Dr. Ahmad  Aljada
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Dr. Ahmad Aljada

Associate Professor
Kind Saud Bin Abdulaziz University for Health Sciences, Saudi Arabia


Highest Degree
Ph.D. in Biochemistry from State University of New York, USA

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Area of Interest:

Biomedical Sciences
100%
Pharmacology
62%
Angiogenesis
90%
Metabolism
75%
Diabetes
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Aljada, A., A. Saleh and S.A. Mousa, 2013. Induction of stress induced premature senescence by sirtuin-7 inhibition: A novel mechanism for multi drug resistance. J. Cancer Sci. Ther., 5: 182-189.
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  2. Aljada, A. and S.A. Mousa, 2012. Metformin and neoplasia: Implications and indications. Pharmacol. Therapeut., 133: 108-115.
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  3. Aljada, A., L. Dong and S.A. Mousa, 2010. Sirtuin-targeting drugs: Mechanisms of action and potential therapeutic applications. Curr. Opin. Invest. Drugs, 11: 1158-1168.
    PubMed  |  
  4. Doria, J. and A. Aljada, 2009. Insulin as Modulator of Adipose Inflammation. In: Adipose Tissue and Inflammation, Awad, A.B. and P.G. Bradford (Eds.). Chapter 6, CRC Press, Boca Raton, FL., USA., ISBN-13: 978-1420091304, pp: 99-114.
  5. Ahmad, A., S.K. Ashwin and S.A. Mousa, 2009. Peroxisome proliferator-activated receptor agonists: Do they increase cardiovascular risk? PPAR Res. 10.1155/2009/460764.
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  6. Mousa, S.A., J.J. Bergh, E. Dier, A. Rebbaa and L.J. O'Connor et al., 2008. Tetraiodothyroacetic acid, a small molecule integrin ligand, blocks angiogenesis induced by vascular endothelial growth factor and basic fibroblast growth factor. Angiogenesis, 11: 183-190.
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  7. Aljada, A., L. O'Connor, Y.Y. Fu and S.A. Mousa, 2008. PPARγ ligands, rosiglitazone and pioglitazone, inhibit bFGF- and VEGF-mediated angiogenesis. Angiogenesis, 11: 361-367.
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  8. Mousa, S.A., F. Zhang, A. Aljada, S. Chaturvedi and M. Takieddin et al., 2007. Pharmacokinetics and pharmacodynamics of oral heparin solid dosage form in healthy human subjects. J. Clin. Pharmacol., 47: 1508-1520.
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  9. Ghanim, H., A. Aljada, N. Daoud, R. Deopurkar, A. Chaudhuri and P. Dandona, 2007. Role of inflammatory mediators in the suppression of insulin receptor phosphorylation in circulating mononuclear cells of obese subjects. Diabetologia, 50: 278-285.
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  10. Dandona, P., A. Aljada, A. Chaudhuri and H. Ghanim, 2007. Oxidative Inflammatory Stress in Obesity and Diabetes. In: Stress in Health and Disease, Arnetz, B. and R. Ekman (Eds.). Wiley-VCH, New York, USA., pp: 307-310.
  11. Chaudhuri, A., D. Janicke, M. Wilson, H. Ghanim, G.E. Wilding, A. Aljada and P. Dandona, 2007. Effect of modified glucose-insulin-potassium on free fatty acids, matrix metalloproteinase and myoglobin in ST-elevation myocardial infarction. Am. J. Cardiol., 100: 1614-1618.
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  12. Iwai, S., A. Aljada, A. Higa, T. Nakanishi-Ueda and S. Fukuda et al., 2006. Activation of AP-1 and increased synthesis of MMP-9 in the rabbit retina induced by lipid hydroperoxide. Curr. Eye Res., 31: 337-346.
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  13. Ghanim, H., S. Dhindsa, A. Aljada, A. Chaudhuri, P. Viswanathan and P. Dandona, 2006. Low-dose rosiglitazone exerts an antiinflammatory effect with an increase in adiponectin independently of free fatty acid fall and insulin sensitization in obese type 2 diabetics. J. Clin. Endocrinol. Metab., 91: 3553-3558.
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  14. Dandona, P., A. Aljada, A. Chaudhuri and P. Mohany, 2006. Endothelial Dysfunction in Diabetes. In: Clinical Diabetes: Translating Research into Practice, Fonseca, V.A. (Ed.). Elsevier Inc., Philadelphia, PA., USA., pp: 78-88.
  15. Aljada, A., J. Friedman, H. Ghanim, P. Mohanty, D. Hofmeyer, A. Chaudhuri and P. Dandona, 2006. Glucose ingestion induces an increase in intranuclear nuclear factor κB, a fall in cellular inhibitor κB and an increase in tumor necrosis factor α messenger RNA by mononuclear cells in healthy human subjects. Metabolism, 55: 1177-1185.
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  16. Dhindsa, S., D. Tripathy, N. Sanalkumar, S. Ravishankar, H. Ghanim, A. Aljada and P. Dandona, 2005. Free fatty acid-induced insulin resistance in the obese is not prevented by rosiglitazone treatment. J. Clin. Endocrinol. Metab., 90: 5058-5063.
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  17. Dandona, P., P. Mohanty, A. Chaudhuri, R. Garg and A. Aljada, 2005. Insulin infusion in acute illness. J. Clin. Invest., 115: 2069-2072.
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  18. Dandona, P., A. Aljada, A. Chaudhuri, P. Mohanty and R. Garg, 2005. Metabolic syndrome: A comprehensive perspective based on interactions between obesity, diabetes and inflammation. Circulation, 111: 1448-1454.
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  19. Mohanty, P., A. Aljada, H. Ghanim, D. Hofmeyer and D. Tripathy et al., 2004. Evidence for a potent antiinflammatory effect of rosiglitazone. J. Clin. Endocrinol. Metab., 89: 2728-2735.
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  20. Ghanim, H., A. Aljada, D. Hofmeyer, T. Syed, P. Mohanty and P. Dandona, 2004. Circulating mononuclear cells in the obese are in a proinflammatory state. Circulation, 110: 1564-1571.
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  21. Dhindsa, S., D. Tripathy, P. Mohanty, H. Ghanim, T. Syed and A. Aljada, 2004. Differential effects of glucose and alcohol on reactive oxygen species generation and intranuclear nuclear factor-κB in mononuclear cells. Metabolism-Clin. Exp., 53: 330-334.
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  22. Dandona, P., A. Chaudhuri and A. Aljada, 2004. The relationship of fasting serum radioimmune insulin levels to incident coronary heart disease in an insulin-treated diabetic cohort. J. Clin. Endocrinol. Metab., 89: 5868-5869.
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  23. Dandona, P., A. Chaudhuri and A. Aljada, 2004. Endothelial dysfunction and hypertension in diabetes mellitus. Med. Clin. North Am., 88: 911-931.
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  24. Dandona, P., A. Aljada, H. Ghanim, P. Mohanty, C. Tripathy, D. Hofmeyer and A. Chaudhuri, 2004. Increased plasma concentration of macrophage migration inhibitory factor (MIF) and MIF mRNA in mononuclear cells in the obese and the suppressive action of metformin. J. Clin. Endocrinol. Metab., 89: 5043-5047.
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  25. Dandona, P., A. Aljada, A. Chaudhuri and P. Mohanty, 2004. Endothelial dysfunction, inflammation and diabetes. Rev. Endocrine Metab. Disorders, 5: 189-197.
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  26. Dandona, P., A. Aljada and A. Bandyopadhyay, 2004. Inflammation: The link between insulin resistance, obesity and diabetes. Trends Immunol., 25: 4-7.
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  27. Dandona, P. and A. Aljada, 2004. Endothelial dysfunction in patients with type 2 diabetes and the effects of thiazolidinedione antidiabetic agents. J. Diabetes Complications, 18: 91-102.
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  28. Dandona, P. and A. Aljada, 2004. Advances in diabetes for the millennium: Diabetes and the endothelium. MedGenMed, Vol. 6. .
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  29. Chaudhuri, A., D. Janicke, M.F. Wilson, D. Tripathy and R. Garg et al., 2004. Anti-inflammatory and profibrinolytic effect of insulin in acute ST-segment-elevation myocardial infarction. Circulation, 109: 849-854.
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  30. Aljada, A., P. Mohanty, H. Ghanim, T. Abdo, D. Tripathy, A. Chaudhuri and P. Dandona, 2004. Increase in intranuclear nuclear factor κB and decrease in inhibitor κB in mononuclear cells after a mixed meal: Evidence for a proinflammatory effect. Am. J. Clin. Nutr., 79: 682-690.
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  31. Aljada, A., H. Ghanim, P. Mohanty, T. Syed, A. Bandyopadhyay and P. Dandona, 2004. Glucose intake induces an increase in activator protein 1 and early growth response 1 binding activities, in the expression of tissue factor and matrix metalloproteinase in mononuclear cells and in plasma tissue factor and matrix metalloproteinase concentrations. Am. J. Clin. Nutr., 80: 51-57.
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  32. Tripathy, D., P. Mohanty, S. Dhindsa, T. Syed and H. Ghanim, A. Aljada and P. Dandona, 2003. Elevation of free fatty acids induces inflammation and impairs vascular reactivity in healthy subjects. Diabetes, 52: 2882-2887.
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  33. Tripathy, D., A. Aljada and P. Dandona, 2003. Free Fatty Acids (FFA) and endothelial dysfunction; role of increased oxidative stress and inflammation. Diabetologia, 46: 300-301.
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  34. Dandona, P., V. Kumar, A. Aljada, H. Ghanim and T. Syed et al., 2003. Angiotensin II receptor blocker valsartan suppresses reactive oxygen species generation in leukocytes, nuclear factor-κB, in mononuclear cells of normal subjects: Evidence of an antiinflammatory action. J. Clin. Endocrinol. Metab., 88: 4496-4501.
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  35. Dandona, P., S. Dhindsa, A. Aljada and R. Garg, 2003. Insulin as an anti-inflammatory and antiatherosclerotic hormone. Clin. Cornerstone Suppl., 4: S13-S20.
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  36. Dandona, P., A. Aljada, P. Mohanty, H. Ghanim, A. Bandyopadhyay and A. Chaudhuri, 2003. Insulin suppresses plasma concentration of vascular endothelial growth factor and matrix metalloproteinase-9. Diabetes Care, 26: 3310-3314.
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  37. Dandona, P., A. Aljada, A. Chaudhuri and A. Bandyopadhyay, 2003. The potential influence of inflammation and insulin resistance on the pathogenesis and treatment of atherosclerosis-related complications in type 2 diabetes. J. Clin. Endocrinol. Metab., 88: 2422-2429.
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  38. Dandona, P., A. Aljada and A. Chaudhuri, 2003. Vascular reactivity and thiazolidinediones. Am. J. Med., 115: 81-86.
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  39. Dandona, P., A. Aljada and A. Bandyopadhyay, 2003. The potential therapeutic role of insulin in acute myocardial infarction in patients admitted to intensive care and in those with unspecified hyperglycemia. Diabetes Care, 26: 516-519.
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  40. Dandona, P., A. Aljada and A. Bandyopadhyay, 2003. Hyperglycemia after myocardial infarction: Response to Dhatariya. Diabetes Care, 26: 2222-2223.
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  41. Aljada, A., 2003. Endothelium, inflammation and diabetes. Metab. Syndrome Related Disord., 1: 3-21.
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  42. Mohanty, P., H. Ghanim, W. Hamouda, A. Aljada, R. Garg and P. Dandona, 2002. Both lipid and protein intakes stimulate increased generation of reactive oxygen species by polymorphonuclear leukocytes and mononuclear cells. Am. J. Clin. Nutr., 75: 767-772.
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  43. Dandona, P., A. Aljada and P. Mohanty, 2002. The anti-inflammatory and potential anti-atherogenic effect of insulin: A new paradigm. Diabetologia, 45: 924-930.
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  44. Dandona, P. and A. Aljada, 2002. A rational approach to pathogenesis and treatment of type 2 diabetes mellitus, insulin resistance, inflammation and atherosclerosis. Am. J. Cardiol., 90: 27-33.
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  45. Aljada, A., H. Ghanim, P. Mohanty, N. Kapur and P. Dandona, 2002. Insulin inhibits the pro-inflammatory transcription factor early growth response gene-1 (Egr)-1 expression in Mononuclear Cells (MNC) and reduces plasma Tissue Factor (TF) and Plasminogen Activator Inhibitor-1 (PAI-1) concentrations. J. Clin. Endocrinol. Metab., 87: 1419-1422.
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  46. Aljada, A., H. Ghanim, E. Assian and P. Dandona, 2002. Tumor necrosis factor-[alpha] inhibits insulin-induced increase in endothelial nitric oxide synthase and reduces insulin receptor content and phosphorylation in human aortic endothelial cells. Metabolism, 51: 487-491.
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  47. Aljada, A., H. Ghanim and P. Dandona, 2002. Translocation of p47phox and Activation of NADPH Oxidase in Mononuclear Cells. In: Oxidants and Antioxidants: Ultrastructure and Molecular Biology Protocols, Armstrong, D. (Ed.). Springer, New York, USA., ISBN-13: 9780896038516, pp: 99-103.
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  48. Aljada, A., H. Ghanim and P. Dandona, 2002. Activation of Nuclear Factor-κB (NF-κB) in Mononuclear Cells (MNC). In: Oxidants and Antioxidants: Ultrastructure and Molecular Biology Protocols, Armstrong, D. (Ed.). Springer, New York, USA., ISBN-13: 9780896038516, pp: 105-110.
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  49. Al-Mubarak, S., S. Ciancio, A. Aljada, P. Mohanty, P. Mohanty, C. Ross and P. Dandona, 2002. Comparative evaluation of adjunctive oral irrigation in diabetics. J. Clin. Periodontol., 29: 295-300.
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  50. Ghanim, H., R. Garg, A. Aljada, P. Mohanty and Y. Kumbkarni et al., 2001. Suppression of nuclear factor-κB and stimulation of inhibitor κB by troglitazone: Evidence for an anti-inflammatory effect and a potential antiatherosclerotic effect in the obese. J. Clin. Endocrinol. Metab., 86: 1306-1312.
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  51. Dandona, P., P. Mohanty, W. Hamouda, H. Ghanim, A. Aljada, R. Garg and V. Kumar, 2001. Inhibitory effect of a two day fast on Reactive Oxygen Species (ROS) generation by leucocytes and plasma ortho-tyrosine and meta-tyrosine concentrations. J. Clin. Endocrinol. Metab., 86: 2899-2902.
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  52. Dandona, P., P. Mohanty, H. Ghanim, A. Aljada and R. Browne et al., 2001. The suppressive effect of dietary restriction and weight loss in the obese on the generation of reactive oxygen species by leukocytes, lipid peroxidation and protein carbonylation. J. Clin. Endocrinol. Metab., 86: 355-362.
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  53. Dandona, P., A. Aljada, P. Mohanty, H. Ghanim, W. Hamouda, E. Assian and S. Ahmad, 2001. Insulin inhibits intranuclear nuclear factor κB and stimulates IκB in mononuclear cells in obese subjects: Evidence for an anti-inflammatory effect? J. Clin. Endocrinol. Metab., 86: 3257-3265.
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  54. Dandona, P., A. Aljada, H. Ghanim, P. Mohanty, W. Hamouda and W. Al-Haddad, 2001. Acute suppressive effect of hydrocortisone on p47phox subunit of nicotinamide adenine dinucleotide phosphate oxidase. Metabolism, 50: 548-552.
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  55. Aljada, A., R. Garg, H. Ghanim, P. Mohanty, W. Hamouda, E. Assian and P. Dandona, 2001. Nuclear factor-κB suppressive and inhibitor-κB stimulatory effects of troglitazone in obese patients with type 2 diabetes: Evidence of an antiinflammatory action? J. Clin. Endocrinol. Metab., 86: 3250-3256.
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  56. Aljada, A., H. Ghanim, R. Saadeh and P. Dandona, 2001. Insulin inhibits NFκB and MCP-1 expression in human aortic endothelial cells. J. Clin. Endocrinol. Metab., 86: 450-453.
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  57. Aljada, A., H. Ghanim, P. Mohanty, D. Hofmeyer, D. Tripathy and P. Dandona, 2001. Hydrocortisone suppresses intranuclear Activator-Protein-1 (AP-1) binding activity in mononuclear cells and plasma Matrix Metalloproteinase 2 and 9 (MMP-2 and MMP-9). J. Clin. Endocrinol. Metab., 86: 5988-5991.
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  58. Aljada, A., H. Ghanim, J. Friedman, R. Garg, P. Mohanty and P. Dandona, 2001. Troglitazone reduces the expression of PPARγ while stimulating that of PPARα in mononuclear cells in obese subjects. J. Clin. Endocrinol. Metab., 86: 3130-3133.
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  59. Mohanty, P., W. Hamouda, R. Garg, A. Aljada, H. Ghanim and P. Dandona, 2000. Glucose challenge stimulates Reactive Oxygen Species (ROS) generation by leucocytes. J. Clin. Endocrinol. Metab, 85: 2970-2973.
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  60. Magsino Jr., C.H., W. Hamouda, V. Bapna, H. Ghanim, I.A. Abu-Reish, A. Aljada and P. Dandona, 2000. Nadolol inhibits reactive oxygen species generation by leukocytes and linoleic acid oxidation. Am. J. Cardiol., 86: 443-448.
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  61. Magsino Jr., C.H., W. Hamouda, H. Ghanim, R. Browne, A. Aljada and P. Dandona, 2000. Effect of triiodothyronine on reactive oxygen species generation by leukocytes, indices of oxidative damage and antioxidant reserve. Metabolism, 49: 799-803.
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  62. Garg, R., Y. Kumbkarni, A. Aljada, P. Mohanty, H. Ghanim, W. Hamouda and P. Dandona, 2000. Troglitazone reduces reactive oxygen species generation by leukocytes and lipid peroxidation and improves flow-mediated vasodilatation in obese subjects. Hypertension, 36: 430-435.
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  63. Dandona, P., R. Karne, H. Ghanim, W. Hamouda, A. Aljada and C.H. Magsino Jr., 2000. Carvedilol inhibits reactive oxygen species generation by leukocytes and oxidative damage to amino acids. Circulation, 101: 122-124.
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  64. Aljada, A., R. Saadeh, E. Assian, H. Ghanim and P. Dandona, 2000. Insulin inhibits the expression of intercellular adhesion molecule-1 by human aortic endothelial cells through stimulation of nitric oxide. J. Clin. Endocrinol. Metab., 85: 2572-2575.
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  65. Aljada, A. and P. Dandona, 2000. Effect of insulin on human aortic endothelial nitric oxide synthase. Metabolism, 49: 147-150.
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  66. Steinhorn, D.M., M.C. Papo, A.T. Rotta, A. Aljada, B.P. Fuhrman and P. Dandona, 1999. Liquid ventilation attenuates pulmonary oxidative damage. J. Crit. Care, 14: 20-28.
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  67. Dandona, P., T. Qutob, W. Hamouda, F. Bakri, A. Aljada and Y. Kumbkarni, 1999. Heparin inhibits reactive oxygen species generation by polymorphonuclear and mononuclear leucocytes. Thrombosis Res., 96: 437-443.
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  68. Dandona, P., P. Mohanty, W. Hamouda, A. Aljada, Y. Kumbkarni and R. Garg, 1999. Effect of dexamethasone on reactive oxygen species generation by leukocytes and plasma interleukin-10 concentrations: A pharmacodynamic study. Clin. Pharmacol. Ther., 66: 58-65.
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  69. Dandona, P., M. Suri, W. Hamouda, A. Aljada, Y. Kumbkarni and K. Thusu, 1999. Hydrocortisone-induced inhibition of reactive oxygen species by polymorphonuclear neutrophils. Crit. Care Med., 27: 2442-2444.
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  70. Dandona, P., A. Aljada, R. Garg and P. Mohanty, 1999. Increase in plasma interleukin-10 following hydrocortisone injection. J. Clin. Endocrinol. Metab., 84: 1141-1144.
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  71. Aljada, A., H. Ghanim, E. Assian, P. Mohanty, W. Hamouda, R. Garg and P. Dandona, 1999. Increased IκB expression and diminished nuclear NF-κB in human mononuclear cells following hydrocortisone injection. J. Clin. Endocrinol. Metab., 84: 3386-3389.
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  72. Ueda, T., T. Ueda, S. Fukuda, R. Browne and E. Jenis et al., 1998. Lipid hydroperoxide-induced Tumor Necrosis Factor (TNF)-α, vascular endothelial growth factor and neovascularization in the rabbit cornea: Effect of TNF inhibition. Angiogenesis, 1: 174-184.
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  73. Harris, L.M., D. Armstrong, R. Browne, A. Aljada and R. Peer et al., 1998. Premature peripheral vascular disease: Clinical profile and abnormal lipid peroxidation. Cardiovasc. Surg., 6: 188-193.
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  74. Dandona, P., R. Weinstock, K. Thusu, E. Abdel-Rahman, A. Aljada and T. Wadden, 1998. Tumor necrosis factor-α in sera of obese patients: Fall with weight loss. J. Clin. Endocrinol. Metab., 83: 2907-2910.
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  75. Armstrong, D., T. Ueda, T. Ueda, T. Hiramitsu and R. Stockton et al., 1998. Lipid Hydroperoxide Induced Retinal Pathology. In: Pathophysiology of Lipid Peroxides and Related Free Radicals, Yagi, K. (Ed.). Japan Scientific Societies Press, Tokyo, Japan, pp: 57-76.
  76. Armstrong, D., T. Ueda, T. Ueda, A. Aljada and R. Browne et al., 1998. Lipid hydroperoxide stimulates retinal neovascularization in rabbit retina through expression of tumor necrosis factor-a, vascular endothelial growth factor and platelet-derived growth factor. Angiogenesis, 2: 93-104.
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  77. Armstrong, D., A. Augustin, R. Spengler, A. Aljada, T. Nickola, F. Grus and F. Koch, 1998. Detection of vascular endothelial growth factor and tumor necrosis factor alpha in epiretinal membranes of proliferative diabetic retinopathy, proliferative vitreoretinopathy and macular pucker. Ophthalmologica, 212: 410-414.
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  78. Aljada, A. and P. Dandona, 1998. Nitric Oxide Synthase. In: Free Radical and Antioxidant Protocols, Armstrong, D. (Ed.). Springer, New York, USA., ISBN: 9780896034723, pp: 191-198.
  79. Fonseca, V.A., A. Stone, M. Munshi, B.S. Baliga and A. Aljada et al., 1997. Oxidative stress in diabetic macrovascular disease: Does homocysteine play a role? South Med. J., 90: 903-906.
    PubMed  |  
  80. Dandona, P., K. Thusu, U. Khurana, J. Love, A. Aljada and S. Mousa, 1996. Calcium, calmodulin and protein kinase C dependence of platelet shape change. Thrombosis Res., 81: 163-175.
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  81. Dandona, P., D. Nix, M.F. Wilson, A. Aljada, J. Love, M. Assicot and C. Bohuon, 1994. Procalcitonin increase after endotoxin injection in normal subjects. J. Clin. Endocrinol. Metab., 79: 1605-1608.
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