Dr. Magdy Abd-ElRehim Sayed Aly
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Dr. Magdy Abd-ElRehim Sayed Aly

Professor
Department of Cytology and Genetics, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt

Highest Degree
Ph.D. in Medical Cytogenetics from Catholic University of Leuven, Belgium

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Biography

Dr. Magdy Abd-ElRehim Sayed Aly obtained his Ph.D. in Medical Cytogenetic from Catholic University of Leuven, Belgium. His area of research experience and interest related to Genetics, experience in Short and Long Term Tissue Culture for Cytogenetic Analysis (Solid Tumors and Hematological Malignancies), Prenatal and Postnatal Cytogenetic Analysis, Slide Preparation, Multi-Colour Fluorescence in Situ Hybridization (FISH) Technique, Ability to Produce Accurate Karyotypes and Analyses in a Timely Manner. He has published 46 articles in journals contributed as author/co-author.

Area of Interest:

Biomedical Sciences
100%
Genetics and Genomics
62%
Clinical Bacteriology
90%
Molecular Genetics
75%
Cancer Biology
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
74
Abstracts
0

Selected Publications

  1. Fawzy, N.M., K.M. Ahmed, H.M. Abo-Salem and M.S. Aly, 2020. New furochromone derivatives as promising in-vitro anti-proliferative agents toward HepG-2 and MCF-7 cell lines with molecular docking studies. J. Heterocycl. Chem., 57: 2748-2761.
    CrossRef  |  Direct Link  |  
  2. Fawzy, N.M., A.E. Sarhan, E.A. Elhefny, A.M. Nasef and M.S. Aly, 2020. Synthesis, cytotoxicity evaluation, and molecular docking studies of novel pyrrole derivatives of khellin and visnagin via one-pot condensation reaction with curcumin. Russ. J. Bioorg. Chem., 46: 1117-1127.
    CrossRef  |  Direct Link  |  
  3. Mohamed, H.M. and M.S. Aly, 2018. Evaluation of genotoxicity of Euphorbia triaculeata Forssk. extract on mice bone marrow cells in vivo. Toxicol. Rep., 5: 625-631.
    CrossRef  |  Direct Link  |  
  4. Borik, R., N. Fawzy, S. Abu-Bakr and M. Aly, 2018. Design, synthesis, anticancer evaluation and docking studies of novel heterocyclic derivatives obtained via reactions involving curcumin. Molecules, Vol. 23. 10.3390/molecules23061398.
    CrossRef  |  Direct Link  |  
  5. Mohamed, H.M., M.S. Aly and T.D. Hussein, 2017. Genetic alterations in benign prostatic hyperplasia patients. GMS German Med. Sci. Interdiscip. J., Vol. 15. 10.3205/000257.
    CrossRef  |  Direct Link  |  
  6. Fawzy, N.M., A.M. Nasef, M.M.E-Baroudy, A.M. Soliman and M.S. Al, 2017. New studying for one-pot multicomponent reactions to prepare novel furochromone compounds with antitumor activity. Chem. Res. J., 2: 293-308.
    Direct Link  |  
  7. Aly, M.S., H.M. Khaled, M. Emara and T.D. Hussein, 2012. Cytogenetic profile of locally advanced and metastatic schistosoma-related bladder cancer and response to chemotherapy. Cancer Genet., 205: 156-162.
    CrossRef  |  PubMed  |  Direct Link  |  
  8. Aly, M.S., A.A. Bahnassy and Z.N. Abdel-Rahman, 2010. Investigation of chromosomal aberrations in Egyptian hepatocellular carcinoma patients by fluorescence in situ hybridization. Indian J. Hum. Genet., 16: 87-93.
    CrossRef  |  Direct Link  |  
  9. Al-Qahtani, A., T. Al-Hazzani, T. Al-Hussain, A. Al-Ghamdi and H. Al-Mana et al., 2010. Correlation between clinical characteristics, survival and genetic alterations in patients with hepatocellular carcinoma from Saudi Arabia. Cancer Genet. Cytogenet., 203: 269-277.
    CrossRef  |  PubMed  |  Direct Link  |  
  10. Al-Fifi, Z.I. and M.S. Aly, 2010. Protective effect of green tea against dimethylnitrosamine induced genotoxicity in mice bone marrow cells. Open Cancer J., 3: 16-21.
    Direct Link  |  
  11. Ismail, M.F., M.S. Aly, H.M. Khaled and H.M. Mohamed, 2009. Detection of Her-2/neu, c-myc amplification and p53 inactivation by FISH in Egyptian patients with breast cancer. GMS German Med. Sci., Vol. 7. .
    PubMed  |  
  12. Hussein, T.D. and M.S. Aly, 2007. Genotoxic and histopathological effects of Amoxicillin on some tissues of albino mice. Egypt. J. Zool., 48: 1-19.
  13. Al-Qahtani, A.A. and M.S. Aly, 2007. Comparison of genetic changes in transitional and squamous bilharzial-related bladder cancers using fluorescence in situ hybridization. Int. J. Cancer Res., 3: 127-133.
    CrossRef  |  Direct Link  |  
  14. Attia, M.N.T. and M.A. Ali, 2006. Hepatoprotective activity of allicin against carbon tetrachloride induced hepatic injury in rats. J. Biol. Sci., 6: 457-468.
    CrossRef  |  Direct Link  |  
  15. Aly, M.S., 2005. XYY male with gastrointestinal stromal tumor. J. Egypt. Ger. Soc. Zool., 48: 19-28.
  16. Aly, M.S., 2005. Interphase cytogenetics of male breast cancer. Breast J., 11: 533-534.
    PubMed  |  
  17. Aly, M.S., 2005. HER-2/neu gene amplification in prostate cancer by fluorescence in situ hybridization. Int. J. Cancer Res., 1: 5-9.
    CrossRef  |  Direct Link  |  
  18. Khaled, H.M., M.S. Aly and N. Mokhtar, 2004. Chromosomal aberrations in Cis and Ta bilharzial bladder cancer: A theory of pathogenesis. Urol. Oncol., 22: 443-447.
    Direct Link  |  
  19. El-Ghore, A.A., S.A. Haroon, M.S. Aly and E.M. Abedella, 2004. Development of specific SCAR-markers for Meloidogyne incognita and Meloidogyne javanica. Arab J. Biotechnol., 7: 37-44.
  20. Aly, M.S. and H.M. Khaled, 2004. Detection of C-erb B2 gene amplification in bilharzial associated bladder cancer using fluorescence in situ hybridization. Urol. Oncol., 22: 448-452.
    Direct Link  |  
  21. Haroon, S.A., A.A. El-Ghore, M.S. Aly and E.M. Abedella, 2003. Identification of different root-knot nematodes and detection of intraspecific and intrapopulation genetic variabilities between different nematode samples using RAPD technique. Arab J. Biotechnol., 6: 247-266.
  22. Haroon, S.A., A.A. El-Ghore, J. Bakker, L. Qin, G. Smant, M.S. Aly and E.M. Abedella, 2003. Cloning full length cDNAs of dorsal gland specifiec genes of putative pathogenictiy factors from potato cyst nematode Globodera rostochiensis. Arab J. Biotechnol., 6: 89-102.
  23. El-Ghore, A.A., S.A. Haroon, J., Bakker, L. Qin, G. Smant, M.S. Aly and E.M. Abedella, 2003. Evaluation of a novel method of RNA fingerprinting based on AFLP to compare between avirulent L19 and virulent L22 of potato cyst nematode Globodera rostochiensis. Arab J. Biotechnol., 6: 79-88.
  24. Aly, M.S., M.B. Ashour, S.M. El-Nahas and M.A.F. Abo-Zeid, 2003. Genotoxicity and cytotoxicity of the anticancer drugs gemcitabine and cisplatin, separately and in combination: In vivo studies. J. Biol. Sci., 3: 961-972.
    CrossRef  |  Direct Link  |  
  25. Aly, M.S., M.B. Ashour, S.M. El-Nahas and H.M. Mohamed, 2002. Mutagenic potential of radiofrequency electromagenetic fields. J. Biol. Sci., 2: 254-258.
    CrossRef  |  Direct Link  |  
  26. Aly, M.S., A. Wojcik, C. Schunck and G. Obe, 2002. Correlation of chromosomal aberrations and sister chromatid exchanges in individual CHO cells pre-labelled with BrdU and treated with DNaseI or X-rays. Int. J. Radiat. Biol., 78: 1037-1044.
    PubMed  |  
  27. Aly, M.S. and H.M. Khaled, 2002. Chromosomal aberrations in early-stage bilharzial bladder cancer. Cancer Genet. Cytogenet, 132: 41-45.
    Direct Link  |  
  28. Khaled, H.M., M.S. Aly and I.T. Magrath, 2000. Loss of Y chromosome in bilharzial bladder cancer. Cancer Genet. Cytogenet., 117: 32-36.
    PubMed  |  
  29. Aly, M.S., E.O. Othman and S.M. El-Nahas, 2000. Aneuploidy in EMF occupationally exposed workers detected by fish. J. Egypt. Ger. Soc. Zool., 31: 9-23.
  30. Aly, M.S., O.E. Othman and S.M. El-Nahas, 1999. Specific numerical chromosomal aberrations induced by adriamycin. Environ. Mol. Mutag., 33: 161-166.
    PubMed  |  Direct Link  |  
  31. Aly, M.S. and H.M. Khaled, 1999. Chromosomal aberrations in Bilharzial bladder cancer as detected by fluorescence in situ hybridization. Cancer Genet. Cytogenet, 114: 62-67.
    Direct Link  |  
  32. Aly, M.S., 1998. Fluorescence in situ hybridizaion: A useful method in addition to routine cytogenetic techniques in neoplastic disorders. Egypt. J. Histol., 21: 33-38.
  33. Aly, M.S., 1998. Chromosomal damage induced in adult mice by carbofuran. J. Egypt. Ger. Soc. Zool., 26: 1-10.
  34. Ceratto, N., C. Dobkin, M. Carter, E. Jenkins and X.L. Yao et al., 1997. Human type I cytokeratin genes are a compact cluster. Cytogenet. Cell Genet., 77: 169-174.
    PubMed  |  
  35. Groenen, P.M.A., E. Garcia, R. Thoelen, M.S. Aly and E.F.P.M. Schoenmakers et al., 1996. Isolation of cosmids corresponding to the chromosome breakpoints of a de novo, autosomal t(6,19)(p21,q13.1) translocation of a patient with multicystic renal dysplasia. Cytogenet. Cell Genet., 75: 210-215.
    PubMed  |  
  36. Van Hoof, C., M.S. Aly, A. Garcia, X. Cayla, J.J. Cassiman, W. Merlevede and J. Goris, 1995. Structural and chromosomal localisation of the human gene of the phosphotyrosyl phosphatase activator (PTPA) of protein phosphatase 2A. Genomics, 28: 261-272.
    PubMed  |  
  37. Dal Cin, P., R. Sciot, M.S. Aly, J. Delabie and M. Stas et al., 1994. Some Desmoid tumors are characterised by trisomy 8. Genes Chromosomes Cancer, 10: 131-135.
    PubMed  |  
  38. Aly, M.S., P. Dal Cin, W. van den Voorde, H. van Poppel, F. Ameye, L. Baert and H. van den Berghe, 1994. Chromosome abnormalities in benign prostatic hyperplasia. Genes Chromosomes Cancer, 9: 227-233.
    PubMed  |  
  39. Aly, M.S., P. Dal Cin, P. Jiskoot, G. Deneffe, P. Marynen and H. van den Berghe, 1994. Competitive in situ hybridization in a mediastinal germ cell tumor. Cancer Genet. Cytogenet., 73: 53-56.
    PubMed  |  
  40. Aly, M.S., P. Dal Cin, P. Moereman, I. de Wever and K. Devriendt et al., 1993. Loss of the Y chromosome in a Malignant Sertoli tumor. Cancer Genet. Cytogenet., 65: 104-106.
    CrossRef  |  
  41. De Clerck, Y., C. Szpirer, M.S. Aly and J.J. Cassiman, 1992. The gene for tissue inhibitor metalloproteinases-2 is localized on the human chromosome arm 17q25. Genomics, 14: 782-784.
    PubMed  |  
  42. Dal Cin, P., M.S. Aly, de Wever, I. Moerman and H. van den Berghe, 1992. Endometrial stromal sarcoma: t(7;17)(p15-21;q12-21) is a non-random chromosome change. Cancer Genet. Cytogenet., 63: 43-46.
    PubMed  |  
  43. Dal Cin, P., C. de Wolf-Peeters, M.S. Aly, G. Deneffe, W. van Mieghem and H. van den Berghe, 1992. Ring chromosome 6 as the only change in a thymoma. Genes Chromosomes Cancer, 6: 234-244.
    CrossRef  |  
  44. Cuneo, A., I. Wlodarska, M.S. Aly, N. Piva and M.G. Carli et al., 1992. Non- radioactive in situ hybridization for the detection and monitoring of trisomy 12 in C-cell chronic lymphocytic leukemia. Br. J. Haematol., 81: 192-196.
    CrossRef  |  
  45. Cin, P.D., W. Sneyers, M.S. Aly, A. Segers and F. Ostijn et al., 1992. Involvement of 19q13 in follicular thyroid adenoma. Cancer Genet. Cytogenet., 60: 99-101.
    CrossRef  |  PubMed  |  Direct Link  |  
  46. Zhang, Z., S. Vekemans, M.S. Aly, M. Jaspers and P. Marynen et al., 1991. The gene for the alpha 4 subunit of the VLA-4 integrin maps to chromosome 2Q31-32. Blood, 78: 2396-2399.
    PubMed  |  Direct Link  |  
  47. Jaspers, M., P. Marynen, M.S. Aly, H. Cuppens and C. Hilliker et al., 1991. Localization of the gene encoding the α2 subunit of the human VLA-2 receptor to chromosome 5q23-31. Somatic Cell Mol. Genet., 17: 505-511.
    CrossRef  |  PubMed  |  Direct Link  |  
  48. Hilliker, C.E., M.I. Darville, M.S. Aly, M. Chikri and C. Szpirer et al., 1991. Human and rat chromosomal localization of two genes for 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase by analysis of somatic cell hybrids and in situ hybridization. Genomics, 10: 867-873.
    CrossRef  |  PubMed  |  Direct Link  |  
  49. Cin, P.D., P. Brock, M.S. Aly, M.C.V. Daele and I.D. Wever et al., 1991. A variant (2;13) translocation in rhabdomyosarcoma. Cancer Genet. Cytogenet., 55: 191-195.
    CrossRef  |  PubMed  |  Direct Link  |  
  50. Amer, S.M. and M.A. Sayed, 1987. Cytogenetic effects of the insecticide methamidophos in mouse bone marrow and cultured mouse spleen cells. Z. Naturforsch., C: Biosci., 42: 21-30.
    PubMed  |