Dr. Samuel Binamin Kombian
My Social Links

Dr. Samuel Binamin Kombian

Professor
Department of Pharmacology and Toxicology, University for Development Studies, Tamale, Northern Region, Ghana

Highest Degree
Ph.D. in Pharmacy from Kuwait University, Kuwait

Share this Profile

Area of Interest:

Pharmacology and Toxicology
100%
Pharmacology
62%
Therapeutics
90%
Pharmacy
75%
Medical Science
55%

Research Publications in Numbers

Books
0
Chapters
1
Articles
74
Abstracts
2

Selected Publications

  1. Kombian, S.B., K.V. Ananthalakshmi, J.A. Zidichouski and T.M. Saleh, 2011. Cocaine sensitization does not alter Substance P effects on locomotion or excitatory synaptic transmission in the nucleus accumbens of rats. Neuropharmacology, .
    PubMed  |  
  2. Kombian, S.B. and O.A. Phillips, 2011. In vitro electrophysiological investigations of the acute effects of linezolid and novel oxazolidinones on central nervous system neurons. Neuroscience, 180: 53-63.
    PubMed  |  
  3. El-Hashim, A.Z., O.I. Edafiogho, S.A. Jaffal, M.H. Yousef, C.I. Ezeamuzie and S.B. Kombian, 2011. Anti-tussive and bronchodilator mechanisms of action for the enaminone E121. Life Sci., 89: 378-387.
    PubMed  |  
  4. Novotny, L., P. Rauko, S.B. Kombian and I.O. Edafiogho, 2010. Selenium as a chemoprotective anti-cancer agent: Reality or wishful thinking?. Neoplasma, 57: 383-391.
    PubMed  |  
  5. Nashawi, H., M.A. Ghazal and S.B. Kombian, 2010. Therapeutic approaches to age-related dementias: Rational search for effective drugs. Kuwait Med. J., 42: 3-14.
  6. Kombian, S.B., K.V. Ananthalakshmi, J.A. Zidichouski and T.M. Saleh, 2009. Substance P and cocaine employ convergent mechanisms to depress excitatory synaptic transmission in the rat nucleus accumbens in vitro. Eur. J. Neurosci., 29: 1579-1587.
    PubMed  |  
  7. Kombian, S.B., K.V. Ananthalakshmi and I.O. Edafiogho, 2008. Norepinephrine and E139 interactions on epileptiform activity in the rat hippocampus in vitro. Med. Princ. Pract., 17: 365-372.
    PubMed  |  
  8. Ananthalakshmi, K.V., T. Bartl, M.H. Aziza,L. Novotný, R. Marek, L. Benes and S.B. Kombian, 2008. Synthesis and structure-activity relationship studies of theophylline analogs on population responses in the rat hippocampus in vitro. Bioorg. Med. Chem., 16: 8142-8150.
    PubMed  |  
  9. Matowe, W.C., K.V. Ananthalakshmi and S.B. Kombian, 2007. Role of protein kinase C in substance P-induced synaptic depression in the nucleus accumbens in vitro. Med. Princ. Pract., 16: 90-99.
    PubMed  |  
  10. Edafiogho, I.O., S.B. Kombian, K.V.V. Ananthalakshmi, N.N. Salama and N.D. Eddington, 2007. Exploring additional therapeutics activities. J. Pharm. Sci., 96: 2509-2531.
  11. Ananthalakshmi, K.V., I.O. Edafiogho and S.B. Kombian, 2007. Anticonvulsant enaminone E139 suppresses epileptiform activity in the rat hippocampal slices. Epilepsy Res., 76: 85-92.
    PubMed  |  
  12. Kombian, S.B., K.V.V. Ananthalakshmi, S.S. Parvathy and W.C. Matowe, 2006. Cholecystokinin-2 receptors couple to cyclic AMP-protein kinase A to depress excitatory synaptic current in the rat nucleus accumbens in vitro. Can. J. Physiol. Pharmacol., 84: 203-211.
  13. Kombian, S.B., K.V. Ananthalakshmi and I.O. Edafiogho, 2006. Enaminones and norepinephrine employ convergent mechanisms to modulate excitatory synaptic transmission in rat nucleus accumbens in vitro. Eur J. Neurosci., 24: 2781-2788.
    PubMed  |  
  14. Fatehi, M., J.A. Zidichouski, S.B. Kombian and T.M. Saleh, 2006. 17beta-estradiol attenuates excitatory neurotransmission and enhances cell excitability in rat parabrachial neurons in vitro. J. Neurosci. Res., 84: 666-674.
    PubMed  |  
  15. Edafiogho, I.O., K.V. Ananthalakshmi and S.B. Kombian, 2006. Anticonvulsant evaluation and mechanism of action of benzylamino- enaminones. Bioorg. Med. Chem., 14: 5266-5272.
    PubMed  |  
  16. Ananthalakshmi, K.V., I.O. Edafiogho and S.B. Kombian, 2006. Concentration-dependent effects of anticonvulsant enaminone methyl 4-(4'-bromophenyl)aminocyclohex-3-en-6-methyl-2-oxo-1-oate on rat neuronal excitability in vitro. Neuroscience, 141: 345-356.
    PubMed  |  
  17. Abel-Hamid, M.E., L.H. Sharaf, S.B. Kombian and F.M.E. Diejomaoh, 2006. Determination of dydrogesterone in human plasma by tandem mass spectrometry: Application to therapeutic drug monitoring of dydrogesterone in gynecological disorders. Chromatographia, 64: 287-292.
    CrossRef  |  
  18. Kombian, S.B., K.V. Ananthalakshmi, S.S. Parvathy and W.C. Matowe, 2005. Cholecystokinin inhibits evoked IPSC in the rat nucleus accumbens indirectly through GABA and GABAB receptors. J. Neurosci. Res., 79: 412-420.
    PubMed  |  
  19. Kombian, S.B., I.O. Edafiogho and K.V. Ananthalakshmi, 2005. Anticonvulsant enaminones depress excitatory synaptic transmission in the rat brain by enhancing extracellular GABA level. Brit. J. Pharmacol., 145: 945-953.
    PubMed  |  
  20. Fatehi, M., S.B. Kombian and T.M. Saleh, 2005. 17beta-estradiol inhibits outward potassium currents recorded in rat parabrachial nucleus cells. Neuroscience, 135: 1075-1086.
    PubMed  |  
  21. Kombian, S.B., K.V. Ananthalakshmi, S.P. Subramanian and W.C. Matowe, 2004. Cholecystokinin activates CCKB receptors to excite cells and depress EPSCs in the rat rostral nucleus accumbens in vitro. J. Physiol., 555: 71-84.
    PubMed  |  
  22. Kombian, S.B., K.V. Ananthalakshmi, S.P. Subramanian and W.C. Matowe, 2003. Ubstance P depresses excitatory synaptic transmission in the nucleus accumbens through dopaminergic and purinergic mechanisms. J. Neurophysiol., 89: 728-737.
  23. Kombian, S.B., K.V. Ananthalakshmi, S.P. Subramanian and W.C. Matowe, 2003. Dopamine and adenosine mediate substance P-induced depression of evoked IPSCs in the rat nucleus accumbens in vitro. Eur. J. Neurosci., 18: 303-311.
    PubMed  |  
  24. Hirasawa, M., D. Mouginot, M.G. Kozoriz, S.B. Kombian and Q.J. Pittman, 2003. Vasopressin differentially modulates non-NMDA receptors in vasopressin and oxytocin neurons in the supraoptic nucleus. J. Neurosci., 23: 4270-4277.
    PubMed  |  
  25. Kombian, S.B., M. Hirasawa, D. Mouginot and Q.J. Pittman, 2002. Modulation of synaptic transmission by oxytocin and vasopressin in the supraoptic nucleus. Prog. Brain Res., 139: 235-246.
    PubMed  |  
  26. Edafiogho, E.E., O.A. Phillips, M. Abdel-Hamid, A.A.M. Ali, W.C. Matowe, A. El-Hashim and S.B. Kombian, 2002. Ultraviolet spectroscopy of anticonvulsant enaminones. Bioorg. Med. Chem., 10: 593-597.
    Direct Link  |  
  27. Kombian, S.B., M. Hirasawa, W.C. Matowe and Q.J. Pittman, 2001. GABAB receptors modulate short-term potentiation of spontaneous excitatory postsynaptic currents in the rat supraoptic nucleus in vitro. Neuropharmacology, 41: 554-564.
    Direct Link  |  
  28. Hirasawa, M., S.B. Kombian and Q.J. Pittman, 2001. Oxytocin retrogradely inhibits evoked, but not miniature EPSCs in the rat supraoptic nucleus: Role of N-and P/Q-type calcium channels. J. Physiol., 532: 595-607.
    Direct Link  |  
  29. Pittman, Q.J., M. Hirasawa, D. Mouginot and S.B. Kombian, 2000. Neurohypophysial peptides as retrograde transmitters in the supraoptic nucleus. Exp. Physiol., 85: 139-144.
    PubMed  |  
  30. Kombian, S.B., M. Hirasawa, D. Mouginot, X. Chen and Q.J. Pittman, 2000. Short term potentiation of miniature excitatory postsynaptic currents causes excitation of supraoptic neurons. J. Neurophysiol., 83: 2542-2553.
    Direct Link  |  
  31. Kombian, S.B., D. Mouginot, M. Hirasawa and Q.J. Pittman, 2000. Vasopressin preferentially depresses excitatory over inhibitory synaptic transmission in the rat supraoptic nucleus in vitro. J. Neuroendocrinology, 12: 361-367.
  32. Chen, X., S.B. Kombian, J.A. Zidichouski and Q.J. Pittman, 1999. Dopamine depresses excitatory synaptic transmission predominantly via presynaptic D1-like receptors in the rat parabrachial nucleus. Neuroscience, 90: 457-468.
  33. Pittman, Q.J., S.B. Kombian, D. Mouginot, X. Chen and F.J. van Eerdenberg, 1998. Electrophysiological studies of neurohypophysial neurons and peptides. Prog. Brain Res., 119: 311-320.
  34. Pittman, Q.J., D. Mouginot and S.B. Kombian, 1998. GABAB receptors and supraoptic neuronal activity. Adv. Exp. Med. Biol., 449: 107-115.
    PubMed  |  
  35. Mouginot, D., S.B. Kombian and Q.J. Pittman, 1998. Activation of presynaptic GABAB receptors inhibits evoked IPSCs in rat magnocellular neurons in vitro. J. Neurophysiol, 79: 1508-1517.
    Direct Link  |  
  36. Saleh, T.M., S.B. Kombian, J.A. Zidichouski and Q.J. Pittman, 1997. Cholecystokinin and neurotensin inversely modulate excitatory synaptic transmission in the parabrachial nucleus in vitro. Neuroscience, 77: 23-35.
    CrossRef  |  
  37. Kombian, S.B., T.M. Saleh, N.I.Y. Fiagbe, X. Chen, J.J. Akabutu, J.K. Boulamwini and Q.J. Pittman, 1997. Ibogaine and a total alkaloidal extract of Voacanga africana modulate neuronal excitability and synaptic transmission in the rat parabrachial nucleus in vitro. Brain Res. Bull., 44: 603-610.
    Direct Link  |  
  38. Kombian, S.B., D. Mouginot and Q.J. Pittman, 1997. Dendritically released peptides act as retrograde modulators of afferent excitation in the supraoptic nucleus in vitro. Neuron, 19: 903-912.
    PubMed  |  
  39. Saleh, T.M., S.B. Kombian, J.A. Zidichouski and Q.J. Pittman, 1996. Peptidergic modulation of synaptic transmission in the parabrachial nucleus in vitro: Importance of degradative enzymes in regulating synaptic efficacy. J. Neurosci., 16: 6046-6055.
    PubMed  |  
  40. Nicola, S.M., S.B. Kombian and R.C. Malenka, 1996. Psychostimulants depress excitatory synaptic transmission in the nucleus accumbens in vitro via activation of a presynaptic D1-like dopamine receptor. J. Neurosci., 16: 1591-1604.
    PubMed  |  
  41. Kombian, S.B., J.A. Zidichouski and Q.J. Pittman, 1996. GABAB receptors presynaptically modulate excitatory synaptic transmission in the supraoptic nucleus of the rat hypothalamus in vitro. J. Neurophysiol., 76: 1166-1179.
    PubMed  |  
  42. Kombian, S.B. and R.C. Malenka, 1994. Simultaneous LTP of non-NMDA and LTD of NMDA receptor-mediated responses in the nucleus accumbens. Nature, 368: 242-246.
    PubMed  |  
  43. Kombian, S.B., R.J. Reiffenstein and W.F. Colmers, 1993. The actions of hydrogen sulfide in dorsal raphe serotonergic neurons in vitro. J. Neurophysiol., 70: 81-95.
    PubMed  |  
  44. Kombian, S.B. and W.F. Colmers, 1992. Neuropeptide Y selectively inhibits slow synaptic potentials in dorsal raphe nucleus by a presynaptic action. J. Neurosci., 12: 1086-1093.
    PubMed  |  
  45. Warenycia, M.W., S..B Kombian and RJ. Reiffenstein, 1990. Stress-induced increases in brainstem amino acid levels are prevented by chronic sodium hydrosulfide treatment. Neurotoxicology, 11: 93-97.
    PubMed  |  
  46. Warenycia, M.W., L.R. Goodwin, D.M. Francom, F.P. Dieken, S.B. Kombian and R.J. Reiffenstein, 1990. Dithiothreitol liberates non-acid labile sulfide from brain tissue of H2S-poisoned animals. Arch. Toxicol., 64: 650-655.
    CrossRef  |  
  47. Warenycia, M.W., K.A. Smith, C.S. Blashko, S.B. Kombian and R.J. Reiffenstein, 1989. Monoamine oxidase inhibition as a sequel of hydrogen sulfide intoxication: Increases in brain catecholamine and 5-hydroxy-tryptamine levels. Arch. Toxicol., 63: 131-136.
    PubMed  |  
  48. Kombian, S.B., M.W. Warenycia, F.G. Mele and R.J. Reiffenstein, 1988. Effects of acute intoxication with hydrogen sulfide on central amino acid transmitter systems. Neurotox, 9: 587-596.
    PubMed  |