Dr. Theofilos M. Kolettis
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Dr. Theofilos M. Kolettis

Professor
University of Ioannina, Greece

Highest Degree
Doctorate in Cardiology from Athens University, Greece

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Area of Interest:

Biomedical Sciences
100%
Cardiology Research
62%
Medical Hypotheses
90%
Heart Blood Circulation
75%
Electrophysiology
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Kolettis, T.M., M. Barton, D. Langleben and Y. Matsumura, 2013. Endothelin in coronary artery disease and myocardial infarction. Cardiol. Rev., 21: 249-256.
    PubMed  |  
  2. Kolettis, T.M., 2013. Coronary artery disease and ventricular tachyarrhythmia: Pathophysiology and treatment. Curr. Opin. Pharmacol., 13: 210-217.
    CrossRef  |  PubMed  |  
  3. Kolentinis, M.K., I.I. Verginadis, Y.V. Simos, N. Tsitou, S.C. Karkabounas, T.M. Kolettis and A.M. Evangelou, 2013. Cardiovascular effects of vanillylmandelic acid in rats. Eur. J. Pharmacol., 703: 46-52.
    CrossRef  |  PubMed  |  
  4. Vlahos, A.P., F.P. Koutsouka, N.D. Papamichael, A. Makis and G.G. Baltogiannis et al., 2012. Determinants of pulmonary hypertension in patients with Beta-thalassemia major and normal ventricular function. Acta Haematol., 128: 124-129.
    CrossRef  |  
  5. Megalou, A.J., C. Glava, A.D. Vilaeti, D.L. Oikonomidis and G.G. Baltogiannis et al., 2012. Transforming growth factor-L inhibition and endothelin receptor blockade in rats with monocrotaline-induced pulmonary hypertension. Pulm Circ., 2: 461-469.
    CrossRef  |  PubMed  |  
  6. Kolettis, T.M. and A. Tsatsoulis, 2012. Subclinical hypothyroidism: An overlooked cause of atrial fibrillation? J. Atr. Fibrillation, 5: 6-8.
  7. Hyphantis, T.N., A.I. Pappas, A.P. Vlahos, A.F. Carvalho, J.L. Levenson and T.M. Kolettis, 2012. Depressive symptoms and neurocardiogenic syncope in children: A 2-year prospective study. Pediatrics, 130: 906-913.
    CrossRef  |  
  8. Bibli, S.I., E.V. Toli, A.D. Vilaeti, V.C. Varnavas and G.G. Baltogiannis et al., 2012. Endothelin-B receptors and left ventricular dysfunction after regional versus global ischaemia-reperfusion in rat hearts. Cardiol. Res. Pract. .
    Direct Link  |  
  9. Bechlioulis, A., K.K. Naka, S.N. Kalantaridou, A. Kaponis and O. Papanikolaou et al., 2012. Increased vascular inflammation in early menopausal women is associated with hot flush severity. J. Clin. Endocrinol. Metab., 97: 760-764.
    PubMed  |  
  10. Varnavas, V.C., K. Kontaras, C. Glava, C.D. Maniotis and M. Koutouzis et al., 2011. Chronic skeletal muscle ischemia preserves coronary flow in the ischemic rat heart. Am. J. Physiol. Heart Circ. Physiol., 301: 1229-1235.
    PubMed  |  
  11. Maniotis, C., D.G. Tsalikakis, A.T. Tzallas, V. Varnavas and K. Kontaras et al., 2011. Chronic skeletal muscle ischemia in rats decreases the inducibility of ventricular tachyarrhythmias after myocardial infarction. In Vivo, 25: 781-786.
    PubMed  |  
  12. Kolettis, T.M., A. Vilaeti, K. Dimos, N. Tsitou and S. Agathopoulos, 2011. Tissue engineering for post-myocardial infarction ventricular remodeling. Mini. Rev. Med. Chem., 11: 263-270.
    PubMed  |  
  13. Kolettis, T.M., 2011. Endothelin-1 during myocardial ischaemia: A double-edged sword? Hypertens Res., 34: 170-172.
    Direct Link  |  
  14. Oikonomidis, D.L., G.G. Baltogiannis and T.M. Kolettis, 2010. Do endothelin receptor antagonists have an antiarrhythmic potential during acute myocardial infarction? Evidence from experimental studies. J. Interv. Card Electrophysiol., 28: 157-165.
    PubMed  |  
  15. Oikonomidis, D.L., D.G. Tsalikakis, G.G. Baltogiannis, A.T. Tzallas and X. Xourgia et al., 2010. Endothelin-B receptors and ventricular arrhythmogenesis in the rat model of acute myocardial infarction. Basic Res. Cardiol., 105: 235-245.
    PubMed  |  
  16. Megalou, A.J., C. Glava, D.L. Oikonomidis, A. Vilaeti and M.G. Agelaki et al., 2010. Transforming growth factor-L inhibition attenuates pulmonary arterial hypertension in rats. Int. J. Clin. Exp. Med., 3: 332-340.
    PubMed  |  
  17. Kolettis, T.M., K. Kontaras, I. Spartinos, C. Maniotis and V. Varnavas et al., 2010. Dose-dependent effects of sildenafil on post-ischaemic left ventricular function in the rat isolated heart. J. Pharm. Pharmacol., 62: 346-351.
    PubMed  |  
  18. Kolettis, T.M., D.N. Lysitsas, D. Apostolidis, G.G. Baltogiannis, E. Sourla and L.K. Michalis, 2010. Improved cut-down technique for transvenous pacemaker lead implantation. Europace, 12: 1282-1285.
    PubMed  |  
  19. Kapatou, E., A. Skyrlas, M.G. Agelaki, C. Pantos, T.M. Kolettis and V. Malamou-Mitsi, 2010. Amiodarone attenuates apoptosis, but induces phospholipidosis in rat alveolar epithelial cells. J. Physiol. Pharmacol., 61: 671-677.
    PubMed  |  
  20. Papathanassiou, K., K.K. Naka, N. Kazakos, C. Kanioglou and D. Makriyiannis et al., 2009. Pioglitazone vs glimepiride: Differential effects on vascular endothelial function in patients with type 2 diabetes. Atherosclerosis, 205: 221-226.
    PubMed  |  
  21. Elaiopoulos, D.A. and T.M. Kolettis, 2009. Antiarrhythmic actions of growth hormone during acute myocardial infarction. J. Electrocardiol., 42: 298-299.
    PubMed  |  
  22. Siedlecka, U., M. Arora, T. Kolettis, G.K. Soppa and J. Lee et al., 2008. Effects of clenbuterol on contractility and Ca2+ homeostasis of isolated rat ventricular myocytes. Am. J. Physiol. Heart Circ. Physiol., 295: H1917-H1926.
    PubMed  |  
  23. Kolettis, T.M., Z.S. Kyriakides, E. Zygalaki, S. Kyrzopoulos and L. Kaklamanis et al., 2008. Endothelin system and atrial fibrillation postcardiac surgery. J. Interv Card Electrophysiol., 21: 203-208.
    PubMed  |  
  24. Kolettis, T.M., V.D. Krikos, D. Apostolidis, K.K. Naka, C.S. Katsouras, E. Sourla and L.K. Michalis, 2008. Outcome of patients with haemodynamically stable ventricular tachycardia treated with an implantable cardioverter-defibrillator. Hellenic J. Cardiol., 49: 248-259.
    PubMed  |  
  25. Kolettis, T.M., G.G. Baltogiannis, D.G. Tsalikakis, A.T. Tzallas and M.G. Agelaki et al., 2008. Effects of dual endothelin receptor blockade on sympathetic activation and arrhythmogenesis during acute myocardial infarction in rats. Eur. J. Pharmacol., 580: 241-249.
    PubMed  |  
  26. Kolettis, T.M., C.S. Katsouras and L.K. Michalis, 2008. Electrical cardioversion of atrial fibrillation using four defibrillation patches. Europace, 10: 451-452.
    PubMed  |  
  27. Fox, K., I. Ford, P.G. Steg, M. Tendera, R. Ferrari and Beautiful Investigators, 2008. Ivabradine for patients with stable coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): A randomised, double-blind, placebocontrolled trial. Lancet, 372: 807-816.
    CrossRef  |  PubMed  |  Direct Link  |  
  28. Beautiful Study Group, R. Ferrari, I. Ford, K. Fox, P.G. Steg and M. Tendera, 2008. The BEAUTIFUL study: Randomized trial of ivabradine in patients with stable coronary artery disease and left ventricular systolic dysfunction-baseline characteristics of the study population. Cardiology, 110: 271-282.
    PubMed  |  
  29. Vlahos, A.P., M. Tzoufi, C.S. Katsouras, T. Barka and I. Sionti et al., 2007. Provocation of neurocardiogenic syncope during head-up tilt testing in children: comparison between isoproterenol and nitroglycerin. Pediatrics, 119: 419-425.
    PubMed  |  
  30. Kyriakides, Z.S., A.G. Manolis and T.M. Kolettis, 2007. The effects of ventricular asynchrony on myocardial perfusion. Int. J. Cardiol., 119: 3-9.
    PubMed  |  
  31. Korantzopoulos, P., T.M. Kolettis, D. Galaris and J.A. Goudevenos, 2007. The role of oxidative stress in the pathogenesis and perpetuation of atrial fibrillation. Int. J. Cardiol., 115: 135-143.
    PubMed  |  
  32. Kolettis, T.M., M.G. Agelaki, G.G. Baltogiannis, A.P. Vlahos, I. Mourouzis, A. Fotopoulos and C. Pantos, 2007. Comparative effects of acute vs. chronic oral amiodarone treatment during acute myocardial infarction in rats. Europace, 9: 1099-1104.
    PubMed  |  
  33. Kolettis, T.M., A. Papathanasiou, D. Tziallas, H.J. Milionis, C.K. Kastanioti and K. Achenbach, 2007. Afternoon nap, meal ingestion and circadian variation of acute myocardial infarction. Int. J. Cardiol., 123: 338-340.
    PubMed  |  
  34. Kolettis, T., A.P. Vlahos, M. Louka, K.E. Hatzistergos and G.G. Baltogiannis et al., 2007. Characterisation of a rat model of pulmonary arterial hypertension. Hellenic J. Cardiol., 48: 206-210.
    PubMed  |  
  35. Hatzistergos, K.E., A.C. Mitsi, C. Zachariou, A. Skyrlas and E. Kapatou et al., 2007. Randomised comparison of growth hormone versus IGF-1 on early post-myocardial infarction ventricular remodelling in rats. Growth Horm IGF Res., 18: 157-165.
    PubMed  |  
  36. Elaiopoulos, D.A., D.G. Tsalikakis, M.G. Agelaki, G.G. Baltogiannis, A.C. Mitsi, D.I. Fotiadis and T.M. Kolettis, 2007. Growth hormone decreases phase II ventricular tachyarrhythmias during acute myocardial infarction in rats. Clin. Sci., 112: 385-391.
    PubMed  |  
  37. Christou, L., M. Economou, G. Economou, T.M. Kolettis and E.V. Tsianos, 2007. Characteristics of ascitic fluid in cardiac ascites. Scand. J. Gastroenterol., 42: 1102-1105.
    PubMed  |  
  38. Agelaki, M.G., C. Pantos, P. Korantzopoulos, D.G. Tsalikakis, G.G. Baltogiannis, A. Fotopoulos and T.M. Kolettis, 2007. Comparative antiarrhythmic efficacy of amiodarone and dronedarone during acute myocardial infarction in rats. Eur. J. Pharmacol., 564: 150-157.
    PubMed  |  
  39. Mitsi, A.C., K.E. Hatzistergos, D. Niokou, L. Pappa and G.G. Baltogiannis et al., 2006. Early, intracoronary growth hormone administration attenuates ventricular remodeling in a porcine model of myocardial infarction. Growth Horm IGF Res., 16: 93-100.
    PubMed  |  
  40. Korantzopoulos, P., T.M. Kolettis, A. Papathanasiou, K.K. Naka and P. Kolios et al., 2006. Propafenone added to ibutilide increases conversion rates of persistent atrial fibrillation. Heart, 92: 631-634.
    PubMed  |  
  41. Korantzopoulos, P., T.M. Kolettis and J.A. Goudevenos, 2006. Effects of N-3 fatty acids on postoperative atrial fibrillation following coronary artery bypass surgery. J. Am. Coll. Cardiol., 47: 467-468.
    PubMed  |  
  42. Kolettis, T.M., 2006. Arrhythmogenesis after cell transplantation post-myocardial infarction. Four burning questions-and some answers. Cardiovasc. Res., 69: 299-301.
    PubMed  |  
  43. Katsouras, C.S., C. Leontaridou, K. Achenbach, G. Maglaras and M.P. Vassiliou et al., 2006. Echocardiographic evidence of posteromedial hypokinesis of the left ventricle in relation to mitral regurgitation in cardiac sarcoidosis. Heart Vessels., 21: 382-384.
    PubMed  |  
  44. Mitsi, A.C., K. Hatzistergos, G.G. Baltogiannis and T.M. Kolettis, 2005. Early, selective growth hormone administration may ameliorate left ventricular remodeling after myocardial infarction. Med. Hypotheses, 64: 582-585.
    PubMed  |  
  45. Korantzopoulos, P., T.M. Kolettis, K. Siogas and J.A. Goudevenos, 2005. The emerging role of inflammation in atrial fibrillation and the potential of anti-inflammatory interventions. Eur. Heart J., 26: 2207-2208.
    PubMed  |  
  46. Korantzopoulos, P., T.M. Kolettis, J.A. Goudevenos and K Siogas, 2005. Errors and pitfalls in the non-invasive management of atrial fibrillation. Int. J. Cardiol., 104: 125-130.
    PubMed  |  
  47. Korantzopoulos, P., T.M. Kolettis, E. Kountouris, V. Dimitroula and P. Karanikis et al., 2005. Oral vitamin C administration reduces early recurrence rates after electrical cardioversion of persistent atrial fibrillation and attenuates associated inflammation. Int. J. Cardiol., 102: 321-326.
    PubMed  |  
  48. Korantzopoulos, P., T.M. Kolettis, E. Kountouris, K. Siogas and J.A. Goudevenos, 2005. Variation of inflammatory indexes after electrical cardioversion of persistent atrial fibrillation. Is there an association with early recurrence rates? Int. J. Clin. Pract., 59: 881-885.
    PubMed  |  
  49. Korantzopoulos, P., T.M. Kolettis and J.A. Goudevenos, 2005. The anti-inflammatory and antioxidant effects of long-chain Q-3 fatty acids or oil-rich fish may favorably affect atrial remodeling in atrial fibrillation. Med. Hypotheses, 64: 1245-1246.
    PubMed  |  
  50. Korantzopoulos, P., T.M. Kolettis and E. Kountouris, 2005. Inflammation and anti-inflammatory interventions in atrial fibrillation. Int. J. Cardiol., 104: 361-362.
    PubMed  |  
  51. Kolettis, T.M., N. Kazakos, C.S. Katsouras, D. Niokou and L. Pappa et al., 2005. 2005. Intrapericardial drug delivery: Pharmacologic properties and long-term safety in swine. Int. J. Cardiol., 99: 415-421.
    PubMed  |  
  52. Kolettis, T.M., K.K. Naka and C.S. Katsouras, 2005. Radiofrequency catheter ablation for electrical storm in a patient with dilated cardiomyopathy. Hellenic J. Cardiol., 46: 366-369.
    PubMed  |  
  53. Kolettis, T.M., G. Oikonomou, I. Novas and D.A. Sideris, 2005. Transient complete atrioventricular block associated with herb intake. Europace, 73: 225-226.
    PubMed  |  
  54. Kolettis, T.M., C.S. Katsouras, K. Pappas and J. Goudevenos, 2005. Myocardial ischemia caused by cold-water submersion. Int. J. Cardiol., 99: 467-469.
    PubMed  |  
  55. Baltogiannis, G.G., D.G. Tsalikakis, A.C. Mitsi, K.E. Hatzistergos and D. Elaiopoulos et al., 2005. Endothelin receptor-A blockade decreases ventricular arrhythmias after myocardial infarction in rats. Cardiovasc Res., 67: 647-654.
    PubMed  |  
  56. Paravolidakis, K.E., E.S. Hamodraka, T.M. Kolettis, S.N. Psychari and T.S. Apostolou, 2004. Management of inadvertent left ventricular permanent pacing. J. Interv. Card Electrophysiol., 10: 237-240.
    PubMed  |  
  57. Korantzopoulos, P., T. Kolettis, E. Kountouris and K. Siogas, 2004. Atrial remodeling in persistent atrial fibrillation: The potential role of aldosterone. Eur. Heart J., Vol. 25. .
    PubMed  |  Direct Link  |  
  58. Katsouras, C.S., L.K. Michalis, I. Leontaridis, T. Kolettis and K.K. Naka et al., 2004. Treatment of acute lower limb ischemia following the use of the Duett sealing device: Report of three cases and review of the literature. Cardiovasc. Intervent Radiol., 27: 268-270.
    PubMed  |  
  59. Katsouras, C.S., G.F. Greakas, J.A. Goudevenos, L.K. Michalis and T. Kolettis et al., 2004. Localization of accessory pathways by the electrocardiogram: which is the degree of accordance of three algorithms in use? Pacing Clin. Electrophysiol., 27: 189-193.
    PubMed  |  
  60. Kyriakides, Z.S., S.N. Psychari, T.M. Kolettis, M. Georgiadis, A. Antoniadis and D.T. Kremastinos, 2003. Usefulness of endothelin(A) receptor antagonists for the prevention of in-stent restenosis in patients with stable angina pectoris or silent myocardial ischemia. Am. J. Cardiol., 91: 476-479.
    PubMed  |  
  61. Korantzopoulos, P., T. Kolettis, K. Siogas and J. Goudevenos, 2003. Atrial fibrillation and electrical remodeling: The potential role of inflammation and oxidative stress. Med. Sci. Monit., 9: RA225-RA229.
    PubMed  |  
  62. Korantzopoulos, P., T. Kolettis and J. Goudevenos, 2003. Atrial fibrillation in hypertension: An established association with several unresolved issues. Cardiology, 100: 105-106.
    PubMed  |  
  63. Kolettis, T.M., Z.S. Kyriakides, D. Leftheriotis, A. Papalambrou, D.T. Kremastinos and D.J. Webb, 2003. Electrophysiologic effects of endothelin receptor-A blockade in patients with coronary artery disease. J. Interv. Card. Electrophysiol., 8: 173-179.
    PubMed  |  
  64. Kolettis, T.M., K.K. Naka, C. Katsouras, L.K. Michalis and K. Bourantas, 2003. Transient intraventricular conduction delay associated with concurrent intake of propafenone and antineoplastic agents. Cardiovasc Drugs Ther., 17: 381-382.
    PubMed  |  
  65. Kolettis, T.M., E. Psarros, Z.S. Kyriakides, C.S. Katsouras, L.K. Michalis and D.A. Sideris, 2003. Haemodynamic and catecholamine response to simulated ventricular tachycardia in man: Effect of baseline left ventricular function. Heart, 89: 306-310.
    PubMed  |  
  66. Kolettis, T.M. and M.T. Kolettis, 2003. Winter swimming: Healthy or hazardous? Evidence and hypotheses. Med. Hypotheses, 61: 654-656.
    PubMed  |  
  67. Michalis, L.K., M.R. Rees, D. Patsouras, C.S. Katsouras and J. Goudevenos et al., 2002. A prospective randomized trial comparing the safety and efficacy of three commercially available closure devices (Angioseal, Vasoseal and Duett). Cardiovasc Intervent Radiol., 25: 423-429.
    PubMed  |  
  68. Michalis, L.K., A.P. Tambaki, C.S. Katsouras, J.A. Goudevenos and T. Kolettis et al., 2002. Platelet hyperaggregability to platelet activating factor (PAF) in non-ST elevation acute coronary syndromes. Curr. Med. Res. Opin., 18: 108-112.
    PubMed  |  
  69. Kyriakides, Z.S., S. Psychari, E.K. Iliodromitis, T.M. Kolettis, E. Sbarouni and D.T. Kremastinos, 2002. Hyperlipidemia prevents the expected reduction of myocardial ischemia on repeated balloon inflations during angioplasty. Chest, 121: 1211-1215.
    PubMed  |  
  70. Kyriakides, Z.S., D.T. Kremastinos, S.N. Psychari, T. Kolettis, E. Sbarouni and D.J. Webb, 2001. Coronary vasoconstriction after coronary angioplasty is attenuated by endothelin a receptor antagonism. Am. J. Cardiol., 87: 1011-1013.
    PubMed  |  
  71. Kyriakides, Z.S., D.T. Kremastinos, T.M. Kolettis, A. Tasouli, A. Antoniadis and D.J. Webb, 2000. Acute endothelin-A receptor antagonism prevents normal reduction of myocardial ischemia on repeated balloon inflations during angioplasty. Circulation, 102: 1937-1943.
    PubMed  |  
  72. Kolettis, T.M., Z.S. Kyriakides, D. Tsiapras, T. Popov, I.A. Paraskevaides and D.T. Kremastinos, 2000. Improved left ventricular relaxation during short-term right ventricular outflow tract compared to apical pacing. Chest, 117: 60-64.
    PubMed  |