Dr. Celia R. Carlini
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Dr. Celia R. Carlini

Senior Researcher
Pontifical Catholic University of Rio Grande do Sul, Brazil

Highest Degree
Ph.D. in Molecular Biology from Universidade de Sao Paulo, Brazil

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Area of Interest:

Biomedical Sciences
100%
Molecualar Biology
62%
Platelet Biology
90%
Chromatography
75%
Biochemistry
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Menegassi, A., R. da Silva e Silva, C.R. Carlini, A. Mithofer and A.B. Becker-Ritt, 2018. Analysis of herbivore stress- and phytohormone-mediated urease expression in soybean (Glycine max). J. Plant Growth Regul., 37: 419-425.
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  2. Carrazoni, T., C. Nguyen, L.F. Maciel, A. Delgado-Canedo and B.A. Stewart et al., 2018. Jack bean urease modulates neurotransmitter release at insect neuromuscular junctions. Pestic. Biochem. Physiol., 146: 63-70.
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  3. Yilamujiang, A., A. Zhu, R. Ligabue-Braun, S. Bartram and C.P. Witte et al., 2017. Coprophagous features in carnivorous Nepenthes plants: A task for ureases. Scient. Rep., Vol. 7. 10.1038/s41598-017-11999-z.
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  4. Scopel-Guerra, A., D. Olivera-Severo, F. Staniscuaski, A.F. Uberti and N. Callai-Silva et al., 2017. The impact of Helicobacter pylori urease upon platelets and consequent contributions to inflammation. Front. Microbiol., Vol. 8. 10.3389/fmicb.2017.02447.
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  5. Rechenmacher, C., B. Wiebke-Strohm, L.A. de Oliveira-Busatt, J.C. Polacco, C.R. Carlini and M.H. Bodanese-Zanettini, 2017. Effect of soybean ureases on seed germination and plant development. Genet. Mol. Biol., 40: 209-216.
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  6. Olivera-Severo, D., A.F. Uberti, M.S. Marques, M.T. Pinto and M. Gomez-Lazaro et al., 2017. A new role for Helicobacter pylori urease: Contributions to angiogenesis. Front. Microbiol., Vol. 8. 10.3389/fmicb.2017.01883.
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  7. Moyetta, N.R., V. Broll, A.P.A. Perin, A.F. Uberti and M.V.C. Grahl et al., 2017. Jaburetox-induced toxic effects on the hemocytes of Rhodnius prolixus (Hemiptera: Reduviidae). Comp. Biochem. Physiol. Part C: Toxicol. Pharmacol., 200: 17-26.
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  8. Martinelli, A.H., F.C. Lopes, V. Broll, M.S. Defferrari and R. Ligabue-Braun et al., 2017. Soybean ubiquitous urease with purification facilitator: An addition to the moonlighting studies toolbox. Process Biochem., 53: 245-258.
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  9. Grossi-de-Sa, M.F., P.B. Pelegrini, I.M. Vasconcelos, C.R. Carlini and M.S. Silva, 2017. Entomotoxic Plant Proteins: Potential Molecules to Develop Genetically Modified Plants Resistant to Insect-Pests. In: Plant Toxins, Gopalakrishnakone, P., C.R. Carlini and R. Ligabue-Braun (Eds.). Springer, Netherlands, ISBN: 978-94-007-6728-7, pp: 415-447.
  10. Fruttero, L.L., N.R. Moyetta, M.S. Krug, V. Broll and M.V.C. Grahl et al., 2017. Jaburetox affects gene expression and enzyme activities in Rhodnius prolixus, a Chagas' disease vector. Acta Trop., 168: 54-63.
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  11. Broll, V., A.H.S. Martinelli, F.C. Lopes, L.L. Fruttero and B. Zambelli et al., 2017. Structural analysis of the interaction between Jaburetox, an intrinsically disordered protein and membrane models. Colloids Surf. B: Biointerfaces, 159: 849-860.
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  12. Becker-Ritt, A.B., C.S. Portugal and C.R. Carlini, 2017. Jaburetox: Update on a urease-derived peptide. J. Venomous Anim. Toxins Incl. Trop. Dis., Vol. 23. 10.1186/s40409-017-0122-y.
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  13. Wiebke-Strohm, B., R. Ligabue-Braun, C. Rechenmacher, L.A. de Oliveira-Busatto, C.R. Carlini and M.H. Bodanese-Zanettini, 2016. Structural and transcriptional characterization of a novel member of the soybean urease gene family. Plant Physiol. Biochem., 101: 96-104.
    CrossRef  |  Direct Link  |  
  14. Nunes, M.L., C.R. Carlini, D. Marinowic, F.K. Neto and H.H. Fiori et al., 2016. Microcephaly and Zika virus: A clinical and epidemiological analysis of the current outbreak in Brazil. J. Pediatr., 92: 230-240.
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  15. Micheletto, Y.M.S., C.F. Moro, F.C. Lopes, R. Ligabue-Braun and A.H.S. Martinelli et al., 2016. Interaction of jack bean (Canavalia ensiformis) urease and a derived peptide with lipid vesicles. Colloids Surf. B: Biointerfaces, 145: 576-585.
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  16. Fruttero, L.L., N.R. Moyetta, A.F. Uberti, M.V.C. Grahl and F.C. Lopes et al., 2016. Humoral and cellular immune responses induced by the urease-derived peptide Jaburetox in the model organism Rhodnius prolixus. Parasites Vectors, Vol. 9. 10.1186/s13071-016-1710-3.
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  17. Carrazoni, T., M. de Avila Heberle, A.P.A. Perin, A.P. Zanatta and P.V. Rodrigues et al., 2016. Central and peripheral neurotoxicity induced by the Jack Bean Urease (JBU) in Nauphoeta cinerea cockroaches. Toxicology, 368: 162-171.
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  18. Carlini, C.R. and R. Ligabue-Braun, 2016. Ureases as multifunctional toxic proteins: A review. Toxicon, 110: 90-109.
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  19. Lopes, F.C., O. Dobrovolska, R. Real-Guerra, V. Broll and B. Zambelli et al., 2015. Pliable natural biocide: Jaburetox is an intrinsically disordered insecticidal and fungicidal polypeptide derived from jack bean urease. FEBS J., 282: 1043-1064.
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  20. Ligabue-Braun, R. and C.R. Carlini, 2015. Poisonous birds: A timely review. Toxicon, 99: 102-108.
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  21. Ligabue-Braun, R. and C.R. Carlini, 2015. Moonlighting Toxins: Ureases and Beyond. In: Plant Toxins, Gopalakrishnakone, P., C.R. Carlini and R. Ligabue-Braun (Eds.). Springer, Netherlands, ISBN: 978-94-007-6728-7, pp: 199-219.
  22. Galvani, G.L., L.L. Fruttero, M.F. Coronel, S. Nowicki and D.R. Demartini et al., 2015. Effect of the urease-derived peptide Jaburetox on the central nervous system of Triatoma infestans (Insecta: Heteroptera). Biochim. Biophys. Acta (BBA)-Gen. Subj., 1850: 255-262.
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  23. Feder, V., L. Kmetzsch, C.C. Staats, N. Vidal-Figueiredo, R. Ligabue-Braun, C.R. Carlini and M.H. Vainstein, 2015. Cryptococcus gattii urease as a virulence factor and the relevance of enzymatic activity in cryptococcosis pathogenesis. FEBS J., 282: 1406-1418.
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  24. Vargas, L.R.B. and C.R. Carlini, 2014. Insecticidal and Antifungal Activities of Ribosome-Inactivating Proteins. In: Ribosome-Inactivating Proteins: Ricin and Related Proteins, Stirpe, F. and D. Lappi (Eds.). Chapter 14, John Wiley & Sons, USA., ISBN-13: 9781118847015, pp: 212-222.
  25. Piovesan, A.R., A.H. Martinelli, R. Ligabue-Braun, J.L. Schwartz and C.R. Carlini, 2014. Canavalia ensiformis urease, Jaburetox and derived peptides form ion channels in planar lipid bilayers. Arch. Biochem. Biophys., 547: 6-17.
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  26. Oliveira, J.T., J.H. Araujo-Filho, T.B. Grangeiro, D.M. Gondim and J. Segalin et al., 2014. Enhanced synthesis of antioxidant enzymes, defense proteins and leghemoglobin in rhizobium-free cowpea roots after challenging with Meloydogine incognita. Proteomes, 2: 527-549.
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  27. Oliveira, G.B., D. Kunz, T.V. Peres, R.B. Leal and A.F. Uchoa et al., 2014. Variant vicilins from a resistant Vigna unguiculata lineage (IT81D-1053) accumulate inside Callosobruchus maculatus larval midgut epithelium. Comp. Biochem. Physiol. Part B: Biochem. Mol. Biol., 168: 45-52.
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  28. Medeiros-Silva, M., W.L. Franck, M.P. Borba, S.B. Pizzato and K.N. Strodtman et al., 2014. Soybean ureases, but not that of Bradyrhizobium japonicum, are involved in the process of soybean root nodulation. J. Agric. Food Chem., 62: 3517-3524.
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  29. Martinelli, A.H., K. Kappaun, R. Ligabue-Braun, M.S. Defferrari and A.R. Piovesan et al., 2014. Structure-function studies on jaburetox, a recombinant insecticidal peptide derived from jack bean (Canavalia ensiformis) urease. Biochim. Biophys. Acta (BBA)-Gen. Subj., 1840: 935-944.
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  30. Gondim, D.M.F., I.M. Vasconcelos, F.B.M.B. Moreno, A.C.O. Monteiro-Moreira and J.H. Araujo-Filho et al., 2014. 2D-PAGE of cashew stem coupled to LC ESI Q-TOF MS/MS reveals abundance of antioxidant enzymes and heat shock proteins, compatible with the crop adaptation to the semi-arid conditions of tropical countries. J. Anal. Bioanal. Tech., Vol. S6. 10.4172/2155-9872.S6-004.
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  31. Fruttero, L.L., D.R. Demartini, E.R. Rubiolo, C.R. Carlini and L.E. Canavoso, 2014. β-chain of ATP synthase as a lipophorin binding protein and its role in lipid transfer in the midgut of Panstrongylus megistus (Hemiptera: Reduviidae). Insect Biochem. Mol. Biol., 52: 1-12.
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  32. Demartini, D.R., L.P. Schilling, J.C. da Costa and C.R. Carlini, 2014. Alzheimer's and Parkinson's diseases: An environmental proteomic point of view. J. Proteomics, 104: 24-36.
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  33. Defferrari, M.S., R. da Silva, I. Orchard and C.R. Carlini, 2014. Jack bean (Canavalia ensiformis) urease induces eicosanoid-modulated hemocyte aggregation in the Chagas' disease vector Rhodnius prolixus. Toxicon, 82: 18-25.
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  34. Defferrari, M.S., D.H. Lee, C.L. Fernandes, I. Orchard and C.R. Carlini, 2014. A phospholipase A2 gene is linked to Jack bean urease toxicity in the Chagas' disease vector Rhodnius prolixus. Biochim. Biophys. Acta (BBA)-Gen. Subj., 1840: 396-405.
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  35. Uberti, A.F., D. Olivera-Severo, G.E. Wassermann, A. Scopel-Guerra and J.A. Moraes et al., 2013. Pro-inflammatory properties and neutrophil activation by Helicobacter pylori urease. Toxicon, 69: 240-249.
    CrossRef  |  Direct Link  |  
  36. Staniscuaski, F., J.P. Paluzzi, R. Real-Guerra, C.R. Carlini and I. Orchard, 2013. Expression analysis and molecular characterization of aquaporins in Rhodnius prolixus. J. Insect Physiol., 59: 1140-1150.
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  37. Real-Guerra, R., F. Staniscuaski and C.R. Carlini, 2013. Soybean Urease: Over a Hundred Years of Knowledge. In: A Comprehensive Survey of International Soybean Research: Genetics, Physiology, Agronomy and Nitrogen Relationships, Board, J. (Ed.). Chapter 15, InTech Publ., Rijeka, Croatia, ISBN: 978-953-51-0876-4, pp: 1505-1543.
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  38. Real-Guerra, R., C.R. Carlini and F. Staniscuaski, 2013. Role of lysine and acidic amino acid residues on the insecticidal activity of Jackbean urease. Toxicon, 71: 76-83.
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  39. Ligabue-Braun, R., R. Real-Guerra, C.R. Carlini and H. Verli, 2013. Evidence-based docking of the urease activation complex. J. Biomol. Struct. Dyn., 31: 854-861.
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  40. Ligabue-Braun, R., F.C. Andreis, H. Verli and C.R. Carlini, 2013. 3-to-1: Unraveling structural transitions in ureases. Naturwissenschaften, 100: 459-467.
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  41. Demartini, D.R., G. Pasquali and C.R. Carlini, 2013. An overview of proteomics approaches applied to biopharmaceuticals and cyclotides research. J. Proteomics, 93: 224-233.
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  42. Wiebke-Strohm, B., G. Pasquali, M. Margis-Pinheiro, M. Bencke and L. Bucker-Neto et al., 2012. Ubiquitous urease affects soybean susceptibility to fungi. Plant Mol. Biol., 79: 75-87.
    CrossRef  |  Direct Link  |  
  43. Staniscuaski, F. and C.R. Carlini, 2012. Plant ureases and related peptides: Understanding their entomotoxic properties. Toxins, 4: 55-67.
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  44. Silva, F.D.A., I.M. Vasconcelos, M.D.P. Lobo, P.G. de Castro and V.G. Magalhaes et al., 2012. Biochemical, physicochemical and molecular characterization of a genuine 2-Cys-peroxiredoxin purified from cowpea [Vigna unguiculata (L.) Walpers] leaves. Biochim. Biophys. Acta (BBA)-Gen. Subj., 1820: 1128-1140.
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  45. Salvadori, J.D.M., M.S. Defferrari, R. Ligabue-Braun, E.Y. Lau, J.R. Salvadori and C.R. Carlini, 2012. Characterization of entomopathogenic nematodes and symbiotic bacteria active against Spodoptera frugiperda (Lepidoptera: Noctuidae) and contribution of bacterial urease to the insecticidal effect. Biol. Control, 63: 253-263.
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  46. Real-Guerra, R., F. Staniscuaski, B. Zambelli, F. Musiani, S. Ciurli and C.R. Carlini, 2012. Biochemical and structural studies on native and recombinant Glycine max UreG: A detailed characterization of a plant urease accessory protein. Plant Mol. Biol., 78: 461-475.
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  47. Postal, M., A.H. Martinelli, A.B. Becker-Ritt, R. Ligabue-Braun and D.R. Demartini et al., 2012. Antifungal properties of Canavalia ensiformis urease and derived peptides. Peptides, 38: 22-32.
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  48. Paluzzi, J.P.V., P. Young, M.S. Defferrari, I. Orchard, C.R. Carlini and M.J. O'Donnell, 2012. Investigation of the potential involvement of eicosanoid metabolites in anti-diuretic hormone signaling in Rhodnius prolixus. Peptides, 34: 127-134.
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  49. Ligabue-Braun, R., H. Verli and C.R. Carlini, 2012. Venomous mammals: A review. Toxicon, 59: 680-695.
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  50. Becker-Ritt, A.B. and C.R. Carlini, 2012. Fungitoxic and insecticidal plant polypeptides. Pept. Sci., 98: 367-384.
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  51. Settembrini, B.P., D. de Pasquale, M. Postal, P.M. Pinto, C.R. Carlini and M.J. Villar, 2011. Distribution and characterization of Corazonin in the central nervous system of Triatoma infestans (Insecta: Heteroptera). Peptides, 32: 461-468.
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  52. Santi, L., L.A.D. e Silva, W.O.B. da Silva, A.P.F. Correa and D.E.N. Rangel et al., 2011. Virulence of the entomopathogenic fungus Metarhizium anisopliae using soybean oil formulation for control of the cotton stainer bug, Dysdercus peruvianus. World J. Microbiol. Biotechnol., 27: 2297-2303.
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  53. Mulinari, F., A.B. Becker-Ritt, D.R. Demartini, R. Ligabue-Braun and F. Staniscuaski et al., 2011. Characterization of JBURE-IIb isoform of Canavalia ensiformis (L.) DC urease. Biochim. Biophys. Acta (BBA)-Proteins Proteomics, 1814: 1758-1768.
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  54. Demartini, D.R., C.R. Carlini and J.J. Thelen, 2011. Proteome databases and other online resources for chloroplast research in Arabidopsis. Methods Mol. Biol., 775: 93-115.
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  55. Demartini, D.R., C.R. Carlini and J.J. Thelen, 2011. Global and targeted proteomics in developing jack bean (Canavalia ensiformis) seedlings: An investigation of urease isoforms mobilization in early stages of development. Plant Mol. Biol., 75: 53-65.
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  56. Defferrari, M.S., D.R. Demartini, T.B. Marcelino, P.M. Pinto and C.R. Carlini, 2011. Insecticidal effect of Canavalia ensiformis major urease on nymphs of the milkweed bug Oncopeltus fasciatus and characterization of digestive peptidases. Insect Biochem. Mol. Biol., 41: 388-399.
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  57. Alexandre, D., R.T. Linhares, B. Queiroz, L. Fontoura and A.F. Uchoa et al., 2011. Vicilin-derived peptides are transferred from males to females as seminal nuptial gift in the seed-feeding beetle Callosobruchus maculatus. J. Insect Physiol., 57: 801-808.
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  58. Aguirre, S.A., L.L. Fruttero, J. Leyria, M.S. Defferrari and P.M. Pinto et al., 2011. Biochemical changes in the transition from vitellogenesis to follicular atresia in the hematophagous Dipetalogaster maxima (Hemiptera: Reduviidae). Insect Biochem. Mol. Biol., 41: 832-841.
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  59. Wassermann, G.E., D. Olivera‐Severo, A.F. Uberti and C.R. Carlini, 2010. Helicobacter pylori urease activates blood platelets through a lipoxygenase‐mediated pathway. J. Cell. Mol. Med., 14: 2025-2034.
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  60. Staniscuaski, F., V. Te Brugge, C.R. Carlini and I. Orchard, 2010. Jack bean urease alters serotonin-induced effects on Rhodnius prolixus anterior midgut. J. Insect Physiol., 56: 1078-1086.
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  61. Oliveira, H.D., D.O. Sousa, J.T. Oliveira, C.R. Carlini and H.P. Oliveira et al., 2010. Gm-TX, a new toxic protein from soybean (Glycine max) seeds with potential for controlling insect pests. Process Biochem., 45: 634-640.
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  62. Nakasu, E.Y., A.A. Firmino, S.C. Dias, T.L. Rocha and H.B. Ramos et al., 2010. Analysis of Cry8Ka5-binding proteins from Anthonomus grandis (Coleoptera: Curculionidae) midgut. J. Invertebr. Pathol., 104: 227-230.
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  63. De Lima, M.E., C.L. Fortes-Dias, C.R. Carlini and J.A. Guimaraes, 2010. Toxinology in Brazil: A big challenge for a rich biodiversity. Toxicon, 56: 1084-1091.
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  64. Staniscuaski, F., V. Te Brugge, C.R. Carlini and I. Orchard, 2009. In vitro effect of Canavalia ensiformis urease and the derived peptide Jaburetox-2Ec on Rhodnius prolixus Malpighian tubules. J. Insect Physiol., 55: 255-263.
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  65. Bertholdo-Vargas, L.R., J.N. Martins, D. Bordin, M. Salvador and A.E. Schafer et al., 2009. Type 1 ribosome-inactivating proteins-Entomotoxic, oxidative and genotoxic action on Anticarsia gemmatalis (Hubner) and Spodoptera frugiperda (J.E. Smith) (Lepidoptera: Noctuidae). J. Insect Physiol., 55: 51-58.
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  66. Barros, P.R., H. Stassen, M.S. Freitas, C.R. Carlini, M.A. Nascimento and C. Follmer, 2009. Membrane-disruptive properties of the bioinsecticide Jaburetox-2Ec: Implications to the mechanism of the action of insecticidal peptides derived from ureases. Biochim. Biophys. Acta (BBA)-Proteins Proteomics, 1794: 1848-1854.
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  67. Vasconcelos, I.M., J.K.S. Morais, E.A. Siebra, C.R. Carlini and D.O.B. Sousa et al., 2008. SBTX, a new toxic protein distinct from soyatoxin and other toxic soybean [Glycine max] proteins and its inhibitory effect on Cercospora sojina growth. Toxicon, 51: 952-963.
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  68. Rosa, T.D., G.E. Wassermann, C.F.V. de Souza, D. Caron, C.R. Carlini and M.A.Z. Ayub, 2008. Microbiological and physicochemical characteristics and aminopeptidase activities during ripening of Serrano cheese. Int. J. Dairy Technol., 61: 70-79.
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  69. Piovesan, A.R., F. Staniscuaski, J. Marco-Salvadori, R. Real-Guerra, M.S. Defferrari and C.R. Carlini, 2008. Stage-specific gut proteinases of the cotton stainer bug Dysdercus peruvianus: Role in the release of entomotoxic peptides from Canavalia ensiformis urease. Insect Biochem. Mol. Biol., 38: 1023-1032.
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  70. Menegassi, A., G.E. Wassermann, D. Olivera-Severo, A.B. Becker-Ritt, A.H.S. Martinelli, V. Feder and C.R. Carlini, 2008. Urease from cotton (Gossypium hirsutum) seeds: Isolation, physicochemical characterization and antifungal properties of the protein. J. Agric. Food Chem., 56: 4399-4405.
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  71. Lubeck, I., W. Arruda, B.K. Souza, F. Staniscuaski, C.R. Carlini, A. Schrank and M.H. Vainstein, 2008. Evaluation of Metarhizium anisopliae strains as potential biocontrol agents of the tick Rhipicephalus (Boophilus) microplus and the cotton stainer Dysdercus peruvianus. Fungal Ecol., 1: 78-88.
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  72. Carlini, C.R. and J.C. Polacco, 2008. Toxic properties of urease. Crop Sci., 48: 1665-1672.
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  73. Tomazetto, G., F. Mulinari, F. Stanisçuaski, B. Settembrini, C.R. Carlini and M.A.Z. Ayub, 2007. Expression kinetics and plasmid stability of recombinant E. coli encoding urease-derived peptide with bioinsecticide activity. Enzyme Microb. Technol., 41: 821-827.
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  74. Ramos, M.V., C.D. Freitas, F. Staniscuaski, L.L. Macedo, M.P. Sales, D.P. Sousa and C.R. Carlini, 2007. Performance of distinct crop pests reared on diets enriched with latex proteins from Calotropis procera: Role of laticifer proteins in plant defense. Plant Sci., 173: 349-357.
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  75. Mulinari, F., F. Staniscuaski, L.R. Bertholdo-Vargas, M. Postal and O.B. Oliveira-Neto et al., 2007. Jaburetox-2Ec: An insecticidal peptide derived from an isoform of urease from the plant Canavalia ensiformis. Peptides, 28: 2042-2050.
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  76. Demartini, D.R., A. Wlodawer and C.R. Carlini, 2007. A comparative study of the expression of serine proteinases in quiescent seeds and in developing Canavalia ensiformis plants. J. Exp. Bot., 58: 521-532.
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  77. Becker-Ritt, A.B., A.H.S. Martinelli, S. Mitidieri, V. Feder and G.E. Wassermann et al., 2007. Antifungal activity of plant and bacterial ureases. Toxicon, 50: 971-983.
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  78. Olivera-Severo, D., G.E. Wassermann and C.R. Carlini, 2006. Ureases display biological effects independent of enzymatic activity: Is there a connection to diseases caused by urease-producing bacteria? Braz. J. Med. Biol. Res., 39: 851-861.
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  79. Olivera-Severo, D., G.E. Wassermann and C.R. Carlini, 2006. Bacillus pasteurii urease shares with plant ureases the ability to induce aggregation of blood platelets. Arch. Biochem. Biophys., 452: 149-155.
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  80. Staniscuaski, F., C.T. Ferreira-DaSilva, F. Mulinari, M. Pires-Alves and C.R. Carlini, 2005. Insecticidal effects of canatoxin on the cotton stainer bug Dysdercus peruvianus (Hemiptera: Pyrrhocoridae). Toxicon, 45: 753-760.
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  81. Follmer, C. and C.R. Carlini, 2005. Effect of chemical modification of histidines on the copper-induced oligomerization of jack bean urease (EC 3.5.1.5). Arch. Biochem. Biophys., 435: 15-20.
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  82. Guimaraes, J.A. and C.R. Carlini, 2004. Most cited papers in toxicon. Toxicon, 44: 345-359.
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  83. Follmer, C., R. Real-Guerra, G.E. Wasserman, D. Olivera-Severo and C.R. Carlini, 2004. Jackbean, soybean and Bacillus pasteurii ureases: Biological effects unrelated to ureolytic activity. FEBS J., 271: 1357-1363.
    CrossRef  |  Direct Link  |  
  84. Follmer, C., G.E. Wassermann and C.R. Carlini, 2004. Separation of jack bean (Canavalia ensiformis) urease isoforms by immobilized metal affinity chromatography and characterization of insecticidal properties unrelated to ureolytic activity. Plant Sci., 167: 241-246.
    CrossRef  |  Direct Link  |  
  85. Follmer, C., F.V. Pereira, N.P. da Silveira and C.R. Carlini, 2004. Jack bean urease (EC 3.5.1.5) aggregation monitored by dynamic and static light scattering. Biophys. Chem., 111: 79-87.
    CrossRef  |  Direct Link  |  
  86. Becker-Ritt, A.B., F. Mulinari, I.M. Vasconcelos and C.R. Carlini, 2004. Antinutritional and/or toxic factors in soybean (Glycine max (L) Merril) seeds: Comparison of different cultivars adapted to the Southern region of Brazil. J. Sci. Food Agric., 84: 263-270.
    CrossRef  |  Direct Link  |  
  87. Pires-Alves, M., M.F. Grossi-de-Sa, G.B. Barcellos, C.R. Carlini and M.G. Moraes, 2003. Characterization and expression of a novel member (JBURE-II) of the urease gene family from jackbean [Canavalia ensiformis (L.) DC]. Plant Cell Physiol., 44: 139-145.
    CrossRef  |  Direct Link  |  
  88. Follmer, C., C.R. Carlini, M.L. Yoneama and J.F. Dias, 2002. PIXE analysis of urease isoenzymes isolated from Canavalia ensiformis (jack bean) seeds. Nucl. Instrum. Methods Phys. Res. Sect. B: Beam Interact. Mater. Atoms, 189: 482-486.
    CrossRef  |  Direct Link  |  
  89. Carlini, C.R. and M.F. Grossi-de-Sa, 2002. Plant toxic proteins with insecticidal properties. A review on their potentialities as bioinsecticides. Toxicon, 40: 1515-1539.
    CrossRef  |  Direct Link  |  
  90. Vasconcelos, I.M., A.A. Maia, E.A. Siebra, J.T. Oliveira and A.F.F.U. Carvalho et al., 2001. Nutritional study of two Brazilian soybean (Glycine max) cultivars differing in the contents of antinutritional and toxic proteins. J. Nutr. Biochem., 12: 55-62.
    CrossRef  |  Direct Link  |  
  91. Follmer, C., G.B. Barcellos, R.B. Zingali, O.L. Machado and E.W. Alves et al., 2001. Canatoxin, a toxic protein from jack beans (Canavalia ensiformis), is a variant form of urease (EC 3.5.1.5): Biological effects of urease independent of its ureolytic activity. Biochem. J., 360: 217-224.
    Direct Link  |  
  92. Francischetti, I.M., M.E. Gombarovits, J.G. Valenzuela, C.R. Carlini and J.A. Guimaraes, 2000. Intraspecific variation in the venoms of the South American rattlesnake (Crotalus durissus terrificus). Comp. Biochem. Physiol. Part C: Pharmacol. Toxicol. Endocrinol., 127: 23-36.
    CrossRef  |  Direct Link  |  
  93. Ferreira-DaSilva, C.T., M.E.C. Gombarovits, H. Masuda, C.M. Oliveira and C.R. Carlini, 2000. Proteolytic activation of canatoxin, a plant toxic protein, by insect cathepsin-like enzymes. Arch. Insect Biochem. Physiol., 44: 162-171.
    Direct Link  |  
  94. Oliveira, A.E.A., V.M. Gomes, M.P. Sales, K.V.S. Fernandes, C.R. Carlini and J. Xavier-Filho, 1999. The toxicity of jack bean [Canavalia ensiformis (L.) DC.] canatoxin to plant pathogenic fungi. Rev. Bras. Biol., 59: 59-62.
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  95. Udedible, A.B.I. and C.R. Carlini, 1998. Crack and cook: A simple and quick process for elimination of concanavalin A (Con A) from Canavalia seeds. Anim. Feeds Sci. Technol., 74: 179-184.
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  96. Udedibie, A.B.I. and C.R. Carlini, 1998. Brazilian Mucuna pruriens seeds (Velvet bean) lack hemagglutinating activity. J. Agric. Food Chem., 46: 1450-1452.
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  97. Udedibie, A.B.I. and C.R. Carlin, 1998. Questions and answers to edibility problem of Canavalia ensiformic seeds. Rev. Anim. Feed Sci. Technol., 74: 95-106.
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  98. Monteiro, R.Q., N. Yamanouye, C.R. Carlini, J.A. Guimaraes, C. Bon and R.B. Zingali, 1998. Variability of bothrojaracin isoforms and other venom principles in individual jararaca (Bothrops jararaca) snakes maintained under seasonally invariant conditions. Toxicon, 36: 153-163.
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  99. Monteiro, R.Q., D.L.S. Dutra, O.L.T. Machado, C.R. Carlini, J.A. Guimaraes, C. Bon and R.B. Zingali, 1998. Bothrops jararaca snakes produce several bothrojaracin isoforms following an individual pattern. Comp. Biochem. Physiol. Part B: Biochem. Mol. Biol., 120: 791-798.
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  100. Francischetti, I.M.B., C.R. Carlini and J.A. Guimaraes, 1998. Human platelets activation by convulxin is accompanied by tyrosyl-phosphorylation of PLCγ2 and occurs independently of integrin αIIbβ3. Platelets, 9: 185-189.
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  101. Francischetti, I.M., H.C. Castro, R.B. Zingali, C.R. Carlini and J.A. Guimaraes, 1998. Bothrops sp. snake venoms: Comparison of some biochemical and physicochemical properties and interference in platelet functions. Comp. Biochem. Physiol. Part C: Pharmacol. Toxicol. Endocrinol., 119: 21-29.
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  102. Francischetti, I.M., F.A. Ghazaleh, R.A. Reis, C.R. Carlini and J.A. Guimaraes, 1998. Convulxin induces platelet activation by a tyrosine-kinase-dependent pathway and stimulates tyrosine phosphorylation of platelet proteins, including PLCγ2, independently of integrin αIIbβ3. Arch. Biochem. Biophys., 353: 239-250.
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  103. Francischetti, I.M., C.R. Carlini and J.A. Guimaraes, 1998. cAMP does not inhibit convulxin-induced tyrosyl-phosphorylation of human platelet proteins, including PLCγ2, but completely blocks the integrin αIIbβ3-dependent dephosphorylation step: Comparisons with RGDS peptide, cytochalasin D and phenylarsine oxide. Arch. Biochem. Biophys., 354: 255-262.
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  104. Monteiro, R.Q., C.R. Carlini, J.A. Guimaraes, C. Bon and R.B. Zingali, 1997. Distinct bothrojaracin isoforms produced by individual jararaca (Bothrops jararaca) snakes. Toxicon, 35: 649-657.
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  105. Ghazaleh, F.A., I.M. Francischetti, M.E.C. Gombarovits and C.R. Carlini, 1997. Stimulation of calcium influx and platelet activation by canatoxin: Methoxyverapamil inhibition and downregulation by cGMP. Arch. Biochem. Biophys., 339: 362-367.
    CrossRef  |  Direct Link  |  
  106. Fuly, A.L., O.L. Machado, E.W. Alves and C.R. Carlini, 1997. Mechanism of inhibitory action on platelet activation of a phospholipase A2 isolated from Lachesis muta (Bushmaster) snake venom. Thrombosis Haemostasis, 78: 1372-1380.
    PubMed  |  Direct Link  |  
  107. Francischetti, I.M., B. Saliou, M. Leduc, C.R. Carlini and M. Hatmi et al., 1997. Convulxin, a potent platelet-aggregating protein from Crotalus durissus terrificus venom, specifically binds to platelets. Toxicon, 35: 1217-1228.
    CrossRef  |  PubMed  |  
  108. Carlini, C.R., A.E. Oliveira, P. Azambuja, J. Xavier-Filho and M.A. Wells, 1997. Biological effects of canatoxin in different insect models: Evidence for a proteolytic activation of the toxin by insect cathepsinlike enzymes. J. Econ. Entomol., 90: 340-348.
    CrossRef  |  Direct Link  |  
  109. Carlini, C.R. and A.B. Udedibie, 1997. Comparative effects of processing methods on hemagglutinating and antitryptic activities of Canavalia ensiformis and Canavalia braziliensis seeds. J. Agric. Food Chem., 45: 4372-4377.
    CrossRef  |  Direct Link  |  
  110. Vasconcelos, I.M., A. Trentim, J.A. Guimaraes and C.R. Carlini, 1994. Purification and physicochemical characterization of soyatoxin, a novel toxic protein isolated from soybeans (Glycine max). Arch. Biochem. Biophys., 312: 357-366.
    CrossRef  |  Direct Link  |  
  111. Sato, A., G.B. Barcellos, E.C. Riedel, J.A. Carneiro, C.R. Carlini and M.A. Esquibel, 1993. The presence of concanavalin A and canatoxin in Canavalia ensiformis DC tissue culture. Plant Cell Rep., 12: 233-236.
    CrossRef  |  Direct Link  |  
  112. Machado, O.L., A.L. Oliveira-Carvalho, R.B. Zingali and C.R. Carlini, 1993. Purification, physicochemical characterization and N-terminal-amino acid sequence of a phospholipase A2 from Bothrops jararaca venom. Braz. J. Med. Biol. Res., 26: 163-166.
    PubMed  |  Direct Link  |  
  113. Fuly, A.L., I.M. Francischetti, R.B. Zingali and C.R. Carlini, 1993. Partial purification and some physicochemical properties of phospholipases A2 from the venom of the bushmaster snake (Lachesis muta). Braz. J. Med. Biol. Res., 26: 459-463.
    PubMed  |  Direct Link  |  
  114. Barcellos, G.B., L.M. Almeida, R.A. Moreira, B.S. Cavada, J.T. de Oliveira and C.R. Carlini, 1993. Canatoxin-, concanavalin A- and canavalin-cross-reactive materials during maturation of Canavalia brasiliensis (Mart.) seeds. Planta, 189: 397-402.
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  115. Ghazaleh, F.A., C.F. Araujo, C. Barja-Fidalgo and C.R. Carlini, 1992. Canatoxin induces activation on mice peritoneal macrophages. Braz. J. Med. Biol. Res., 25: 1033-1035.
    PubMed  |  Direct Link  |  
  116. Benjamin, C.F., C.R. Carlini and C. Barja-Fidalgo, 1992. Pharmacological characterization of rat paw edema induced by canatoxin, the toxic protein from Canavalia ensiformis (jack bean) seeds. Toxicon, 30: 879-885.
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  117. Barja-Fidalgo, C., C.R. Carlini, J.A. Guimaraes, C.A. Flores, F.Q. Cunha and S.H. Ferreira, 1992. Role of resident macrophages in canatoxin-induced in vivo neutrophil migration. Inflammation, 16: 1-12.
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  118. Alves, E.W., A.T. da Silva Ferreira, C.T. da Silva Ferreira and C.R. Carlini, 1992. Effects of canatoxin on the Ca2+-ATPase of sarcoplasmic reticulum membranes. Toxicon, 30: 1411-1418.
    CrossRef  |  Direct Link  |  
  119. Carlini, C.R. and J.A. Guimaraes, 1991. Plant and microbial toxic proteins as hemilectins: Emphasis on canatoxin. Toxicon, 29: 791-806.
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  120. Campos, M.M., C.R. Carlini, J.A. Guimaraes, V.M. Marques-Silva and V.M. Rumjanek, 1991. Effect of canatoxin on cell cultures. Cell Biol. Int. Rep., 15: 581-594.
    CrossRef  |  Direct Link  |  
  121. Barja-Fidalgo, C., J.A. Guimaraes and C.R. Carlini, 1991. Lipoxygenase-mediated secretory effect of canatoxin the toxic protein from Canavalia ensiformis seeds. Toxicon, 29: 453-459.
    CrossRef  |  Direct Link  |  
  122. Barja-Fidalgo, C., J.A. Guimaraes and C.R. Carlini, 1991. Canatoxin, a plant protein, induces insulin release from isolated pancreatic islets. Endocrinology, 128: 675-679.
    CrossRef  |  Direct Link  |  
  123. Zingali, R.B., G.R. Carlini, I.M. Francischetti and J.A. Gulmaraes, 1990. Bothrops jararaca snake venom: Effects on platelet aggregation. Thrombosis Res., 58: 303-316.
    PubMed  |  Direct Link  |  
  124. Ribeiro-DaSilva, G., R. Pires-Barbosa, J.F. Prado and C.R. Carlini, 1989. Convulsions induced by canatoxin in rats are probably a consequence of hypoxia. Braz. J. Med. Biol. Res., 22: 877-880.
    PubMed  |  Direct Link  |  
  125. Ribeiro-DaSilva, G., R. Pires-Barbosa and C.R. Carlini, 1989. Effect of canatoxin on the circulating levels of gonadotropins and prolactin in rats. Braz. J. Med. Biol. Res., 22: 387-395.
    PubMed  |  Direct Link  |  
  126. Ribeiro-DaSilva, G., C.B. Collares, D.M. Grassi, J.F. Prado, A. Zappellini and C.R. Carlini, 1989. Alterations in rat carbohydrate metabolism induced by canatoxin as a probable consequence of primary hypoxia. Braz. J. Med. Biol. Res., 22: 1405-1413.
    PubMed  |  Direct Link  |  
  127. Zingali, R.B., I.M. Francischetti, C.R. Carlini and J.A. Guimaraes, 1988. Biochemical and pharmacological screening of snake (Bothrops) venoms: Characterization of components acting on blood coagulation and platelet aggregation. Braz. J. Med. Biol. Res., 21: 763-765.
    PubMed  |  Direct Link  |  
  128. Carlini, C.R., G.B. Barcellos, A.D. Baeta-Neves and J.A. Guimaraes, 1988. Immunoreactivity for canatoxin and concanavalin A among proteins of leguminous seeds. Phytochemistry, 27: 25-30.
    CrossRef  |  Direct Link  |  
  129. Barja-Fidalgo, C., J.A. Guimaraes and C.R. Carlini, 1988. The secretory effect of canatoxin on rat brain synaptosomes involves a lipoxygenase-mediated pathway. Braz. J. Med. Biol. Res., 21: 549-552.
    PubMed  |  
  130. Ribeiro-DaSilva, G., C.R. Carlini, R. Pires-Barbosa and J.A. Guimaraes, 1986. Blood glucose alterations induced in rats by canatoxin, a protein isolated from jack bean (Canavalia ensiformis) seeds. Toxicon, 24: 775-782.
    CrossRef  |  Direct Link  |  
  131. Carlini, C.R., J.A. Guimaraes and J.M.C. Ribeiro, 1985. Platelet release reaction and aggregation induced by canatoxin, a convulsant protein: Evidence for the involvement of the platelet lipoxygenase pathway. Br. J. Pharmacol., 84: 551-560.
    CrossRef  |  Direct Link  |  
  132. Carlini, C.R., C. Gomes, J.A. Guimaraes, R.P. Markus, H. Sato and G. Trolin, 1984. Central nervous effects of the convulsant protein canatoxin. Basic Clin. Pharmacol. Toxicol., 54: 161-166.
    CrossRef  |  Direct Link  |  
  133. Carlini, C.R. and J.A. Guimaraes, 1981. Isolation and characterization of a toxic protein from Canavalia ensiformis (jack bean) seeds, distinct from concanavalin A. Toxicon, 19: 667-675.
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