Dr. Alexandros G. Georgakilas
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Dr. Alexandros G. Georgakilas

Assistant Professor
National Technical University of Athens, Greece

Highest Degree
Ph.D. in Radiation Biology from National Technical University of Athens, Greece

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Area of Interest:

Biomedical Sciences
100%
Inflammation
62%
Carcinogenesis
90%
Oxidative Stress
75%
Radiation Biology
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Nowsheen, S., K. Aziz, T.B. Kryston, N.F. Ferguson and A. Georgakilas, 2012. The Interplay between Inflammation and Oxidative Stress in Carcinogenesis. Curr. Mol. Med., 12: 672-680.
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  2. Nowsheen, S., K. Aziz, M.I. Panayiotidis and A.G. Georgakilas, 2012. Molecular Markers for Cancer Prognosis and Treatment: Have We Struck Gold? Cancer Lett., 327: 142-152.
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  3. Hanafi, R., I. Anestopoulos, G.P. Voulgaridou, R. Franco and A.G. Georgakilas et al., 2012. Oxidative Stress Based-Biomarkers in Oral Carcinogenesis: How Far Have We Gone? Curr. Mol. Med., 12: 698-703.
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  4. Georgakilas, A.G., 2012. Oxidative Stress, DNA Damage and Repair in Carcinogenesis: Have We Established A Connection? Cancer Lett., 327: 3-4.
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  5. Georgakilas, A.G. and M.I. Panayiotidis, 2012. Biomarkers of oxidative stress and cancer: from chemistry, biology to clinical applications and personalized therapy. Curr. Mol. Med., 12: 653-654.
    CrossRef  |  PubMed  |  
  6. Aziz, K., S. Nowsheen, G. Pantelias, G. Iliakis and V.G. Gorgoulis et al., 2012. Targeting DNA Damage and Repair: Embracing the Pharmacological Era for Successful Cancer Therapy. Pharmacol. Ther., 133: 334-350.
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  7. Stewart, R.D., V.K. Yu, A.G. Georgakilas, C. Koumenis and J.H. Park et al., 2011. Effects of Radiation Quality and Oxygen on Clustered DNA Lesions and Cell Death. Radiation Res., 176: 587-602.
    PubMed  |  Direct Link  |  
  8. Sideridou, M., R. Zakopoulou, K. Evangelou, M. Liontos and A. Kotsinas et al., 2011. Cdc6 Expression Represses E-Cadherin Transcription and Activates Adjacent Replication Origins. J. Cell Biol., 195: 1123-1140.
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  9. Martin, O.A., C.E. Redon, A.J. Nakamura, J.S. Dickey and A.G. Georgakilas et al., 2011. Systemic DNA Damage Related to Cancer. Cancer Res., 71: 3437-3441.
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  10. Kryston, T.B., A. Georgiev, P. Pissis and A.G. Georgakilas, 2011. Role of oxidative stress and DNA damage in human carcinogenesis. Mutat. Res., 711: 193-201.
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  11. Georgakilas, A.G., 2011. From Chemistry of DNA Damage to Repair and Biological Significance. Comprehending the Future. Mutation Res., 711: 1-2.
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  12. Georgakilas, A., 2011. Detection of Clustered DNA Lesions: Biological and Clinical Applications. World J. Biol. Chem., 2: 173-176.
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  13. Baird, B.J., J.S. Dickey, A.J. Nakamura, C.E. Redon and P. Parekh et al., 2011. Hypothermia postpones DNA damage repair in irradiated cells and protects against cell killing. Mutat. Res., 711: 142-149.
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  14. Ziech, D., R. Franco, A.G. Georgakilas, S. Georgakila and V. Malamou-Mitsi et al., 2010. The role of reactive oxygen species and oxidative stress in environmental carcinogenesis and biomarker development. Chem. Biol. Interact., 188: 334-339.
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  15. Zeich, D., Georgakilas, A.G., R. Franco, A. Pappa and V. Malamou-Mitsi et al., 2010. The role of epigenetics in environmental and occupational carcinogenesis. Chem. Biol. Interac., 188: 340-349.
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  16. Redon, C., J.S. Dickey, A.J. Nakamura, I.G. Karevaa and D. Naf et al., 2010. Tumors induce complex DNA damage in distant proliferative tissues in vivo. Proc. Natl. Acad. Sci. USA., 107: 17992-17997.
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  17. Peddi, P., C.W. Loftin, J.S. Dickey, J.M. Hair and K.J. Burns et al., 2010. DNA-PKcs deficiency leads to persistence of oxidatively induced clustered DNA lesions in human tumor cells. Free Radic. Biol. Med., 48: 1435-1443.
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  18. Kalogerinis, P., J.E. Poulos, A. Morfesis, A. Daniels, S. Georgakila, T. Daignualt and A.G. Georgakilas, 2010. Duodenal carcinoma at the ligament of Treitz. A molecular and clinical perspective. BMC Gastroenterol., 10: 109-117.
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  19. Hair, J.M., G.I. Terzoudi, V.I. Hatzi, K.A. Lehockey and D. Srivastava et al., 2010. BRCA1 role in the mitigation of radiotoxicity and chromosomal instability through repair of clustered DNA lesions. Chem. Biol. Interact., 188: 350-358.
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  20. Georgakilas, A.G., W.G. Mosley, S. Georgakila, D. Zeich, M.I. Panayiotidis and A. Georgakilas, 2010. Viral-induced human carcinogenesis: An oxidative stress perspective. Mol. Biosystems., 6: 1162-1172.
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  21. Georgakilas, A.G., S.M. Holt, J.M. Hair and C.W. Loftin, 2010. Measurement of oxidatively-induced clustered DNA lesions using a novel adaptation of single cell gel electrophoresis (comet assay). Curr. Protoc. Cell Biol., 47: 1-17.
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  22. Somaira N., R.L. Wukovich, K. Aziz, P.T. Kalogerinis and C.C. Richardson et al., 2009. Accumulation of oxidatively-induced clustered DNA lesions in human tumor tissues. Mutat. Res. Genet. Toxicol. Environ. Mutagen., 674: 131-136.
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  23. Kalogerinis, P.K., A.F. Morfesis, S. Georgakila and A.G. Georgakilas, 2009. Correction of anal prolapse associated with resolution of cloacogenic polyp lesions. Implications to anorectal cancer. J. Biochem. Technol., 1: 62-64.
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  24. Holt, S.S., J. Scemama, M.I. Panayiotidis and A.G. Georgakilas, 2009. Compromised repair of clustered DNA damage in the human acute lymphoblastic leukemia MSH2-deficient NALM-6 cells. Mutat. Res. Genet. Toxicol. Environ. Mutagen., 674: 123-130.
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  25. Georgakilas, A.G., K. Aziz, D. Ziech, S. Georgakila and M.I. Panayiotidis, 2009. BRCA1 involvement in toxicological responses and human cancer etiology. Toxicol. Lett., 188: 77-83.
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  26. Poulos, J.E., A.G. Georgakilas, P.T. Kalogerinis, T. Daignaut and G.A. Lujan, 2008. A patient with granular cell tumor of the colon. Pract. Gastroenterol., 32: 51-53.
    Direct Link  |  
  27. Peddi, P., D.C. Francisco, A. Cecil, J.M. Hair, M.I. Panayiotidis and A.G. Georgakilas, 2008. Processing of clustered DNA damage in human breast cancer cells MCF-7 with partial DNA-PKcs deficiency. Cancer Lett., 269: 174-183.
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  28. Hada, M. and A.G. Georgakilas, 2008. Formation of clustered DNA damage after high-LET irradiation: A review. J. Radiat. Res., 49: 203-210.
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  29. Georgakilas, A.G., 2008. Processing of DNA damage clusters in human cells: Current status of knowledge. Mol. Biosyst., 4: 30-35.
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  30. Georgakilas, A.G., 2008. A possible role of repair proteins BRCA1 and DNA-PK in the processing of oxidative DNA damage. J. Biochem. Technol., 1: 9-10.
    Direct Link  |  
  31. Franco, R., O. Schoneveld, A.G. Georgakilas and M.I. Panayiotidis, 2008. Oxidative stress, DNA methylation and carcinogenesis. Cancer Lett., 266: 6-11.
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  32. Francisco, D.C., P. Peddi, J.M. Hair, B.A. Flood and A.M. Cecil et al., 2008. Induction and processing of complex DNA damage in human breast cancer cells MCF-7 and nonmalignant MCF-10A cells. Free Radical Biol. Med., 44: 558-569.
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  33. Tsao, D., P. Kalogerinis, I. Tabrizi, M. Dingfelder, R.D. Stewart and A.G. Georgakilas, 2007. Induction and processing of oxidative clustered DNA lesions in 56Fe-ion-irradiated human monocytes. Radiat. Res., 168: 87-97.
    PubMed  |  Direct Link  |  
  34. Lally, B.E., G.A. Geiger, S. Kridel, A.E. Arcury-Quandt and M.E. Robbins et al., 2007. Identification and biological evaluation of a novel and potent small molecule radiation sensitizer via an unbiased screen of a chemical library. Cancer Res., 67: 8791-8799.
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  35. Holt, S.M. and A.G. Georgakilas, 2007. Detection of complex DNA damage in γ-irradiated acute lymphoblastic leukemia Pre-b NALM-6 cells. Radiat. Res., 168: 527-534.
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  36. Gollapalle, E., R. Wong, R. Adetolu, D. Tsao, D. Francisco, G. Sigounas and A.G. Georgakilas, 2007. Detection of oxidative clustered DNA lesions in X-irradiated mouse skin tissues and human MCF-7 breast cancer cells. Radiat. Res., 167: 207-216.
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  37. Georgakilas, A., P.V. Bennett, D.M. Wilson and B.M. Sutherland, 2004. Processing of bistranded abasic DNA clusters in γ-irradiated human hematopoietic cells. Nucleic Acids Res., 32: 5609-5620.
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  38. Sutherland, B.M., P.V. Bennett, A.G. Georgakilas and J.C. Sutherland, 2003. Evaluation of number average length analysis in quantifying double strand breaks in genomic DNAs. Biochemistry, 42: 3375-3384.
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  39. Sutherland, B.M., A.G. Georgakilas, P.V. Bennett, J. Laval and J.C. Sutherland, 2003. Quantifying clustered DNA damage induction and repair by gel electrophoresis, electronic imaging and number average length analysis. Mutat. Res., 531: 93-107.
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  40. Konsta, A., E.E. Visvardis, K.S. Haveles, A.G. Georgakilas and E.G. Sideris, 2002. Detecting radiation-induced DNA damage: From changes in dielectric properties to programmed cell death. J. Non-Cryst. Solids, 305: 295-302.
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  41. Georgakilas, A.G., P.V. Bennett and B.M. Sutherland, 2002. High efficiency detection of bi-stranded abasic clusters in γ-irradiated DNA by putrescine. Nucleic Acids Res., 30: 2800-2808.
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  42. Sideris, E.G., A.G. Georgakilas, K.S. Haveles, A.A. Konsta, V. Sophianopoulou and E.E. Visvardis, 2001. The balkan syndrome of depleted uranium effected leukemia: Facts and fears. J. Balkan Union Oncol., 6: 231-235.
  43. Georgakilas, A.G., A.A. Konsta, L. Sakelliou and E.G. Sideris, 2001. Dielectric and UV Spectrophotometric study of physicochemical effects of ionizing radiation on mammalian macromolecular DNA. IEEE Trans. Dielectr. Electr. Insul., 8: 549-554.
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  44. Haveles, K.S., A.G. Georgakilas, E.G. Sideris and V. Sophianopoulou, 2000. Effects of radical scavengers on radiation-induced DNA double strand breaks. Int. J. Radiat. Biol., 76: 51-59.
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  45. Georgakilas, A.G., K.S. Haveles, V. Sophianopoulou, L. Sakelliou, G. Zarris and E.G. Sideris, 2000. Alpha-particle-induced changes in the stability and size of DNA. Radiat. Res., 153: 258-262.
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  46. Georgakilas, A.G., K.S. Haveles, V. Sophianopoulou, G. Zarris, L. Sakelliou and E.G. Sideris, 1999. Alpha and gamma radiation induced changes on the stability and size of mammalian DNA in solutions. Phy. Med. 15: 198-200.
  47. Georgakilas, A.G., E.G. Sideris, L. Sakelliou and C.A. Kalfas, 1999. Low Doses of α- and γ-radiation enhance DNA thermal stability. Biophys. Chemis., 80: 103-118.
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  48. Zarris, G., A.G. Georgakilas, L. Sakelliou, K. Sarigiannis and E.G. Sideris, 1998. α- and γ-irradiation of aqueous DNA solutions. Radiat. Meas., 29: 611-617.
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  49. Georgakilas, A.G., L. Sakelliou, L.H. Margaritis, E.G. Sideris and V. Sophianopoulou, 1998. Effects of gamma rays on the stability and size of DNA. Radiat. Res., 150: 488-491.
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  50. Georgakilas, A.G., A.A. Konsta, K.S. Haveles and E.G. Sideris, 1998. Dielectric study of the double helix to single coil transition of DNA. IEEE Trans. Dielectr. Electr. Insul., 5: 26-32.
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  51. Georgakilas, A.G., V. Sophianopoulou and E.G. Sideris, 1997. Enhanced DNA stability as a result of low doses of alpha and gamma irradiation. Radioprotection, 32: 101-102.
  52. Georgakilas, A.G., K.S. Haveles, L.C. Margaritis, L. Sakelliou and E.G. Sideris, 1997. Conformational changes induced on the DNA by exposure to low doses of alpha and gamma irradiation. Radiat. Res., 148: 503-504.
  53. Kalfas, C.A., G.K. Loukakis, A.G. Georgakilas and E.G. Sideris, 1996. Flexibility and thermal denaturation (melting) of irradiated DNA. J. Biol. Syst., 4: 405-423.
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