Dr. Clotilde Castaldo
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Dr. Clotilde Castaldo

Research Scientist, Assistant Professor
University of Naples Federico II, Italy

Highest Degree
M.D. in Medicine and Surgery from University of Naples Federico II, Italy

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Area of Interest:

Biomedical Sciences
100%
Pharmaceutical Research
62%
Surgical Pathology
90%
Stem Cell
75%
Medicine
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Sirico, F., S. Miressi, C. Castaldo, R. Spera, S. Montagnani, F. Meglio and D. Nurzynska, 2018. Habits and beliefs related to food supplements: Results of a survey among Italian students of different education fields and levels. PloS One, Vol. 13, No. 1. 10.1371/journal.pone.0191424.
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  2. Iaconetta, G., D. Solari, A. Villa, C. Castaldo and R.M. Gerardi et al., 2018. The Hypoglossal Nerve: Anatomical study of its entire course. World neurosurg.,` 109: e486-e492.
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  3. Sirico, F., F. Ricca, F. DI Meglio, D. Nurzynska, C. Castaldo, R. Spera and S. Montagnani, 2017. Local corticosteroid versus autologous blood injections in lateral epicondylitis: meta-analysis of randomized controlled trials. Eur. J. Phys. Rehabil. Med., 53: 483-491.
    CrossRef  |  Direct Link  |  
  4. Pagano, F., F. Angelini, C. Castaldo, V. Picchio and E. Messina et al., 2017. Normal versus pathological cardiac fibroblast-derived extracellular matrix differentially modulates cardiosphere-derived cell paracrine properties and commitment. Stem. Cells Int., 2017: 1-9.
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  5. Di Meglio, F., D. Nurzynska, V. Romano, R. Miraglia and I. Belviso et al., 2017. Optimization of Human Myocardium Decellularization Method for the construction of Implantable patches. Tissue Eng. Part C Methods, 23: 525-539.
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  6. Puzzo, D., R. Raiteri, C. Castaldo, R. Capasso and E. Pagano et al., 2016. CL316,243, a β3-adrenergic receptor agonist, induces muscle hypertrophy and increased strength. Sci. Rep., 10.1038/srep37504 (2016).
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  7. Nappi, F., M. Fraldi, C. Spadaccio, A.R. Carotenuto and S. Montagnani et al., 2016. Biomechanics drive histological wall remodeling of neoaortic root: A mathematical model to study the expression levels of ki 67, metalloprotease, and apoptosis transition. J. Biomed. Mater. Res. A., 104: 2785-2793.
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  8. Nappi, F., C. Spadaccio, C. Castaldo, F. Di Meglio and D. Nurzynska et al., 2014. Reinforcement of the pulmonary artery autograft with a polyglactin and polydioxanone mesh in the Ross operation: experimental study in growing lamb. J. Heart Valve Dis., 23: 145-148.
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  9. Chiono, V., P. Mozetic, M. Boffito, S. Sartori and E. Gioffredi et al., 2014. Polyurethane-based scaffolds for myocardial tissue engineering. Interface Focus., 10.1098/rsfs.2013.0045..
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  10. Postiglione, L., L. De Santo, G. Di Spigna, C. Castaldo and G. Guerra et al., 2013. Cardiac remodeling in postischemic end-stage human hearts: Involvement of extracellular matrix and angiogenesis-related molecules. World J. Cardiovasc Dis., 3: 91-99.
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  11. Nurzynska, D., P.l. Maria-Elena, C. Castaldo, P. Muller-Best and F. Di Meglio, 2013. Application of biotechnology in myocardial regeneration-tissue engineering triad: cells, scaffolds, and signaling molecules. Bio. Med. Res. Int., 2013: 1-3.
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  12. Nurzynska, D., F. Di Meglio, V. Romano, R. Miraglia and A.M. Sacco et al., 2013. Cardiac primitive cells become committed to a cardiac fate in adult human heart with chronic ischemic disease but fail to acquire mature phenotype: genetic and phenotypic study. Basic Res. Cardiol., 108: 320-320.
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  13. Locci, M., G. Nazzaro, M. Miranda, E. Salzano, S. Montagnani, C. Castaldo and G. De Placido, 2013. Vaginal lactoferrin in asymptomatic patients at low risk for pre-term labour for shortened cervix: cervical length and interleukin-6 changes. J. Obstet Gynaecol., 33: 144-148.
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  14. Castaldo, C., F. Di Meglio, R. Miraglia, A.M. Sacco and V. Romano et al., 2013. Cardiac fibroblast-derived extracellular matrix (biomatrix) as a model for the studies of cardiac primitive cell biological properties in normal and pathological adult human heart. Biomed. Res. Int., 10.1155/2013/352370.
    CrossRef  |  Direct Link  |  
  15. Nurzynska, D., F. Di Meglio, C. Castaldo, F. Latino and V. Romano et al., 2012. Flatfoot in children: Anatomy of decision making. Ital. J. Anat. Embryol., 117: 98-106.
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  16. Nurzynska, D., C. Castaldo, S. Montagnani and F. Di Meglio, 2012. Cardiac Progenitor and Stem Cell Biology and Therapy. In: Progenitor and Stem Cell Technologies and Therapies, Atala, A. (Ed.)., Woodhead Publishing Limited, Cambridge, pp: 418-442.
  17. Di Meglio, F., D. Nurzynska, C. Castaldo, R. Miraglia and V. Romanoet al., 2012. Cardiac shock wave therapy: Assessment of safety and new insights into mechanisms of tissue regeneration. J. Cell Mol. Med., 16: 936-942.
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  18. Di Meglio, F., C. Castaldo, D. Nurzynska, V. Romano, R. Miraglia and S. Montagnani, 2010. Epicardial cells are missing from the surface of hearts with ischemic cardiomyopathy: a useful clue about the self-renewal potential of the adult human heart? Int. J. Cardiol., 145: e44-e46.
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  19. Di Meglio, F., C. Castaldo, D. Nurzynska, V. Romano and R. Miraglia et al., 2010. Epithelial-mesenchymal transition of epicardial mesothelium is a source of cardiac CD117-positive stem cells in adult human heart. J Mol Cell Cardiol. 49: 719-727.
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  20. Di Meglio, F., C. Castaldo, D. Nurzynska, R. Miraglia and V. Romano et al., 2010. Localization and origin of cardiac CD117-positive cells: identification of a population of epicardially-derived cells in adult human heart. Ital. J. Anat. Embryol., 115: 71-78.
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  21. Nurzynska, D., F. Di Meglio, C. Castaldo, A. Arcucci and E. Marlinghaus et al., 2008. Shock waves activate in vitro cultured progenitors and precursors of cardiac cell lineages from the human heart. Ultrasound Med. Biol., 34: 334-342.
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  22. Corte, A.D., C. Quarto, C. Bancone, C. Castaldo and F. Di Meglio et al., 2008. Spatiotemporal patterns of smooth muscle cell changes in ascending aortic dilatation with bicuspid and tricuspid aortic valve stenosis: Focus on cell-matrix signaling. J. Thorac. Cardiovasc. Surg., 135: 8-18.
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  23. Castaldo, M.D., F. Di Meglio, D. Nurzynska, G. Romano and C. Maiello et al., 2008. CD117-positive cells in adult human heart are localized in the subepicardium, and their activation is associated with laminin-1 and α6 integrin expression. 1723–1731 Stem Cells,: 1723-1731.
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  24. Di Meglio, F., D. Nurzynska, C. Castaldo, S. Russo, B. Corrado, E.M. Corrado and S. Montagnani, 2007. Shock waves hit cardiac muscle: Extracorporeal cardiac shock wave therapy proves safe and beneficial in patients with chronic ischemic heart disease. ISMST Newslettter, 3: 10-11.
  25. Di Meglio, F., D. Nurzynska, C. Castaldo, A. Arcucci and L. De Santo et al., 2007. In vitro cultured progenitors and precursors of cardiac cell lineages from human normal and post-ischemic hearts. Eur. J. Histochem., 51: 275-282.
    PubMed  |  Direct Link  |  
  26. Postiglione, L., S. Montagnani, P. Ladogana, C. Castaldo and G. Di Spigna et al., 2006. Granulocyte Macrophage-Colony Stimulating Factor receptor expression on human cardiomyocytes from end-stage heart failure patients. Eur. J. Heart Fail., 8: 564-567.
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  27. Postiglione, L., P. Ladogana, S. Montagnani, G. di Spigna and C. Castaldo et al., 2005. Effect of granulocyte macrophage-colony stimulating factor on extracellular matrix deposition by dermal fibroblasts from patients with scleroderma. J. Rheumatol., 32: 656-664.
    PubMed  |  Direct Link  |  
  28. Linke, A., P. Müller, D. Nurzynska, C. Casarsa and D. Torella et al., 2005. Stem cells in the dog heart are self-renewing, clonogenic, and multipotent and regenerate infarcted myocardium, improving cardiac function. Proc. Natl. Acad. Sci. USA., 102: 8966-8971.
    CrossRef  |  Direct Link  |  
  29. Cotrufo, M., De L. Santo, A.D. Corte, F. Di Meglio and G. Guerra et al., 2005. Basal lamina structural alterations in human asymmetric aneurismatic aorta. Eur. J. Histochem., 49: 363-370.
    PubMed  |  Direct Link  |  
  30. Cotrufo, M., A.D. Corte, L.S. De Santo, C. Quarto andM. De Feo et al., 2005. Different patterns of extracellular matrix protein expression in the convexity and the concavity of the dilated aorta with bicuspid aortic valve: preliminary results. J. Thorac. Cardiovasc. Surg., 130: 504-511.
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  31. Kajstura, J., A. Leri, C. Castaldo, B. Nadal-Ginard and P. Anversa, 2004. Myocyte growth in the failing heart. Surg. Clin. N Am., 84: 161-177.
    CrossRef  |  Direct Link  |  
  32. Urbanek, K., F. Quaini, G. Tasca, D. Torella and C. Castaldo et al., 2003. Intense myocyte formation from cardiac stem cells in human cardiac hypertrophy. Proc. Natl. Acad. Sci. USA, 100: 10440-10445.
  33. Postiglione, L., G.D. Domenico, S. Montagnani, G.D. Spigna and S. Salzano et al., 2003. Granulocyte-macrophage colony-stimulating factor (GM-CSF) induces the osteoblastic differentiation of the human osteosarcoma cell line SaOS-2. Calcif. Tissue Int., 72: 85-97.
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  34. Postiglione, L., G. Di Domenico, G. Giordano-Lanza, P. Ladogana, M. Turano and C. Castaldo, 2003. Effect of human granulocyte macrophage-colony stimulating factor on differentiation and apoptosis of the human osteosarcoma cell line SaOS-2. Eur. J. Histochem., 47: 309-316.
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  35. Postiglione, L., S. Montagnani, A. Riccio, N. Montuori and S. Sciorio et al., 2002. Enhanced expression of the receptor for granulocyte macrophage colony stimulating factor on dermal fibroblasts from scleroderma patients. J. Rheumatol., 29: 94-101.
    PubMed  |  Direct Link  |  
  36. Montagnani, S., L. Postiglione, G. Giordano-Lanza, F.D. Meglio and C. Castaldo et al., 2001. Granulocyte macrophage colony stimulating factor (GM-CSF) biological actions on human dermal fibroblasts. Eur. J. Histochem., 45: 219-228.
    PubMed  |  Direct Link  |  
  37. Montagnani, S., C. Castaldo, F. Di Meglio, S. Sciorio and G. Giordano-Lanza, 2000. Extra cellular matrix features in human meninges. Ital. J. Anat. Embryol., 105: 167-177.
    PubMed  |  Direct Link  |