Dr. Manuel Campos Toimil
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Dr. Manuel Campos Toimil

Professor
University of Santiago de Compostela, Spain

Highest Degree
PostDoc. in Pharmacology from University Louis Pasteur, Strasbourg, France

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Area of Interest:

Pharmacology and Toxicology
100%
Pharma Nutrition
62%
Drug Delivery
90%
Pharmaceutical Sciences
75%
Toxicologic Pathology
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Munin, J., E. Quezada, M. Campos-Toimil, E. Cano, E. Uriarte and D. Vina, 2017. Synthesis and vasorelaxant and antiplatelet activities of a new series of (4-benzylphthalazin-1-ylamino) alcohol derivatives. Med. Chem. Res., 26: 1682-1688.
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  2. Leal, M.A., A.T. Dias, M.L. Porto, B.F. Brun and A.L. Gava et al., 2017. Sildenafil (Viagra®) prevents Cox-1/TXA2 pathway-mediated vascular hypercontractility in ApoE-/- mice. Cell. Physiol. Biochem., 44: 1796-1809.
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  3. Garcia-Morales, V., M. Luaces-Regueira and M. Campos-Toimil, 2017. The cAMP effectors PKA and Epac activate endothelial NO synthase through PI3K/Akt pathway in human endothelial cells. Biochem. Pharmacol., 145: 94-101.
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  4. Garcia-Morales, V., J. Friedrich, L.M. Jorna, M. Campos-Toimil, H.P. Hammes, M. Schmidt and G. Krenning, 2017. The microRNA-7-mediated reduction in EPAC-1 contributes to vascular endothelial permeability and eNOS uncoupling in murine experimental retinopathy. Acta Diabetol., 54: 581-591.
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  5. Segade, M., R. Bermejo, A. Silva, F. Paiva-Martins, J. Gil-Longo and M. Campos-Toimil, 2016. Involvement of endothelium in the vasorelaxant effects of 3,4-DHPEA-EA and 3,4-DHPEA-EDA, two major functional bioactives in olive oil. J. Funct. Foods, 23: 637-646.
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  6. Cuinas, A., V. Garcia-Morales, D. Vina, J. Gil-Longo and M. Campos-Toimil, 2016. Activation of PKA and Epac proteins by cyclic AMP depletes intracellular calcium stores and reduces calcium availability for vasoconstriction. Life Sci., 155: 102-109.
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  7. Munin, J., E. Quezada, A. Cuinas, M. Campos-Toimil, E. Uriarte, L. Santana and D. Vina, 2014. Synthesis, biological evaluation and structure-activity relationships of new phthalazinedione derivatives with vasorelaxant activity. Eur. J. Med. Chem., 82: 407-417.
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  8. Garcia-Morales, V., A. Cuinas, J. Elies and M. Campos-Toimil, 2014. PKA and Epac activation mediates cAMP-induced vasorelaxation by increasing endothelial NO production. Vasc. Pharmacol., 60: 95-101.
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  9. Elies, J., A. Cuinas, D.A. MacDougall, J. Leiro and M. Campos-Toimil, 2013. Trans-resveratrol down-regulates caveolin-1, up-regulates endothelial NO synthase and reduces their interaction in vascular smooth muscle and endothelial cells. Food Biosci., 1: 31-38.
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  10. Cuinas, A., J. Elies, F. Orallo and M. Campos-Toimil, 2013. Cyclic AMP relaxation of rat aortic smooth muscle is mediated in part by decrease of depletion of intracellular Ca2+ stores and inhibition of capacitative calcium entry. Vasc. Pharmacol., 58: 98-104.
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  11. Yanez, M., J. Gil-Longo and M. Campos-Toimil, 2012. Calcium Binding Proteins. In: Calcium Signaling, Islam, M.S. (Ed.). Springer, Dordrecht, Netherlands, ISBN: 978-94-007-2888-2, pp: 461-482.
  12. Elies, J., A. Cuinas, V. Garcia‐Morales, F. Orallo and M. Campos-Toimil, 2011. Trans-resveratrol simultaneously increases cytoplasmic Ca2+ levels and nitric oxide release in human endothelial cells. Mol. Nutr. Food Res., 55: 1237-1248.
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  13. Quezada, E., G. Delogu, C. Picciau, L. Santana and G. Podda et al., 2010. Synthesis and vasorelaxant and platelet antiaggregatory activities of a new series of 6-halo-3-phenylcoumarins. Molecules, 15: 270-279.
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  14. Campos-Toimil, M., T. Keravis, F. Orallo, K. Takeda and C. Lugnier, 2008. Short-term or long-term treatments with a Phosphodiesterase-4 (PDE4) inhibitor result in opposing agonist-induced Ca2+ responses in endothelial cells. Br. J. Pharmacol., 154: 82-92.
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  15. Pickett, J.A., M. Campos-Toimil, P. Thomas and J.M. Edwardson, 2007. Identification of SNAREs that mediate zymogen granule exocytosis. Biochem. Biophys. Res. Commun., 359: 599-603.
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  16. Campos-Toimil, M., J. Elies, E. Alvarez, I. Verde and F. Orallo, 2007. Effects of trans- and cis-resveratrol on Ca2+ handling in A7r5 vascular myocytes. Eur. J. Pharmacol., 577: 91-99.
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  17. Campos-Toimil, M. and F. Orallo, 2007. Effects of (−)-epigallocatechin-3-gallate in Ca2+-permeable non-selective cation channels and voltage-operated Ca2+ channels in vascular smooth muscle cells. Life Sci., 80: 2147-2153.
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  18. Thomas, P., T. Bagrij, M. Campos-Toimil and J.M. Edwardson, 2006. Mitochondria play a critical role in shaping the exocytotic response of rat pancreatic acinar cells. Cell Calcium, 39: 57-63.
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  19. Alvarez, E., M. Campos-Toimil, H. Justiniano-Basaran, C. Lugnier and F. Orallo, 2006. Study of the mechanisms involved in the vasorelaxation induced by (−)-epigallocatechin-3-gallate in rat aorta. Br. J. Pharmacol., 147: 269-280.
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  20. Campos-Toimil, M., J. Elies and F. Orallo, 2005. Trans- and cis-resveratrol increase cytoplasmic calcium levels in A7r5 vascular smooth muscle cells. Mol. Nutr. Food Res., 49: 396-404.
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  21. Alvarez-Castro, E., M. Campos-Toimil and F. Orallo, 2004. (−)-Epigallocatechin-3-gallate induces contraction of the rat aorta by a calcium influx-dependent mechanism. Naunyn-Schmiedeberg's Arch. Pharmacol., 369: 496-506.
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  22. Campos-Toimil, M., T. Bagrij, J.M. Edwardson and P. Thomas, 2002. Two modes of secretion in pancreatic acinar cells: Involvement of phosphatidylinositol 3-kinase and regulation by capacitative Ca2+ entry. Curr. Biol., 12: 211-215.
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  23. Campos-Toimil, M., J.M. Edwardson and P. Thomas, 2002. Acetylcholine-induced zymogen granule exocytosis: Comparison between acini and single pancreatic acinar cells. Pancreas, 24: 179-183.
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  24. Campos-Toimil, M., F. Orallo, L. Santana and E. Uriarte, 2002. Synthesis and vasorelaxant activity of new coumarin and furocoumarin derivatives. Bioorg. Med. Chem. Lett., 12: 783-786.
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  25. Scherberich, A., M. Campos-Toimil, P. Ronde, K. Takeda and A. Beretz, 2000. Migration of human vascular smooth muscle cells involves serum-dependent repeated cytosolic calcium transients. J. Cell Sci., 113: 653-662.
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  26. Orallo, F., E. Rosa, T. Garcia-Ferreiro, M. Campos-Toimil, M.I. Cadavid and M.I. Loza, 2000. Cardiovascular effects of ketanserin on normotensive rats in vivo and in vitro. Gen. Pharmacol.: Vasc. Syst., 35: 95-105.
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  27. Campos-Toimil, M., J.M. Edwardson and P. Thomas, 2000. Real-time studies of zymogen granule exocytosis in intact rat pancreatic acinar cells. J. Physiol., 528: 317-326.
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  28. Campos-Toimil, M., C. Lugnier, M.T. Droy-Lefaix and K. Takeda, 2000. Inhibition of type 4 phosphodiesterase by rolipram and Ginkgo biloba extract (EGb 761) decreases agonist-induced rises in internal calcium in human endothelial cells. Arterioscler. Thromb. Vasc. Biol., 20: e34-e40.
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  29. Campos-Toimil, M., C. Lugnier and K. Takeda, 2000. Inhibition of agonist-induced rises in internal calcium in human endothelial cells by Ginkgo biloba extract (EGb 761) and rolipram. Rev. Fed. Argentina Cardiol., 29: 361-365.
  30. Arranz, E., J.A. Diaz, S. Vega, M. Campos-Toimil and F. Orallo et al., 2000. Synthesis and pharmacological evaluationof 2,3-dihydro-3-oxo-4H-thieno[3,4-e][1,2,4]thiadiazine 1,1-dioxidesas voltage-dependent calcium channel blockers. Eur. J. Med. Chem., 35: 751-759.
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  31. Campos-Toimil, M., I. Estevez, E. Ravina and F. Orallo, 1998. Pyridazine derivatives XIV. Study of the vasorelaxant action of 6-aryl-5-piperidino-3-hydrazinopyridazines in isolated rat thoracic aorta: Comparison with hydralazine. Gen. Pharmacol.: Vasc. Syst., 30: 201-207.
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  32. Orallo, F., A.F. Alzueta, M. Campos-Toimil and J.M. Calleja, 1995. Study of the in vivo and in vitro cardiovascular effects of (+)-glaucine and N-carbethoxysecoglaucine in rats. Br. J. Pharmacol., 114: 1419-1427.
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  33. Moina, M.J., B. Bardan, M.C. Toimil, A.F. Alzueta, J. Gil-Longo and F. Orallo, 1994. Effects of hydralazine on contractile responses to α1 and α2-adrenoceptor agonists in isolated rubbed rat aorta. Gen. Pharmacol.: Vasc. Syst., 25: 165-172.
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  34. Campos-Toimil, M., F. Orallo, J. Gil-Longo, I. Verde, I. Loza and A. Fernandez-Alzueta, 1994. Pharmacological study of several effects of hydralazine in the bisected rat vas deferens. Eur. J. Pharmacol., 251: 83-90.
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  35. Orallo, F., A.F. Alzueta, M.I. Loza, N. Vivas and A. Badia et al., 1993. Study of the mechanism of the relaxant action of (+)-glaucine in rat vas deferens. Br. J. Pharmacol., 110: 943-948.
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  36. Orallo, F., J.A. Fontenla, M.I. Loza, M. Campos and J.M. Calleja, 1992. Effect of urethane on hydralazine-induced tachycardia in rats. Gen. Pharmacol., 23: 1143-1147.
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  37. Orallo, F., I. Verde, M.I. Loza, A.F. Alzueta, M. Campos and M. Freire-Garabal, 1992. Effects of platelet activating factor on contractions and Ca influx induced by noradrenaline and potassium in rat rubbed and intact aorta. Comparison with Its hypotensive effect in anaesthetized normotensive rats. J. Pharm. Pharmacol., 44: 344-348.
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  38. Gil-Longo, J., F. Orallo, I. Verde, M. Campos and J. Calleja, 1992. Role of the endothelial system in Bay K 8644 enantiomer and nifedipine vasomodulator action in rat aorta. Eur. J. Pharmacol., 221: 1-8.
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