Dr. Qunwei  Zhang
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Dr. Qunwei Zhang

Associate Professor
University of Louisville, USA


Highest Degree
Ph.D. in Medical Science from University of Fukui, Japan

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Biography

Dr. Qunwei Zhang is currently working as Associate Professor, Associate Scientist in James Graham Brown Cancer Center, and Member of Center for Genetics and Molecular Medicine at University of Louisville, USA. He is also serving as Adjunct Professor in Zhejiang Academy of Medical Sciences, P.R of China, Member of Center for Environmental Genomics and Integrative Biology, Faculty Mentor in Environmental Health Sciences Training Grant, Adjunct Professor at School of Public Health, Peking University, and School of Public Health, Fujiang Medical University. Dr. Zhang received his MD degree from Fujiang Medical University and his MPH degree from the School of Public Health at Zhejiang University, China. After three years of experimental and clinical studies on the treatment of Pneumoconiosis by whole Lung Lavage, he entered a graduate program in the University of Fukui School of Medicine, Japan, and was got his PhD degree in 2000 for study of the Mechanism of Pulmonary effects of Metals Nano-Particles. His subsequent post-doctoral training was in laboratory at New York University School of Medicine where he studied the Molecular Mechanisms of Metal Toxicity and Carcinogenesis. He was then recruited to the Institute for Environmental Medicine at the University of Pennsylvania Medical Center as a Research Associate and Institute Associate Investigator, where he studied on the Mechanism of Oxidative Injury in Lung Ischemia-reperfusion. He has supervised 7 students thesis. Dr. Zhang received honors includes Faculty Award, Scientific Importance, Research! Louisville, Walter A. Rosenblith New Investigator Award from Health Effects Institute, Travel Grant, Third British Epidemiology and Public Health Course, Hiroshima, Japan, and Outstanding Scientific Researcher in Zhejiang Academy of Medical Sciences, Zhejiang Province, P.R. of China. His main area of scientific research focuses on Nanotoxicology, Pulmonary Toxicology, Metal Toxicology, Genotoxicology and Carcinogenesis, Lung Ischemia and Ion Channels, Free Radicals and Pulmonary Diseases, Gene expression and function, Ambient Ultrafine particles and NADPH Oxidase, and signal transduction involved in Tumor Promotion, Prevention and Cellular Function. He is professional member of Society of Toxicology, American Thoracic Society, and Kentucky Public Health Association. He is also serving as reviewer for number of journals, proposal regarding the potential publications, and reviewer for abstract for conference, and grants and study sections. He has published 7 book chapters, 74 research articles in peer review journals, 92 abstracts and presentations contributed as author/co-author. He also completed number of granted projects as principal investigator.

Area of Interest:

Pharmacology and Toxicology
100%
Pulmonary Toxicology
62%
Genotoxicology
90%
Carcinogenesis
75%
Free Radicals
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Yang, X., H. Shao, W. Liu, W. Gu and X. Shu et al., 2015. Endoplasmic reticulum stress and oxidative stress are involved in ZnO nanoparticle-induced hepatotoxicity. Toxicol. Lett., 234: 40-49.
    Direct Link  |  
  2. Xu, C., Q. Liu, Q. Zhang, Z. Jiang and A. Gu, 2015. Urinary enterolactone associated with liver enzyme levels in U.S. adults: NHANES survey. Br. J. Nutr. .
  3. Xu, C., Q. Liu, Q. Zhang, Z. Jiang and A. Gu, 2015. Urinary Enterolactone is Associated with Obesity and Metabolic Alteration in Men in the US National Health and Nutrition Examination Survey 2001-2010. Br. J. Nutr., 113: 683-690.
    PubMed  |  
  4. Feng, L., Y. Zhang, M. Jiang, Y. Mo and R. Wan et al., 2015. Up-regulation of Gadd45α after exposure to metal nanoparticles: The role of hypoxia inducible factor 1α. Environ. Toxicol., 30: 490-499.
    PubMed  |  
  5. Skeete, Z., H. Cheng, E. Crew, S. Shan and W. Zhao et al., 2014. Design of functional nanoparticles and assemblies for theranostic applications. ACS Applied Mater. Interfaces, 6: 21752-21768.
    PubMed  |  
  6. Wan, R., Y. Mo, L. Feng, S. Chien, D.J. Tollerud and Q. Zhang, 2012. DNA damage caused by metal nanoparticles: The involvement of oxidative stress and activation of ATM. Chem. Res. Toxicol., 25: 1402-1411.
    PubMed  |  
  7. Mo, Y., R. Wan, S. Chien, D.J. Tollerud and Q. Zhang, 2012. Combination effects of Cigarette smoke extract and ambient ultrafine particles on endothelial cells. Toxicol. In vitro, 26: 295-303.
    PubMed  |  
  8. Wan, R., Y. Mo, S. Chien, Y. Li, Y. Li, D.J. Tollerud and Q. Zhang, 2011. The role of hypoxia inducible factor-1α in MMP-2 and MMP-9 production by human monocytes exposed to nickel nanoparticles. Nanotoxicology, 5: 568-582.
    PubMed  |  
  9. Pushpakumar, S.B., G. Perez-Abadia, C. Soni, R. Wan and N. Todnem et al., 2011. Enhancing complement control on endothelial barrier reduced renal post-ischemia dysfunction. J. Surg. Res., 170: e263-e270.
    PubMed  |  
  10. Yu, M., Y. Mo, R. Wan, S. Chien, X. Zhang and Q. Zhang, 2010. Regulation of plasminogen activator inhibitor-1 expression in endothelial cells with exposure to metal nanoparticles. Toxicol. Lett., 195: 82-89.
    PubMed  |  
  11. Wattamwar, P.P., Y. Mo, R. Wan, R. Palli, Q. Zhang and T.D. Dziubla, 2010. Antioxidant activity of degradable polymer poly(trolox) to suppress oxidative stress injury in cells. Adv. Funct. Mater., 20: 147-154.
    Direct Link  |  
  12. Wang, L., J. Zhang, Y. Zheng, J. Yang, Q. Zhang and X. Zhu, 2010. Bioeffects of CdTe quantum dots on human umbilical vein endothelial cells. J. Nanosci. Nanotechnol., 10: 8591-8596.
    PubMed  |  
  13. Wang, J., R. Wan, Y. Mo, Q. Zhang, L. Sherwood and S. Chien, 2010. Creating a long-term diabetic rabbit model. Exp. Diabetes Res., Vol. 2010. 10.1155/2010/289614.
    CrossRef  |  Direct Link  |  
  14. Wang, J., R. Wan, Y. Mo, M. Li, Q. Zhang and S. Chien, 2010. Intracellular delivery of ATP enhanced healing process in full thickness skin wounds in diabetic animals. Am. J. Surg., 199: 823-832.
    PubMed  |  
  15. Wang, J., Q. Zhang, R. Wan, Y. Mo, M. Li, M. Tseng and S. Chien, 2009. Intracellular ATP enhanced skin wound healing in rabbits. Ann. Plastic Surg., 64: 180-186.
    PubMed  |  
  16. Mo, Y., R. Wan, S. Chien, D.J. Tollerud and Q. Zhang, 2009. Activation of endothelial cells after exposure to ambient ultrafine particles: The role of NADPH oxidase. Toxicol. Applied Pharmacol., 236: 183-193.
    PubMed  |  
  17. Mo, Y., R. Wan, J. Wang, S. Chien, D.J. Tollerud and Q. Zhang, 2009. Diabetes is associated with increased sensitivity of alveolar macrophages to urban particulate matter exposure. Toxicology, 262: 130-137.
    PubMed  |  
  18. Zhang, Q., S. Chatterjee, Z. Wei, W. Liu and A.B. Fisher, 2008. Rac and PI3 kinase mediate endothelial cell reactive oxygen species generation during normoxic lung ischemia. Antioxid Redox Signall., 10: 679-690.
    PubMed  |  
  19. Wan, R., Y. Mo, X. Zhang, S. Chien, D.J. Tollerud and Q. Zhang, 2008. Matrix metalloproteinase-2 and -9 are induced differently by metal nanoparticles in human monocytes: The role of oxidative stress and protein tyrosine kinase activation. Toxicol. Applied Pharmacol., 233: 276-285.
    PubMed  |  
  20. Mo, Y., X. Zhu, X. Hu, D.J. Tollerud and Q. Zhang, 2008. Cytokine and NO release from peripheral blood neutrophils after exposure to metal nanoparticles: In vitro and ex vivo studies. Nanotoxicology, 2: 79-87.
    Direct Link  |  
  21. Zhang, Q., I. Matsuzaki, S. Chatterjee and A.B. Fisher, 2005. Activation of endothelial NADPH oxidase during normoxic lung ischemia is KATP channel dependent. Am. J. Physiol. Lung Cell. Mol. Physiol., 289: L954-L961.
    PubMed  |  
  22. Matsuzaki, I., S. Chatterjee, Y. Manevich, K. DeBolt, Q. Zhang and A.B. Fisher, 2005. Membrane depolarization and NADPH oxidase activation in aortic endothelium during ischemia reflect altered mechanotransduction. Am. J. Physiol. Heart Circulatory Physiol., 288: 336-343.
    PubMed  |  
  23. Zhao, J., H. Chen, T. Davison, T. Kluz, Q. Zhang and M. Costa, 2004. Nickel-induced 1,4-alpha-glucan branching enzyme 1 upregulation via the hypoxic signaling pathway. Toxicol. Applied Pharmacol., 196: 404-409.
    PubMed  |  
  24. Davidson, T., T. Kluz, F. Burns, T. Rossman and Q. Zhang et al., 2004. Exposure to chromium (VI) in the drinking water increased susceptibility to UV-induced skin tumors in hairless mice. Toxicol. Applied Pharmacol., 196: 431-437.
    PubMed  |  
  25. Zhang, Q., Y. Kusaka, X. Zhu, K. Sato, Y. Mo, T. Kluz and K. Donaldson, 2003. Comparative toxicity of standard nickel and ultrafine nickel in lung after intratracheal instillation. J. Occupat. Health, 45: 20-32.
    PubMed  |  
  26. Zhang, Q., K. Salnikow, T. Kluz, L. Chen, W. Su and M. Costa, 2003. Inhibition and reversal of nickel-induced transformation by histone deacetylase inhibitor trichostatin A. Toxicol. Applied Pharmacol., 192: 201-211.
    PubMed  |  
  27. Salnikow, K., T. Davidson, Q. Zhang, L.C. Chen, W. Su and M. Costa, 2003. The involvement of hypoxia-inducible transcription factor-1-dependent pathway in nickel carcinogenesis. Cancer Res., 63: 3524-3530.
    Direct Link  |  
  28. Mo, Y., S.I. Feinstein, Y. Manevich, Q. Zhang, L. Lu, Y.S. Ho and A.B. Fisher, 2003. Mouse 1-Cys peroxiredoxin highly related intronless gene is an expressed pseudogene. FEBS Lett., 555: 192-198.
    PubMed  |  
  29. Zhang, Q., T. Kluz, K. Salnikow and M. Costa, 2002. Comparison of the cytotoxicity, cellular uptake and DNA- protein crosslinks induced by potassium chromate in lymphoblast cell line derived from three different individuals. Biol. Trace Element Res., 86: 11-22.
    PubMed  |  
  30. Costa, M., K. Salnikow, J.E. Sutherland, L. Broday, W. Peng, Q. Zhang and T. Kluz, 2002. The role of oxidative stress in nickel and chromate genotoxicity. Mol. Cell. Biochem., 234: 265-275.
    Direct Link  |  
  31. Cangul, H., L. Broday, K. Salnikow, J. Sutherland and W. Peng et al., 2002. Molecular mechanism of nickel carcinogenesis. Toxicol. Lett., 127: 69-75.
    PubMed  |  
  32. Zhang, Q., Y. Mo, J. Lou, X. Zhu, L. He and H. Zhong, 2001. Determination the platelet activating factor in silicotic patients and its effect on the fibroblast cells. Environ. Health Prevent. Med., 5: 134-137.
    PubMed  |  
  33. Sutherland, J.E., W. Peng, Q. Zhang and M. Costa, 2001. The histone acetylase inhibitor trichostatin A reduce nickel- induced gene silicening in yeast and mamalian cells. Mutat. Res., 497: 225-233.
    PubMed  |  
  34. Huang, C., Q. Zhang, J. Li, M. Ding and X. Shi et al., 2001. Involvement of Erks activation in cadmium-induced AP-1 transactivation in vivo and in vitro. Mol. Cell. Biochem., 222: 141-147.
    PubMed  |