Dr. Uma  Devi M. Palanisamy
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Dr. Uma Devi M. Palanisamy

Associate Professor
Monash University, Malaysia


Highest Degree
Ph.D. in Biochemistry from University of Cambridge, UK

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Biography

Uma completed her undergraduate degree in Biochemistry and furthered to obtain an MPhil from the University of Malaya. She pursued her PhD at Cambridge on the design of affinity ligands to purify biopharmaceuticals. While in the UK she won several awards including the Roche Young Investigators award and Queens` Award for Technological Advancement. Prior to joining academia, she was in a research institute for a period of 15 years, where she carried out extensive work to aid Natural Product Research in Malaysia. She has developed a range of expertise which includes both in vitro and in vivo techniques to establish mechanism of actions, bioassay-guided purification of phytochemicals, bioavailability and toxicology studies of natural plant compounds. Her current research interest are in bioactive phytochemicals that ameliorate metabolic syndrome symptoms.

Area of Interest:

Pharmacology and Toxicology
100%
Metabolic Syndrome
62%
Nutraceuticals
90%
Bioactives
75%
Drug Discovery
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Tan, B.H., N. Ahemad, Y. Pan, U.D. Palanisamy, I. Othman, B.C. Yiap and C.E. Ong, 2018. Cytochrome P450 2C9-natural antiarthritic interactions: Evaluation of inhibition magnitude and prediction from in vitro data. Biopharmaceut. Drug Dispos., (In Press). 10.1002/bdd.2127.
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  2. Dong, A.N., Y. Pan, U.D. Palanisamy, B.C. Yiap, N. Ahemad and C.E. Ong, 2018. Site-directed mutagenesis of cytochrome P450 2D6 and 2C19 enzymes: Expression and spectral characterization of naturally occurring allelic variants. Applied Biochem. Biotechnol., (In Press). 10.1007/s12010-018-2728-0.
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  3. Chung, A.P., S. Gurtu, S. Chakravarthi, M. Moorthy and U.D. Palanisamy, 2018. Geraniin protects high-fat diet-induced oxidative stress in Sprague Dawley rats. Front. Nutr., Vol. 5. 10.3389/fnut.2018.00017.
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  4. Arumugam, B., U.R. Kuppusamy, C.K. Heng and U.D. Palanisamy, 2018. Studies on the Effects of Chemical Constituents from Syzygium malaccense on Diabetes Mellitus and its Related Complications. In: Recent Progress in Medicinal Plants, Volume 46: Metabolic Disorder Diabetes, Part II, Govil, J.N. and S. Kumar (Eds.). Chapter 14, Studium Press LLC, USA., ISBN-10: 1626990832.
  5. Tee, L.H., B. Yang, B.T. Tey, E.S. Chan and A. Azlan et al., 2017. Valorization of Dacryodes rostrata fruit through the characterization of its oil. Food Chem., 235: 257-264.
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  6. Rehman, I.U., D.B.C. Wu, S.M.P. Lai, U.D. Palanisamy, L.S. Kun and T.M. Khan, 2017. Translation of the 5D itching scale from English to Malay and its validation among patients with chronic kidney disease in Malaysia. Front. Med., Vol. 4. 10.3389/fmed.2017.00189.
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  7. Kanathasan, J.S., V. Swamy, U.D. Palanisamy and A.K.G. Radhakrishnan, 2017. Legumain targeting peptide conjugated fluorescent porous silicon nanoparticles for breast cancer imaging. Adv. Sci. Technol., 102: 45-50.
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  8. Jacob, S.A., U.D. Palanisamy and C.M.C. Chung, 2017. Perception of a privilege walk activity and its impact on pharmacy students' views on social justice in a service learning elective: A pilot study. J. Pharm. Pract. Res., 47: 449-456.
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  9. Aisyah, A.A.S., U.D. Palanisamy, B.A. Tejo, M.F. Chew, H.W. Tham and S.S. Hassan, 2017. Geraniin extracted from the rind of Nephelium lappaceum binds to dengue virus type-2 envelope protein and inhibits early stage of virus replication. Virol. J., Vol. 14. 10.1186/s12985-017-0895-1.
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  10. Ser, H.L., U.D. Palanisamy, W.F. Yin, K.G. Chan, B.H. Goh and L.H. Lee, 2016. Streptomyces malaysiense sp. nov.: A novel Malaysian mangrove soil actinobacterium with antioxidative activity and cytotoxic potential against human cancer cell lines. Scient. Rep., Vol. 6. 10.1038/srep24247.
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  11. Ser, H.L., L.T.H. Tan, U.D. Palanisamy, S.N. Abd Malek and W.F. Yin et al., 2016. Streptomyces antioxidans sp. nov., a novel mangrove soil actinobacterium with antioxidative and neuroprotective potentials. Front. Microbiol., Vol. 7. 10.3389/fmicb.2016.00899.
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  12. Ser, H.L., J.W.F. Law, N. Chaiyakunapruk, S.A. Jacob and U.D. Palanisamy et al., 2016. Fermentation conditions that affect clavulanic acid production in Streptomyces clavuligerus: A systematic review. Front. Microbiol., Vol. 7. 10.3389/fmicb.2016.00522.
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  13. Jacob, S.A., J.R. Chin, T.Y. Qi and U.D. Palanisamy, 2016. The needs of the deaf and hard of hearing when seeking pharmaceutical care. Res. Social Admin. Pharm., 12: 664-665.
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  14. Arumugam, B., U.D. Palanisamy, K.H. Chua and U.R. Kuppusamy, 2016. Potential antihyperglycaemic effect of myricetin derivatives from Syzygium malaccense. J. Funct. Foods, 22: 325-336.
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  15. Subramania, S., A. Radhakrish, S. Chakravart, U.D. Palanisamy and N. Haleagraha, 2015. Antihyperglycemic effects of nephelium lappaceum rind extract in high fat-induced diabetic rats. Int. J. Pharmacol., 11: 542-551.
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  16. Ser, H.L., U.D. Palanisamy, W.F. Yin, S.N. Abd Malek, K.G. Chan, B.H. Goh and L.H. Lee, 2015. Presence of antioxidative agent, Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro- in newly isolated Streptomyces mangrovisoli sp. nov. Front. Microbiol., Vol. 6. 10.3389/fmicb.2015.00854.
    CrossRef  |  PubMed  |  Direct Link  |  
  17. Ser, H.L., N. Zainal, U.D. Palanisamy, B.H. Goh, W.F. Yin, K.G. Chan and L.H. Lee, 2015. Streptomyces gilvigriseus sp. nov., a novel actinobacterium isolated from mangrove forest soil. Antonie Van Leeuwenhoek, 107: 1369-1378.
    CrossRef  |  PubMed  |  
  18. Perera, A., S.H. Ton and D.V. Palanisamy, 2015. Perspectives on Geraniin, a multifunctional natural bioactive compound. Trends Food Sci. Technol., 44: 243-257.
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  19. Palanisamy, U.D., M. Sivanathan, T. Subramaniam, A.K. Radhakrishnan, N. Haleagrahara, U. Sundralingam and G.S. Chiew, 2015. Refining ostrich oil and its stabilization with curcumin. J. Nutr. Health Food Eng., Vol. 2. .
    Direct Link  |  
  20. Palanisamy, U.D. and T. Manaharan, 2015. Syzygium aqueum leaf extracts for possible antidiabetic treatment. Acta Horticult. 10.17660/ActaHortic.2015.1098.1.
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  21. Gaddam, A., C. Galla, S. Thummisetti, R.K. Marikanty, U.D. Palanisamy and P.V. Rao, 2015. Role of Fenugreek in the prevention of type 2 diabetes mellitus in prediabetes. J. Diabetes Metabol. Disorders, 14: 1-10.
    CrossRef  |  PubMed  |  
  22. Elendran,S., L.W. Wand, R. Prankerd and U.D. Palanisamy, 2015. The physicochemical properties of geraniin, a potential antihyperglycemic agent. Pharmaceut. Biol., 53: 1719-1726.
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  23. Palanisamy, U.D., T. Manaharan and T. Masilami, 2014. Anti-hyperglycemic agents from tropical plant extracts. Acta Hortcult., 1040: 231-233.
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  24. Palanisamy, U.D., 2014. Plants as effective agents in treating diabetes and its complications. J. Nutr. Health Food Sci., 1: 1-2.
    CrossRef  |  
  25. Manaharan, T., S. Chakravarthi, A.K. Radhakrishnan and U.D. Palanisamy, 2014. In vivo toxicity evaluation of a standardized extract of Syzygium aqueum leaf. Toxicol. Rep., 1: 718-725.
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  26. Chung, A.Y.S., S. Gurtu, T.S. Ha and U.D. Palanisamy, 2014. Geraniin ameliorates metabolic risks in high-fat diet-induced obese sprague dawley rats. J. Funct. Foods, 9: 173-182.
  27. Arumugam, B., T. Manaharan, K.H. Chua, U.R. Kuppusamy and U.D. Palanisamy, 2014. Antioxidant and antiglycemic potentials of a standardized extract of Syzygium malaccense. LWT-Food Sci. Technol., 59: 707-712.
    CrossRef  |  Direct Link  |  
  28. Manaharan, T., C.H. Ming and U.D. Palanisamy, 2013. Syzygium aqueum leaf extract and its bioactive compounds enhances pre-adipocyte differentiation and 2-NBDG uptake in 3T3-L1 cells. Food Chem., 136: 354-363.
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  29. Subramaniam, S., S. Chakravarthi, U.D. Palanisamy, A. Radhakrishnan and N. Haleagrahara, 2012. Acute and sub chronic oral toxicity assessment of the Ethanolic extract from the rind of Nephelium lappaceum in rats. J. Pharmacol. Toxicol., 7: 378-385.
    Direct Link  |  
  30. Perera, A., D. Appleton, L.H. Ying, S. Elendran and U.D. Palanisamy, 2012. Large scale purification of geraniin from Nephelium lappaceum rind waste using reverse-phase chromatography. Separat. Purif. Technol., 98: 145-149.
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  31. Manaharan, T., U.D. Palanisamy and C.H. Ming, 2012. Tropical plant extracts as potential antihyperglycemic agents. Molecules, 17: 5915-5923.
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  32. Manaharan, T., D. Appleton, H.M. Cheng and U.D. Palanisamy, 2012. Flavonoids isolated from Syzygium aqueum leaf extract as potential antihyperglycaemic agents. Food Chem., 132: 1802-1807.
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  33. Ling, L.T., Y. Saito, U.D. Palanisamy, H.M. Cheng and N. Noguchi, 2012. Cytoprotective effects of geraniin against peroxynitrite- and peroxyl radical-induced cell death via free radical scavenging activity. Food Chem., 132: 1899-1907.
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  34. Ling, L.T. and U.D. Palanisamy, 2012. Review: Potential Antioxidants from Tropical Plants. In: Food Industrial Processes-Methods and Equipment, Valdez, B. (Ed.). InTech Publisher, Rijeka, Croatia, ISBN-13: 9789533079059, pp: 63-74.
  35. Kumar, S., S. Chakravarthi, G.S. Chiew, T. Subramaniam, U.D. Palanisamy, A. Radhakrishnan and N. Haleagrahara, 2012. Protective effects of Nephelium lappaceum rind extract against Collagen-induced arthritis in dark agouti rats. J. Biol. Sci., 12: 385-392.
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  36. Palanisamy, U.D., S. Muniswaran, A.K. Radhakrishnan, H.S. Nagaraja, T. Subramaniam and G.S. Chiew, 2011. Optimizing ostrich oil bleaching technique. Molecules, 16: 5709-5719.
  37. Palanisamy, U.D., L.T. Ling, T. Manaharan, V. Sivapalan, T. Subramaniam, M.H. Helme and T. Masilamani, 2011. Standardized extract of Syzygium aqueum: A safe cosmetic ingredient. Int. J. Cosmetic Sci., 33: 269-275.
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  38. Palanisamy, U.D., L.T. Ling, T. Manaharan and D. Appleton, 2011. Rapid isolation of geraniin from Nephelium lappaceum rind waste and its anti-hyperglycemic activity. Food Chem., 127: 21-27.
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  39. Palanisamy, U., T. Manaharan, L.L. Teng, A.K.C. Radhakrishnan, T. Subramaniam and M. Masilamani, 2011. Rambutan rind in the management of hyperglycemia. Food Res. Int., 44: 2278-2282.
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  40. Nathan, F.M., V.A. Singh, A. Dhanoa and U.D. Palanisamy, 2011. Oxidative stress and antioxidant status in primary bone and soft tissue sarcoma. BMC Cancer, Vol. 11. 10.1186/1471-2407-11-382.
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  41. Manaharan, T., L.L. Teng, D. Appleton, C.H. Ming, T. Masilamani and U.D. Palanisamy, 2011. Antioxidant and antiglycemic potential of Peltophorum pterocarpum plant parts. Food Chem., 129: 1355-1361.
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  42. Hashim, P., H. Sidek, M.H.M. Helan, A. Sabery, U.D. Palanisamy and M. Ilham, 2011. Triterpene composition and bioactivities of Centella asiatica. Molecules, 16: 1310-1322.
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  43. Ling, L.T., U.D. Palanisamy and H.M. Cheng, 2010. Prooxidant/antioxidant ratio (ProAntidex) as a better index of net free radical scavenging potential. Molecules, 15: 7884-7892.
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  44. Ling, L.T., A.K. Radhakrishnan, T. Subramaniam, H.M. Cheng and U.D. Palanisamy, 2010. Assessment of antioxidant capacity and cytotoxicity of selected Malaysian plants. Molecules, 15: 2139-2151.
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