Dr. Enas Mahmoud  Moustafa
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Dr. Enas Mahmoud Moustafa

Postdoctoral Research
Atomic Energy Authority, Egypt


Highest Degree
Ph.D. in Physiology from Ain Shams University, Egypt

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Biography

Enas Mahmoud Moustafa, is an Postdoctoral Research Associate at Department of Radiation Biology,
National Centre for Radiation Research and Technology, Atomic Energy Authority, Egypt. Over 12 scientific papers and projects either presented or published. Im internationally recognized expert in many areas of cancer which is one of the major causes of death. I believe that future improvements can increase sustainability, such as antitumor drugs, and many others of novel applications. My research has focused on molecular evolution and the regulatory regions of genes involved in cancer and the synergistic effect between antitumor and radiation. Also, My research focuses on the biological effects of low radiation doses and mixed beams of radiation of different LET, mechanisms of radiation-induced chromosomal aberrations, biomarkers of radiation exposure and biological dosimetry. I am concerned in how environment-associated accumulation of oxidative modifications to proteins affects their structure and function. Also, I am interested in how environmental toxins affect protein-protein and DNA-protein interactions. my Laboratory Skills as DNA isolation, chromatography, absorbance spectroscopy, steady state and pre-steady state kinetics, fluorescent microscopy, SDSPAGE, sterile technique, culture maintenance, media preparation,restriction enzyme digestion, expression, plate assays, redox assays, Calibration and use of scanners and radiation shielding, Measurement of radiation doses.

Area of Interest:

Molecular Sciences
100%
Environmental Toxins
62%
Molecular Biology
90%
Cancer Research
75%
Radiation Biology
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Thabet, N.M., M.K. Abdel-Rafei and E.M. Moustafa, 2020. Boswellic acid protects against Bisphenol-A and gamma radiation induced hepatic steatosis and cardiac remodelling in rats: role of hepatic PPAR-α/P38 and cardiac Calcineurin-A/NFATc1/P38 pathways. Arch. Physiol. Biochem., 10.1080/13813455.2020.1727526.
    CrossRef  |  Direct Link  |  
  2. Moustafa, E.M., S.I. Ibrahim and F.A.F. Salem, 2020. Methylsulfonylmethane inhibits lung fibrosis progression, inflammatory response, and epithelial-mesenchymal transition via the transforming growth factor-Β1/SMAD2/3 pathway in rats exposed to both γ-radiation and Bisphenol-A. Toxin Rev., 10.1080/15569543.2020.1728337.
    CrossRef  |  Direct Link  |  
  3. Moustafa, E.M., L.A. Rashed, M.M. El-Sebaie, N.M. Thabet and M.K. Abdel-Rafei, 2020. Crosstalk between ER-stress and apoptosis in irradiated HepG2 cells with gemcitabine: implication of PI3K/AKT and IκB/NF-κB signaling pathways. J. Radiat. Res. Appl. Sci., 13: 144-154.
    CrossRef  |  Direct Link  |  
  4. Moustafa, E.M., A.A. Hassan, I.H. EL-Khashab and S.Z. Mansour, 2020. The role of Garcinol in abrogating cyclophosphamide/radiation nephrotoxicity via suppressing Mincle/Syk/NF-κB signaling pathway. Toxin Rev., 10.1080/15569543.2020.1780450.
    CrossRef  |  Direct Link  |  
  5. Moustafa, E.M., A.A. Hassan, I.H. EL-Khashab and S.Z. Mansour, 2020. The role of Garcinol in abrogating cyclophosphamide/radiation nephrotoxicity via suppressing Mincle/Syk/NF-κB signaling pathway. Toxin Rev., 10.1080/15569543.2020.1780450.
    CrossRef  |  Direct Link  |  
  6. Thabet, N.M. and E.M. Moustafa, 2017. Synergistic effect of ebselen and gamma radiation on breast cancer cells. Int. J. Radiat. Biol., 93: 784-792.
    CrossRef  |  PubMed  |  Direct Link  |  
  7. Moustafa, E.M., M.A. Mohamed and N.M. Thabet, 2017. Gallium nanoparticle-mediated reduction of brain specific serine protease-4 in an experimental metastatic cancer model. Asian Pac. J. Cancer Prev., 18: 895-903.
    CrossRef  |  PubMed  |  Direct Link  |  
  8. Moustafa, E.M. and N.M. Thabet, 2017. Beta-sitosterol upregulated paraoxonase-1 via peroxisome proliferator-activated receptor-γ in irradiated rats. Can. J. Physiol. Pharmacol., 95: 661-666.
    CrossRef  |  PubMed  |  Direct Link  |  
  9. Mansour, S.Z., E.M. Moustafa, A.A. Hassan and N.M. Thabet, 2017. Estrogen deficiency induced neurodegenerative in ovariectomized rats. Indian J. Exp. Biol., 55: 279-285.
  10. Enas, M.M., Z.M. Somaya and I.I. Sahar, 2017. Attenuation of spirulina platensis on acute liver injury in rats exposed to both gamma-radiation and carbon tetrachloride. Fresenius Environ. Bull., 26: 216-224.
  11. Thabet, N.M., E.M. Moustafa and I.H. El-Khashab, 2016. Evaluation of pro-apoptotic activity of Chelidonium majus L. and/or gamma-radiation against ehrlich as carcinoma transplanted in mice. Biosci. J., 32: 1657-1668.
    CrossRef  |  Direct Link  |  
  12. Moustafa, E.M., N.M. Thabet and K.S. Azab, 2016. Boswellic acid disables signal transduction of IL-6-STAT-3 in Ehrlich ascites tumor bearing irradiated mice. Biochem. Cell Biol., 94: 307-313.
    CrossRef  |  PubMed  |  Direct Link  |  
  13. Moustafa, E.M., M.K. Abdel-Rafei, N.M. Thabet and H.F. Hasan, 2015. Moringa oleifera leaf ethanolic extract subsidized by low doses of gamma irradiation modulates the thioacetamide induced fibrotic signs in liver of albino rats. Pak. J. Zool., 47: 793-802.
    Direct Link  |  
  14. Abdel-Rafei, M.K., H.F. Hasan, E.M. Moustafa and K.S. Azab, 2015. Moringa oleifera extract hinders the cascades of amiodarone mediated thyrotoxicosis in albino rats. Int. J. Pharm. Biol. Sci., 5: 192-200.