical characterization of alkaline serine protease from Caesalpinia bonducella. Nat. Prod. Commun., 5: 931-934.
    PubMed  |  
  72. Kassim, M., M. Achoui, M.R. Mustafa, M.A. Mohd and K.M. Yusoff, 2010. Ellagic acid, phenolic acids, and flavonoids in Malaysian honey extracts demonstrate in vitro anti-inflammatory activity. Nut. Res., 30: 650-659.
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  73. Achoui, M., D. Appleton, M.A. Abdulla, K. Awang, M.A. Mohd and M.R. Mustafa, 2010. In vitro and in vivo anti-inflammatory activity of 17-O-acetylacuminolide through the inhibition of cytokines, NF-κB translocation and IKKβ activity. PLoS One, Vol. 5. 10.1371/journal.pone.0015105.
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  74. Subramaniam, G., F.I. Achike and M.R. Mustafa, 2009. Effect of acidosis on the mechanism (s) of insulin-induced vasorelaxation in normal Wistar-Kyoto (WKY) rat aorta. Regulatory Peptides, 155: 70-75.
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  75. Subramaniam, G., F.I. Achike and M.R. Mustafa, 2009. Characterizing the mechanisms of insulin vasodilatation of normal and streptozotocin-induced diabetic rat aorta. J. Cardiovascular Pharmacol., 53: 333-340.
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  76. Leong, X.F., M.N.M. Najib, S. Das, M.R. Mustafa and K. Jaarin, 2009. Intake of repeatedly heated palm oil causes elevation in blood pressure with impaired vasorelaxation in rats. Tohoku J. Exp. Med., 219: 71-78.
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  77. Chung, L.Y., W.K. Soo, M.R. Mustafa, S.H. Goh and Z. Imiyabir, 2009. 5-Hydroxytryptamine1A receptor binding activity of bisbenzyltetrahydroisoquinoline alkaloids from Popowia odoardi. Pharm. Biol., 47: 1130-1136.
    Direct Link  |  
  78. Chung, L.Y., W.K. Soo, K.Y. Chan, M.R. Mustafa, S.H. Goh and Z. Imiyabir, 2009. Lipoxygenase inhibiting activity of some Malaysian plants. Pharm. Biol., 47: 1142-1148.
    Direct Link  |  
  79. Chung, L.Y., M.W. Lo, M.R. Mustafa, S.H. Goh and Z. Imiyabir, 2009. 5‐Hydroxytryptamine2A receptor binding activity of compounds from Litsea sessilis. Phytotherapy Res., 23: 330-334.
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  80. Tamil, E.M., T.S. Tey, M.R. Mustafa, M.Y.I. Idris and M. Nasir, 2008. Automated clinical research mice movement detection system. Int. J. Technol. Knowledge Soc., 4: 63-76.
  81. Raj, V.L., C.K. Liam, A.K. Radhakrishnan and R. Naidu, 2008. Association between β-adrenoceptor polymorphisms and receptor function in Malaysian asthmatics. Fundamental Clin. Pharmacol., Vol. 22. .
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  82. Mukhtar, M.R., A.H.A. Hadi, D. Rondeau, P. Richomme, M. Litaudon, M.R. Mustafa and K. Awang, 2008. New proaporphines from the bark of Phoebe scortechinii. Nat. Prod. Res. Part A, 22: 921-926.
    Direct Link  |  
  83. Hussein, H., R. Mustafa, K.F. Quek, N.S. Hassanudin and S. Shahid, 2008. Cross‐cultural adaptation and validation of the Malay health assessment questionnaire for use in rheumatoid arthritis. Int. J. Rheumatic Dis., 11: 237-240.
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  84. Einstein, J.W., M.R. Mustafa, I. Nishigaki, B. Rajkapoor and M.A. Moh, 2008. Protective effect of different parts of Cassia fistula on human umbilical vein endothelial cells against glycated protein-induced toxicity in vitro. Methods Findings Exp. Clin. Pharmacol., 30: 599-605.
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  85. Dharmani, M., M.R. Mustafa, F.I. Achike and M.K. Sim, 2008. Involvement of AT1 angiotensin receptors in the vasomodulatory effect of des-aspartate-angiotensin I in the rat renal vasculature. Peptides, 29: 1773-1780.
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  86. Chung, L.Y., K.F. Yap, S.H. Goh, M.R. Mustafa and Z. Imiyabir, 2008. Muscarinic receptor binding activity of polyoxygenated flavones from Melicope subunifoliolata. Phytochemistry, 69: 1548-1554.
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  87. Amudha, K., A.M. Choy, M.R. Mustafa and C.C. Lang, 2008. Short‐term effect of atorvastatin on endothelial function in healthy offspring of parents with type 2 diabetes mellitus. Cardiovascular Therapeutics, 26: 253-261.
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  88. Machha, A., F.I. Achike, M.A. Mohd and M.R. Mustafa, 2007. Baicalein impairs vascular tone in normal rat aortas: Role of superoxide anions. Eur. J. Pharmacol., 565: 144-150.
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  89. Machha, A., F.I. Achike, A.M. Mustafa and M.R. Mustafa, 2007. Quercetin, a flavonoid antioxidant, modulates endothelium-derived nitric oxide bioavailability in diabetic rat aortas. Nitric. Oxide., 16: 442-447.
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  90. Dharmani, M., M.R. Mustafa, F.I. Achike and M.K. Sim, 2007. Effects of angiotensin 1-7 on the actions of angiotensin II in the renal and mesenteric vasculature of hypertensive and streptozotocin-induced diabetic rats. Eur. J. Pharmacol., 561: 144-150.
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  91. Chin, L.C., F.I. Achike and M.R. Mustafa, 2007. Hydrogen peroxide modulates angiotensin II-induced contraction of mesenteric arteries from streptozotocin-induced diabetic rats. Vascular Pharmacol., 46: 223-228.
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  92. Awang, K., M.R. Mukhtar, M.R. Mustafa, M. Litaudon, K. Shaari, K. Mohamed and A.H.A. Hadi, 2007. New alkaloids from pheobe scortechini. Nat. Prod. Res., 21: 704-709.
  93. Ajay, M., H.J. Chai, A.M. Mustafa, A.H. Gilani and M.R. Mustafa, 2007. Mechanisms of the anti-hypertensive effect of Hibiscus sabdariffa L. calyces. J. Ethnopharmacol., 109: 388-393.
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  94. Ajay, M., F.I. Achike and M.R. Mustafa, 2007. Modulation of vascular reactivity in normal, hypertensive and diabetic rat aortae by a non-antioxidant flavonoid. Pharmacol. Res., 55: 385-391.
    PubMed  |  
  95. Othman, R., H. Ibrahim, M.A. Mohd, M.R. Mustafa and K. Awang, 2006. Bioassay-guided isolation of a vasorelaxant active compound from Kaempferia galanga L. Phytomedicine, 13: 61-66.
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  96. Ajay, M., F.I. Achike, A.M. Mustafa and M.R. Mustafa, 2006. Effect of quercetin on altered vascular reactivity in aortas isolated from streptozotocin-induced diabetic rats. Diabetes Res. Clin. Pract., 73: 1-7.
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  97. Ajay, M., F.I. Achike, A.M. Mustafa and M.R. Mustafa, 2006. Direct effects of quercetin on impaired reactivity of spontaneously hypertensive rat aortae: Comparative study with ascorbic acid. Clin. Exp. Pharmacol. Physiol., 33: 345-350.
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  98. Mustafa, M.R., A.A. Mahmood, K. Sidik and S.M. Noor, 2005. Evaluation of wound healing potential of Ageratum conyzoides leaf extract in combination with honey in rats as animal model. Int. J. Mol. Med. Adv. Sci., 1: 406-410.
  99. Machha, A. and M.R. Mustafa, 2005. Chronic treatment with flavonoids prevents endothelial dysfunction in spontaneously hypertensive rat aorta. J. Cardiovascular Pharmacol., 46: 36-40.
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  100. Dharmani, M., M.R. Mustafa, F.I. Achike and M.K. Sim, 2005. Effect of des-aspartate-angiotensin I on the actions of angiotensin II in the isolated renal and mesenteric vasculature of hypertensive and STZ-induced diabetic rats. Regulatory Peptides, 129: 213-219.
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  101. Chung, L.Y., K.F. Yap, M.R. Mustafa, S.H. Goh and Z. Imiyabir, 2005. Muscarinic receptor activity of some Malaysian plant species. Pharm. Biol., 43: 672-682.
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  102. Mustafa, M.R., M. Dharmani, N.K. Kunheen and M.K. Sim, 2004. Effects of des-aspartate-angiotensin I on the actions of angiotensin III in the renal and mesenteric vasculature of normo-and hypertensive rats. Regulatory Peptides, 120: 15-22.
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  103. Lang, C.C., S.K. Jamal, Z. Mohamed, M.R. Mustafa, A.M. Mustafa and T.C. Lee, 2003. Evidence of an interaction between nifedipine and nafcillin in humans. Br. J. Clin. Pharmacol., 55: 588-590.
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  104. Ajay, M., A.H. Gilani and M.R. Mustafa, 2003. Effects of flavonoids on vascular smooth muscle of the isolated rat thoracic aorta. Life Sci., 74: 603-612.
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  105. Othman, R., H. Ibrahim, M.A. Mohd, K. Awang, A.H. Gilani and M.R. Mustafa, 2002. Vasorelaxant effects of ethyl cinnamate isolated from Kaempferia galanga on smooth muscles of the rat aorta. Planta Med., 68: 655-657.
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  106. Mustafa, M.R. and E.J. Johns, 2001. The role of haem oxygenase in renal vascular reactivity in normotensive and hypertensive rats. J. Hypertension, 19: 1105-1111.
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  107. Mustafa, M.R. and F.I. Achike, 2000. Dicentrine is preferentially antagonistic to rat aortic than splenic alpha 1-adrenoceptor stimulation. Acta Pharmacol. Sin., 21: 1165-1168.
  108. Othma, I., A.R. Fathilah, J.M. Saad, M.M. Yusof, M.R. Mustaffa and N. Azila, 1996. Studies on the venomous coelenterate: Rhopilema hispidum. J. Nat. Toxins, 5: 361-375.
  109. Orchard, C.H., M.R. Mustafa and E. White, 1995. Oscillations and waves of intracellular [Ca2+] in cardiac muscle cells. Chaos Solitons Fractals, 5: 447-458.
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  110. Mustafa, M.R., E. White, K. Hongo, I. Othman and C.H. Orchard, 1995. The mechanism underlying the cardiotoxic effect of the toxin from the jellyfish Chironex fleckeri. Toxicol. Applied Pharmacol., 133: 196-206.
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  111. Mustafa, M., R. Mohamad, L. Din and S. Wahid, 1995. Smooth muscle relaxant activities of compounds isolated from Malaysian medicinal plants on rat aorta and guinea‐pig ileum. Phytotherapy Res., 9: 555-558.
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