Dr. Touil-Boukoffa  Chafia
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Dr. Touil-Boukoffa Chafia

Head of Department
University of Sciences and Technology, Algeria


Highest Degree
Ph.D. in Biochemistry and Immunology from University of Science and Technology Houari Boumediene, Algeria

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Biography

Prof .Chafia Touil-Boukoffa obtained her Doctorate Degree in Biochemistry-Immunology in 1998 at the university of sciences and technology (USTHB) ,Algiers, Algeria. Since this period, she has developed many projects in the field of immunology and biotechnology in collaboration with Curie Institute-Interferon and cytokine research-365 Unit-Paris -France). Since 2000, she is a head of ‘’Cytokines and NO Synthases’’ Team and director of cellular and molecular biology laboratory (www.lbcm.USTHB.dz). Her project is about the study of cytokines and NO Synthases involvement in the mechanisms of pathogenesis and immune response in parasite disease and in auto-immune and inflammatory disease which are endemic in Algeria(Uveitis, Behçet disease, inflammatory bowel disease, systemic inflammatory vasculitis.). She is an author of many publications in the immunology and biomedicine field and she has received international and national awards for her works.

Area of Interest:

Pharmacology and Toxicology
100%
Cytokines
62%
Nitric Oxide
90%
Neuroinflammation
75%
Inflammatory Disorders
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Fagone, P., K. Mangano, R.D. Marco, C.T. Boukoffa and T. Chikovan et al., 2016. Expression of DNA methylation genes in secondary progressive multiple sclerosis. J Neuroimmunol 290: 66-69.
    CrossRef  |  Direct Link  |  
  2. Soufli, I., R. Toumi, H. Rafa, M. Amri and C.T. Boukoffa et al., 2015. Crude extract of hydatid laminated layer from Echinococcus granulosus cyst attenuates mucosal intestinal damage and inflammatory responses in Dextran Sulfate Sodium induced colitis in mice. J. Inflamm., 10.1186/s12950-015-0063-6.
    CrossRef  |  Direct Link  |  
  3. Boukercha, A., H.M. Amroun, A. Bouzidi, H. Saoula, M. Nakkemouche, M. Roy, J.P. Hugot and C.T. Boukoffa, 2015. NOD2/CARD15 gene mutations in North Algerian patients with inflammatory bowel disease. World J. Gastroenterol., 21: 7786-7794.
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  4. Belguendouz, H., K.L. Belguendouz, D. Messaoudene, Z. Djeraba and F. Otmani et al., 2015. Cytokines Modulate the ''Immune-Metabolism'' Interactions during Behcet Disease: Effect on Arginine Metabolism. Int. J. Inflammation, 2015: 1-9.
    CrossRef  |  Direct Link  |  
  5. Belguendouz, H., D. Messaoudene, K.L. Belguendouz, Z. Djeraba and F. Otmani et al., 2015. In vivo and in vitro IL-18 production during uveitis associated with Behcet disease: effect of glucocorticoid therapy. J. Fr Ophtalmol., 38: 206-212.
    CrossRef  |  Direct Link  |  
  6. Behairi, N., M. Belkhelfa, H.M. Amroun, H. Rafa, S. Belarbi, M. Tazir and C.T. Boukoffa, 2015. All-trans-Retinoic Acid Modulates Nitric Oxide and Interleukin-17A Production by Peripheral Blood Mononuclear Cells from Patients with Alzheimer's Disease. Neuroimmunomodulation, 22: 385-393.
    CrossRef  |  Direct Link  |  
  7. Amri, M. and C.T. Boukoffa, 2015. A protective effect of the laminated layer on Echinococcus granulosus survival dependent on upregulation of host arginase. Acta Trop., 149: 186-194.
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  8. Djeraba, Z., K. Boumedine, A.A. Lammali, F. Otmani, H. Belguendouz and C.T. Boukoffa, 2014. Ex vivo immunomodulatory effect of all-trans-retinoic acid during Behcet's disease: a study in Algerian patients. Immunopharmacol. Immunotoxicol., 36: 78-86.
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  9. Toumi, R., K. Abdelouhab, H. Rafa, I. Soufli, D.R. Kerboua, Z. Djeraba and C.T. Boukoffa, 2013. Beneficial role of the probiotic mixture Ultrabiotique on maintaining the integrity of intestinal mucosal barrier in DSS-induced experimental colitis. Immunopharmacol. Immunotoxicol., 35: 403-409.
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  10. Rafa, H., H. Saoula, M. Belkhelfa, O. Medjeber and I. Soufli et al., 2013. IL-23/IL-17A Axis Correlates with the Nitric Oxide Pathway in Inflammatory Bowel Disease : Immunomodulatory Effect of Retinoic acid. J. Interferon Cytokine Res., 37: 355-368.
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  11. Fagone, P., F. Patti, K. Mangano, S. Mammana and M. Coco et al., 2013. Heme oxygenase-1 expression in peripheral blood mononuclear cells correlates with disease activity in multiple sclerosis. J. Neuroimmunol., 261: 82-86.
    CrossRef  |  Direct Link  |  
  12. Bouteldja R.Z., M. Amri, S. Bouaziz, D. Mezioug and C.T. Boukoffa, 2013. Comparative study of nitric oxide (NO) production during human hydatidosis : relationship w ith cystic fluid fertility. Parasitol. Res., 112: 649-654.
    CrossRef  |  Direct Link  |  
  13. Belguendouz, K.L., H. Belguendouz, D. Hartani, O.S.L. Boukoffa, F.B. Boulaneb and C.T. Boukoffa, 2013. Effets du peroxynitrite derive du monoxyde d'azote sur des explants oculaires bovins en culture. J. Fr. Ophtalmologie, 36: 41-49.
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  14. Amroun, H.M., A. Boukercha, H. Saoula, M. Nekmouche and C.T. Boukoffa, 2013. Maladie de Crohn et polymorphisme du gene NOD2 en Algerie. Ann. Biol. Clin., 71: 43-92.
  15. Ider, F.D., S. Chaib, H. Belguendouz, D. Talbi and C.T. Boukoffa, 2012. T cells activation and interferon-Y/nitric oxide production during Behcet disease: a study in Algerian patients. Ocul. Immunol. Inflamm., 20: 215-217.
    CrossRef  |  Direct Link  |  
  16. Bourouba, M., A. Boukercha, A.A. Zergoun, A. Zebboudj and M. Elhadjan et al., 2012. Increased production of nitric oxide correlates with tumor growth in Algerian patients with nasopharyngeal carcinoma. Biomarkers, 17: 618-624.
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  17. Abdelouhab, K., H. Rafa, R. Toumi, S. Bouaziz, O. Medjeber and C.T. Boukoffa, 2012. Mucosal intestinal alteration in experimental colitis correlates with nitric oxide production by peritoneal macrophages : Effect of probiotics and prebiotics. Immunopharmacol. Immunotoxicol., 34: 590-597.
    CrossRef  |  Direct Link  |  
  18. Messaoudene, D., H. Belguendouz, M.L. Ahmedi, T. Benabdekader and F. Otmani et al., 2011. Ex vivo effects of flavonoids extracted from Artemisia herba alba on cytokines and nitric oxide production in Algerian patients with Adamantiades-Behcet's disease J. Inflammation, 10.1186/1476-9255-8-35.
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  19. Lammali, A.A., Z. Djeraba, M. Belkhelfa, H. Belguendouz, D. Hartani, O.L. Boukoffa and C.T. Boukoffa, 2011. Early involvement of Nitric Oxide in pathogenesis mechanisms of experimental autoimmune uveitis induced by Interphotoreceptor Retinoid-Binding Protein(IRBP). J. Fr Ophtalmol., 35: 251-259.
    CrossRef  |  Direct Link  |  
  20. Bourouba, M., A.B. Boufennara, N. Terki, F.E.K. Baraka, K. Bouzid and C.T. Boukoffa, 2011. Epidermal growth factor receptor (EGFR) abundance correlates with p53 and Bcl-2 accumulation and patient's age in a small cohort of North African nasopharyngeal carcinomas patients. Eur. Cytokine Network, 22: 38-44.
    CrossRef  |  Direct Link  |  
  21. Belguendouz, H., D. Messaoudene, K. Lahmar, L. Ahmedi and O. Medjeber et al., 2011. Interferon-Y and Nitric Oxide Production During Behcet Uveitis : Immunomodulatory Effect of Interleukin-10. J. Interferon Cytokine Res., 31: 643-651.
    CrossRef  |  Direct Link  |  
  22. Rafa, H., M. Amri, H. Saoula, M. Belkhelfa and O. Medjeber et al., 2010. Involvement of Interferon-Y in Bowel Disease Pathogenesis by Nitric Oxide Pathway:A Study in Algerian Patients. J. Interferon Cytokine Res., 30: 691-697.
    CrossRef  |  Direct Link  |  
  23. Djeraba, Z., A.A. Lammali, O. Medjeber, H. Belguendouz, D. Hartani, O.S.L. Boukoffa and C.T. Boukoffa, 2010. Nitric oxide, biomarker of experimental autoimmune uveitis induced by S antigen. J. Fr Ophtalmol., 33: 693-700.
    CrossRef  |  Direct Link  |  
  24. Belguendouz, H., K. Lahmar, M.L. Ahmedi, O.S. Lahlou, D. Hartani, H. Djennet and C.T. Boukoffa, 2010. NOS/arginase balance modulation by IFNY during Behcet disease. Cytokine, 52: 17-34.
  25. Zeghir-bouteldja, R., M. Amri, S.A. Aissa, S. Bouaziz, D. Mezioug and C.T. boukoffa, 2009. In vitro study of nitric oxide metabolites effects on human hydatid of Echinococcus granulosus. J. Parasitol. Res, 2009: 1-7.
    CrossRef  |  Direct Link  |  
  26. Mezioug, D. and C.T. Boukoffa, 2009. Cytokine profile in human hydatidosis.Possible role in the immunosurveillance of patients infected with Echinococcocus granulosus. Parasite, 16: 57-64.
    Direct Link  |  
  27. Belguendouz, K.L., H. Belguendouz, D. Hartani, O.S.L. Boukoffa, Z. Djeraba, A. Lammali and C.T. Boukoffa, 2009. Effets deleteres des derives stables du monoxyde d'azote, marqueur inflammatoire des uveites, sur les differentes tuniques de l'oeil de boeuf en culture. J. Fr. Ophtalmologie, 32: 247-256.
    CrossRef  |  Direct Link  |  
  28. Belguendouz, H., D. Messaoudene, M.L. Ahmedi, K. Lahmar, F. Otmani, D. Hakem and C.T. Boukoffa, 2009. Inflammatory versus anti-Inflammatory IL-6 during Behcet Disease : Dual effect of Nitric Oxide and TGF-Beta. Cytokine, 48: 96-97.
    CrossRef  |  Direct Link  |  
  29. Amri, M., D. Mezioug and C.T. Boukoffa, 2009. Involvement of IL-10 and IL-4 in evasion strategies of Echinococcus granulosus to host immune response. Involvement of IL-10 and IL-4 in evasion strategies of Echinococcus granulosus to host immune response. Eur. Cytokine Network, 20: 63-68.
    CrossRef  |  Direct Link  |  
  30. Belguendouz, H., D. Messaoudene, M.L. Ahmedi, K. Lahmar and F.Z. Ider et al., 2008. IFNY modulation by IL 18, IL 4 and IL 10 during BEHCET disease evolution. Cytokine, 43: 257-257.
  31. Belguendouz, H., D. Messaoudene, D. Hartani, L. Chachoua and M.L. Ahmedi et al., 2008. Effet de la corticotherapie sur la production des interleukines 8, 12 et du monoxyde d'azote au cours des uveites. J. Fr. Ophtalmologie, 31: 387-395.
    CrossRef  |  Direct Link  |  
  32. Amri, M., D. Mezioug, S.A. Aissa and C.T. Boukoffa, 2008. In vivo IL-12 and IL-8 production in hydatic patients and their possible diffusion in hydatid cysts. Eur. Cytokine Network, 19: 142-148.
    CrossRef  |  Direct Link  |  
  33. Amri, M., S.A. Aissa, H. Belguendouz, D. Mezioug and C.T. Boukoffa, 2007. In Vitro Antihydatic Action of Gamma Interferon (IFN) is Dependent of Nitric Oxide (NO) pathway. J. Interferon Cytokine Res., 22: 781-788.
    CrossRef  |  Direct Link  |  
  34. Hartani, D., H. Belguendouz, H. Guenane, L. Chachoua, O.S.L. Boukoffa and C.T. Boukoffa, 2006. Etude de l'effet des nitrites et des nitrates sur les retines in vitro. J. Fr. Ophtalmologie, 29: 32-36.
    Direct Link  |  
  35. Guenane, H., D. Hartani, L. Chachoua, O.S.L. Boukoffa, S. Mazari and C.T. Boukoffa, 2006. Production des cytokines Th1 /Th2 et du monoxyde d'azote au cours de l'uveite Behcet et de l'uveite idiopathique : impact sur le pronostic des deux pathologies. J. Fr. Ophtalmologie, 29: 146-152.
  36. Aissa, S.A., M. Amri, R. Bouteldja, J. Wietzerbin and C.T. Boukoffa, 2006. Alteration in Interferon Y and Nitric oxide production in human echinococcosis : IFNγ and NO in anti-hydatic immune response. Bio. Cell. Mol., 52: 65-70.